myexperiment @ nettab
DESCRIPTION
Digital Identity is fundamental to collaboration in bioinformatics research and development because it enables attribution, contribution, publication to be recorded and quantified. However, current models of identity are often obsolete and have problems capturing both small contributions "microattribution" and large contributions "mega-attribution" in Science. Without adequate identity mechanisms, the incentive for collaboration can be reduced, and the utility of collaborative social tools hindered. Using examples of metabolic pathway analysis with the taverna workbench and myexperiment.org, this talk will illustrate problems and solutions to identifying scientists accurately and effectively in collaborative bioinformatics networks on the Web.TRANSCRIPT
Who Are You? Managing collaborative digital identities in bioinformatics with myExperiment
Duncan HullPostdoctoral Research AssociateManchester Biocentremib.ac.uk, School of ChemistryUniversity of Manchester, UKNETTAB 2009, Catania, Italy, June 2009
• Intro: Collaborative social software on the Web generally
– Scientists and the web
– Publishing
– Digital Identity
• Sets to the scene for http://www.myexperiment.org in a nutshell
– The What, Who and Why and How of myexperiment
– Building an online community where Scientists share data more efficiently
– Encouraging people to share and re-use data (especially experimental protocols)
• Overcoming publish or perish culture
• Incentives to share data, tooling to make it as easy as possible
• Case Study: REFINE Project http://www.nactem.ac.uk/refine
– Refining Pathway models, myExperiment from a personal user point of view (40 minutes)
• Demonstration of myexperiment (30 minutes)
@
Social software for collaborating on the Web < 10 yrs old
Designed to allow communication by sharing data with friends, colleagues and other people
http://tinyurl.com/myscience
Some people call this “Web 2.0”
Unfortunately
• Many scientists don’t use these tools for serious work (if at all)
• Why?
• It’s complicated but…
Galileo Galilei (1632) Dialogo sopra i due massimi sistemi del mondo
Scientific publishing has worked this way for centuries
• Publishing the main (perhaps only) way of sharing data and communicating:
• “Publish or Perish”
Digital Data Driven Science• Science is increasingly digital and data-driven
– Scientists contributions are increasingly digital
– Not just digital publications in electronic journals…
– wiki edits, software development, workflows, database curation, ontology development, blog posts
– Traditional journal publishing is often inadequate for sharing this kind of data and attributing it to individual people
Burying or Destroying Data and Metadata?
• Publishing can be inadequte, difficult to mine
Barend MonsWikiproteins
Why bury it [data] first and then mine it again?
Which gene did you mean?http://pubmed.gov/15941477
BMC Bioinformatics. 2005 Jun 7;6:142.
In other cases important data and metadata gets destroyed completely
(author, title, gene, protein, chemical names etc)
Make digital libraries difficult to useDefrosting the Digital Library Hull, Pettifer and Kellhttp://www.pubmed.gov/18974831 PLoS Computational Biology 2008 Oct;4(10):e1000204
Double Trouble!
1. Scientists reluctant to share data until published in peer-reviewed journals
2. When they do publish, data often gets badly damaged or destroyed in the process. Digital Identity of people gets especially mangled…
CC licensed double trouble picture by Puck90 http://www.flickr.com/photos/puck90/2480833393/
Digital Identity is currently a mess (part 1)
• One person, can be identified by many different URIs
• People who know Paolo can tell the difference
– People who don’t (and software) face a significant challenge to disambiguate
• Digital Identity is a second-class citizen on the Web (see http://www.flickr.com/photos/dullhunk/3618998907/ for web e.g.)
1. http://www.nettab.org/promano/ (nettab organiser)2. mailto:[email protected]. http://www.paoloromano.it/ 4. en.wikipedia.org/wiki/Paolo_Romano (sculptor)5. it.wikipedia.org/wiki/Paolo_Romano (actor)6. www.linkedin.com/in/paoloromano7. http://pubmed.gov?Term=Paolo+Romano[author]8. myspace.com/paoloromano (musician)9. www.paoloromano.net/ (politician and friend of Berlusconi)10.citeulike.org/tag/paolo-romano11. ...uni-trier.de/~ley/db/indices/a-tree/r/Romano_0001:Paolo.html
Will the real Paolo Romano please stand up?
