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BBC Congress 2014 “MODULATING THE BRAIN: FACTS, FICTION, FUTURE” PHARMACOLOGICAL MODULATION ELECTRICAL MODULATION BEHAVIOURAL MODULATION COGNITION, MOVEMENT DISORDERS, EPILEPSY, HEADACHES, PAIN & PSYCHIATRIC

DISORDERS

4 October 2014

ICC Ghent

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Patients Associations

(N= 17)

Clinical & Basic Neuroscience

Societies (N=19)

↓ ↓ ↓ ↓

Industrial Stakeholders

(N=11)

↘ ↘

↓ ↓

Belgian EDAB Rep. (N=1)

↘

↓ ↓

↙ ↙

Belgian Brain Council

↓↓ Board of

Directors (N=22)

(linguistic parity)

Organizing Committee Belgian Brain Congress 2014 Dirk VAN ROOST (Neurosurgery - chair) Wim FIAS (Neurosciences co-chair) Rebecca MÜLLER (Ups & Downs) Franco GIANNI (Together for the Brain) Steven LAUREYS (Neurology) Amelia LE ROY (Brain tumours)

Roland POCHET (Neurosciences - treasurer) Jean SCHOENEN (Neurology - coordinator) Bart STULENS (Medtronic) Charles VAN DER STRATEN (MS League) Paul VERBANCK (Psychiatry) Rufin VOGELS (Neurosciences)

Administrative Secretary Marina Van Oirschot secretariaat@vlaamseneurologen.be Tel: +32 3 322 28 50 - fax: +32 3 322 45 14

Congress Organizing Company A+A Communication bvba/sprl info@aplusa.be Tel: +32 9 220 56 29 – Fax: +32 9 270 3 270

Belgian Brain Congress 2014

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After Genval (2006), Ostend (2008), Brussels (2010) and Liège (2012), Ghent welcomes the 5th edition of the Belgian Brain Congress. By definition, the BBC congresses aim to be multidisciplinary even “transdisciplinary”, meaning they are evolving simultaneously between, through and beyond disciplines and focus on helping to understand the complexity of the brain and brain diseases.

During the last decade it has become evident that activity of brain areas and circuits can be modulated by a number of different so-called neuromodulatory methods ranging from electrical stimulation to drug treatment and behavioural therapies. Neuromodulation has opened novel perspectives to alleviate neurological and psychiatric symptoms in various brain disorders and dysfunctions. Neuromodulation has also raised much interest in the general population because it has the potential to modify function and performance of the normal human brain.

It seems timely therefore to present and discuss comprehensively the advantages and limitations of the different neuromodulation methods in brain disorders and to have an overview on present knowledge of the mechanisms of action of these methods. It is also a crucial societal issue to know whether neuromodulation methods should be recommended for cognitive enhancement and what the risks of such interventions are.

Novel therapeutic treatment of nervous system disorders represents one of the most significant and unmet needs in modern medicine. Deep-brain Stimulation (DBS) strategies have been shown to be remarkably effective for treating a number of neurological and psychiatric conditions including Parkinson’s Disease, dystonia, essential tremor, epilepsy, chronic pain, major depression, migraines, as well as a number of other conditions.

The BBC 2014 congress aims at providing this information to health providers, but also to patients and caregivers, in a transdisciplinary program spanning from the basic to the clinical neurosciences, and to medico-social matters.

The Ghent BBC 2014 Congress, as a participant of the “2014 Year of the Brain”, will be launched as a forum in which European researchers and clinicians will communicate and interact with a large panel of stakeholders including patients associations and policy makers interested in this innovative field.

