multifunctional nanoparticles and nanostructures suitable ... · magnetic biodistribution study •...
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Multifunctional Nanoparticles and Nanostructuressuitable for Bio-applications
Xavier Batlle
Departament de Física de la Matèria Condensada andInstitut de Nanociència i Nanotecnologia, IN2UBUniversitat de Barcelona
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Ana Conde-RubioPostdoc
M. García del MuroAgregada
Òscar IglesiasAgregat
Xavier BatlleCatedràtic
(group leader)
Amílcar LabartaCatedràtic
(group leader)
Mariona EscodaPhD student
Javier RodríguezPhD Student
Carlos MoyaPostdoc
+ master & bachelor students
Arantxa FraileAgregada
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Fe3O4@SiO2
Fe columnsCoFe2O4
Fe3O4
I. Nanoparticles by chemical routes
Fe atomic columns
3 nm
Fe3O4@albumin
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5 nm 12 nm
20 nm 26 nm
Size ControlUniformity
Sub-nanometeranalysis of single
nanoparticles
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Nanomedicine 5 (2010)
Magnetic biodistribution study
• Sensitivity of about 10-4 (in mass fraction), and even down to 10-5
• Intravenous injection (% of uptake): 35% liver, 1.5% spleen and 0.5% kidney
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Són útils?Vehiculació dirigida de fàrmacs cap a cèl·lules tumorals
Agents de contrast per diagnòstic basat en imatges de ressonància magnètica
Tractaments anticancerígens per escalfament local
Internalització amb citotoxicitat reduïda
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Detecció de quantitats molt petites de
proteïnes, antibiòtics, cèl·lules tumorals,
hormones...
II. Gold nano-elements for bio-detection
Límits actuals (Crystal violet i Mercaptopyridine)
1. Gota: 10-9 molar2. Una monocapa
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III. Goals
Iron oxide – Au nanoparticles: combined contrast agents for magnetic resonance imaging (MRI) and local heating by external magnetic field and/or light (magnetic hyperthermia and/or thermal ablation)
Iron oxide – Bi2S3 nanoparticles: contrast agents for both MRI and X-ray computerized tomography (CT)
Chiral Au nanoelements: detection of enantiomers of relevant chiral biomolecules: nucleic acids, proteins, drugs…