nanoco technologies · pdf file3 key personnel • professor paul o’brien –...
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Nanoco Technologies Ltd
“illuminated by Nanoco”“Nanoco Illuminating the Future ”
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Who is Nanoco?• Nanotechnology Spin-out from University of Manchester
established in 2002
• Manufacturing company, producing fluorescent semiconductor nanoparticles "quantum dot“ and quantum dot products
• Develop and own key technology and intellectual property for the production of Quantum Dots
• Manufacture Quantum Dots which is a “platform technology” with many applications in different industry sectors
• Currently supply emerging research and commercial markets with prefabricated quantum dot
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Key Personnel
• Professor Paul O’Brien– Co-founder and Technical Advisor– World leading academic in field inorganic chemistry, nano-material
science– Over 300 papers published and patents filed
• Dr Nigel Picket– Co-founder and Technical Director– Leading expert on semi-conducting nano-crystals– Previous employment for Japanese Government and US Navy
• Dr Michael Edelman– CEO– Experienced entrepreneur in starting and running high growth
technology driven global companies
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What are Quantum Dots?
• Fluorescent Nano-crystalline particles of semiconductor material – Cadmium Selenide. The same materials used in many electronic devices
• Size quantization effect - tune physical properties by changing the size of the particle between 2-10 nanometers (e.g. change color by changing particle size)
• Unique chemical and electronic properties gives rise to their potential use in many applications
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What is a Quantum Dot?
O POP
O
P
O
P
O POP
O
P
O
P
The size of both core and shell of the particle can be changed
The capping agent can be changed
The organic groups on the capping agent can be functionalized for further chemical synthesis
O POP
O
P
O
P
O POP
O
P
O
P
O POP
O
P
O
P
O POP
O
P
O
P
The size of both core and shell of the particle can be changed
The capping agent can be changed
The organic groups on the capping agent can b further chemical synthesis
High-resolution transmission electron microscopy image showing the lattice plans of a nano-crystalline Quantum Dot, measuring 5nm
across (80,000 times smaller than the width of a human hair)
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What do Quantum Dots do?
• Quantum dots absorb light over a wide wavelength range but have narrow emission spectra.
• The solutions, all contain the same semiconductor material (CdSe) but are different colours because unlike bulk CdSe, when below a certain size limit, we can control the electrical properties of the particles, by simply changing their size.
300 400 500 600 700 800
Wavelenght (nm)
Abs
orba
nce
(a.u
.)PLUV
526
511
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How Quantum Dots Work1. UV light excites QD and kicks out electron creating electron-hole
pair2. As electron relaxes back into hole a photon is emitted – visible light3. Size quantization effect – wavelength emitted depends on physical
size of QD
e-
UV light
e-
Visible light
e-
electron relaxes back into hole
UV light excites QD kicks out electron
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Nanoco - What We Do:
• Manufacturer of large volumes of quantum dots > 40g per a batch
– High quality (sharper color)– Consistent (batch to batch)
• Patented technology
Electron micrograph of CdSe-ZnS QD
Nanoco Products:
- Organic-solvent soluble quantum dots- Water soluble functionalized quantum dots
- Second generation Ultrabright®quantum dots
- Quantum dot containing beads
QD under Fluorescent light
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Applications for Quantum DotsWhy use Quantum Dots?
• Replacement for luminescent dyes and inorganic materials • Better optical and electronic efficiencies• More stable (photo-bleaching)• More versatile (tune from UV to near IR)
• Biological screening
• Imaging• Sunscreen
• Light emitting diodes• Chemical\biological
sensors• Flat panel displays• Solar cells
• Solar cells• Data storage• Security
application/ Bar coding
• Single electron devices
• Quantum computing
10 – 30 yearsCurrent applications
1 – 5 years 6 – 10 years
QD
Vol
ume
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Solar cell devices/Plastic solar cells/roofing tiles
Sun Light
• Capture full spectrum of radiation• Quantum dots can be processed into inks• High efficiency of quantum dots• Tune the quantum dots to the radiation that you want to capture
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Flat Screen Displays and QD-LED’s
• Low energy consumption• Same material for all colours• High efficiency
Low energy UV Light
Red
Green
Blue
Full colour displays by size control of quantum dotsusing a low energy consumption UV back light
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Quantum Dots used in Biological Applications
Bioconjugation of quantum dots with cell
(COOH and NH2 functionalised QD)
Cell
Biocompatible polymercoating
Labelling cell
Affinity LigandQuantum dot
Cell
Biocompatible polymercoating
Labelling cell
Affinity LigandQuantum dot
Confocal pictures of different size (A) 615nm, (B) 489nm CdSe/ZnS QDs labeling Lymphocyte Cells
Small quantities of quantum dots required
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Quantum Dots used in Biological Probes• Healthcare and Life Sciences Luminescent component in biological probes
• n colours and m intensities nm-1
2 nm 3 nm 4 nm
O P
OP
OP
OP
O P
OP
OP
OP
48 0 53 0 58 0 63 0 68 0
Counts, (a. u.)
Wav
wle
ng
th (
nm)
O POP
OP
OP
O POP
OP
OP
O POP
OP
OP
O POP
OP
OP
0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
0.4
400 450 500 550 600 650
Wavelength (nm)
Abso
rban
ce (a
.u.)
15nm
CdSe nanoparticle Encapsulated in a
Polymer bead
Receptor LigandsAntibodiesAntigens
Nucleic acidProteinsEnzymes
Narrow Emission SpectraWide Absorption Spectra
CellVirusDNA
Chemical agent
Cell
CellVirusDNA
Chemical agent
Cell
350 400 450 500 550 600 650
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Quantum dot containing beads – encoded beads
400 450 500 550 600 650 700
Wavelength (nm)
Cou
nts
(a.u
.)
Quantum dot-containing encoded beads
• High throughput screening• Anti-counterfeiting • Phosphors• Monitoring flow systems
Schematic of a polymer bead containing three different colours of quantum dots to
give an optical barcode
450 500 550 600 650 700 750
wavelength (nm)
450 500 550 600 650 700 750
wavelength (nm)
312555
25644
2733
422
No of combinations
No of intensities
No of colours
Microscope image of a polymer bead containing three different sizes of quantum dots and the photoluminescent emission spectrum of 3 different bead encodings
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Other ApplicationsAnti-counterfeiting tags (CD’s, packaging, fabric, documents currency...)
$10
CCDScanner
via internet
$10
Normal light UV Light
Readable covert code
350 400 450 500 550 600 650
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Progress - Initial discussions with
• major ink company • major display technology company• solar cell company• A number of companies in the biological area
Investment –
• MTF – Manchester Technology Fund
• NWSF – North West Seed Fund
• YFM – Yorkshire Fund Managers
• UMIP – University of Manchester Intellectual Property Ltd
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Nanoco Ltd,Manchester Innovation, The Incubator Building,48 Grafton Street, ManchesterM13 9XX0161 606 7254 Fax: 0161 606 7300 [email protected]
Illuminating the future