nanotechnology and integrated bioengineering centre...
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Nanotechnology and Integrated Bioengineering Centre
(NIBEC)
Healthcare Sensors Systems
H2020 Funding
The Healthcare Sensor Systems Group
Dr David Steel Research Associate
Global Drivers
FDA approves edible electronic pills
that sense when you take your
medication
http://www.digitaltrends.com/home/f
da-approves-edible-electronic-
pills/#ixzz2v87CKxZW
Pillcam
Proteus
Biomedical
PH Pill
Personalised Sensors
Flexible Thin Sensors
Wearables
Multi-disciplinary research centre applying nanotechnology and bioengineering to the following thrusts:
The Connected Health Innovation Centre
(CHIC) is focused on business led research
in the area of connected health.
The Multidisciplinary Assessment of
Technology Centre for Healthcare
(MATCH) is a well-established research
collaboration between four leading UK
universities (Birmingham, Brunel,
Nottingham & Ulster) and a cohort of
industrial partners
CACR
Key current research topics in Connected Health
AF sensing/pattern
recognition
Sleep Apnoea early warning
Smart MEWS based multi-
sensing Algorithms
Novel Wearable Electrode
Systems
De-hydration Sensing
NIBP systems and Pulse
Wave Velocity
Perfusion and CO sensing
systems
SpO2 chest sensing
Integrated VS/Blood/unrine
Cardiac Mapping
Remote Foetal monitoring
Hypo- detection in Diabetics
Non-Invasive Glucose Monitoring (IR)
Point of Care Diagnostics – Microfluidic Systems
Integrated Photonic-CCD Systems
Wi-FI Hospital integration to an FDA standard
Point of Care – Biomarker analytics
Multiple data analysis – MVA, Big Data analytics
PCR Platforms
Healthcare Sensors
Systems Group : NIBEC
3-Lead ECG
Respiration Motion
(3-axis accelerometer)
Automatic
Arrhythmia Detection
Wi-Fi Vital Signs – Point of Care Systems/Devices
Connected Health Devices – functional code
Algorithms derived from Big Data sets for Smart Sensing
Over 30 years experience of driving higher sensitivities,
higher specificities and lower false positives for improved
predictivity (MEWS)
Prof. Jim McLaughlin
Prof Omar Escalona
Dr Dewar Finlay
Smart: ECG Pattern Recognition (FDA Approved)
Bradyarrhythmia
Ventricular Tachycardia
Supra Ventricular Tachycardia
Self-terminating Ventricular Fibrillation
Asystole
Atrial Flutter
Atrial Fibrillation
1st Degree Heart Block
2nd Degree Heart Block
3rd Degree Heart Block
•Congenital
heart defects
•Congestive
heart failure
•Heart muscle
disease
•Heart valve
disorders
•Other
diseases, such
as lung
conditions
•External
forces such as
electric shock
or severe chest
injury Fall Detection
Multiparameter analysis
Sensitivity are all greater than 90%
Specificity are all greater than 90%
False Positives lower than 1 per 10 patients per data
Alarm
Total No.
True
Positives
Total No.
False
Positives
False
Positive
Rate
(#FPs/pati
ent/day)
False
Positive
Rate 24
Bed
System/da
y
Sustained
Low
Respiratio
n Rate
149 5 0.05 1.20
Sustained
High
Respiratio
n Rate
817 2 0.02 0.48
Total 966 7 0.07 1.68
False alarm rates for aingeal arrhythmia algorithms (Ulster hospital and Ulster clinic)
Re(Z) ≡ Z’ = Z cos(θ) and Im(Z) ≡ Z” = Z sin(θ)
Z(ω) = |Z| exp( jθ),
θ=tan-1(Z”/Z’) , Z =[(Z”)2 +(Z’)2] 1/2
(θ: Phase angle , Z: Impedance magnitude. )
Arrays of Biomarkers (with Vital Signs Input)
High Resolution micro-dotting, integrated optics/IDE for high sensitivity
Higher levels of predictively following on-board statistically derived algorithms
Higher levels of stratified decision making approaches following clinically marked-up data as produced from smart-sensing systems with control.
