morbidity and mortality rounds subarachnoid hemorrhage diagnostic challenges in the ed neil collins
TRANSCRIPT
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Morbidity and Mortality Rounds
Subarachnoid HemorrhageDiagnostic Challenges in the ED
Neil Collins
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47 y.o. maleDay 8 of headachePLC ED
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Mr. K.T.
ED VISIT SAH
state of wellness Rehabilitation
Headache
May 1 9 15
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History
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History
• Features of headache at onset
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History
• Features of headache at onset– Sudden– Severe– Ongoing pain
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History
• Associated features– No neck pain, photophobia, neuro symptoms
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Physical Exam
• BP 138/98, afebrile• Neuro “normal”• Neck supple• GCS 15/15
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Lab
• CBC, lytes, Cr., Gluc all normal
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Lumbar Puncture
• 2000 hrs– RBC 1045 X106/L– WBC 1.7 X106/L– Xanthochromia negative– Protein 0.60 (0.15 – 0.45)– Glucose normal
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NEXT STEPS?
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Repeat LP
• 2300 hrs• RBC #1 1308• RBC #4 878
• 2000 hrs• RBC #1 954• RBC #4 1045
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NEXT STEPS?
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Objectives
• Explore the significance of SAH in the context of headache presentations to the ED
• Understand the principles of the diagnosis of SAH – role of advanced imaging and lumbar puncture
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Epidemiology
• 100 per year in Calgary• 50% mortality
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Pathophysiology
• Aneurysmal 85%• Perimesencephalic bleeding 10%
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(a) Preoperative digital subtraction angiographic (DSA) three-dimensional reformation of wide-necked basilar tip aneurysm.
Tähtinen O I et al. Radiology 2009;253:199-208
©2009 by Radiological Society of North America
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Scope of the Problem
• HA comprises 1% of ED visits• Benign HA is 50 times more common than SAH1% of all headaches = SAH
10% of all “thunderclap headaches” = SAH
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“Cannot Miss” Headaches• SAH• Cervico-cranial Artery Dissections• Temporal Arteritis• Acute narrow Angle Closure Glaucoma• Hypertensive Emergencies• CO poisoning• Meningitis encephalitis• Dural Sinus Thrombosis• Hemorrhagic Stroke• ?Mass Lesions
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Cognitive Errors
• Diagnostic Momentum/Anchoring• Outcome Bias• Feedback Sanction• Overconfidence Bias• Frequency Bias
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Diagnosis of SAH
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• Physicians Consistently Misdiagnose SAH
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• Patients with the greatest likelihood of benefitting from surgery are the ones who most often receive an incorrect diagnosis
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Reasons For Misdiagnosis
• Failure to know the spectrum of presentations of SAH
• Failure to understand the limitations of CT• Failure to perform an LP• Failure to interpret CSF results correctly
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Reasons For Misdiagnosis
• Failure to know the spectrum of presentations of SAH
• Failure to understand the limitations of CT• Failure to perform an LP• Failure to interpret CSF results correctly
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Classic Presentation
• Abrupt onset of severe unique exertional headache/neck pain with meningismus and altered LOC
• Neurologic abnormalities– Third nerve palsy– Seizure– Motor deficit
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Other Clinical Presentations
• Less obvious scenarios– Acute confusional state– New seizure– Trauma with subarachnoid blood– Altered LOC and ECG changes
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Neurologically Intact Patient With Sentinel Bleed
• 20 – 50 % of patients report a distinct unusually severe headache in the days or weeks preceding the index episode of SAH
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Clinical Features
• Sudden Onset (Thunderclap)
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Differential Diagnosis of TCH
• SAH• Benign Cough Headache• Intracerebral Hemorrhage• Dissection• Sinus Thrombosis• Reversible vasospasm• Sexual Activity Headache
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Prospective study of TCHResults for the SAH cohort
Timing of Onset
Almost instantaneous 50%
2 – 60 seconds 24%
1- 5 minutes 19%
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Prospective Study of TCH
• 23 patients (11%) had SAH
• Unable to distinguish on clinical grounds– Activity at onset– Location– Intensity– Hx of migraine– Pain relief with analgesia
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Prospective Study of TCHSymptom SAH (%) Non-SAH (%)
Nausea 91 61
Neck Stiffness 61 10
Altered LOC 17 9
Occipital location 57 38
Scintillating Scotomata 0 7
Exploding pain 61 47
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Clinical Features Summary
• Most describe abrupt onset• Unique• Severe• Nausea/vomiting, syncope, seizure, diplopia
