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Myths and Misinformation About Saturated Fat and Cholesterol: How Bad Science and Big Business
Created the Obesity Epidemic
Departments of Psychology, Molecular Pharmacology and Physiology, University of South Florida
and Research and Development Service, J.A. Haley Veterans Hospital
David Diamond, Ph.D.
2005 2006 2007 2008 2009 2010 2011 20120
100
200
300
400
500
600
700
800
Years
Bad News: Abnormal Blood Lipids
Triglycerides (mg/dl)
Heart Disease Risk
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Bad News: Abnormal Blood Lipids
Years
Total/HDL
2005 2006 2007 2008 2009 2010 2011 20124.5
5.0
5.5
6.0
6.5
7.0
Heart Disease Risk
The Solution: Diet Changes and Exercise
Total/HDL
2005 2006 2007 2008 2009 2010 2011 20124.5
5.0
5.5
6.0
6.5
7.0
Heart Disease Risk
Years
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Diet Skinless Chicken, Low Fat Foods (Cheese, Yogurt), Olive Oil, Bread,
Vegetables, Fruit, Nuts, Cereal, Potatoes Total/HDL
2005 2006 2007 2008 2009 2010 2011 20124.5
5.0
5.5
6.0
6.5
7.0
Heart Disease Risk
Years
Total/HDL
2005 2006 2007 2008 2009 2010 2011 20124.5
5.0
5.5
6.0
6.5
7.0
Heart Disease Risk
X Diet
Skinless Chicken, Low Fat Foods (Cheese, Yogurt), Olive Oil, Bread, Vegetables, Fruit, Nuts, Cereal, Potatoes
Years
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Total/HDL
2005 2006 2007 2008 2009 2010 2011 20124.5
5.0
5.5
6.0
6.5
7.0
Heart Disease Risk
X Diet
Skinless Chicken, Low Fat Foods (Cheese, Yogurt), Olive Oil, Bread, Vegetables, Fruit, Nuts, Cereal, Potatoes
Years
Really Scary News
2005 2006 2007 2008 2009 2010 2011 20120
100
200
300
400
500
600
700
800
Heart Disease Risk
Triglycerides (mg/dl)
!!
Years
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2005 2006 2007 2008 2009 2010 2011 20124.5
5.0
5.5
6.0
6.5
7.0Total/HDL
Heart Disease Risk
!!
Years
Really Scary News
Obesity and Heart Disease in My Future
Years 2005 2006 2007 2008 2009 2010 2011 20120
145
150
155
160
165
170
175
weight in 1980
Body Weight (lb) !!
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Myths and Misinformation:
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease
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Myths and Misinformation:
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease
Myth #2: - Cholesterol clogs arteries and causes heart disease -
You will live longer if you take medication to lower your cholesterol
Myths and Misinformation:
Misinformation: Food and Drug Company-Supported Research and the government have provided incorrect recommendations on ideal sources of food
for optimal health – we have been misled
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease
Myth #2: - Cholesterol clogs arteries and causes heart disease -
You will live longer if you take medication to lower your cholesterol
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Obesity
Heart Disease
Diabetes
Alzheimer s Disease
Hypertension
Stroke
Cancer
Arthritis
Metabolic Syndrome
Historical Perspective on Diet, Obesity and Health (1864 - Present)
5 5 >200 lbs Obesity-related health problems
William Banting (1797 – 1878)
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Historical Perspective on Diet, Obesity and Health (1864 - Present)
His doctor (Dr. William Harvey) prescribed a low carbohydrate diet:
Unlimited consumption of meat No potatoes, bread or sugar
William Banting (1797 – 1878)
5 5 >200 lbs Obesity-related health problems
Historical Perspective on Diet, Obesity and Health (1864 - Present)
His doctor (Dr. William Harvey) prescribed a low carbohydrate diet:
Unlimited consumption of meat No potatoes, bread or sugar
The Banting diet was a great success Banting lost 46 lbs, enjoyed great
health, and lived into his 80 s. (no clogged arteries!)
William Banting (1797 – 1878)
5 5 >200 lbs Obesity-related health problems
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An obese person ! may be given a diet of meat, excluding bread and potatoes, and
the patient will reduce to his normal weight. As soon as the patient returns to
his diet of bread and potatoes, he straightaway begins to increase in weight.