Target audience:

• Health care professionals interested in neurological issues • Neuroscientists and students • Members of patients & family associations • Policy makers • Health journalists • Industrial stakeholders

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Programme

09.00 – 10.00 Main Auditorium PLENARY SESSION 1 (chairpersons: R. Vogels, J. Schoenen)

ELECTRICAL NEUROMODULATION

09.00 – 09.30 Mechanisms of action of invasive neurostimulation

Nikos Logothetis, Tübingen

09.30 – 10.00 Mechanisms of action of non-invasive neurostimulation

Walter Paulus, Göttingen

10.00 – 11.00 Forum POSTER Session 1

Breakout room Van Eyck Satellite Symposium 1

Exhibitions, Coffee

Neurotransmitter imaging: a tool for detecting and monitoring brain modulation (General Electric)

11.00 – 12.40

Breakout room VanderGoes TOPICAL SESSION 1 (chairpersons: P. Santens, S. Henri)

Breakout room Van Eyck TOPICAL SESSION 2 (chairpersons: K. Audenaert, R. Müller)

11.00 – 11.20 Movement disorders Obsessive compulsive disorder

Alain Maertens de Noordhout, Liège Bart Nuttin, Leuven

11.20 – 11.40 Epilepsy Depression

Dirk Van Roost - Paul Boon, Ghent Chris Baeken, Ghent-Brussels

11.40 -12.00 Pain Consciousness disorders

Benoît Pirotte, Brussels Steven Laureys, Liège

12.00 – 12.20 Tinnitus Stroke

Dirk De Ridder, Antwerp Yves Vandermeeren, Mont-Godinne

12.20 – 12.40 Headache Addiction

Delphine Magis, Liège Jürgen Voges, Magdeburg

12.40 – 14.00

Forum POSTER Session 2 Exhibitions, Lunch

Breakout room Van Eyck Satellite Symposium 2

The Concept of Continuous Evidence based Neuromodulation (Medtronic SA/NV)

14.00 – 15.00 Main Auditorium

PLENARY SESSION 2 (chairpersons: W. Fias, J. De Keyser)

BEHAVIOURAL NEUROMODULATION

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14.00 Critical appraisal of cognitive enhancement Nicole Wenderoth, Zürich

For last minute changes, please consult the website: http://www.belgianbraincouncil.be/congress2014/index.html

14.30 Mechanisms of action of behavioural modulation

Hubert Dinse, Bochum

15.00- 17.00

Forum Exhibitions, Coffee

Breakout room VanderGoes Breakout room Van Eyck

15.00 – 16.00 Satellite Symposium 3 OnabotulinumtoxinA as a biologic neuromodulator – motor effect ok, but a sensory effect? (Allergan)

15.00 – 16.30 Medico-Social Workshop Ethics, economics and quality of life in neuromodulation anno 2014-Year of the Brain. Chairpersons: Gianni Franco and Mary Baker, European Brain Council

16.30 – 18.00 Main Auditorium TOPICAL SESSION 3: (Chairpersons: A. Ivanoiu, G. Moonen)

16.30 – 16.50 Hypnosis

Marie-Elisabeth Faymonville, Liège

16.50 – 17.10 Cognitive revalidation

Steve Majerus, Liège

17.10 – 17.30 Neurofeedback

Bettina Sorger, Maastricht

17.30 – 17.50 Mindfulness

Rudi De Raedt, Ghent

17.50 – 18.20 PLENARY SESSION 3

Perspectives in neuromodulation

Optogenetics

Wim Vanduffel, Leuven-Boston

18.20 -18.30

Poster Prizes

18:30 – 19.30 Farewell cocktail & Musical Neuromodulation.  

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15.00  –  16.30   Medico-­‐Social  Workshop  Ethics,economics  and  quality  of  life  in  neuromodulation  anno  2014-­‐Year  of  the  Brain.  CO-­‐CHAIRS:  Gianni  Franco  and  Mary  Baker,  Past-­‐President  European  Brain  Council    

Breakout  room  Van  Eyck     (co-­‐chairpersons:A.  Leroy,  M.  Mormal,  Ch.  van  der  Straten)  

    HOW  CAN  NEUROMODULATION  

IMPROVE  QUALITY  OF  LIFE?    Bruno  KASCHTEN,  Belgian  Society  for  Stereotactic  and  Functional  Neurosurgery  president,  Neurosurgeon  ULg,  Frederic  SUPIOT,  Neurologist  ULB.  

  SOCIO-­‐ETHICAL,  ECONOMICAL  AND  POLITICAL  POINTS  OF  VIEW.  