0 250 500 750 1000 125085000
90000
95000
100000
105000
Time (Sec)
|Z| (
Ohm
)
Anti-rabbit R100 vs time.z
0 250 500 750 1000 1250
-66
-65
-64
-63
-62
Time (Sec)
thet
a
NIBEC WiFi Impedimetric Point of Care Blood
Diagnostic System
Commercialisation – Spin-outs
Cardiac Mapping
PRIME ECG Mapping
• Cardiac Mapping –led by Professor Jennifer Adgey and Professor John Anderson
• Electrodes – JMcL and EMcA
• Numerous MD programmes
• Led to large volume of high quality published / patented output
• Commercialised as PRIME-Meridian- Heartscape – Verathon and now Roper.
The first HeartSine
defibrillator was the AED –
The Automated External
Defibrillator- Launched in
2008
HeartSine samaritan® PAD
.
The Defibrillator in every
building is still the vision.
FDA cleared AED’s in 44
countries
Key algorithms to assist
CPR – using ICG
The body-worn
wireless patch
based ecg,
respiration rate,
temperature and
activity with on
board smart
algorithms
designed for the
hospital and
home (Zensor)
CHIC Industry led R&D
Projects.
ECHA (Collaborative Networks,
Large industry, Government and Academic European
Partnership)
NI
CH ECO System
R&D and Innovation --- Business Led --- ECO System of Users
Manchester ECO Oulu ECO Catalonia ECO New York E Health
Collaborative
CH NI Task and Finish Group, CHAP, NIMAC, CHIP
NI ECO
System
Innovation, Economic and Health Benefits via Collaboration
ERI: Industry Interactions and Routes to Impact
Keys Initiatives CHIC (industry led Competence Centre) –
Connected Health at Ulster and the NI CH Eco System (With ECHA)
NIACE and NIACCE (industry led Competence Centre)
Mass Customisation Facility Innovation – McColgan Innovation Award, ERI
Timeline of Innovation and the ERI Impact Hall of Innovation
Keys Initiatives ERI Lecture Series (weekly) Engineering Advisory Panel NISP, W5 and Ulster Museum Exhibitions All Party Science Forum, MATRIX Board Roles STEM Forum Industry Advisory Group Impact Strategic Forum Interdisciplinary Research
HORIZON 2020
Sensors: (2001-2013): Warthe (Marie-Curie-H2020) PhD studentships
CEC-MEST-CT-2005-021024, Neural stimulation (CEC-FPV-N IHP) and
Neuropro, Microtrans, Microcard, DiAdvisor (FP7) projects;
Photocatalysis Materials: solar disinfection of water in developing
countries Sodiswater-CEC-FP-6-INCO-DEV), solar energy conversion
and surface sterilisation e.g. medical devices. (CEC-FP5-Env.-PEBCAT)
or for water splitting CEC-FP5-COCON.
Plasma processing: COLAPE-CEC-FPV-R
Nanomaterials: NMP4-CT-2004-505626-DesynIT
Previous EU projects
Brand New Connected Health H2020 (last six months)
H2020 Pathway – 550k Euros (Connected Health)
H2020 CHESS – 550k (Connected Health)
2 Marie Currie H2020 (Connected Health) (£500k – Prof Escalona and Dr McEneaney)
2 Cost Action – CH and General
PATHway (euro 4.9M, 44 months and 8 EU Pratners
Individualized rehabilitation programs - socially inclusive
exercise sessions - a personalized comprehensive
lifestyle intervention program (exercise/physical activity
(PA), smoking, diet, stress management, alcohol use,
medication compliance)
to enable patients to both better understand and deal with
their own condition and to lead a healthier lifestyle in
general.
