multiple myeloma
TRANSCRIPT
Multiple Myeloma Plasmacytoma Heavy Chain Disease Waldenstroms Macrogloblinemia Monoclonal Gammapathy Of Unsignificance Primary Amyloidosis
50-60 yrs. Men 1% death Pathogenesis: IL 6,-proliferation and survival of plasma cells MIP1alpha and RANKL -osteolysis Molecular pathology Deletions of 13q,translocations on 14q32,
Derangements of cyclin D1 and D3.
Plasmacytoma
Heavy Chain Disesase
Primary Immunocyte Associated Amyloidosis