national toxicology program · f2_m3 c number: c99037b lock date: 11/20/2006 cage range: all date...
TRANSCRIPT
F2_M3C Number: C99037B
Lock Date: 11/20/2006
Cage Range: ALL
Date Range: ALL
Reasons For Removal: 25022 ACCK 25021 TSAC 25020 NATD
25019 MSAC 25018 DACC
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 2.2.0
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
DAY ON TEST
B6C3F1 MICE MALE
0731
0649
0568
0731
0729
0729
0730
0730
0730
0731
0731
0498
0730
0730
0730
0729
0731
0603
0730
0731
0730
0631
0730
0731
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + A + + + + + + + + + + + + + + A + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + M + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + A + + + + + + +Leiomyosarcoma
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X XHepatoblastoma XHepatoblastoma, MultipleHepatocellular Adenoma X X X XHepatocellular Adenoma, Multiple X X X X X X XHepatocellular Carcinoma X X X X X XHepatocellular Carcinoma, Multiple X XHepatocholangiomaHistiocytic Sarcoma XLymphoma Malignant X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 2
DAY ON TEST
B6C3F1 MICE MALE
0731
0649
0568
0731
0729
0729
0730
0730
0730
0731
0731
0498
0730
0730
0730
0729
0731
0603
0730
0731
0730
0631
0730
0731
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Mesentery + +Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Leiomyosarcoma, Metastatic, Intestine Small,
JejunumLymphoma Malignant X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
TongueFibroma
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant XSubcapsular, Adenoma X X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 3
DAY ON TEST
B6C3F1 MICE MALE
0731
0649
0568
0731
0729
0729
0730
0730
0730
0731
0731
0498
0730
0730
0730
0729
0731
0603
0730
0731
0730
0631
0730
0731
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Pheochromocytoma Malignant
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X X
Parathyroid Gland + + + M + + + + + + + M + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + M + + + + +
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Follicular Cell, AdenomaFollicular Cell, Carcinoma
GENERAL BODY SYSTEM
Tissue NOS +Hepatocellular Carcinoma, Metastatic, Liver X
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
Penis +
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Prostate + + + + + + + + + + + M + + + + + + + + + + + + +Lymphoma Malignant X
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 4
DAY ON TEST
B6C3F1 MICE MALE
0731
0649
0568
0731
0729
0729
0730
0730
0730
0731
0731
0498
0730
0730
0730
0729
0731
0603
0730
0731
0730
0631
0730
0731
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Testes + + + + + + + + + + + + + + + + + + + + + + + + +Interstitial Cell, Adenoma X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X X
Lymph Node + + +Lymphoma Malignant XIliac, Lymphoma Malignant XMediastinal, Lymphoma Malignant X XPancreatic, Lymphoma Malignant XRenal, Lymphoma Malignant XThoracic, Alveolar/Bronchiolar Carcinoma,
Metastatic, LungX
Lymph Node, Mandibular + + + + + + + + + + + + + + I M + + + + + + + + +Lymphoma Malignant X
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant XPlasma Cell Tumor Malignant
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +HemangiosarcomaLymphoma Malignant X X
Thymus + + + M + + + + + + + + + + + + + + M + + + + + +Hepatocellular Carcinoma, Metastatic, Liver X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 5
DAY ON TEST
B6C3F1 MICE MALE
0731
0649
0568
0731
0729
0729
0730
0730
0730
0731
0731
0498
0730
0730
0730
0729
0731
0603
0730
0731
0730
0631
0730
0731
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Lymphoma Malignant X X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +Osteoma
Skeletal Muscle +Hemangiosarcoma X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X XAlveolar/Bronchiolar Carcinoma X X X XHepatocellular Carcinoma, Metastatic, Liver X XLeiomyosarcoma, Metastatic, Intestine Small,
JejunumLymphoma Malignant X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 6
DAY ON TEST
B6C3F1 MICE MALE
0731
0649
0568
0731
0729
0729
0730
0730
0730
0731
0731
0498
0730
0730
0730
0729
0731
0603
0730
0731
0730
0631
0730
0731
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Lymphoma Malignant X
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X X XCarcinoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX
Lymphoma Malignant X
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 7
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0604
0729
0677
0730
0598
0729
0731
0581
0730
0729
0730
0731
0729
0476
0731
0729
0729
0731
0731
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + A + + + + + + A + + M + M + + + + M + + + + 43
Intestine Large, Cecum + + + + + + + I + + A + + + + + + + + + + + + + + 48
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + A + + + + + + + + + + + + + + 48
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Jejunum + + + + + + + A + + + + + + + + + + + + + + + + + 48Leiomyosarcoma X 1
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 2Hepatoblastoma X 2Hepatoblastoma, Multiple X 1Hepatocellular Adenoma X X X X X X 10Hepatocellular Adenoma, Multiple X X X X X X X 14Hepatocellular Carcinoma X X X X X X X 13Hepatocellular Carcinoma, Multiple X 3Hepatocholangioma X 1Histiocytic Sarcoma 1Lymphoma Malignant 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 8
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0604
0729
0677
0730
0598
0729
0731
0581
0730
0729
0730
0731
0729
0476
0731
0729
0729
0731
0731
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Mesentery + + 4Leiomyosarcoma, Metastatic, Intestine Small,
JejunumX 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Leiomyosarcoma, Metastatic, Intestine Small,
JejunumX 1
Lymphoma Malignant 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 1
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Tongue + 1Fibroma X 1
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 2
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 1Subcapsular, Adenoma 2
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + M + + 49
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 9
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0604
0729
0677
0730
0598
0729
0731
0581
0730
0729
0730
0731
0729
0476
0731
0729
0729
0731
0731
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Pheochromocytoma Malignant X 1
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X X 4
