muscles &muscle tissue chapter 10. functions of skeletal muscles 1.produce skeletal movement...
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Muscles &Muscle Tissue
Chapter 10
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Functions of Skeletal Muscles
1. Produce skeletal movement
2. Maintain body position
3. Support soft tissues
4. Guard body openings
5. Maintain body temperature
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Functional Characteristics of Muscle
• Excitability (irritability)– Can receive and respond to stimuli.
• Stimuli can include nerve impulses, stretch, hormones or changes in the chemical environment.
• Contractility – the ability to shorten with increasing tension.
• Extensibility – the ability to stretch.
• Elasticity – the ability to snap back (recoil) to their resting length after being stretched.
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Three types of muscle
Skeletal Smooth Cardiac
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Characteristics of Skeletal Muscle
• Striated
• Multinucleate (it is a syncytium)
• Voluntary
• Parallel fibers
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Organization of
Connective Tissues
Figure 10–1
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Formation of Skeletal Muscle Fibers
• Skeletal muscle cells are called fibers
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Organization of Skeletal Muscle Fibers
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Anatomy of a myofibril
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A Triad
• Is formed by 1 T tubule and 2 terminal cisternae
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Sarcomeres
Figure 10–4
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Muscle Striations
• A striped or striated pattern within myofibrils:– alternating dark, thick filaments (A bands) and
light, thin filaments (I bands)
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M Lines and Z Lines
• M line:– the center of the A band– at midline of sarcomere
• Z lines:– the centers of the I bands– at 2 ends of sarcomere
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Zone of Overlap
• The densest, darkest area on a light micrograph
• Where thick and thin filaments overlap
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The H Zone
• The area around the M line
• Has thick filaments but no thin filaments
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Titin
• Are strands of protein
• Reach from tips of thick filaments to the Z line
• Stabilize the filaments
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Sarcomere Structure
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Summary of skeletal muscle anatomy:muscles are made of fascicles
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Fascicles are made of fibers, fibers are made of myofibrils
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Figure 10–6 (1 of 5)
Level 1: Skeletal Muscle
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Level 2: Muscle Fascicle
Figure 10–6 (2 of 5)
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Level 3: Muscle Fiber
Figure 10–6 (3 of 5)
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Level 4: Myofibril
Figure 10–6 (4 of 5)
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Level 5: Sarcomere
Figure 10–6 (5 of 5)
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Fibrils are divided into sarcomeres,sarcomeres are made of myofilaments
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Myofilamentsare made of
protein molecules
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A Thin Filament
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4 Thin Filament Proteins
1. F actin:– is 2 twisted rows of globular G actin– the active sites on G actin strands bind to
myosin
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4 Thin Filament Proteins
2. Nebulin:– holds F actin strands together
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4 Thin Filament Proteins
3. Tropomyosin:– is a double strand– prevents actin–myosin interaction
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4 Thin Filament Proteins
4. Troponin:– a globular protein– binds tropomyosin to G actin– controlled by Ca2+
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Troponin and Tropomyosin
Figure 10–7b
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A Thick Filament
Figure 10–7c
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Thick Filaments
• Contain twisted myosin subunits
• Contain titin strands that recoil after stretching
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The Mysosin Molecule
Figure 10–7d
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Muscle Contraction:the Sliding Filament Theory
• Muscle contraction requires:– Stimulus – the generation of an action
potential.– Crossbridge formation – interaction between
the thick and thin myofilaments. This is triggered by Ca++ ions released from the sarcoplasmic reticulum.
– Energy – ATP to energize the myosin molecules.
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Sliding Filaments
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Skeletal Muscle
Contraction
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T- tubules supply the stimulus,Sarcoplasmic Reticulum supplies the Ca++,
Mitochondria supply the ATP.
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The Process of Contraction
• Neural stimulation of sarcolemma:– causes excitation–contraction coupling
• Cisternae of SR release Ca2+:– which triggers interaction of thick and thin
filaments– consuming ATP and producing tension
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Skeletal Muscle Innervation
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Skeletal Muscle InnervationFigure 10–10c
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The Neuromuscular Junction
• Is the location of neural stimulation
• Action potential (electrical signal):– travels along nerve axon– ends at synaptic terminal
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A neuromuscular junction (NMJ).
