1 1

MitosisMitosis is the process in

which the nucleus divides to form two new nuclei. What disease is mitosis gone wild?

4 4

CANCERIn cancer, cells divide and grow uncontrollably,

forming malignant tumors, and invade nearby parts of the body.

Cancer Video Cancer Video 2

How do little elephants grow up to be BIG elephants?

Your life begins after a sperm fertilizes an egg, and you are

smaller than a period in a newspaper.

Animal Mitosis -- preview

Interphase

                                              

              

Prophase

                                             

               

Metaphase

                                              

              

Anaphase

                                             

               

Telophase

                                              

              

Cytokineses

                                             

               

Animated Mitosis Cyclehttp://www.cellsalive.com/mitosis.htm

• Interphase

• Prophase

• Metaphase

• Anaphase

• Telophase

• Cytokinesis

• Chromosomes are replicated (amount of DNA doubles)

• Chromosomes appear as threadlike coils (chromatin)

CELL MEMBRANENucleus

Cytoplasm

Animal Cell Plant Cell

Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm

• Chromatin condenses into chromosomes• Centrioles (or poles) appear and begin to

move to opposite end of the cell of animal cells.

• Spindle fibers form from centrioles.Centrioles

Sister chromatids

Spindle fibers

Animal Cell Plant Cell

Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm

Spindle fibers

• Chromosomes line up along the metaphase plate

• Spindle fibers attach to the centromeres of each chromosome

Centrioles

Spindle fibers

Animal Cell Plant Cell

Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm

• Sister chromatids pulled apart by shortening spindle fibers.

Centrioles

Spindle fibers

Animal Cell Plant Cell

Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm

• Nuclear membranes form around chromosomes.

• Mitosis ends.

NucleiNuclei

Chromatin

Animal Cell Plant Cell

Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm

• Cell membrane moves inward to create two daughter cells – each with its own nucleus with identical chromosomes.

Plant Mitosis -- ReviewInterphase

                                                        

    

Prophase

                                                       

     

Metaphase

                                                        

    

Anaphase

                                                       

     

Telophase

                                                        

    

Cytokinesis

                                                       

     

IInterphase PProphase MMetaphase AAnaphase TTelophase CCytokinesis

II PPayay MMoney oney AAtt TThe he CCashierashier

30

31 31

Confused? Here are links to fun resources that

further explain mitosis:

Mitosis, kinetochore animation video (WEHI Movies)

Mitosis Main Page on the Virtual Cell Biology Classroom

of Science Prof Online.

“Imitosis” music video by Andrew Bird.

DNA Replication step-through animation by John Kyrk.

Mitosis & Cytokinesis animated video by McGraw-Hill.

Mitosis animation, step-through and quiz, Sadava, et al., Life: The Science of Biology, 9th Edition, Sinauer Associates.

Mitosis step through animation from CellsAlive.com.

“That Spells DNA” song by Jonathan Coulton.

(You must be in PPT slideshow view to click on links.)From the Virtual Cell Biology Classroom on ScienceProfOnline.com