nanometer resolution detection
DESCRIPTION
Nanometer Resolution Imaging and Computational Analysis of Axonal Transport Defects in Drosophila Models of Alzheimer’s Disease. Minhua Qiu Department of Biomedical Engineering Advisor: Dr. Ge Yang. Analysis of Axonal Transport Defects in Fly Models of AD. Nanometer Resolution Detection. - PowerPoint PPT PresentationTRANSCRIPT
A typical Fluorescence Image taken by Nikon Eclipse TE2000-U inverted microscope with a 100×/1.40 NA oil objective
Nanometer Resolution Detection
Nanometer Resolution Imaging and Computational Analysis of Axonal Transport Defects in Drosophila Models of Alzheimer’s Disease
Minhua QiuDepartment of Biomedical Engineering
Advisor: Dr. Ge Yang
System Verification
Nikon Eclipse TE2000-U inverted microscope
Fluorescent beads
NanometerResolution Piezo Stage
0 nm
8 nm
16 nmOperated by Labview
Multi-peakFitting
0 2 4 6 secs
Analysis of Axonal Transport Defects in Fly Models of AD
Brain Segmental
Nerves
Distance: 88 µm
FluorescenceImaging
APP-YFP vesicle imaged
NanometerResolutionDetection
TrajectoryRecovery
PatternRecognition
Library ofTransport
Defects