URI’s are used for identifying people on the web
Digital attribution
Neil Smalheiser and Vetle Torvik
Attribution would seem to be a simple process and yet it represents a
major, unsolved problem for information science.
Author name disambiguationChapter published in Volume 43 (2009) of the Annual Review of Information Science and Technology (ARIST) (edited by B. Cronin) which is available from the publisher Information Today, Inc
http://www.hbs.edu/units/tom/seminars/2007/docs/Author%20Name%20Disambiguation.pdf
Misattribution
Google Scholar thinks I’m Maurice Wilkins
Dr. Duncan HullHumble Postdoc
Articleabout
Authored-by
Authored-by
Wrong!
“DNA mania”
title
http://tinyurl.com/mistakenid
Digital identity is currently a mess (part 2)
• On three levels, the three A’s:
– Authentication: is Paolo is who he says he is? Or a fake?
– Authorisation: is Paolo authorised to view/operate-on workflow?
– Attribution: Paolo AuthorOf Nettab-Workflow or
Paolo Reused Workshop-Workflow
Currently done through combination of username-and-password
http://tinyurl.com/too-many-passwords
Paolo Romano
Simon Willison(The Guardian)
The average user has
[at least]
18 user accounts
and 3.49 passwords”
Digital Identity Really Matters
• Digital Identity is fundamental to collaboration because it enables
– Attribution …
– Contribution…
– Publication … to be recorded and quantified.
• Important decisions made on digital identity
– Hiring, funding, promotion, collaboration
– Selecting appropriate reviewers for grants and publications
– attributing published data
• This is the envionment which myexperiment operates in:
– A “Publish or perish” culture in science
– Encourage workflow sharing before, during & after traditional publication
• Via the website www.myexperiment.org and it’s various API’s
– Get digital attribution done right, with more reliable digital identities
What is myExperiment?• Facebook for Scientists?
• Collaborative software for sharing and finding experimental protocols on the web
User Profiles Groups Friends Sharing Tags Workflows Developer interface Credits and Attributions Fine control over privacy Packs Federation Enactment
What is myExperiment?What is myExperiment?
Unique Selling Points, key differentiators to Facebook etc
Kepler
Triana
BPEL
Ptolemy II
Taverna
Trident
BioExtract
Who is involved in myExperiment?
• Small team of developers (2-3 full time)
• 1500 users have uploaded 560 workflows, 150 files and 40 packs in 130 groups
Carole Goble
David De Roure
Open ID is quickly becoming widespread
“42,235 sites are now enabled to accept OpenID logins” sourcehttp://blog.janrain.com/2009/05/relying-party-stats-as-of-may-1-2009.html
But you can’t force OpenID on people…(yet)
http://romano.myopenid.com/
nettab
OR
Password handled by third partyOpenID provider
+84%
16%
Once logged in, each user gets a profile pageidentified by a URI
Search Engine
reviewsratingsgroupsfriendships
tags
Enactor
filesworkflows
`
HTML
For DevelopersFor Developers
RDF Store
SPAR
QL
endp
oint
Managed REST API
iGoogle
android
XML
APIconfig
mySQL
profiles
packscredits
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>PREFIX myexp: <http://rdf.myexperiment.org/ontology#>PREFIX sioc: <http://rdfs.org/sioc/ns#>select ?friend1 ?friend2 ?acceptedat where {?z rdf:type<http://rdf.myexperiment.org/ontology#Friendship> . ?z myexp:has-requester?x .?x sioc:name ?friend1 . ?z myexp:has-accepter ?y . ?y sioc:name ?friend2 .?z myexp:accepted-at ?acceptedat }
All accepted Friendships including accepted-at time Semantically-Interlinked
Online Communities
SPARQL endpoint: maximises data re-useSPARQL endpoint: maximises data re-use
future workPhase 2
• Repository integration (institutional: EPrints, Fedora)