11889922
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=
1972 1864
Eat Meat (fat): Lose weight But is it a healthy diet?
Does eating red meat, full fat cheese, butter and eggs increase serum cholesterol?
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HDL (good cholesterol) Total Cholesterol Triglycerides
LDL (bad cholesterol) Ratio Total/HDL Blood Glucose
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Low Carb Diet (unlimited red meat): Lose Weight and Lower Cholesterol!
If a low carb diet reduces serum cholesterol, will a high carb diet (sugar) increase serum
cholesterol?
Low Carb Diet (unlimited red meat): Lose Weight and Lower Cholesterol!
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0 2 4 6 8 10 12 14 16 18 20
0
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300
400
500
600
0 2 4 6 8 10 12 14 16 18 20
150
200
250
300
350
Triglycerides (mg/dl)
Cholesterol (mg/dl)
Normal Diet No Sugar + Sugar No Sugar
Weeks
2005 2006 2007 2008 2009 2010 2011 20120
100
200
300
400
500
600
700
800
Years
My Diet (2007 – Present) Eggs, Butter, Beef, Chicken (with the skin), Full Fat Cheese, Coconut,
Dark Chocolate, Nuts and Vegetables (Broccoli) Small Quantities of Fruit, Bread, Potatoes and Sugar
Heart Disease Risk
Triglycerides (mg/dl)
Low Carb Diet
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2005 2006 2007 2008 2009 2010 2011 20120
100
200
300
400
500
600
700
800
Triglycerides (mg/dl)
Years
Heart Disease Risk
70% Fat 20% Protein 10% Carbs
Low Carb Diet
My Diet (2007 – Present) Eggs, Butter, Beef, Chicken (with the skin), Full Fat Cheese, Coconut,
Dark Chocolate, Nuts and Vegetables (Broccoli) Small Quantities of Fruit, Bread, Potatoes and Sugar
Years 2005 2006 2007 2008 2009 2010 2011 2012
4.5
5.0
5.5
6.0
6.5
7.070% Fat
20% Protein 10% Carbs
Heart Disease Risk
Total/HDL
Low Carb Diet
My Diet (2007 – Present) Eggs, Butter, Beef, Chicken (with the skin), Full Fat Cheese, Coconut,
Dark Chocolate, Nuts and Vegetables (Broccoli) Small Quantities of Fruit, Bread, Potatoes and Sugar
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2005 2006 2007 2008 2009 2010 2011 20120
145
150
155
160
165
170
175
Body Weight (lb)
Years
weight in 1980
70% Fat 20% Protein 10% Carbs
Low Carb Diet
My Diet (2007 – Present) Eggs, Butter, Beef, Chicken (with the skin), Full Fat Cheese, Coconut,
Dark Chocolate, Nuts and Vegetables (Broccoli) Small Quantities of Fruit, Bread, Potatoes and Sugar
Our Current State of Confusion
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Consequences of the Fat Phobia
Carbohydrates
Fats
Protein
1970 1980 1990 2000
Excess Consumption of Carbs
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Simple Message to the Obese: Stop the Vilification of the Atkins Diet
It s ok to eat meat, lose weight!
Eat Less Carbs: Less Potatoes, Bread and Anything Sweet
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Myths and Misinformation:
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease
Myths and Misinformation:
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease X
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How Did Food Recommendations Go Awry?
Deaths from Cardiovascular Disease
Lloyd-Jones et al, 2010. Circulation
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Deaths from Cardiovascular Disease
Lloyd-Jones et al, 2010. Circulation
Keys (1953). Journal of the Mount Sinai Hospital New York
There is a remarkable relationship between death rate from heart
disease and the proportion of fat calories
in the national diet
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Keys (1953). Journal of the Mount Sinai Hospital New York
- Ancel Keys cheated - He selected data from 6 countries to create the
linear relationship. Data were actually
available from a total of 22 countries!
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No Significant Relation Between Fat Consumption and Heart Disease
Mortality (r2=0.1, p > 0.05)
Significant Relation Between Sugar Consumption and Heart Disease
Mortality (r2=0.41, p < 0.05)
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A generation of citizens has grown up since the Diet/Heart Hypothesis was launched as official dogma. They have been misled by the greatest scientific deception of our times: the notion that consumption of animal fat causes heart disease.