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The actual synapse
acetylcholine
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Synaptic Terminal
• Releases neurotransmitter (acetylcholine or ACh)
• Into the synaptic cleft (gap between synaptic terminal and motor end plate)
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The Neurotransmitter
• Acetylcholine or ACh:– travels across the synaptic cleft – binds to membrane receptors on sarcolemma
(motor end plate)– causes sodium–ion rush into sarcoplasm– is quickly broken down by enzyme
(acetylcholinesterase or AChE)
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Action Potential
• Generated by increase in sodium ions in sarcolemma
• Travels along the T tubules
• Leads to excitation–contraction coupling
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Excitation–Contraction Coupling
• Action potential reaches a triad:– releasing Ca2+
– triggering contraction
• Requires myosin heads to be in “cocked” position:– loaded by ATP energy
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Exposing the Active Site
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The Contraction Cycle
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The Contraction Cycle
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The Contraction Cycle
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The Contraction Cycle
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5 Steps of the Contraction Cycle
1. Exposure of active sites
2. Formation of cross-bridges
3. Pivoting of myosin heads
4. Detachment of cross-bridges
5. Reactivation of myosin
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Show the animation
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A Review of Muscle Contraction
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Excitation-Contraction coupling
• Stimulus or excitation is required for muscles to contract.
• In skeletal muscle, the stimulus is from a motor neuron.
• The stimulus is in the form of an action potential.
• This action potential starts at the neuromuscular junction (NMJ).
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Excitation-contraction coupling
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Show NMJ animation
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Micrograph of an NMJ
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A Synapse
Synaptic vesicles
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Tension and Sarcomere Length
Figure 10–14
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Length–Tension Relationship
• Number of pivoting cross-bridges depends on:– amount of overlap between thick and thin
fibers
• Optimum overlap produces greatest amount of tension:– too much or too little reduces efficiency
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Length–Tension Relationship
• Normal resting sarcomere length:– is 75% to 130% of optimal length
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Frequency of Stimulation
• A single neural stimulation produces:– a single contraction or twitch – which lasts about 7–100 msec
• Sustained muscular contractions:– require many repeated stimuli
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Tension in a Twitch
• Length of twitch depends on type of muscle
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Myogram
• A graph of twitch tension development Figure 10–15b (Navigator)
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3 Phases of Twitch
1. Latent period before contraction:– the action potential moves through
sarcolemma– causing Ca2+ release
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3 Phases of Twitch
2. Contraction phase: – calcium ions bind– tension builds to peak
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3 Phases of Twitch
3. Relaxation phase: – Ca2+ levels fall– active sites are covered– tension falls to resting levels
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Treppe
• A stair-step increase in twitch tensionFigure 10–16a
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Treppe
• Repeated stimulations immediately after relaxation phase:– stimulus frequency < 50/second
• Causes a series of contractions with increasing tension
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Wave Summation
• Increasing tension or summation of twitches
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Wave Summation
• Repeated stimulations before the end of relaxation phase:– stimulus frequency > 50/second
• Causes increasing tension or summation of twitches
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Incomplete Tetanus
• Twitches reach maximum tension Figure 10–16c
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Incomplete Tetanus
• If rapid stimulation continues and muscle is not allowed to relax, twitches reach maximum level of tension
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Complete Tetanus
Figure 10–16d
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Complete Tetanus
• If stimulation frequency is high enough, muscle never begins to relax, and is in continuous contraction
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Comparative speed of different muscles
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Tension Produced by Whole Skeletal Muscles
• Depends on:– internal tension produced by muscle fibers– external tension exerted by muscle fibers on