Parathyroid Gland + + + + + + + + + + + + M + M M + + + + + M + + M 43
Pituitary Gland + + + + + + + + + + + + M + + + + + + + + + + + + 48
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + M + + + 49Follicular Cell, Adenoma X 1Follicular Cell, Carcinoma X 1
GENERAL BODY SYSTEM
Tissue NOS 1Hepatocellular Carcinoma, Metastatic, Liver 1
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
Penis 1
Preputial Gland + + + + + + + M + + + + + + + + + + + + + + + + + 49Lymphoma Malignant 1
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 49Lymphoma Malignant 1
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 10
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0604
0729
0677
0730
0598
0729
0731
0581
0730
0729
0730
0731
0729
0476
0731
0729
0729
0731
0731
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Interstitial Cell, Adenoma 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 3
Lymph Node 3Lymphoma Malignant 1Iliac, Lymphoma Malignant 1Mediastinal, Lymphoma Malignant 2Pancreatic, Lymphoma Malignant 1Renal, Lymphoma Malignant 1Thoracic, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + M + + + + + + + 47Lymphoma Malignant 1
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + M + + + + + + 49Lymphoma Malignant 1Plasma Cell Tumor Malignant X 1
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X 1Lymphoma Malignant 2
Thymus + + + M + + + M + + + + + + + + + + + + + M M + + 44Hepatocellular Carcinoma, Metastatic, Liver 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 11
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0604
0729
0677
0730
0598
0729
0731
0581
0730
0729
0730
0731
0729
0476
0731
0729
0729
0731
0731
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Lymphoma Malignant 2
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Osteoma X 1
Skeletal Muscle + 2Hemangiosarcoma X 2
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X 7Alveolar/Bronchiolar Carcinoma X X 6Hepatocellular Carcinoma, Metastatic, Liver X X 4Leiomyosarcoma, Metastatic, Intestine Small,
JejunumX 1
Lymphoma Malignant 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 12
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0604
0729
0677
0730
0598
0729
0731
0581
0730
0729
0730
0731
0729
0476
0731
0729
0729
0731
0731
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Lymphoma Malignant 1
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X X X X X 8Carcinoma X 2
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung1
Lymphoma Malignant 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 1
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1Lymphoma Malignant 4
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 13
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0730
0654
0731
0729
0730
0729
0674
0730
0731
0731
0730
0654
0729
0731
0730
0731
0730
0663
0731
0731
0729
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + + + + A + + + + + + + + + + M + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + A + + + + A + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + A + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + A + + + + M + + + + A + + + + + + + + +Carcinoma X X
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X XHepatoblastoma X X XHepatocellular Adenoma X X X X XHepatocellular Adenoma, Multiple X X X X XHepatocellular Carcinoma X X X X X X X X XHepatocellular Carcinoma, Multiple X X X XMast Cell Tumor Malignant X X
Mesentery + + +Hemangiosarcoma X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 14
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0730
0654
0731
0729
0730
0729
0674
0730
0731
0731
0730
0654
0729
0731
0730
0731
0730
0663
0731
0731
0729
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Sarcoma X
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Sarcoma, Metastatic, Mesentery X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Subcapsular, Adenoma X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Bilateral, Pheochromocytoma Benign
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +AdenomaAdenoma, Multiple
Parathyroid Gland + + + + + M + + + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pars Distalis, Adenoma X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 15
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0730
0654
0731
0729
0730
0729
0674
0730
0731
0731
0730
0654
0729
0731
0730
0731
0730
0663
0731
0731
0729
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
Tissue NOSHemangiosarcoma
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + + + + + + I + + +Hemangiosarcoma
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +Sarcoma, Metastatic, Mesentery X
Testes + + + + + + + + + + + + + + + + + + + + + + + + +Interstitial Cell, Adenoma
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Mast Cell Tumor Malignant X X
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +Mast Cell Tumor Malignant X
Lymph Node, Mesenteric + + + + + + + + + + M + + + + M + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 16
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0730
0654
0731
0729
0730
0729
0674
0730
0731
0731
0730
0654
0729
0731
0730
0731
0730
0663
0731
0731
0729
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Histiocytic SarcomaLymphoma Malignant
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma MalignantMast Cell Tumor Malignant X X
Thymus M + + + + + + + + + M M + + + M + + + + + + + + +Lymphoma Malignant
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Mast Cell Tumor Malignant XSubcutaneous Tissue, Hemangiosarcoma XSubcutaneous Tissue, Osteosarcoma,
Metastatic, Uncertain Primary SiteX
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle +Sarcoma X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 17
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0730
0654
0731
0729
0730
0729
0674
0730
0731
0731
0730
0654
0729
0731
0730
0731
0730
0663
0731
0731
0729
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X XAlveolar/Bronchiolar Adenoma, Multiple XAlveolar/Bronchiolar Carcinoma X X XHepatocellular Carcinoma, Metastatic, Liver X X X X X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X X X X XCarcinoma XBilateral, Adenoma
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Urethra
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 18
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0730
0654
0731
0729
0730
0729
0674
0730
0731
0731
0730
0654
0729
0731
0730
0731
0730
0663
