Mobile Phone Readout of Rapid Diagnostics for Infectious Disease

Kim Hamad-SchifferliFall 2015

Aedes aegyptiCDC.gov

Messina, Trends in Microbiology 2014

Threat of infectious diseases: Dengue• Mosquito borne disease• Disease burden: 2.5B people

at risk– >50M cases/year– >500K hospitalizations– Up to 5% fatality rates

• Emerging disease burden– Increasing dramatically

• No treatment, vaccine• Potential biothreat agent

NYTimes 2014

MMDx concept• Goal: Build point of care rapid diagnostic that is

multiplexed, machine readable, rugged, requires no special reagents, easy to use, cheap

• Provides diagnosis and real time reporting

Hand held diagnostic

Machine readableTime/GPS info

Map of diagnostic data

Image recognition and real-time monitoring

• Quantifies band intensity• Mobile phone readout app for Android: GIS data, time/date• No cradle• Open source• Flip phone

Mapping test GPS data

• GIS data uploaded to data base, Google Maps

Project Goals

• Mobile phone app that can:– Take image of diagnostic test– Analyze image and make diagnosis– Upload to server with time/location stamp

• System requirements:– Mobile phone (Android, maybe iPhone?)– Web server