Coronary Heart Disease – Doing the Wrong Things
Nutrition Today (July, 1985)
George Mann, Sc.D., M.D. Professor, Nutritional Biochemist,
Vanderbilt University Associate Director of the Framingham Study
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Intake of total fat was not significantly associated with coronary events (heart attacks) or mortality
Intake of saturated fat (animal fat) was not significantly
associated with coronary events or mortality
Fatal heart disease was not reduced by low-fat diets or by replacing saturated (animal) fats with polyunsaturated
(vegetable) fats
Walter Willett, M.D. Chair, Department of Nutrition
Harvard School of Public Health
data on nearly 300,000 individuals ! clearly contradict the low-fat-is-good-health message ! the exclusive focus on adverse effects of fat may have contributed to the obesity
epidemic.
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Ancel Keys – Created the Artificial Link Between Fat and CHD Became Editor of Circulation
on the cover of Time Magazine, January, 1961
In 1977, a Senate Committee led by George McGovern released its "Dietary Goals for the United States." Without any evidence to support their conclusions, the committee identified fat as the
culprit causing obesity.
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The President of the US National Academy of Sciences, Dr. Philip Handler, an expert on metabolism, referred to
McGovern s Dietary Goals as nonsense .
Steak for Dinner, Angioplasty for Dessert? The Myth That Cholesterol Clogs Arteries
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Thanks solely to Madison Avenue promotion by commercial food producers and the American Heart Association, a great
many people imagine that if they lower their blood cholesterol ! they will prevent heart disease... Few people realize that there has
never been a proven, scientific relationship between lowering blood cholesterol levels and preventing heart disease
The Cholesterol Controversy, 1973
by Edward Pinckney, M.D. Editor of Journal of the American Medical Association
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An almost endless number of observations and experiments have effectively falsified the hypothesis that dietary cholesterol and fats, and a high cholesterol play a role in the causation of atherosclerosis and cardiovascular disease. The hypothesis is
maintained because allegedly supportive, but insignificant findings, are inflated and most contradictory results are ignored.
A hypothesis out-of-date: The diet-heart idea
by Uffe Ravnskov, M.D., Ph.D. Journal of Clinical Epidemiology, 55:1057-1063, 2002
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- of 480,000 men, screened the top 5% in cholesterol level (290 mg/dl) to be in the study
-!followed for 7.4 years, treated with cholestyramine or placebo
24% reduction in heart disease-related deaths!
- of 480,000 men, screened the top 5% in cholesterol level (290 mg/dl) to be in the study
-!followed for 7.4 years, treated with cholestyramine or placebo
24% reduction in heart disease-related deaths!
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Start: 480,000 men
98% (Placebo) vs 98.4% (Treated) Survived
Start: 480,000 men
0.4% becomes 24%
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Start: 480,000 men
0.4% becomes 24%
96.3% (Placebo) vs 96.4% (Treated) Survived
Start: 480,000 men
The $120 Million Study That Produced a Non-Significant Treatment Difference of 3 People!
= 0.1%
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The Drug Trial Failed Miserably – Lowering Cholesterol Had no Significant
Effect on Mortality
The Drug Trial Failed Miserably – Lowering Cholesterol Had no Significant
Effect on Mortality
The Lead Investigators Declared Victory – Predicting Heart Disease Would Be Eradicated With Drugs
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No sensible person can avoid the conclusion that the NCEP is an expensive fraud perpetuated by avaricious business
enterprises and dishonest scientists.