0731
0731
0729
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic SarcomaLymphoma Malignant
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 19
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0004
0715
0730
0529
0731
0687
0731
0731
0730
0730
0730
0731
0729
0730
0731
0731
0731
0729
0730
0731
0729
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + A + + + + I + + + + M + + + + + + 45
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + M + + + + + + + + + + + + + + + + + 49
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + A I + + + + + + + + + + + + + + + 46
Intestine Small, Ileum + + + + + + + + + + + + + + + + M + + + + + + + + 48
Intestine Small, Jejunum + + + + + + + + A + + + + + + + + + + + + + + + + 46Carcinoma 2
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X 3Hepatoblastoma 3Hepatocellular Adenoma X X X X X X X X X X 15Hepatocellular Adenoma, Multiple X X X 8Hepatocellular Carcinoma X X X X X X X X X 18Hepatocellular Carcinoma, Multiple X X X X 8Mast Cell Tumor Malignant 2
Mesentery + 4Hemangiosarcoma 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 20
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0004
0715
0730
0529
0731
0687
0731
0731
0730
0730
0730
0731
0729
0730
0731
0731
0731
0729
0730
0731
0729
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Sarcoma 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Sarcoma, Metastatic, Mesentery 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcapsular, Adenoma X X X 4
Adrenal Medulla + + + + M + + + + + + + + + + + + + + + + + + + + 49Bilateral, Pheochromocytoma Benign X 1
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1Adenoma, Multiple X 1
Parathyroid Gland + + + + I + + + + + + + + + + + + + + + + + + + + 48
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Pars Distalis, Adenoma 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 21
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0004
0715
0730
0529
0731
0687
0731
0731
0730
0730
0730
0731
0729
0730
0731
0731
0731
0729
0730
0731
0729
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
GENERAL BODY SYSTEM
Tissue NOS + 1Hemangiosarcoma X 1
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Hemangiosarcoma X 1
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50Sarcoma, Metastatic, Mesentery 1
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Interstitial Cell, Adenoma X 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Mast Cell Tumor Malignant 2
Lymph Node, Mandibular + + + + + + + + M + + + + + + + + + + + + + + + + 49Mast Cell Tumor Malignant 1
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 48
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 22
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0004
0715
0730
0529
0731
0687
0731
0731
0730
0730
0730
0731
0729
0730
0731
0731
0731
0729
0730
0731
0729
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Histiocytic Sarcoma X 1Lymphoma Malignant X 1
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X 1Mast Cell Tumor Malignant 2
Thymus + + + + + + + I + + M + + + + + + + + + + + + M + 43Lymphoma Malignant X 1
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Mast Cell Tumor Malignant 1Subcutaneous Tissue, Hemangiosarcoma 1Subcutaneous Tissue, Osteosarcoma,
Metastatic, Uncertain Primary Site1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skeletal Muscle 1Sarcoma 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 23
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0004
0715
0730
0529
0731
0687
0731
0731
0730
0730
0730
0731
0729
0730
0731
0731
0731
0729
0730
0731
0729
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma 3Alveolar/Bronchiolar Adenoma, Multiple X 2Alveolar/Bronchiolar Carcinoma X 4Hepatocellular Carcinoma, Metastatic, Liver X X X 8
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X X X 8Carcinoma X 2Bilateral, Adenoma X 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Urethra + 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 24
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0004
0715
0730
0529
0731
0687
0731
0731
0730
0730
0730
0731
0729
0730
0731
0731
0731
0729
0730
0731
0729
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 1Lymphoma Malignant X X 2
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 25
DAY ON TEST
B6C3F1 MICE MALE
0688
0731
0730
0729
0729
0729
0729
0696
0698
0677
0729
0691
0729
0729
0589
0730
0730
0730
0729
0730
0729
0729
0730
0729
0729
6 MG/KGANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder A + + + + M + + + + + + + + + + + + + + + + M + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma X
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma
Intestine Small, Jejunum + + + + + + + M + + + + + + + + + + + + + + + + +Carcinoma XLymphoma Malignant X X
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XHepatoblastoma XHepatocellular Adenoma X X X X X X X XHepatocellular Adenoma, Multiple X X X X X X X XHepatocellular Carcinoma X X X X X XHepatocellular Carcinoma, Multiple X X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 26
DAY ON TEST
B6C3F1 MICE MALE
0688
0731
0730
0729
0729
0729
0729
0696
0698
0677
0729
0691
0729
0729
0589
0730
0730
0730
0729
0730
0729
0729
0730
0729
0729
6 MG/KGANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
males(cont...)
Lymphoma Malignant X
Mesentery + +Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Squamous Cell Papilloma
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
Tooth
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX
Lymphoma Malignant X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Subcapsular, Adenoma
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 27
DAY ON TEST
B6C3F1 MICE MALE
0688
0731
0730
0729
0729
0729
0729
0696
0698
0677
0729
0691
0729
0729
0589
0730
0730
0730
0729
0730
0729
0729
0730
0729
0729
6 MG/KGANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
males(cont...)
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma
Parathyroid Gland + + + + + + + + + + + M + + + + + + + + + + M + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + M + + + +
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
GENERAL BODY SYSTEM
Tissue NOS +Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 28
DAY ON TEST
B6C3F1 MICE MALE
0688
0731
0730
0729
0729
0729
0729
0696
0698
0677
0729
0691
0729
0729
0589
0730
0730
0730
0729
0730
0729
0729
0730
0729
0729
6 MG/KGANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
males(cont...)
