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Introduction to

Nanobiotechnology

Assignment # 2

Nano-gate Implant

Submitted to: Dr. Zahra

Submitted by: Irum

Date: 2Nov, 2015

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Nano-Gate Implant

What is Nano-gate implant

Nano-gate implant is a nanostructured-material based technology designed for constant

passive diffusion of drug through a Nano-pore membrane engineered to exact size and

requirement of individual molecules.

he !ompany developed Nano-"#$, a %mall !ylindri!al implant in%erted under the %&in

providing a !ontinuou% alpha inter'eron relea%e 'or () month%.

Composition and structure of Nano-gate implant

Nano-gate implant i% !ompo%ed o' Nano-pore membrane% that are important 'or the

'abri!ation o' Nano-gate implant, and %ili!on 'ilm% *ith parallel re!tangular !hannel%

array% o' +50 nm in diameter.

Nano-gate implant i% 'itted around by +00 mi!roliter re%ervoir% 12!m in length and (5!m

diameter !apped at both end% o' Nano-gate implant, membrane% !ontrol% the di''u%ion o'

drug% 'rom the !ap%ule, providing a !ontinuou% relea%e o' drug 'or 'rom (-) month%. Nano-gate implant i% +-5mm in diameter and 20-(5mm in length *ith a 5-(00mi!rolitre

re%ervoir that !ontain a %u%pen%ion or %olid-%tate drug 'ormula.

he !arrier i% 'itted *ith t*o %ili!one -ring% and in%erted into the titanium en!a%ement.

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Fig1.

This is structure of Nano-gate implant capped at both ends, having nano-pore membrane

of mm !idth, fitted !ith "-rings of silicon inserted into titanium encasement.

Biocompatibility of Nano-gate implant

io!ompatibility o' Nano-gate implant i% due to non-'ouling o' %ili!on Nano-pore membrane%.

#'ter !onta!t *ith body, *hen !ell% protein% and other biologi!al !omponent% adhere to the

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%ur'a!e the%e do not limit di''u%ion o' mole!ule%. So Nano-gate implant i% !ompletely 'un!tional

in-vivo, and relea%e drug !on%tantly over e/tended time period.

Applications of Nano-gate implantNano gate implant u%e in:

#rug delivery system

Nano gate in io 'iltration.

Nano-gate implant in drug delivery

he nano-gate implant i% u%ed in drug delivery %y%tem.

Principle

#% implant i% !ompo%ed o' nanpore membrane %o the drug i% 'illed upon arranging the membrane

*ith titanium grate opening. Nano-pore membrane that i% made up o' %ili!on 'ilm !ontrol% the

drug di''u%ion. ore %ie i% de%igned a!!ording to %ie o' drug mole!ule%.

Nano-gate implant te!hnology i% di''u%ion driven, that provide more %pa!e 'or drug 'ormulation.

It !an be u%ed 'or targeted delivery o' alpha-inter'eron to the tumor %ite but %ide e''e!t% may be

ob%erved.

It i% %uitable 'or the delivery o' protein and peptide drug%.

Advantages

Drug i% prote!ted by immunologi!al rea!tion o' body by nano-pore membrane, it relea%e%

the drug but prevent the entry o' un*anted !ell%. hey are bio!ompatible and biodegradable

rovide% !ontrolled relea%e and improve %olubility o' hydrophobi! drug%.