elastic extracellular fibers– total number of muscle fibers stimulated
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Motor Units in a Skeletal Muscle
Figure 10–17
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Motor Units in a Skeletal Muscle
• Contain hundreds of muscle fibers
• That contract at the same time
• Controlled by a single motor neuron
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Recruitment (Multiple Motor Unit Summation)
• In a whole muscle or group of muscles, smooth motion and increasing tension is produced by slowly increasing size or number of motor units stimulated
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Maximum Tension
• Achieved when all motor units reach tetanus
• Can be sustained only a very short time
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Sustained Tension
• Less than maximum tension
• Allows motor units to rest in rotation
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2 Types of Skeletal Muscle Tension
1. Isotonic contraction
2. Isometric contraction
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Isotonic Contraction
Figure 10–18a, b
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Isotonic Contraction
• Skeletal muscle changes length:– resulting in motion
• If muscle tension > resistance:– muscle shortens (concentric contraction)
• If muscle tension < resistance:– muscle lengthens (eccentric contraction)
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Isometric Contraction
Figure 10–18c, d
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Isometric Contraction
• Skeletal muscle develops tension, but is prevented from changing length
Note: Iso = same, metric = measure
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Resistance and Speed of Contraction
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Resistance and Speed of Contraction
• Are inversely related
• The heavier the resistance on a muscle:– the longer it takes for shortening to begin– and the less the muscle will shorten
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ATP and Muscle Contraction
• Sustained muscle contraction uses a lot of ATP energy
• Muscles store enough energy to start contraction
• Muscle fibers must manufacture more ATP as needed
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ATP and CP Reserves
• Adenosine triphosphate (ATP): – the active energy molecule
• Creatine phosphate (CP):– the storage molecule for excess ATP energy
in resting muscle
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Recharging ATP
• Energy recharges ADP to ATP:– using the enzyme creatine phosphokinase
(CPK)
• When CP is used up, other mechanisms generate ATP
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Energy Storage in Muscle Fiber
Table 10–2
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ATP Generation
• Cells produce ATP in 2 ways:– aerobic metabolism of fatty acids in the
mitochondria– anaerobic glycolysis in the cytoplasm
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Aerobic Metabolism
• Is the primary energy source of resting muscles
• Breaks down fatty acids
• Produces 34 ATP molecules per glucose molecule
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Anaerobic Glycolysis
• Is the primary energy source for peak muscular activity
• Produces 2 ATP molecules per molecule of glucose
• Breaks down glucose from glycogen stored in skeletal muscles
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Anaerobic Metabolism:
a losing proposition
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Energy Use and Muscle Activity
• At peak exertion:– muscles lack oxygen to support mitochondria– muscles rely on glycolysis for ATP– pyruvic acid builds up, is converted to lactic
acid
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Muscle Metabolis
m
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Muscle Metabolism
Figure 10–20b
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Muscle Metabolism
Figure 10–20c
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Results of Muscle Fatigue
1. Depletion of metabolic reserves
2. Damage to sarcolemma and sarcoplasmic reticulum
3. Low pH (lactic acid)
4. Muscle exhaustion and pain
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The Recovery Period
• The time required after exertion for muscles to return to normal
• Oxygen becomes available
• Mitochondrial activity resumes
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The Cori Cycle
• The removal and recycling of lactic acid by the liver
• Liver converts lactic acid to pyruvic acid
• Glucose is released to recharge muscle glycogen reserves
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Oxygen Debt
• After exercise:– the body needs more oxygen than usual to
normalize metabolic activities – resulting in heavy breathing
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Muscle Performance
• Power:– the maximum amount of tension produced
• Endurance:– the amount of time an activity can be
sustained
• Power and endurance depend on:– the types of muscle fibers– physical conditioning
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3 Types of Skeletal Muscle Fibers
1. Fast fibers
2. Slow fibers
3. Intermediate fibers
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Fast Fibers
• Contract very quickly
• Have large diameter, large glycogen reserves, few mitochondria