Lymphoma Malignant XInterstitial Cell, Adenoma X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Lymph Node +Bronchial, Lymphoma Malignant XIliac, Lymphoma Malignant XMediastinal, Lymphoma Malignant XRenal, Lymphoma Malignant X
Lymph Node, Mandibular + + + + + + + + + + + + + + + + M + + + M + + + +Lymphoma Malignant X
Lymph Node, Mesenteric + + + + + + + + + M + + + + + + + + + + M + + + +Lymphoma Malignant X
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XLymphoma Malignant X X X X
Thymus + + + + + + + + + + + M + + + + + + + + + + + + +Lymphoma Malignant X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 29
DAY ON TEST
B6C3F1 MICE MALE
0688
0731
0730
0729
0729
0729
0729
0696
0698
0677
0729
0691
0729
0729
0589
0730
0730
0730
0729
0730
0729
0729
0730
0729
0729
6 MG/KGANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
males(cont...)
Skin + + + + + + + + + + + + + + + + + + + + + + + + +
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle + +HemangiosarcomaLymphoma Malignant X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X X XAlveolar/Bronchiolar Carcinoma X XAlveolar/Bronchiolar Carcinoma, Multiple X XHepatocellular Carcinoma, Metastatic, Liver X X X X XLymphoma Malignant X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +Fibroma
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 30
DAY ON TEST
B6C3F1 MICE MALE
0688
0731
0730
0729
0729
0729
0729
0696
0698
0677
0729
0691
0729
0729
0589
0730
0730
0730
0729
0730
0729
0729
0730
0729
0729
6 MG/KGANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
males(cont...)
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X XCarcinoma XLymphoma Malignant X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX
Lymphoma Malignant XRenal Tubule, Adenoma
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X X X X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 31
DAY ON TEST
B6C3F1 MICE MALE
0730
0729
0664
0731
0730
0730
0729
0704
0730
0729
0731
0730
0730
0731
0730
0729
0730
0730
0731
0731
0675
0730
0729
0729
0729
6 MG/KGANIMAL ID
00126
00127
00128
00129
00130
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + A + + + + + + + + + + + + + M + + + M + + + + 44
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + A + + + + 49
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma 1Carcinoma 1
Intestine Small, Ileum M + + + + I + + + + + + + + + + + + + + + + + + + 48Carcinoma X 1
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 49Carcinoma X 2Lymphoma Malignant 2
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X 2Hepatoblastoma 1Hepatocellular Adenoma X X X X X X X X 16Hepatocellular Adenoma, Multiple X X X X X X 14Hepatocellular Carcinoma X X X X X X X X X 15Hepatocellular Carcinoma, Multiple X X X X X X 8
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 32
DAY ON TEST
B6C3F1 MICE MALE
0730
0729
0664
0731
0730
0730
0729
0704
0730
0729
0731
0730
0730
0731
0730
0729
0730
0730
0731
0731
0675
0730
0729
0729
0729
6 MG/KGANIMAL ID
00126
00127
00128
00129
00130
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150 * TOTALS
Lymphoma Malignant 1
Mesentery + 3Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X 2
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Squamous Cell Papilloma X 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Tooth + 1
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX 2
Lymphoma Malignant X 2
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcapsular, Adenoma X X 2
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 33
DAY ON TEST
B6C3F1 MICE MALE
0730
0729
0664
0731
0730
0730
0729
0704
0730
0729
0731
0730
0730
0731
0730
0729
0730
0730
0731
0731
0675
0730
0729
0729
0729
6 MG/KGANIMAL ID
00126
00127
00128
00129
00130
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150 * TOTALS
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1
Parathyroid Gland + + + + + + M + + + + + + + + + + + + + + + + + + 47
Pituitary Gland + + + + + + + + + + + + + + + + + M + + + + + + + 48
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 1
GENERAL BODY SYSTEM
Tissue NOS 1Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung1
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X 2
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X 1
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 34
DAY ON TEST
B6C3F1 MICE MALE
0730
0729
0664
0731
0730
0730
0729
0704
0730
0729
0731
0730
0730
0731
0730
0729
0730
0730
0731
0731
0675
0730
0729
0729
0729
6 MG/KGANIMAL ID
00126
00127
00128
00129
00130
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150 * TOTALS
Lymphoma Malignant 1Interstitial Cell, Adenoma 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X 2
Lymph Node 1Bronchial, Lymphoma Malignant 1Iliac, Lymphoma Malignant 1Mediastinal, Lymphoma Malignant 1Renal, Lymphoma Malignant 1
Lymph Node, Mandibular + + + M + + + + + + + + M + + + + + + + + + + + + 46Lymphoma Malignant 1
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + M + + + + 47Lymphoma Malignant X 2
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X X 3Lymphoma Malignant X 5
Thymus + + + + + M + + + + + M + + + M + + + + M M + + + 44Lymphoma Malignant X 2
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 35
DAY ON TEST
B6C3F1 MICE MALE
0730
0729
0664
0731
0730
0730
0729
0704
0730
0729
0731
0730
0730
0731
0730
0729
0730
0730
0731
0731
0675
0730
0729
0729
0729
6 MG/KGANIMAL ID
00126
00127
00128
00129
00130
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150 * TOTALS
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skeletal Muscle + 3Hemangiosarcoma X 1Lymphoma Malignant 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X 8Alveolar/Bronchiolar Carcinoma X X X X 6Alveolar/Bronchiolar Carcinoma, Multiple X 3Hepatocellular Carcinoma, Metastatic, Liver X X X X 9Lymphoma Malignant 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibroma X 1
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 36
DAY ON TEST
B6C3F1 MICE MALE
0730
0729
0664
0731
0730
0730
0729
0704
0730
0729
0731
0730
0730
0731
0730
0729
0730
0730
0731
0731
0675
0730
0729
0729
0729
6 MG/KGANIMAL ID
00126
00127
00128
00129
00130
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150 * TOTALS
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X X 4Carcinoma X X 3Lymphoma Malignant 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX 2
Lymphoma Malignant X 2Renal Tubule, Adenoma X 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X 2
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X X 7
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 37
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0604
0730
0731
0729
0619
0730
0729
0730
0729
0730
0608
0731
0731
0652
0730
0677
0730
0691
0730
0579
0729
0730
0730
12 MG/KGANIMAL ID
00151
00152
00153
00154
00155
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + M
Gallbladder + + A + I + A + + + M + + + + M + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + A + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + A + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + A + + + A + + + + + A + + A + + + + + + + + +Adenoma X
Intestine Small, Ileum + + A + + + A + + + + + A + + + + + + + + + + + +Carcinoma
Intestine Small, Jejunum + + A + + + A + + + + + A + + A + + + + + + + + +Carcinoma XLymphoma Malignant X
Liver + + + + + + + + + + + + + + + + + + + + + + + + +CholangiomaHemangiosarcoma XHepatoblastomaHepatocellular Adenoma X X X X X XHepatocellular Adenoma, Multiple X X X X X X X X XHepatocellular Carcinoma X X X X X X X X X XHepatocellular Carcinoma, Multiple X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 38
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0604
0730
0731
0729
0619
0730
0729
0730
0729
0730
0608
0731
0731
0652
0730
0677
0730
0691
0730
0579
0729
0730
0730
12 MG/KGANIMAL ID
00151
00152
00153
00154
00155
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
males(cont...)