George Mann, Sc.D., M.D. Professor, Nutritional Biochemist,
Vanderbilt University
The Missing Conflict of Interest Statement
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ATP III Update 2004: Financial Disclosure
Dr. Grundy has received honoraria from Merck, Pfizer, Sankyo, Bayer, Merck/Schering-Plough, Kos, Abbott, Bristol-Myers Squibb, and AstraZeneca; he has received research grants from Merck, Abbott, and Glaxo Smith Kline. Dr. Grundy Dr. Cleeman has no financial relationships to disclose. Dr. Bairey Merz has received lecture honoraria from Pfizer, Merck, and Kos; she has served as a consultant for Pfizer, Bayer, and EHC (Merck); she has received unrestricted institutional grants for Continuing Medical Education from Pfizer, Procter & Gamble, Novartis, Wyeth, AstraZeneca, and Bristol-Myers Squibb Medical Imaging; she has received a research grant from Merck; she has stock in Boston Scientific, IVAX, Eli Lilly, Medtronic, Johnson & Johnson, SCIPIE Insurance, ATS Medical, and Biosite. Dr. Brewer has received honoraria from AstraZeneca, Pfizer, Lipid Sciences, Merck, Merck/Schering-Plough, Fournier, Tularik, Esperion, and Novartis; he has served as a consultant for AstraZeneca, Pfizer, Lipid Sciences, Merck, Merck/Schering-Plough, Fournier, Tularik, Sankyo, and Novartis. Dr. Clark has received honoraria for educational presentations from Abbott, AstraZeneca, Bristol-Myers Squibb, Merck, and Pfizer; he has received grant/research support from Abbott, AstraZeneca, Bristol-Myers Squibb, Merck, and Pfizer. Dr. Hunninghake has received honoraria for consulting and speakers bureau from AstraZeneca, Merck, Merck/Schering-Plough, and Pfizer, and for consulting from Kos; he has received research grants from AstraZeneca, Bristol-Myers Squibb, Kos, Merck, Merck/Schering-Plough, Novartis, and Pfizer. Dr. Pasternak has served as a speaker for Pfizer, Merck, Merck/Schering-Plough, Takeda, Kos, BMS-Sanofi, and Novartis; he has served as a consultant for Merck, Merck/Schering-Plough, Sanofi, Pfizer Health Solutions, Johnson & Johnson-Merck, and AstraZeneca. Dr. Smith has received institutional research support from Merck; he has stock in Medtronic and Johnson & Johnson. Dr. Stone has received honoraria for educational lectures from Abbott, AstraZeneca, Bristol-Myers Squibb, Kos, Merck, Merck/Schering-Plough, Novartis, Pfizer, Reliant, and Sankyo; he has served as a consultant for Abbott, Merck, Merck/Schering-Plough, Pfizer, and Reliant.
Dr. Grundy ! honoraria from Merck, Pfizer, Sankyo, Bayer, Merck/Schering-Plough, Kos, Abbott, Bristol-Myers Squibb and AstraZeneca; ! research grants from Merck, Abbott and Glaxo Smith Kline.
ATP III Update 2004: Financial Disclosure
Dr. Grundy has received honoraria from Merck, Pfizer, Sankyo, Bayer, Merck/Schering-Plough, Kos, Abbott, Bristol-Myers Squibb, and AstraZeneca; he has received research grants from Merck, Abbott, and Glaxo Smith Kline. Dr. Grundy Dr. Cleeman has no financial relationships to disclose. Dr. Bairey Merz has received lecture honoraria from Pfizer, Merck, and Kos; she has served as a consultant for Pfizer, Bayer, and EHC (Merck); she has received unrestricted institutional grants for Continuing Medical Education from Pfizer, Procter & Gamble, Novartis, Wyeth, AstraZeneca, and Bristol-Myers Squibb Medical Imaging; she has received a research grant from Merck; she has stock in Boston Scientific, IVAX, Eli Lilly, Medtronic, Johnson & Johnson, SCIPIE Insurance, ATS Medical, and Biosite. Dr. Brewer has received honoraria from AstraZeneca, Pfizer, Lipid Sciences, Merck, Merck/Schering-Plough, Fournier, Tularik, Esperion, and Novartis; he has served as a consultant for AstraZeneca, Pfizer, Lipid Sciences, Merck, Merck/Schering-Plough, Fournier, Tularik, Sankyo, and Novartis. Dr. Clark has received honoraria for educational presentations from Abbott, AstraZeneca, Bristol-Myers Squibb, Merck, and Pfizer; he has received grant/research support from Abbott, AstraZeneca, Bristol-Myers Squibb, Merck, and Pfizer. Dr. Hunninghake has received honoraria for consulting and speakers bureau from AstraZeneca, Merck, Merck/Schering-Plough, and Pfizer, and for consulting from Kos; he has received research grants from AstraZeneca, Bristol-Myers Squibb, Kos, Merck, Merck/Schering-Plough, Novartis, and Pfizer. Dr. Pasternak has served as a speaker for Pfizer, Merck, Merck/Schering-Plough, Takeda, Kos, BMS-Sanofi, and Novartis; he has served as a consultant for Merck, Merck/Schering-Plough, Sanofi, Pfizer Health Solutions, Johnson & Johnson-Merck, and AstraZeneca. Dr. Smith has received institutional research support from Merck; he has stock in Medtronic and Johnson & Johnson. Dr. Stone has received honoraria for educational lectures from Abbott, AstraZeneca, Bristol-Myers Squibb, Kos, Merck, Merck/Schering-Plough, Novartis, Pfizer, Reliant, and Sankyo; he has served as a consultant for Abbott, Merck, Merck/Schering-Plough, Pfizer, and Reliant.
