8/8/2019 Multiple Sclerosis - Chinese and English version

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MultipleSclerosis 

   

 

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多发性硬化症的症状 

多 发性硬化症的症状差异很大，从一丧人到另一丧人在一段时间内。多发性硬化症的

症状包括肠和/或膀胱功能障碍，认知能力的变化，头晕眼花，情绪问题，疲劳， 行

走困难，麻木或“如坐针毡，” 痛，视力问题，头痛，听力並失，瘙痒，抽搐，痉挛，

言语不清，吞咽困难硬化症和震颤。大多数人会经历不是在同一时间只有其 丨的一些

症状，也许吧。  

多发性硬化症的症状通常出现在急性发作期的恶化（复发，病情加重，发作或攻击），

在一丧渐进的神经功能逐渐恶化，或两者兼而有之。  

多 发性硬化的最常见的表现是临床分离综合征（独联体）。在独联体国家丨，病人有

攻击脱髓鞘暗示，但不履行多发性硬化症的标准。只有 30至 70％的人经历独联 体后

来发展多发性硬化症。这种疾病通常与感官礼物（46％的情况下），视觉（33％），

小脑（30％）和汽车（26％）的症状。许多罕见的初期症状也有报 道，包括失语，精

神异常和癫痫。患者先就医目前常用的多种病症。最初的迹象和多发性硬化症的症状

往往是短暂的，温和，自我限制。这些迹象和症状往往不提示 一丧人求医，有时只发

现了一次回顾性多发性硬化症的诊断已经取得进展。多发性硬化症的案件过程丨发现，

有时顺带其他原因进行神经学检查。这种情况被称为亚 临床多发性硬化症。  

用 v几乎任何人都可以承受或神经系统症状包括感觉（感觉迟钝和感觉异常），肌肉

无力，肌肉痉挛，或难以改变移动签署; 协调与平衡（共济失调）的困难，在言语问

题（构音障碍）或吞咽（吞咽困难），视觉问题（眼球震颤，视神经炎，或复视），

疲劳，急性或慢性疼痛，膀胱及肠道 困难。不同程度和情绪抑郁或情绪不稳定的症状，

认知功能障碍也很常见。残疾的主要进展和临床症状的严重程度是衡量扩展残疾状态

量表或 EDSS评分。  

多 发性硬化症复发往往不可预测，在没有任何警告，没有明显的煽动因素。一些攻击，

但是，前面常见触发器。复发更频繁地发生在春季和夏季。如普通感冒，流行性 感冒，

肠胃炎或增加感染的 relapse.Stress风险也可能会触发攻击。妊娠可能影响易感性复

发，在过去三丧月提供保护，例如。在分娩后的最初几丧 月，但复发的危险性增加。

总体而言，怀孕似乎不影响长期残疾。许多潜在的触发经检查，发现不影响MS复发

率。没有任何证据表明，流感，乙肝，水痘，破伤 风，结核疫苗接种增加了复发的危

险。身体创伤不会触发复发。  

8/8/2019 Multiple Sclerosis - Chinese and English version

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Multiple Sclerosis (MS)

Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinalcord. It damages the myelin sheath, the material that surrounds and protects your

nerve cells. This damage slows down or blocks messages between your brain andyour body, leading to the symptom of multiple sclerosis. They can include;

  Visual disturbances  Muscle weakness  Trouble with coordination and balance  Sensations such as numbness, prickling, or "pins and needles"  Thinking and memory problems

Today, several therapies are available that can ameliorate the symptoms of multiple

sclerosis and, in some cases, slow disease progression. These treatments include thebeta interferons (Betaseron®, Rebif®, Avonex®), and copolymer 1 (Copaxone®,also called glatiramer acetate), a mixture of peptide fragments. The NIH supportedthe research that led to the development and approval of Avonex® and funded thebasic research that led to the development of Copaxone®. For severe forms of multiple sclerosis of relapsing remitting and secondary progressive multiple sclerosis,the FDA approved mitoxantrone (Novantrone®), an immunosuppressant. Mostrecently, the FDA approved natalizumab (Tysabri®), an antibody-based therapy thatrepresents a new class of immunomodulatory agents, for a restricted population of patients with multiple sclerosis.

No one knows what causes multiple sclerosis. It may be an autoimmune disease,which happens when your body attacks itself. Multiple sclerosis affects woman morethan men. Most people experience their first symptoms between the ages of 20 and40; the initial symptom of multiple sclerosis is often blurred or double vision, red-green color distortion, or even blindness in one eye.  Most multiple sclerosis patientsexperience muscle weakness in their extremities and difficulty with coordination andbalance.  These symptoms may be severe enough to impair walking or evenstanding. In the worst cases, multiple sclerosis can produce partial or completeparalysis.  Most people with multiple sclerosis also exhibit paresthesias, transitoryabnormal sensory feelings such as numbness, prickling, or "pins and needles"

sensations.  Some may also experience pain.  Speech impediments, tremors, anddizziness are other frequent complaints. Occasionally, people with multiple sclerosishave hearing loss. Approximately half of all people with multiple sclerosis experiencecognitive impairments such as difficulties with concentration, attention, memory, andpoor judgment, but such symptoms are usually mild and are frequentlyoverlooked.  Depression is another common feature of multiple sclerosis.

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Multiple sclerosis was firstrecognized as a disorder inthe late nineteenth century,but it wasn't until thenineteen sixties that

researchers began tounderstand some of thedisease processes thatcause symptoms and long-term disability in multiplesclerosis. These processesseemed to involveinflammation and the loss of myelin, a protectivecovering around nerve

fibers. The first standardguidelines for the diagnosisof multiple sclerosis and adisability rating scale werealso established in thenineteen sixties, setting thestage for controlledresearch to test newtherapies. In the late sixties,the first controlled clinical

trials for multiple sclerosistherapy showed thattreatment withadrenocorticotropichormone speeded recoveryfrom an attack. While thistherapy helped to reduce

inflammation during the acute symptoms of an attack, it did not slow theprogression of multiple sclerosis.

Today, multiple sclerosis is recognized as a chronic, inflammatory, demyelinatingautoimmune disease of the central nervous system (CNS). The damage to themyelin covering and to the underlying nerve cell fibers leads to slowed or blockedtransmission of signals, which results in reduced or lost functions. Improved imagingtechniques show that damage to nerve fibers can happen even at very early stagesof the disease.

There are a number of myths about multiple sclerosis that are not based in research.First, multiple sclerosis is not contagious. Second, contact with heavy metals cancause damage to the nerves but there is no evidence of heavy metals or mercuryfrom amalgam in dental fillings being linked with multiple sclerosis. Third, a number

of  viruses have been and are under study in relationship with multiple sclerosis.However, no virus has been found to cause multiple sclerosis.