Leiomyosarcoma, Metastatic, Stomach,Glandular
Mesentery + + +Hemangioma XLeiomyosarcoma, Metastatic, Stomach,
Glandular
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Hepatoblastoma, Metastatic, LiverLeiomyosarcoma, Metastatic, Stomach,
Glandular
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Squamous Cell CarcinomaSquamous Cell Papilloma X
Stomach, Glandular + + A + + + + + + + + + + + + + + + + + + + + + +LeiomyosarcomaMast Cell Tumor Malignant XSquamous Cell Carcinoma, Metastatic,
Stomach, Forestomach
Tongue
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Hepatoblastoma, Metastatic, Liver
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 39
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0604
0730
0731
0729
0619
0730
0729
0730
0729
0730
0608
0731
0731
0652
0730
0677
0730
0691
0730
0579
0729
0730
0730
12 MG/KGANIMAL ID
00151
00152
00153
00154
00155
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
males(cont...)
Schwannoma Malignant
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Leiomyosarcoma, Metastatic, Stomach,
GlandularSubcapsular, Adenoma X X X X X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X
Parathyroid Gland + M + M + + + + + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + M + +
Thyroid Gland + + + M + + + + + + + + + + + + + + + + + + + + +Follicular Cell, Adenoma X
GENERAL BODY SYSTEM
Tissue NOS
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
Penis +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 40
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0604
0730
0731
0729
0619
0730
0729
0730
0729
0730
0608
0731
0731
0652
0730
0677
0730
0691
0730
0579
0729
0730
0730
12 MG/KGANIMAL ID
00151
00152
00153
00154
00155
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
males(cont...)
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +Leiomyosarcoma, Metastatic, Stomach,
Glandular
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X
Lymph NodeHepatoblastoma, Metastatic, LiverMediastinal, Hepatoblastoma, Metastatic, Liver
Lymph Node, Mandibular + + + + + + + + + + + M + + + + + + + + + + + + +
Lymph Node, Mesenteric + + A + + + + + + + + + + + + + + M + + + + + + +Leiomyosarcoma, Metastatic, Stomach,
Glandular
Spleen + + A + + + + + + + + + + + + + + + + + + + + + +Squamous Cell Carcinoma, Metastatic,
Stomach, Forestomach
Thymus + + + M + + I + + + + + + + + + + M M I + + + + M
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 41
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0604
0730
0731
0729
0619
0730
0729
0730
0729
0730
0608
0731
0731
0652
0730
0677
0730
0691
0730
0579
0729
0730
0730
12 MG/KGANIMAL ID
00151
00152
00153
00154
00155
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
males(cont...)
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, FibromaSubcutaneous Tissue, Hemangiosarcoma X
MUSCULOSKELETAL SYSTEM
Bone I + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal MuscleHepatoblastoma, Metastatic, Liver
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X XAlveolar/Bronchiolar Carcinoma X XAlveolar/Bronchiolar Carcinoma, Multiple XHepatoblastoma, Metastatic, LiverHepatocellular Carcinoma, Metastatic, Liver X X XSchwannoma Malignant, Metastatic, Heart
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 42
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0604
0730
0731
0729
0619
0730
0729
0730
0729
0730
0608
0731
0731
0652
0730
0677
0730
0691
0730
0579
0729
0730
0730
12 MG/KGANIMAL ID
00151
00152
00153
00154
00155
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
males(cont...)
