my tortuous path to a pathology career - stanford...
TRANSCRIPT
My Tortuous Path to a Pathology Career
My Life as a Veterinary Pathologist
in a Medical School (or Why I have had the best job in the world…)
Donna M. Bouley DVM, Ph.D, DACVP
Professor, Department of Comparative Medicine
Stanford University School of Medicine
How did I get here…?
• Youth
• Dancer
• Gymnast
• Loved horses
• 4-H (equine)
• No intention of becoming a vet…
BS Animal Science,
U Mass, (’76)
U Mass Equestrian teams
University of Tennessee
College of Veterinary Medicine
Returned to UTCVM
Anatomic Pathology Residency/PhD (‘88-’95)
PhD
Immunopathology of Herpetic Stromal Keratitis
Cellular immunology
Cellular adoptive transfers
BALB/C, SCID, IFN-g KO mice
Ocular pathology
Son Philip born 1990
Post Residency/PhD
• Crossroad – Research or Pathology
Boards??
• Cincinnati Children’s Hospital Research
Center in OH
• Anatomic Pathology Instructor, Texas
A&M CVM (’95-’97)
While at A&M in TX (95-97)
• Everything is big
• Lots of Necropsy and Biopsy work
• Trained anatomic pathology residents
• Studied my tail off for Pathology Board
Certification
• Passed boards (’96) became DACVP
• Offered Faculty appointment at A&M
• Considering Pharmaceutical Job –
near family…
• Life-changing phone call from Dr.
Linda Cork, Chair Comparative
Medicine, Stanford School of
Medicine
A Real Job!!!
• Stanford School of Medicine
• Department of Comparative Medicine
• Assistant Professor (’97-’03)
• Associate Professor (‘03-08)
• Professor (‘08 - 18)
• Professor Emeritus (’18 – 20)
What did I bring to this job…
• Extrovert
• Very visual
• Detail oriented
• Organized
• Exceptional time management
• Self-motivated
• Liked variety
• Natural teacher
• Strong research training
• Boards
• 4 papers
Faculty Lines DCM Faculty
• University Tenure
Line (UTL)
• Medical Center Line
(MCL)
• Clinical Educator (CE)
• Research/Non-tenure line
• Teaching/Non-tenure line
(very few)
• UTL (4)• 2 PhD, 1 DVM PhD,
1 DVM/MD
• MCL (8)• ACVIM (1), ACLAM (3),
ACVAA (1), ACVP (2),
MPH/ACVPM (1)• 7 are DVM, 7 have PhD
• CE (2)• ACLAM
• ACVP
DCM Oversees the
Veterinary Service Center
• VSC
• Staff Vets (2)
ACLAM
• Residents (Lab
Animal - 4)
• ~ 120 employees,
• RAF1, RAF2 ~
80,000 sq.ft,
• 17 additional sites
• ~ 200,000 animal
census
• 90-95% are rodents
• Largest service
center on campus
MCL Duties
• Clinical service
• Scholarly activity
• Teaching
• Similar to faculty positions at
Veterinary School – “3 hats”
The 3 R’s • The use of animals as models of human and animal
diseases is a privilege and all animals must be
treated respectfully, carefully, and responsibly.
• Specialty trained veterinarians (ACLAM)
• 3 R’s
• replacement
• reduction
• refinement
• Excellent vet care, welfare, husbandry and
enrichment
• Institutional Animal Care and Use Committee
(IACUC)
Necropsy and Histology• = to human autopsy
• Make histology slides
• Investigate cause of death
• Culture tissues for pathogens
• Diagnose cancer, other age relate conditions
• Animals get the same disease as humans
• “One Health”
In addition…
• Research Support• Pathology consultation at experimental design
level as well as support at experiment
completion
• Train researchers in necropsy, tissue
harvesting, tissue trimming etc.