• Have strong contractions, fatigue quickly
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Slow Fibers
• Are slow to contract, slow to fatigue
• Have small diameter, more mitochondria
• Have high oxygen supply
• Contain myoglobin (red pigment, binds oxygen)
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Intermediate Fibers
• Are mid-sized
• Have low myoglobin
• Have more capillaries than fast fiber, slower to fatigue
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Fast versus Slow Fibers
Figure 10–21
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Comparing Skeletal Muscle Fibers
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Muscles and Fiber Types
• White muscle:– mostly fast fibers– pale (e.g., chicken breast)
• Red muscle:– mostly slow fibers – dark (e.g., chicken legs)
• Most human muscles:– mixed fibers– pink
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Muscle Hypertrophy
• Muscle growth from heavy training:– increases diameter of muscle fibers– increases number of myofibrils– increases mitochondria, glycogen reserves
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Muscle Atrophy
• Lack of muscle activity:– reduces muscle size, tone, and power
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Structure of Cardiac Tissue
• Cardiac muscle is striated, found only in the heart
Figure 10–22
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7 Characteristics of Cardiocytes
• Unlike skeletal muscle, cardiac muscle cells (cardiocytes):– are small– have a single nucleus– have short, wide T tubules
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7 Characteristics of Cardiocytes
– have no triads– have SR with no terminal cisternae– are aerobic (high in myoglobin, mitochondria)– have intercalated discs
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Intercalated Discs
• Are specialized contact points between cardiocytes
• Join cell membranes of adjacent cardiocytes (gap junctions, desmosomes)
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Functions of Intercalated Discs
• Maintain structure
• Enhance molecular and electrical connections
• Conduct action potentials
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Coordination of Cardiocytes
• Because intercalated discs link heart cells mechanically, chemically, and electrically, the heart functions like a single, fused mass of cells
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4 Functions of Cardiac Tissue
1. Automaticity:– contraction without neural stimulation– controlled by pacemaker cells
2. Variable contraction tension:– controlled by nervous system
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4 Functions of Cardiac Tissue
3. Extended contraction time
4. Prevention of wave summation and tetanic contractions by cell membranes
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Structure of Smooth Muscle
• Nonstriated tissueFigure 10–23
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Comparing Smooth and Striated Muscle
• Different internal organization of actin and myosin
• Different functional characteristics
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8 Characteristics of Smooth Muscle Cells
1. Long, slender, and spindle shaped
2. Have a single, central nucleus
3. Have no T tubules, myofibrils, or sarcomeres
4. Have no tendons or aponeuroses
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8 Characteristics of Smooth Muscle Cells
5. Have scattered myosin fibers
6. Myosin fibers have more heads per thick filament
7. Have thin filaments attached to dense bodies
8. Dense bodies transmit contractions from cell to cell
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Functional Characteristics of Smooth Muscle
1. Excitation–contraction coupling
2. Length–tension relationships
3. Control of contractions
4. Smooth muscle tone
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Excitation–Contraction Coupling
• Free Ca2+ in cytoplasm triggers contraction
• Ca2+ binds with calmodulin: – in the sarcoplasm– activates myosin light chain kinase
• Enzyme breaks down ATP, initiates contraction
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Length–Tension Relationships
• Thick and thin filaments are scattered
• Resting length not related to tension development
• Functions over a wide range of lengths (plasticity)
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Control of Contractions
• Subdivisions:– multiunit smooth muscle cells:
• connected to motor neurons
– visceral smooth muscle cells:• not connected to motor neurons• rhythmic cycles of activity controlled by pacesetter
cells
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Smooth Muscle Tone
• Maintains normal levels of activity
• Modified by neural, hormonal, or chemical factors
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Smooth Muscle
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Varicosities
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Skeletal Smooth Diameter 10 - 100 m 3 - 8 m
Connective tissue Epi-, Peri- & Endomysium
Endomysium only
SR Yes, complex Barely, simple
T - tubules yes no
Sarcomeres yes no
Gap Junctions no yes
voluntary yes no
Neurotransmitters Acetylcholine (Ach)
Ach, epinephrine, norepinephrine, et al
Regeneration Very little Lots, for muscle
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Future governors of Califorina?