by the provision of a home based internet-enabled sensor-
based home exercise platform that allows remote participation in CR exercise programs
PATHway
PATHway
Title: PATHway – Technology enabled behavioural
change as a pathway towards better self-
management of CVD
Programme: Horizon 2020 – Programme under Research and
Innovation action
Instrument: PHC-26-2014: Self management of health and
disease: citizen engagement and mHealth
Total Cost: 4,899,080.00€
EC Contribution: 100%
Duration: 44 months – February 2015 until September
2018
Coordinator: Dublin City University (DCU), Ireland
Consortium: 8 partners from 7 countries
PATHway
PATHway
CHESS
Call: H2020-MSCA-ITN-2015
Topic: MSCA-ITN-2015-ETN Action: MSCA-ITN-ETN
Partners
•Caregiver Control University College Dublin, Ireland
•Clinician Education, University College Dublin, Ireland
•Go-to-market strategies, University College Dublin, Ireland
•Orthopaedic rehabilitation, Beacon Hospital, Ireland
•Gamification for Health Coaching, Salumedia, Spain
•Clinical Trials, Grenoble Ecole de Management, France
•Multi-sided Markets, Grenoble Ecole de Management, France
•Well-being, Grenoble Ecole de Management, France
•Patient Responsibility, Aristotle University of Thessaloniki, Greece
•Visualizations, University of Oulu, Finland
•Health Data Ownership, University of Oulu, Finland
•Inverting value creation, University of Oulu, Finland
•BP Monitoring, University of Ulster, N. Ireland
•AF Detection, University of Ulster, N. Ireland
•Information Needs in Connected Health (INCH), Philips Electronics, Netherlands
CHESS (Connected Health
Early Stage Researcher
Support System) has been
funded to the tune of €3.9
million under the Horizon2020
People Programme.
It is Europe’s first networked
Connected Health PhD training
programme.
What is CHESS?
Connected health puts the correct information in the correct hands at
the correct time allowing patients, clinicians, and planners to make
better decisions.
CHESS will develop connected health scientists and champions who
can understand multiple domains, communicate in an interdisciplinary
world and operate across the education, industry, health and policy
sectors.
It will include intersectoral secondments and a programme of
interrelated research projects in health economics, use of big data,
personal sensing, business modelling, navigating markets and
ecosystems, change management and user-led design.
Work Package 3: Data Lead beneficiary: UU,
Partners involved: INT, CAH, VTT, LOC, AUTH, UO, Philips.
This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 676201
www.chessitn.eu
Objective
• To investigate, develop, and evaluate new algorithms and models to support the acquisition to exploitation lifecycle for “data” in CH applications.
• Involves:
– Data acquisition
– Processing
– Utilisation
www.chessitn.eu
ESR8 (Ulster)
• Title: – Cuff-less Non-Invasive Blood Pressure Monitoring
• Objectives: – To explore a suitable method for continuous BP monitoring that does not
require a cuff
• Expected Results: – Methods and techniques to acquire challenging signal-capture – Algorithms for high quality signal processing, with high ROC curve UTC values
and low false alarms, and for correction of inter/intra individual variability in captured signals
– ESR with experience in signal capture and processing in challenging health environments.
• Planned secondment(s): – Intelesens Device Build and Test Lab and Electrode Fabrication Facility
(Industry Partner),10 months (M 12-21) to develop methods/techniques to acquire challenging signal-capture
www.chessitn.eu
ESR9 (Ulster)
• Title: – Development of Advanced Algorithms for AF Detection in the Wearable Device
Setting
• Objectives: – To develop an improved model for the detection of atrial fibrillation
• Expected Results: – Investigation of new AF analytical techniques, knowledge pooling of clinical
experts and mining of large AF datasets – Improved data analytic algorithms, including wearable device development for
algorithm support – Early stage technical training process at CAH – ESR with experience in analytical techniques and wearable device
development.
• Planned secondment(s): – Craigavon Area Hospital (Clinical Partner), 6 months (M 20-25) in the
cardiovascular research unit to gain an understanding of the hospital’s capability to integrate key data
www.chessitn.eu
ESR10 (UO)
• Title: – MyData as an Enabler for Personalised Health Services
• Objectives: – To explore the effect of data changes in making healthcare services more
personalised and human centred
• Expected Results: – Identification of key factors for wider adoption of MyData in health and well-
being services – Validation of MyData impact in designing and delivering health and well-being
services – Theoretical models of successful value co-creation with MyData in health
domain – An ESR with experience in health data management and health policy.