Dr. Grundy ! honoraria from Merck, Pfizer, Sankyo, Bayer, Merck/Schering-Plough, Kos, Abbott, Bristol-Myers Squibb and AstraZeneca; ! research grants from Merck, Abbott and Glaxo Smith Kline.
$150,000/drug company x 10 = $1,500,000/year!
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ATP III Update 2004: Financial Disclosure
Dr. Grundy has received honoraria from Merck, Pfizer, Sankyo, Bayer, Merck/Schering-Plough, Kos, Abbott, Bristol-Myers Squibb, and AstraZeneca; he has received research grants from Merck, Abbott, and Glaxo Smith Kline. Dr. Grundy Dr. Cleeman has no financial relationships to disclose. Dr. Bairey Merz has received lecture honoraria from Pfizer, Merck, and Kos; she has served as a consultant for Pfizer, Bayer, and EHC (Merck); she has received unrestricted institutional grants for Continuing Medical Education from Pfizer, Procter & Gamble, Novartis, Wyeth, AstraZeneca, and Bristol-Myers Squibb Medical Imaging; she has received a research grant from Merck; she has stock in Boston Scientific, IVAX, Eli Lilly, Medtronic, Johnson & Johnson, SCIPIE Insurance, ATS Medical, and Biosite. Dr. Brewer has received honoraria from AstraZeneca, Pfizer, Lipid Sciences, Merck, Merck/Schering-Plough, Fournier, Tularik, Esperion, and Novartis; he has served as a consultant for AstraZeneca, Pfizer, Lipid Sciences, Merck, Merck/Schering-Plough, Fournier, Tularik, Sankyo, and Novartis. Dr. Clark has received honoraria for educational presentations from Abbott, AstraZeneca, Bristol-Myers Squibb, Merck, and Pfizer; he has received grant/research support from Abbott, AstraZeneca, Bristol-Myers Squibb, Merck, and Pfizer. Dr. Hunninghake has received honoraria for consulting and speakers bureau from AstraZeneca, Merck, Merck/Schering-Plough, and Pfizer, and for consulting from Kos; he has received research grants from AstraZeneca, Bristol-Myers Squibb, Kos, Merck, Merck/Schering-Plough, Novartis, and Pfizer. Dr. Pasternak has served as a speaker for Pfizer, Merck, Merck/Schering-Plough, Takeda, Kos, BMS-Sanofi, and Novartis; he has served as a consultant for Merck, Merck/Schering-Plough, Sanofi, Pfizer Health Solutions, Johnson & Johnson-Merck, and AstraZeneca. Dr. Smith has received institutional research support from Merck; he has stock in Medtronic and Johnson & Johnson. Dr. Stone has received honoraria for educational lectures from Abbott, AstraZeneca, Bristol-Myers Squibb, Kos, Merck, Merck/Schering-Plough, Novartis, Pfizer, Reliant, and Sankyo; he has served as a consultant for Abbott, Merck, Merck/Schering-Plough, Pfizer, and Reliant.
Dr. Bairey Merz ! honoraria from Pfizer, Merck, and Kos; she has served as a consultant for Pfizer, Bayer and Merck; she has received grants from Pfizer, Procter & Gamble, Novartis, Wyeth, AstraZeneca and Merck; she has stock in Boston Scientific, IVAX, Eli Lilly, Medtronic, Johnson & Johnson ...