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Hepatoblastoma, Metastatic, Liver
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 43
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0004
0709
0730
0456
0729
0729
0730
0730
0470
0545
0730
0731
0731
0518
0730
0730
0729
0730
0729
0730
0731
0730
12 MG/KGANIMAL ID
00176
00177
00178
00179
00180
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195
00196
00197
00198
00199
00200 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 49
Gallbladder + + + + + + A + + + + A + + + + M + M + + + + + + 41
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 49
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 49
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 46Adenoma 1
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 47Carcinoma X 1
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 46Carcinoma 1Lymphoma Malignant 1
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Cholangioma X 1Hemangiosarcoma 1Hepatoblastoma X X 2Hepatocellular Adenoma X X X X X X X X X X 16Hepatocellular Adenoma, Multiple X X X 12Hepatocellular Carcinoma X X X 13Hepatocellular Carcinoma, Multiple X X 3
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 44
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0004
0709
0730
0456
0729
0729
0730
0730
0470
0545
0730
0731
0731
0518
0730
0730
0729
0730
0729
0730
0731
0730
12 MG/KGANIMAL ID
00176
00177
00178
00179
00180
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195
00196
00197
00198
00199
00200 * TOTALS
Leiomyosarcoma, Metastatic, Stomach,Glandular
X 1
Mesentery + + + + 7Hemangioma 1Leiomyosarcoma, Metastatic, Stomach,
GlandularX 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatoblastoma, Metastatic, Liver X 1Leiomyosarcoma, Metastatic, Stomach,
GlandularX 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Squamous Cell Carcinoma X 1Squamous Cell Papilloma 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 49Leiomyosarcoma X 1Mast Cell Tumor Malignant 1Squamous Cell Carcinoma, Metastatic,
Stomach, ForestomachX 1
Tongue + 1
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatoblastoma, Metastatic, Liver X 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 45
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0004
0709
0730
0456
0729
0729
0730
0730
0470
0545
0730
0731
0731
0518
0730
0730
0729
0730
0729
0730
0731
0730
12 MG/KGANIMAL ID
00176
00177
00178
00179
00180
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195
00196
00197
00198
00199
00200 * TOTALS
Schwannoma Malignant X 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Leiomyosarcoma, Metastatic, Stomach,
GlandularX 1
Subcapsular, Adenoma 5
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma 1
Parathyroid Gland + + + + + + M + + + + + + + + + + + M + + + + + + 46
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Follicular Cell, Adenoma 1
GENERAL BODY SYSTEM
Tissue NOS + 1
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
Penis 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 46
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0004
0709
0730
0456
0729
0729
0730
0730
0470
0545
0730
0731
0731
0518
0730
0730
0729
0730
0729
0730
0731
0730
12 MG/KGANIMAL ID
00176
00177
00178
00179
00180
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195
00196
00197
00198
00199
00200 * TOTALS
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50Leiomyosarcoma, Metastatic, Stomach,
GlandularX 1
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1
Lymph Node + 1Hepatoblastoma, Metastatic, Liver X 1Mediastinal, Hepatoblastoma, Metastatic, Liver X 1
Lymph Node, Mandibular + + + + + + M + + + + + + + + + + + I + + + + + + 47
Lymph Node, Mesenteric + + + + + + + + M + + + + + + + + + + + + + + + + 47Leiomyosarcoma, Metastatic, Stomach,
GlandularX 1
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 49Squamous Cell Carcinoma, Metastatic,
Stomach, ForestomachX 1
Thymus + I + + + + I + + + + + + + + + M + + + + + M + + 40
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 47
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0004
0709
0730
0456
0729
0729
0730
0730
0470
0545
0730
0731
0731
0518
0730
0730
0729
0730
0729
0730
0731
0730
12 MG/KGANIMAL ID
00176
00177
00178
00179
00180
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195
00196
00197
00198
00199
00200 * TOTALS
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Fibroma X 1Subcutaneous Tissue, Hemangiosarcoma 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 49
Skeletal Muscle + 1Hepatoblastoma, Metastatic, Liver X 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X 6Alveolar/Bronchiolar Carcinoma X 3Alveolar/Bronchiolar Carcinoma, Multiple 1Hepatoblastoma, Metastatic, Liver X 1Hepatocellular Carcinoma, Metastatic, Liver X X 5Schwannoma Malignant, Metastatic, Heart X 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 48
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0004
0709
0730
0456
0729
0729
0730
0730
0470
0545
0730
0731
0731
0518
0730
0730
0729
0730
0729
0730
0731
0730
12 MG/KGANIMAL ID
00176
00177
00178
00179
00180
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195
00196
00197
00198
00199
00200 * TOTALS
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma 1Carcinoma X 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatoblastoma, Metastatic, Liver X 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 49
DAY ON TEST
B6C3F1 MICE MALE
0183
0135
0239
0291
0731
0731
0268
0239
0351
0729
0729
0731
0241
0365
0288
0250
0729
0212
0274
0190
0334
0729
0220
0136
0249
25 MG/KGANIMAL ID
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
00221
00222
00223
00224
00225
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + M + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + M + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocellular Adenoma X XHepatocellular Adenoma, Multiple X X X XHepatocellular CarcinomaHepatocellular Carcinoma, Multiple X
Mesentery + +
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 50
DAY ON TEST
B6C3F1 MICE MALE
0183
0135
0239
0291
0731
0731
0268
0239
0351
0729
0729
0731
0241
0365
0288
0250
0729
0212
0274
0190
0334
0729
0220
0136
0249
25 MG/KGANIMAL ID
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
00221
00222
00223
00224
00225
males(cont...)
Squamous Cell Papilloma
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X
Parathyroid Gland + M + + + + + + + + + M + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 51
DAY ON TEST
B6C3F1 MICE MALE
0183
0135
0239
0291
0731
0731
0268
0239
0351
0729
0729
0731
0241
0365
0288
0250
0729
0212
0274
0190
0334
0729
0220
0136
0249
25 MG/KGANIMAL ID
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
00221
00222
00223
00224
00225
males(cont...)
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node, Mandibular + + + + + + M + M + + + + + + + + + + + + + + + +
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +
Thymus + + + + + + + + + + + I + + + + + + + + + + + + +
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Keratoacanthoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 52
DAY ON TEST
B6C3F1 MICE MALE
0183
0135
0239
0291
0731
0731
0268
0239
0351
0729
0729
0731
0241
0365
0288
0250
0729
0212
0274
0190
0334
0729
0220
0136
0249
25 MG/KGANIMAL ID
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
00221
00222
00223
00224
00225
males(cont...)
