Multi-dimensional Dynamic Visualization of Clinical DataJianmei Wang

Roche Products Limited

October 9 2015

January 23 1930

January 29 1930

January 23 1930

January 29 1930

Background

Software tool: Not open source. Uses Adobe Flash. Online tool Google Motion Chart offers limited functionality

“Joy of Stats”

by Hans Rosling

Opportunity

Roche Data Visualization Tool: A new software tool to create animated graphics to visualize time series data from clinical trial

Now Future

• Long tables of summary data over time

• Long listings of individual patient data over time

• Line plots or 1 variable at a time

• Large dataset embedded in animated graphics

• Many questions can be answered in the visualization without a new outputs

Example 1. Neutrophil depression in a paediatric studyBackground: Drug cause depression of neutrophil count, potentially increasing risk of infections. A better understanding of the abnormal labs is needed.

Table 1 Patients with a Depression in Neutrophils to CTC Grade 3 or Worse

Current output:

Example 1. Demo of Animated Graphics

Study day

Example 2. Different aspect of treatment response in two clinical studies

Background: Disease activity measured in composite score. Drug effect not fully captured by the score.

Active

Current outputs:

One component at a time

Example 2. Demo of Animated Graphics

Demo of Graphics Tool

More Information: http://rochewiki.roche.com/confluence/display/RDVT/Home

Recommendation from the tool designers

• Explain it well the first time

• Treat the animated graphic analysis as exploratory analysis

• Follow data sharing guideline, as the underlying data is embedded in the .svg output files

• Use animation only when it adds value

Inappropriate

animation could distract from the message

Potential use

• Data monitoring for safety and data quality?

• Communication?

• Exploratory analysis?

• Quick review of large datasets?

Thanks!

Internal collaborator: Jeff Tomlinson, Olivier Harari

Sponsor: Roche global medical affairs

Developer: BrainyPro Inc.

Doing now what patients need next