Dr. Grundy ! honoraria from Merck, Pfizer, Sankyo, Bayer, Merck/Schering-Plough, Kos, Abbott, Bristol-Myers Squibb and AstraZeneca; ! research grants from Merck, Abbott and Glaxo Smith Kline.
$150,000/drug company x 10 = $1,500,000/year!
* These guidelines were developed by people with a financial conflict of interest.
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Are they wrong?
A Different Opinion From Scientists Unsupported by the Statin Industry
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*These guidelines were developed by people with a financial conflict of interest. **These guidelines have been disputed by scientists without a conflict of interest.
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Isn t there a benefit from statins in the reduction of cardiac events?
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"What if you put 250 people in a room and told them they would each pay $1,000 a year for a drug they would have to
take every day, that many would get diarrhea and muscle pain, and that 249 would have no benefit?"
Jerome R. Hoffman, M.D.
Professor of Clinical Medicine, UCLA School of Medicine
Isn t there a benefit from statins in the reduction of cardiac events?
Adverse Side Effects of Statins
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Adverse Side Effects of Statins: Erectile Dysfunction, Type 2 Diabetes, Rhabdomyolysis,
Acute Renal Failure, Cancer and Liver Dysfunction
Final 2 Issues:
What Caused the Increase in Deaths from Cardiovascular Disease in the 20th Century?
How is Cholesterol Involved in Heart Disease? Villain or Misunderstood Hero?
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Lloyd-Jones et al, 2010. Circulation
Does Butter or Saturated Fat Consumption Parallel the Increase in Heart Disease-Related Death?
Deaths from Cardiovascular Disease
No Relation of Butter Consumption to Heart
Disease
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No Relation of Saturated Fat Consumption to
Heart Disease
Deaths from Cardiovascular Disease
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Clear Relation of Smoking to Heart
Disease
Deaths from Cardiovascular Disease
Cross Section of a Damaged Artery What Causes Coronary Heart Disease?
sugar
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What Causes Coronary Heart Disease?
What Causes Coronary Heart Disease?
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LDL
WBC
What Causes Coronary Heart Disease?
Thickening of the Artery Wall Following Repeated Injury and Repair
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Myths and Misinformation:
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease
Myths and Misinformation:
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease X
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Myths and Misinformation:
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease
Myth #2: - Cholesterol clogs arteries and causes heart disease -
You will live longer if you take medication to lower your cholesterol
X
Myths and Misinformation:
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease
Myth #2: - Cholesterol clogs arteries and causes heart disease -
You will live longer if you take medication to lower your cholesterol
X X
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Myths and Misinformation:
Misinformation: We have been misled
Myth #1: Consumption of food high in saturated fat and cholesterol (beef, butter) makes people fat and causes heart disease
Myth #2: - Cholesterol clogs arteries and causes heart disease -
You will live longer if you take medication to lower your cholesterol
X X The Bittersweet End Of Humans as Hunters
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My Mentors
Anthony Colpo Gary Taubes Barry Groves
Paul Rosch, M.D. Jeff Volek, Ph.D. Rodney Hayward, M.D. Walter Willett, M.D. Joel Kauffman, Ph.D. John Abramson, M.D. Walter Willett, M.D., Ph.D. Robert C. Atkins, M.D. Uffe Ravnskoff, M.D., Ph.D. Germain Brisson, Ph.D. James H. Salisbury, M.D. Emmet Densmore, M.D. C. De Lacy Evans Marcia Angell, M.D. Jean Anthelme Brillat-Savarin John Abramson, M.D. George Mann, ScD., M.D. James H. Salisbury, M.D. Duane Graveline, M.D. Kilmer McCully, M.D. Nancy Appleton, Ph.D. Bruce Fife, C.N., N.D. Jay S. Cohen, M.D. William Rothstein, Ph.D. Edward H. Ahrens, M.D. Michael F. Oliver, M.D.
Edward R. Pinckney, M.D. and Cathey Pinckney Sally Fallon and Mary G. Enig, Ph.D.
Are there any questions?