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NANOPARTICLES AND NANOTECHNOLOGY

Intelligent Nanomaterials

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CORPORATE PURPOSE

INTENANOMAT: Intelligent NanomaterialsABOUT US

DESIGN AND FABRICATION OF NANOPARTICLESFabrication, characterization and integration of nanomaterials into new products.

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N M APPLICATIONS OF NANOPARTICLESNANOPARTICLES

NanoparticleNanoparticle

Textiles

BiomedicalRenewableEnergy

FoodAgriculture

Health CareEnviroment

Electronics

Industrial

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WHAT IS A NANOPARTICLE?

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0.1 nm 1 nm 10 nm 100 nm 1 μm 10 μm 100 μm 1 mm

Water DNA Virus Bacteria Red Blood Cell Hair FleaGlucose

NANOMATERIALS

Nanoparticles NanocompositeNanotubesThin Films

WHAT IS A NANOPARTICLE?THE NANOSCALE

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N M WHAT IS A NANOPARTICLE?THE NANOSCALE

Nanoparticle

Soccer Ball

Earth

Order 10‐7

Order 1

Order 10 7

Nanoparticles are small compared to most particlesCan reach sites not accessible with larger particles with superior properties

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WHY NANOPARTICLES?

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Things are different at the nanoscale

Size really does matter!

WHY NANOPARTICLES?THE NANOSCALE

BulkBulk

Silver Gold

Nanoscale

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TYPES OFNANOPARTICLES

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Metal Nanoparticles Semiconducting Nanoparticles(Quantum Dots)

Magnetic Nanoparticles Metal Oxide Nanoparticles

Carbon‐based Nanomaterials

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N M NOBLE METAL NANOPARTICLES

107.86

Ag47

Silver

169.96

Au79

Gold

195.08

Pt78

Platinum

Strong Absorption of Light

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Shape DependenceAu Nanoparticles

Size DependenceAu Nanoparticles

8 nm 12 nm 30 nm 50 nm 70 nm 110 nm

150 nm

150 nm 150 nm

150 nm

NOBLE METAL NANOPARTICLES

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Optical properties of Metal NPs: Determined by size, shape, assembly

and environment of NPs.

NOBLE METAL NANOPARTICLES

Full‐Spectrum Absorption Of Light  Full‐Spectrum Absorption Of Light  

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N M SEMICONDUCTING NANOPARTICLES

ZnS PbSCdSe PbSe

2 nm 6 nmDiameter (nm)

Absorption and Photoluminescence

CdTe

InP

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Materials of Interest: Chalcogenide Semiconductors (II-VI and IV-VI)

ZnS (2.5 nm)

ZnSe (3.8 nm)

400 nm 700 nm 2500 nmUV VISIBLE IR

200 nm

CdS (2.8 nm)

CdSe (4.9 nm)

PbS (18 nm)

PbSe (46 nm)

PbTe (150 nm)

CdTe (6.5 nm)

Bohr Radius

SEMICONDUCTING NANOPARTICLES

Full‐Spectrum Source Of Light  Full‐Spectrum Source Of Light  

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N M MAGNETIC NANOPARTICLES

169.96

Co79

Fe3O4

Superparamagnetism

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N M METAL OXIDE NANOPARTICLES

SiO2

ZnOTiO2 NiO

PhotoCatalytic Properties

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N M CARBON‐BASED NANOMATERIALS

Nanodiamonds Nanotubes

GraphenePolymers

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N M METAL OXIDES AND OTHER NANOPARTICLES

Nanodiamonds

SiO2 Fe3O4

100 nm

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APPLICATIONS IN BIOTECHNOLOGY

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Surface FuntionalizationLarge Surface Area

Bioactive Nanoparticles

NP

WHY?WHY?

