Modulation of plant TPC channels by polyunsaturated fatty acids Paul Vijay Kanth Gutla, Anna Boccaccio, Alexis De Angeli, Franco Gambale and Armando Carpaneto

Supplementary material: Supplemental Fig. 1 Supplemental Fig. 2 Supplemental Table 1

abbreviation acid structure

DHA docosahexaenoic 22:6 !-3

AA arachidonic 20:4 !-6

ALA linolenic 18:3 !-3

LA linoleic 18:2 !-6

OA oleic 18:1 !-9

ARA arachidic 20:0

PA palmitic 16:0

Me-DHA docosahexaenoic-me

Me-ALA linolenic-me

CH3

CH3

Supplemental figure 1: List of fatty acids used in this study.  

Supplemental figure 2: Three-dimensional conformation of the different fatty acids used in the experiments. It is visible that fatty acids harbouring a higher number of double bonds in the acyl-chains present a more compact folding. The efficacy of inhibition of the fatty acid correlates with the highest degree of bending of the fatty acid. Atoms are: grey carbon, red oxygen, white hydrogen.