• Controlled vocabularies
• Relationships between items (in and between packs)
• Recommendations
• Improved search ranking and faceted browsing
• Indexing of packs
• New contribution types (Meandre, Kepler, e-books)
• Further blog / wiki integration
• Biocatalogue integration
Phase 2Phase 2
Representing Evidence For Interacting Network Elements
http://www.biomodels.net
http://www.sbml.org
http://pubmed.gov
Case Study REFINE Project: Improving SBML models
Metabolic reconstruction
Difficult
Document level
“tools and resources” - fairly straightforward
Example from Glycolysis in Yeast
reactant
reactant product
productmodifier
This is just one reaction, there are at least another 1700+ in Yeast
Refine Workflow:
1. Given SBML file, list all reactions
2. For each reactant, get synonms (e.g. synonyms of “D-glucose”)
3. Construct PubMed queries and execute them
4. Rank results
5. Display results to user
Workflow itself not rocket science (just a tool that needed to be built)
Services 2 and 4 have been based on other people’s workflows
saved lots of effort re-inventing the wheel
Services 1, 3 and 5 are “private” during prototyping
• Of the 661 workflows, 531 are publicly visible whereas 502 are publicly downloadable.
• 3% of the workflows with restricted access are entirely private to the contributor and for the remaining they elected to share with individual users and groups.
• 69 workflows (over 10%) have been shared, with the owner granting edit permissions to specific users and groups.
• In addition there are 52 instances where users have noted that a workflow is based on another workflow on the site.
• The most viewed workflow has 1566 views.
• There are 50 packs, ranging from tutorial examples to bundles of materials relating to specific experiments.
C
Some preliminary data: First few months of use
Conclusions
• myExperiment experience so far has been
• Scientists do share data but…
– you need to get digital identity right (still an unsolved problem)
– Get digital attribution right
• Allow fine grained control over what is shared and when with who and with what license…
Conclusions: Aristocracy 2.0 or Democracy 2.0?
Web 2.0 Science 1.0 ?
Wisdom of Crowds Wisdom of experts
Lightly filtered information (or not filtered at all)
Heavily filtered information (peer review)
Democratic (“a link is a vote”) andTechnocratic (“The geeks shall inherit the earth”)
Artistocratic? (program committees, editorial boards, funding panels, academic faculty staff etc)
Low barrier to entry, inclusive High barrier to entry, exclusive
What will Science 2.0 look like once scientists start sharing more data on the web?
We live in exciting times!
Conclusions: Participation Inequality:
http://www.useit.com/alertbox/participation_inequality.html
Dr. Jakob Nielsen
90% of users in online communities are “lurkers” who never contribute
We need you!
• It’s all about collaboration
• Sign up for an account at http://www.myexperiment.org
• Please get in touch if you’d like to join in
• Mailing list [email protected]
• Questions?
• … and now for a live demonstration
Grazie!
• Paolo Romano, Rosalba Guigno and the organisers / delegates of NETTAB 2009
• Università degli Studi di Catania (University of Catania) for hosting
• Rete Nazionale de Bioinformatica Oncologica (Italian Network for Oncology Bioinformatics) http://www.rnbio.it for funding
• myExperiment team, led by Dave De Roure, Carole Goble, also Jiten Bhagat, Danius Michaelides, Don Cruickshank, Sergejs Aleksejevs, Paul Fisher, ( Also Kell Group lab members, Paul Dobson and Neil Swainston)
• REFINE project, Sophia Ananiadou, Douglas Kell, Steve Pettifer, Jun'ichi Tsujii, Yoshimasa Tsuruoka funded by BBSRC and at http://www.nactem.ac.uk