Ignaas  Devisch  (Philosopher,  UGent)    Dominique  Jacquemin  (Ethics,  UCL)  Jean  Noel  MISSA  (Philosopher-­‐  sociology,  ULB)    Jo  Vandeurzen  (Flemish  Minister  for  Welfare,  Public  Health  and  Family)  Monica  De  Coninck  (  Federal  Minister  of  Employment)  

  THE  REALITY  OF  LIFE  IN  BELGIUM   R.  Deridder  (Director  General  INAMI-­‐RIZIV)  

        DEBATE  with  the  assembly,  only  via  questions  from  the  floor  (collected  before  the  

meeting  on  paper  sheets)              

Satellite Symposium 1

General Electric Healthcare

Breakout room Van Eyck 10.00  –  11.00   Neurotransmitter  imaging:  a  tool  for  detecting  and  monitoring  brain  

modulation  

1)    10  years  of  Datscan®  in  Belgium    Interactive  session  between  a  neurologist  and  a  nuclear  medicine  physician  on  specific  clinical  cases.    

Koen  Van  Laere  (KUL),  Michel  Gonce  (CHR  Liège)  

2)    Early  Diagnosis  of  Alzheimer’s  disease,  contribution  of  amyloid  plaques  imaging.     Presentations  of  last  development  and  data  on  Flutemetamol  PET  imaging.  

  Adrian  Ivanoiu  (UCL)  

 

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Satellite Symposium 2

Medtronic SA/NV

Breakout room Van Eyck 12:40  –  14.00   Deep  brain  stimulation  at  an  earlier  stage  of  Parkinson’s  disease  

  CHAIR:  Günther  Deuschl  (D)  

 1)   Neurostimulation  for  PD  with  early  motor  complications:                                  Michael  Schüpbach  (Bern,CH)      2)   Early  application  of  DBS,  clinical  and  ethical  aspects:                                Pierre  Pollak  (Genève,CH)    3)   Stimulation  of  the  STN  at  an  early  stage  of  Parkinson’s  disease:                                Günther  Deuschl  (Kiel,D)      Case-­‐based  presentations  and  interactive  discussion  with  audience.  

Satellite Symposium 3

Allergan SA/NV

Breakout room VanderGoes 15:00  –  16.00   “OnabotulinumtoxinA  in  the  neurologist’s  patients  –  not  only  motor  effects,  

but  also  sensory  effects  ?”      CO-­‐CHAIRS  :  Prof  K.Paemeleire  (UG)  &  Prof  J.Schoenen(Ulg)    Introduction:  Chronic  Migraine  recommendations  of  the  Belgian  Headache  Society    Jean  Schoenen  (Ulg)    1)    Science  of  onabotA’s  neuromodulating  mechanism  of  action:  an  accepted  motor  effect  but  a  surprising  sensory  effect  ?  Oliver  Dolly  (Dublin,IRL)        2)    OnabotA  neuromodulation  in  clinical  management  of  chronic  migraine  symptoms.    Michel  Vandenheede  (CHC  Liège)    3)    OnabotA  neuromodulation  in  clinical  management  of  chronic  post-­‐stroke  symptoms.  Kristine  Oostra  (UZ  Gent)  

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Posters  &  abstracts:  

Free  communications  are  very  wellcome  on  any  basic  or  clinical  neuroscience  topic.  They  will  presented  as  posters.  There  will  be  poster  discussions  and  a  prize  for  the  3  best  posters.    Deadline  for  poster  submission:  July  1st,  2014    Maximum  Poster  size:  100  cm  large  x  120  cm  high  (portrait).    Posters  should  be  hung  on  the  numbered  poster  boards  between  8  :15  and  8  :45  hrs  and  visible  the  whole  day.  There  are  2  dedicated  poster  discussion  sessions  from  10-­‐11hrs  and  12.40-­‐14hrs.      Each  poster  abstract  should  contain  a  short  comment  (max  150  words)  on  the  significance  of  the  research  work  presented  in  the  abstract  and  the  potential  relevance  for  patient  care.  Abstracts  to  be  submitted  either  in  English,  Dutch  or  French  (one  language).    All  accepted  abstracts  will  be  published  and  accessible  via  the  Frontiers  website  (see    http://www.frontiersin.org/events/Belgian_Brain_Council_2014MODULATING_THE_BRAIN_FACTS_FICTION_FUTURE/2177      The  printed  abstract  book  will  contain:  

