MIRC for NIH Research Consortia

InfoRad, RSNA, 2004

John Pearson, Ph.D.Siemens Corporate Research

Princeton, NJ

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

Introduction: MIRC for NIH Research “Networks”• New U54 Program Announcements establish multi-institutional,

inter-disciplinary consortia• Consortia are formed to pool expertise, validate approaches,

forge common instrumentation platforms, and rapidly translate promising new medical imaging technologies toward clinical trials.

• One such consortia is the “Breast Cancer Diffuse Optical Imaging” (BCDOI) network, sponsored by the NCI’s “Networks for Translational Research: Optical Imaging” (NTROI). – 5 year, $18M program started Sept. 2003– UCI (B. Tromberg, PI), MIT/MGH, Dartmouth, UPENN, SCR, U. Illinois, NIH

• This talk introduces the BCDOI’s plans for developing a MIRC-based infra-structure to support multi-institutional imaging research

• Our extensions to MIRC, called C-MIRC (“C” for “Collaboration), will be made in a general way to support multi-institutional imaging research projects

• The spirit of C-MIRC is to provide a “Collaborative Lab Notebook” to enable the multi-institutional team to function as a seamless organization – we invite your suggestions!

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

C-MIRC Hierarchical Data Representation

Program

Project

Experiment

Subject

Study

Series

Data

The Data can be in many formats and containers, including DICOM/PACS, but also unstructured documents – whatever is convenient to the researcher.

(e.g., Multimodal Fusion)

(e.g., MR/Optical Fusion, or Tomosynthesis/Optical Fusion)

(e.g., MR/Optical with UPENN imager using ICG contrast)

Research Category Levels

Data Levels

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

PACS

Files

Centralized Management of Metadata, Forms, User Accounts, Distributed Local Storage of Data

Forms,Users,

Metadata

PACS

Files

FilesPACS

FilesLabData

PACSPACSLab

Data

Dartmouth UPENN

UCI

SCR

Secure Connection

Links toImage/Lab

Data

Links toImage/Lab

Data

MIT-MGH

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

C-MIRC Service Overview

C-MIRCC-MIRC

C-MIRC

C-MIRC

C-MIRC

Data Exchange via XMLover the InternetExperiment

Submit

MIRC Core Services

ExperimentCollection

TreeStorage

TreeQuery

CollaborativeNotification

ComputePlugins

CLN: Collaborative Lab Notebook

Metadata

CLN Specific Services

MIRC Extension Services

CLNIntegrated

Bulletin Board

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

Enter Username and Password to logon to the system.

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

„Where Am I“ Navigation within HierachyRecent Messages and tasks pending.

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

List of Experiments we can currenty access

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

We can link data to a Study be selecting a PACS.

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

Browse the PACS structure and add pictures.

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

We want to searchfor some data at the C-MIRC at UPENN.

Select UPENN fromThe listbox in theProgram tab

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

We want to searchfor some data at the C-MIRC at UPENN.

Select UPENN fromThe listbox in theProgram tab

To see which projects there are within this program click the Project Tab

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

There are currentlyonly two projects at UPENN.

We select the DOT/MR Fusion Project ...

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

There are currentlyonly two projects at UPENN.

We select the DOT/MR Fusion Project ...

... And hit the search button.

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

As a result we get the records found as a tree.

To make the tree simpler, we can change the hierachy level to Experiment.

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

Now the tree starts with the Experiment.

By clicking on Listview we get a list of all Experiments (Hierachy Level).

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

This Project contains one Expertiment.By Clicking on the Experiment, we get the Subjects below.

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

This Experiment contains two Subjects. Notice, that the Hierachy chanced to Subject.

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

Next Steps

• Sept 2004: Project started• Currently refining user interface concepts and data

architecture with university partners• Jan 2005: First MIRC system deployed to “get feet wet”• June 2005; First C-MIRC deployed to UPENN• Oct 2005: begin deploy C-MIRC to all consortia members,

expand functionality based on feedback during the next year.

• We welcome your feedback!

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

MIRC Extension Service

• Tree Query Service: Enables MIRC users to query data stored within NOMIC systems.

• Tree Submit Service: Enables MIRC users to place MIRC documents within the tree structure of NOMIC.

• Smart Notification Service : Send Messages in relation to information stored in a NOMIC system.

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

NOMIC Sample Experiment Data

Program

Project

Experiment

Subject

Study

Series

Data

Breath Caner Vaccines

Caner Vaccines

Vaccine HER-2 on Residual DNA

Andrea, Johnson; 09/10/1978 ..Study Attribute Data

Date 7/14/2004; 11:00

Type of Device Frequ. Domain

Frequency 100 – 400

Sources 8

Power (mW) 10

Detectors 16

Wavelength 6

... ...

Series Attribute Data

Scan Time 1 sek

Detector Separation

2, 4, 6

Source Separation

4

Hb +2uM

HbO2 -1 um

H2O OK

Lipid + 10 %

... ...

Lab Attribute Data

Solution Time (h) 4

Sensor Tissue Direct

Pressure 300

Breast Diameter 10

A priori data MRI

Beacon LDL Receptor

Fluorochome Cy 5,5

... ...

Callibration Data

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

NOMIC Functionality Overview

• Use RSNA MIRC multi-site web technology for sharing, distributing and collecting medical experiment data

• While NOMIC focuses on the experiment hierarchy model, MIRC focuses on the teaching document model. They have shared data elements.

• NOMIC will function as a collaboratory lab notebook (CLN) to support experiment submission, query and collection among multiple NOMIC sites

• NOMIC can exchange experiment records over the internet using MIRC based XML Schema

S I

E M

E N

S

C O

R P

O R

A T

E

R E

S E

A R

C H

CLN Specific Services

• Experiment Submit Service: Link data from PACS/FTP/File Servers to RDBMS.

• Experiment Collection Service: Automatic collecting experitment data from multiple NOMIC sites; The output forms of collected data will be based on format criteria such as Excel and CVS

• CLN Plugin Service: Interface for advanced lab data online analysis.