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X XAlveolar/Bronchiolar CarcinomaAlveolar/Bronchiolar Carcinoma, Multiple XHepatocellular Carcinoma, Metastatic, Liver X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 53
DAY ON TEST
B6C3F1 MICE MALE
0183
0135
0239
0291
0731
0731
0268
0239
0351
0729
0729
0731
0241
0365
0288
0250
0729
0212
0274
0190
0334
0729
0220
0136
0249
25 MG/KGANIMAL ID
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
00221
00222
00223
00224
00225
males(cont...)
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 54
DAY ON TEST
B6C3F1 MICE MALE
0117
0206
0276
0729
0171
0295
0731
0239
0221
0253
0729
0729
0232
0233
0683
0687
0225
0331
0731
0253
0604
0374
0731
0191
0729
25 MG/KGANIMAL ID
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
00246
00247
00248
00249
00250 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + M + + + + M + + + + + + + A + + + + A + + A M 43
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 49
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + M + + + + + + A + + + + + + + + + 48
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + A + + + + 49
Intestine Small, Jejunum + + A + A + + + A + + + + + + A + + + A A + + A + 43
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocellular Adenoma X X X X 6Hepatocellular Adenoma, Multiple X X X 7Hepatocellular Carcinoma X X 2Hepatocellular Carcinoma, Multiple X X 3
Mesentery + 3
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 55
DAY ON TEST
B6C3F1 MICE MALE
0117
0206
0276
0729
0171
0295
0731
0239
0221
0253
0729
0729
0232
0233
0683
0687
0225
0331
0731
0253
0604
0374
0731
0191
0729
25 MG/KGANIMAL ID
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
00246
00247
00248
00249
00250 * TOTALS
Squamous Cell Papilloma X 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 2
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48
Pituitary Gland + + + + + + + + + + + + + + + + + + M + + + + + + 49
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 56
DAY ON TEST
B6C3F1 MICE MALE
0117
0206
0276
0729
0171
0295
0731
0239
0221
0253
0729
0729
0232
0233
0683
0687
0225
0331
0731
0253
0604
0374
0731
0191
0729
25 MG/KGANIMAL ID
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
00246
00247
00248
00249
00250 * TOTALS
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node, Mandibular + + + + + M + + + + M + I + M + + + + + + + + + + 44
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50
Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 49
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Keratoacanthoma 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 57
DAY ON TEST
B6C3F1 MICE MALE
0117
0206
0276
0729
0171
0295
0731
0239
0221
0253
0729
0729
0232
0233
0683
0687
0225
0331
0731
0253
0604
0374
0731
0191
0729
25 MG/KGANIMAL ID
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
00246
00247
00248
00249
00250 * TOTALS
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X 6Alveolar/Bronchiolar Carcinoma X 1Alveolar/Bronchiolar Carcinoma, Multiple X 2Hepatocellular Carcinoma, Metastatic, Liver 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + M + + + + + + + + + + 49Adenoma X 2
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 58
DAY ON TEST
B6C3F1 MICE MALE
0117
0206
0276
0729
0171
0295
0731
0239
0221
0253
0729
0729
0232
0233
0683
0687
0225
0331
0731
0253
0604
0374
0731
0191
0729
25 MG/KGANIMAL ID
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
00246
00247
00248
00249
00250 * TOTALS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50
*** END OF MALE DATA ***
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 59
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0715
0733
0095
0733
0732
0732
0732
0296
0564
0733
0733
0733
0733
0733
0691
0669
0733
0320
0733
0732
0628
0732
0142
0732
0 MG/KGANIMAL ID
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + A + + + + + + + A + + + + + + + + + + + + + + +
Intestine Large, Cecum + A + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + A + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + A + + + + + + + M + + + + + + + + + + + A + + +
Intestine Small, Ileum + A + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + A + + + + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XHepatocellular Adenoma X X X XHepatocellular Adenoma, Multiple XHepatocellular Carcinoma XHepatocellular Carcinoma, MultipleHistiocytic Sarcoma XLymphoma Malignant X XPlasma Cell Tumor Malignant X
Mesentery + + + +Schwannoma Malignant, Metastatic, Skin
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 60
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0715
0733
0095
0733
0732
0732
0732
0296
0564
0733
0733
0733
0733
0733
0691
0669
0733
0320
0733
0732
0628
0732
0142
0732
0 MG/KGANIMAL ID
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
females(cont...)
Pancreas + A + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma
Salivary Glands + M + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Glandular + A + + + + + + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +AdenomaLymphoma Malignant XPlasma Cell Tumor Malignant X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + A + + + + + + + + + + + + + + + + + + + + + + +Adenoma X
Parathyroid Gland + + + + + + M + + M + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + M +Pars Distalis, Adenoma X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 61
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0715
0733
0095
0733
0732
0732
0732
0296
0564
0733
0733
0733
0733
0733
0691
0669
0733
0320
0733
0732
0628
0732
0142
0732
0 MG/KGANIMAL ID
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
females(cont...)