• Abstracts  of  invited  speakers  (250  words)  • Short  comments  in  Dutch  and  French  on  the  significance  and  the  potential  relevance  for  

patient  care  of  the  research  work  presented  in  each  poster  abstract  

Poster  Prizes  A  jury  composed  of  Jacques  De  Keyser  (VUB),  Wim  Fias  (UGent),  Rachelle  Franzen  (ULg),  Rebecca  Muller  (Ups  &Downs)  and  Jan  Versijpt  (VUB)  will  select  during  the  congress  the  three  best  posters  (quality  of  the  discussion  during  poster  viewing,  innovation  of  the  research/results,  design  of  the  poster).  The  3  winners  will  be  interviewed  and  video-­‐recorded  for  podcasting.  The  recipients  of  the  3  Prizes  (250  €  each)  will  be  announced  at  the  closing  ceremony.  Only  poster  authors  who  are  present  at  the  closing  ceremony  will  receive  the  Prize  (presence  mandatory).  In  case  presenters  of  the  best  posters  are  absent,  the  2nd  best  will  receive  the  prize.    

 

Webcasts  

Webcasts  will  be  produced  during  the  congress.  Invited  speakers,  selected  poster  presenters  and  representatives  from  the  patients’  associations  will  be  asked  to  briefly  summarize  their  message  and  significance  for  understanding  brain  functions  and  managing  its  dysfunctions.  These  webcasts  will  be  posted  on  the  BBC  website  at  http://www.belgianbraincouncil.be    

 

Jean  Schoenen  &  Rufin  Vogels    on  behalf  of  the  organizing  committee.  

   

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Participants’ fee (to be completed on line: see: http://www.belgianbraincouncil.be/congressII/regist.php Category Until

Aug. 16

After Aug. 17

On site

A Academic & MD 125€ 150€ 175€

B Other health professionals

60€ 75€ 100€

C Industry 200€ 250€ 300€

D Resident & PhD below 30

0€ 0€ 25€

E Patient Associations member

0€ 0€ 25€

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Practical information:

Date: 4 October 2014 Venue: ICC GHENT

Citadelpark B-9000 GHENT Tel. +32 (0)9 242 89 00 http://www.iccghent.com/typo/index.php

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How to reach the ICC

BY CAR Coming from Kortrijk, Lille, Paris:

E17 direction Antwerp Take the Exit 'Gent -Centrum' (see below)

Coming from Brussels: E40 Brussels - Ostend Follow E17, direction Antwerp at the Zwijnaarde traffic junction Take the Exit 'Gent-Centrum' (see below)

Coming from Ostend, London E40 Ostend – Brussels Follow E17, direction Antwerp at the Zwijnaarde traffic junction Take the Exit 'Gent-Centrum' (see below)

At the exit Gent Centrum: Follow the Exit ‘Andere richtingen’ (You are now leaving the highway) Turn left at the traffic lights beneath the overpass You are now entering the St.-Lievenslaan Follow direction S.M.A.K. at the third traffic lights Drive along the S.M.A.K. museum (on your right hand side) 50 m further you will find the ICC International Convention Centre Ghent on your right hand side.

Using PUBLIC TRANSPORTATION (train) Coming from Lille, Paris:

Take a train to Brussels, change at Brussels Midi and take an IC train to Ostend or Knokke-Blankenberge. Ghent is the first stop (Gent-Sint-Pieters).

Coming from Ostend, London: Take an IC train to Brussels. Ghent is the second stop (Gent-Sint-Pieters) (first stop is Bruges).

On your arrival at the Gent-Sint-Pieters Railway Station you can either walk to the ICC (1.1 km = 15 minutes - to walk click here) or take bus 70 or 71 or 72 or 76 (bus station platforms 15 & 16) that all stop at the Ledeganckstraat directly opposite the entrance of the ICC. All of these as well as the lines 73 and 74 drive from the Ledeganckstraat to the Gent-Sint-Pieters Railway Station. www.belgianrail.be (train) www.delijn.be (bus)