• Review basic histology
• 3 R’s + 1
• “Organ/tissue sharing”
• Dr. B’s brain collections
Diagnostic Work and Pathology Support for
Investigators working with Animal Models
• Mice, rats, guinea pigs, voles, Octagon degu, ferrets,
gerbils, rabbits, dogs, pigs, sheep, goats, squirrel monkeys,
macaques (rhesus, cynomolgus, pig-tailed), baboons,
mouse lemurs, barn owls, chickens, frogs (Xenopus laevis,
Rana pipiens), salamanders, anoles, goldfish, zebra fish,
other…
Scholarly Activity - Manuscripts by Category
Topic/Category Order of Publication Species Total Number
Spontaneous Disease 5, 7, 9, 10, 11, 16, 19, 20, 7,
28, 30, 33, 36, 85, 88
Frogs, puppy, snake,
macaque15
Tg, KO, mutant mice 2, 8, 18, 22, 38, 39, 40, 46,
52, 55, 66, 76
Mice 12
Exp. Infectious Disease Research (host & pathogen)
1, 3, 4, 6, 14, 15, 21, 23, 34,
45, 56, 74, 81, 82, 84, 87
Mice 16
Cancer Biology 35, 64, 67, 68, 69, 71, 72, 73,
75, 79,
Mice 10
General pathology 13, 29, 31, 32, 48, 53, 80 Mice, rabbit, frogs 7
Interventional Radiology/Imaging
12, 17, 24, 25, 26, 37, 41, 2,
43, 44, 49, 50, 51, 57, 58, 9,
60, 61, 62, 63, 77, 78, 83, 86
Pig, rabbit, dog, rats,
macaque24
Wildlife/exotics 54, 70 Elephants 2
Education 47, 65 Mice, frog 2
88
Pacinian corpuscles contribute to
detection of seismic waves in elephants
My Teaching
• “Classes”• Fr/Soph Sem, / Sophomore College
• Comparative Anatomy & Physiology
of Mammals
• Open classes
• Imaging Anatomy in Animal Models
• Introduction to Mouse Histopathology
• Independent study
• Mouse Necropsy and Intro to
Histology
Outside the “Classroom”
• Founder and Director of Stanford
Undergraduate Pre-Vet Society (SUPVS)
• Supervision of Undergraduates Research
and Clinical Projects
• Mentor other health professional students
(pre-med, pre-dental, pre-nursing,
biomedical research)
• Train Lab Animal residents
• 1 Post Doc
• 1 Masters student
Pre-Vet Expos (I- V)
• Outreach to regional high school and college
students, academic counselors, and parents, in the
form of day-long symposia
• Offers a glimpse into the diversity of the veterinary
profession and insight into the “pathway” to
veterinary school.
• AM lectures, “Eat Lunch with a Vet, Afternoon
Veterinary and Veterinary Student Panels, Posters,
hands-on activities
• Supported by Undergraduate Education
Additional Activities
• Stanford One Health Symposia
• Kid’s Day
– Friday before graduation weekend
Climate Change and Its Impact
on Human and Animal Health
“Vets for Healthy Pets” Clinics
• Free preventive care for San Jose homeless
populations’ pets
• Collaboration with Dr. Kathy Tyson (Stanford
‘96), San Jose Animal Care and Services,
pre-vets and HAAS Institute (Donald
Kennedy fellowship)
• Bass Fellow funds provides $ for supplies
• 3 recipients
• Andy Meislin – (summer 2016 – spring 2017)
• Marleyna Mohler (spring 2017 – spring 2018)
• Nina Wagner (spring 2018 – spring 2019)
• Maria Maguire - ??
Visits to Veterinary Schools• 22 so far
• Meet with Admissions groups
• Tour teaching hospital
• Meet with various faculty
• Give lunchtime seminar
• My role of a Veterinary Pathologist in a Medical School
• Meet casually with vet students
• There are no “typical” pre-vets or vet students…
SUPVS History• Total of ~65 students/affiliates – gone to or
currently in vet school (that I know of)
• 19 different vet schools
• 4 -6? lab animal, 3 anatomic pathologists
• 2 DVM/PhD
• 2 Zoo vets
• Numerous board specialties (Internal
medicine, surgery, equine sports med,
radiology, laboratory animal medicine,
pathology)
• There are no “typical” pre-vets or vet students…
• It is never too late to pursue a veterinary career
• If you like variety…
A Career in Comparative/Experimental Pathology
is for YOU!