• Planned secondment(s): – LocalTapiola (SME), 3 months (M12-14) to determine the ethical challenges
facing companies using digital data in health services.
www.chessitn.eu
ESR11 (PHIL)
• Title: – Paving the Way from Personal Health to Public Health Policies
• Objectives: – To improve coordinated care and telehealth by developing integrated
procedures and methods for the management, analysis, visualisation, and study of widespread data in key health related performance areas
• Expected Results: – Unified framework of health related KPIs that can be applied at
different scales – Visual exploration and quantitative analysis procedures and scenarios – An ESR with experience in co-ordinated care – analysis and policy.
• Planned secondment(s): – Secondment 1: AUTH (Academic Partner), 6 months M13-18 & 4
months M22-25
www.chessitn.eu
EU Funding at Ulster in the area of Connected Health (over £5M since 2005)
Title Start Date Amount
CARDIWORKBENCH: Drug design for cardiovascular diseases:
Integration of in silico and in vitro analysis 1/12/05 £187,345
PHIME: Public health impact of long-term, low level mixed element
exposure in susceptible population strata 25/2/06 £517,740
Advanced methods and technologies for bioinformatics. 2/4/06 £5,520
COG-KNOW - Helping People with mild dementia navigate their day. 1/9/06 £262,551
Wide Area Research Training in Health Engineering: WARTHE 1/9/06 £303,185
CREATE 1/1/07 £13,591
NETWELL 1/2/07 £30,607
LIPGENE EXT: Diet, genomics and the metabolic syndrome nutrition,
agro-food, social and economic analysis 5/6/07 £10,698
MyHealth@Age - Improved Health and Safety for Elderly People living
in Northern Periphery regions: Preparatory Project 1/7/07 £1,040
DESYGN IT: Design synthesis and growth of nanotubes for industrial
technology - extension 1/9/07 £8,921
EUROCAT: Surveillance of congenital anomalies in Europe 2006103 1/9/07 £426,865
Neuros; Neuropro; Tuluzit etc 2011 £500,000
Myhealth @ Age 1/1/08 £196,702
Electronic's Production and Innovation Technology Centre (EPI Centre) 1/1/08 £186,164
BRAIN - BCI'S with Rapid Automated Interfaces for Non-experts 1/9/08 £306,226
Science and the treatment of autism: A multimedia package for parents
and professionals: STAMPPP 1/10/08 £128,526
World Mental Health Survey 1/2/09 £13,055
Innovation for Competitive Enterprises (ICE) 1/4/09 £486,861
SAFE- COMMS 1/4/09 £140,380
Pro-fit: Fieldlab sport innovation & stimulation 25/9/09 £187,333
MaPEeR: Making Progress and Economic Enhancement a Recalling for
SMEs 1/11/09 £120,714
STAR: Skills Training and Re-Skilling for Carers of People with Dementia 1/12/10 £37,900
Eurocat: European surveillance of congenital anomalies 1/1/11 £949,738
MICHELANGELO: Patient-centric Model for Remote Management,
Treatment and Rehabilitation of Autistic Children 1/10/11 £202,058
BESECURE - Best practices for enhancing security policy in urban zones. 1/4/12 £450,000
SULA: Sustainable Living Assistance 1/12/12 £124,811
EU Funding at Ulster in the area of Connected Health
Excellent Science
European Research Council (ERC)
Future and Emerging Technologies (FET)
Marie Skłodowska-Curie Actions (MSCA)
Research Inf rastructures
Industrial Leadership
Leadership in Enabling and Industrial
Technologies (LEIT) -ICT, KETs, Space
Access to Risk Finance
Innovation in SMEs
Societal Challenges
Health and Wellbeing
Food security
Transport
Energy
Climate action
Societies
Security
Widening Participation; Science with and for Society
European Institute of
Innovation and Technology
(EIT)
Joint Research Centre
(JRC)EURATOM
Thank You !
Acknowledgements to
all within CHIC and my
Research Group-
Healthcare Sensor
Systems at UU
Acknowledgements to all
funders: EPSRC, DEL, INI,
US-IRL (NSF); Wellcome
Trust; British Council, TSB
and FP&/H2020 EU