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Reasons For Misdiagnosis
• Failure to know the spectrum of presentations of SAH
• Failure to understand the limitations of CT• Failure to perform an LP• Failure to interpret CSF results correctly
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Sensitivity of CT
• Problems with interpretation of the literature– Predominance of retrospective studies– Heterogeneity of post headache “time to CT”– Different CT scanners– Neuroradiologist reads
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Sensitivity of CT for SAH inside 12 hours
• Best case is 100%– Perry, J et al (100% sensitivity inside 6 hrs)– Boseger et al (100% sensitivity inside 6 hrs)
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Sensitivity of 100%
• Cortnum et al, (Neurosurgery 2010)• Retrospective chart review of patients
referred to a neurosurgical center with confirmed SAH or suspicion of SAH (60% had SAH)
• 99.7% sensitive, only miss was at day 5
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Studies with < 100%
• van der Wee N, et al 1995 – 117/119 (98%) in 12 hours– 14/15 (93%) in 24 hours
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Studies with <100%
• Byyny et al 2008– Retrospective– Overall sensitivity 93%– Neurologically intact 91%
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CT negative, SAH with aneurysmAge Headache GCS Headache
durationCSF supernate
RBC Vascular anomaly
42 SS, LOC 15 <12 h Na 70,000 aneurysm
22 SS 15 <12 h Xantho 370,000 aneurysm
21 SS 15 <12h na pos aneurysm
79 SS 15 24 h Clear 93,500 aneurysm
55 SS 15 3 days Clear 2770 aneurysm
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Sensitivity of CT for SAHSensitivity Days after bleed
?93% <1
86 1
76 2
58 5
Near zero 14
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Reasons For Misdiagnosis
• Failure to know the spectrum of presentations of SAH
• Failure to understand the limitations of CT• Failure to perform an LP• Failure to interpret CSF results correctly
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WHY LP in SAH?
• Unruptured aneurysms of <7mm have a very low risk of bleeding
• 3-5% incidence of aneurysms in general populations
• 10% morbidity/mortality in surgery• Technology creep
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“Cannot Miss” Headaches• SAH• Cervico-cranial Artery Dissections• Temporal Arteritis• Acute narrow Angle Closure Glaucoma• Hypertensive Emergencies• CO poisoning• Meningitis encephalitis• Dural Sinus Thrombosis/(benign IC Hypertension)• Hemorrhagic Stroke• ?Mass Lesions
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Frequency of LP after negative CT
• 2010 study on those who listed R/O SAH as reason for CT– 59% before educational program– 64% after educational program
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Reasons For Misdiagnosis
• Failure to know the spectrum of presentations of SAH
• Failure to understand the limitations of CT• Failure to perform an LP• Failure to interpret CSF results correctly
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Positive LP
• Persistently bloody CSF• Xanthochromia
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RBC’s
• Immediately present, persist for ?2 weeks• <5 (X 106) is “negative”• SAH with RBC’s in the low 100’s rare
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Traumatic Tap
• Can a decline in RBC between tubes 1 and 4 be used to distinguish between SAH and traumatic tap?
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• Swadron 2007
• Retrospective look at SAH dx by CT and LP
• 65% of patients with confirmed SAH had a decline in RBC, most by >25%
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Traumatic Tap
• D-Dimer• Increased opening pressure• Repeat LP
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xanthochromia
• Not reliably present until 12 hours• Persists for ? 2 weeks
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Xanthochromia
• Specificity reduced by invitro production– centrifuge delay– Hemolysis from pneumatic tube system
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Xanthochromia
• Spectrophotometry vs visual inspection
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TCH DiagnosticsVascular imaging pos Vascular imaging neg
CSF Pos Sentinel bleed Low risk
CSF Neg Low Risk N/A
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CT Scan
Thunderclap Headache
negative positive
CTA and consult
< 6 hrs > 6 hrs or high pretest probabilityBenign
TCHLP
negativeXanthochromiaPersistent RBC
Consider CTA or NSX Consult if ambiguous LP, > 10 days, or very high risk
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Mr KT
• Normal CT head 9 days from headache onset• Persistently bloody (minor) CSF without
xanthochromia
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Mr. KT Events
• Two Aneurysms on CTA– 5 X 5 X 8 mm Anterior Communicating Artery– 4 X 4 X 4 left M1 bifurcation
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MR KT Events
• FMC admit
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Digital Subtraction Angiography
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Mr. KT Events
• Discharge May 13 with diagnosis of headache NYD and ?incidental intracranial aneurysms
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• May 14, large SAH• May 15 Craniotomy
– ACA culprit– ACA and MCA clipped– Post op course complicated by edema
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Major Points
• LP after CT (?within 6 hours)
• Caution with ambiguous LP results
• Caution with delayed presentations