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100‐nm Au nanoparticle can take 200.000 molecules

Crushed

Single Particle(Diameter 1 cm)

Cluster of 1015 Particles(Diameter 100 nm)

Surface Area 3 cm2 Surface Area 30 m2

INCREASE OF 100.000 TIMES

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N M NANOPARTICLE FUNTIONALIZATION

+ Bioconjugation

BioActive Nanoparticles

QD

BioActive MoleculeProtein, Peptide, Gene, DNA, siRNA, Antibody, Drugs…

Nanoparticle

QD

Easy functionalization of Nanoparticles

NANOPARTICLES IN BIOTECHNOLOGY

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N M CLASSICAL MEDICINE VS NANOMEDICINE

NanoDrugsNanoDrugs

DISPERSION in all body

TARGETINGon Inflammed Cells

Targeting oninflammed zoneInflammed

Zone

HealthyCell

HealthyPart of Colon

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QD

QD

QD

Selective Binding to Cancer Cells

Targeting Agent

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N M THERAPY: DRUG DELIVERY

Cell Targeting and Drug Release

Membrane Cell

CellReceptors

BioActive Nanoparticles

Targeting Agent

Therapeutic Agent

1. Cell Targeting 2. Drug Release

Cell

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Magnetic Hyperthermia Therapy

Magnetic Nanoparticles

Targeting AgentFe3O4Fe3O4

Magnet

42‐46 ºC

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Theranostics: Simultaneous Diagnostics and Therapy

Theranostics: Simultaneous Diagnostics and Therapy

THERANOSTICS

Diagnostics(Imaging)

Nanoparticles

Therapy(Drug Delivery)(Hypertermia)

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(HYPERTHERMIA)

THERANOSTICS

TUMOUR CELL TUMOUR CELL HEALTHY CELL

Targeting Agent

Au@QD Nanoparticle

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APPLICATIONS IN FOOD

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SENSORS BASED ON METAL NANOPARTICLES

Smart Packaging for Food Spoilage ControlSmart Packaging for Food Spoilage Control

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APPLICATIONS IN RENEWABLE ENERGY

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from 20‐30% to as high as 65% from 20‐30% to as high as 65% 

PHOTOVOLTAIC CELLS

Theoretical increase of solar power efficiency

SOLAR CELLS BASED ON QUANTUM DOTS

ITO

SUN LIGHT

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APPLICATIONS IN OPTOELECTRONICS

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QLEDFLUORESCENTLAMPS

LEDs BASED ON QUANTUM DOTS

INCANDESCENT BULBS

Full‐Spectrum Source Of Light  Full‐Spectrum Source Of Light  

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APPLICATIONS IN ENVIROMENT

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Photocatalysis Based On Metal Nanoparticle

Au‐ZnO Film

Pollutant

Photodecomposition Process

DestroyedPollutant

Au NPZnO Film

SUN LIGHT

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N M CURRENT ACTIVITYINTENANOMAT

RESEARCH IN FABRICATION OF NANOPARTICLES FOR RENEWABLE, ENERGY, OPTOELECTRONICS, ENVIROMENT, SENSING…

COMMERCIALIZATION OF NANOPARTICLES FOR COSMETICSAu, Pt Nanoparticles and Nanodiamonds

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1. Accelerating Commercialization of Nanomaterials and Internationalization

OUR GOAL

2. Research Projects Based on NanoScience

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N M THE TEAMINTENANOMAT

Prof. Dr. José L. ValdésCEOProf. AstronomyCo‐Founder>120 Research Papers5 Patents

Prof. Juan P. Martínez‐PastorHead of UMDO Group at Uni. Valenciawww.uv.es/umdoProf. Applied PhysicsCo‐Founder>200 Research Papers. 6 Patents

Dr. Rafael AbarguesChief Technology OfficerPhD ChemistryCo‐Founder>60 Research Papers9 Patents

Ms. Sandra AlbertSynthesisMSc Chemistry6 Research Papers

Dr. Pedro J. Rodríguez‐CantoChief Production OfficerPhD Chemistry>20 Research Papers1 Patent

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info@intenanomat.es

THANK YOU

INTENANOMATFROM SYNTHESIS TO APPLICATIONS