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
Tissue NOS +Plasma Cell Tumor Malignant X
GENITAL SYSTEM
Clitoral Gland + M + + + + + + + + + + + + + + + + M + + + + + +
Ovary + A + + + + + + + + + + + + + + + + + + + + + + +ChoriocarcinomaCystadenoma X XPlasma Cell Tumor Malignant X
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XPolyp Stromal
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XPlasma Cell Tumor Malignant X
Lymph Node + + + +Histiocytic Sarcoma XPlasma Cell Tumor Malignant XIliac, Histiocytic Sarcoma XIliac, Lymphoma Malignant X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 62
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0715
0733
0095
0733
0732
0732
0732
0296
0564
0733
0733
0733
0733
0733
0691
0669
0733
0320
0733
0732
0628
0732
0142
0732
0 MG/KGANIMAL ID
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
females(cont...)
Inguinal, Histiocytic Sarcoma XMediastinal, Lymphoma Malignant XMediastinal, Plasma Cell Tumor Malignant XPancreatic, Histiocytic SarcomaRenal, Histiocytic Sarcoma XRenal, Lymphoma Malignant X
Lymph Node, Mandibular + M + + + + + + + + + + + + + + + + + M + + + + +Lymphoma MalignantPlasma Cell Tumor Malignant X
Lymph Node, Mesenteric + A + + + + + + + + + + + + + + I + + + + + + + +Histiocytic SarcomaLymphoma MalignantPlasma Cell Tumor Malignant X
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XHistiocytic SarcomaLymphoma Malignant X XPlasma Cell Tumor Malignant X
Thymus + + + + + + + + + A M + + I + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 63
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0715
0733
0095
0733
0732
0732
0732
0296
0564
0733
0733
0733
0733
0733
0691
0669
0733
0320
0733
0732
0628
0732
0142
0732
0 MG/KGANIMAL ID
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
females(cont...)
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Fibrosarcoma X XSubcutaneous Tissue, Hemangiosarcoma XSubcutaneous Tissue, Sarcoma XSubcutaneous Tissue, Schwannoma Malignant
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle +RhabdomyosarcomaSchwannoma Malignant, Metastatic, Skin
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +Cranial Nerve, Schwannoma Malignant
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar AdenomaAlveolar/Bronchiolar Adenoma, MultipleAlveolar/Bronchiolar Carcinoma XFibrosarcoma, Metastatic, Skin XHistiocytic Sarcoma XLymphoma Malignant XPlasma Cell Tumor Malignant X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 64
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0715
0733
0095
0733
0732
0732
0732
0296
0564
0733
0733
0733
0733
0733
0691
0669
0733
0320
0733
0732
0628
0732
0142
0732
0 MG/KGANIMAL ID
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
females(cont...)
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant XPlasma Cell Tumor Malignant X
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Plasma Cell Tumor Malignant X
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 65
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0733
0733
0733
0733
0733
0733
0732
0732
0732
0732
0683
0731
0731
0731
0731
0731
0733
0700
0580
0246
0733
0 MG/KGANIMAL ID
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + I + + A + + + + + + A A A + 43
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + A + 48
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 49
Intestine Large, Rectum + + + + + + + + + + + + + + I + + + + + + + + + + 49
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + A + 46
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + A + 48
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + A + A + 47
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1Hepatocellular Adenoma X X X X X X 10Hepatocellular Adenoma, Multiple X X 3Hepatocellular Carcinoma X 2Hepatocellular Carcinoma, Multiple X 1Histiocytic Sarcoma X 2Lymphoma Malignant 2Plasma Cell Tumor Malignant 1
Mesentery + + + + + + 10Schwannoma Malignant, Metastatic, Skin X 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 66
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0733
0733
0733
0733
0733
0733
0732
0732
0732
0732
0683
0731
0731
0731
0731
0731
0733
0700
0580
0246
0733
0 MG/KGANIMAL ID
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300 * TOTALS
Pancreas + + + + + + + + + + + + + + + + + + + + + + + A + 48Histiocytic Sarcoma X 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 49Lymphoma Malignant X 1
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + A + 48
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1Lymphoma Malignant 1Plasma Cell Tumor Malignant 1
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + A + 48Adenoma 1
Parathyroid Gland + M + + + + + + + + + + + + + + + + + + + M M + + 45
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Pars Distalis, Adenoma X 2
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 67
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0733
0733
0733
0733
0733
0733
0732
0732
0732
0732
0683
0731
0731
0731
0731
0731
0733
0700
0580
0246
0733
0 MG/KGANIMAL ID
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300 * TOTALS
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
GENERAL BODY SYSTEM
Tissue NOS 1Plasma Cell Tumor Malignant 1
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48
Ovary + M + + + + + + + + + + + + + + + + + + + + + + + 48Choriocarcinoma X 1Cystadenoma 2Plasma Cell Tumor Malignant 1
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1Polyp Stromal X 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1Plasma Cell Tumor Malignant 1
Lymph Node + + 6Histiocytic Sarcoma 1Plasma Cell Tumor Malignant 1Iliac, Histiocytic Sarcoma 1Iliac, Lymphoma Malignant X 2
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 68
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0733
0733
0733
0733
0733
0733
0732
0732
0732
0732
0683
0731
0731
0731
0731
0731
0733
0700
0580
0246
0733
0 MG/KGANIMAL ID
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300 * TOTALS
Inguinal, Histiocytic Sarcoma 1Mediastinal, Lymphoma Malignant X 2Mediastinal, Plasma Cell Tumor Malignant 1Pancreatic, Histiocytic Sarcoma X 1Renal, Histiocytic Sarcoma 1Renal, Lymphoma Malignant X 2
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 48Lymphoma Malignant X 1Plasma Cell Tumor Malignant 1
Lymph Node, Mesenteric + + + + + + + + + + + I + + + + + + + + + + + M + 46Histiocytic Sarcoma X 1Lymphoma Malignant X X 2Plasma Cell Tumor Malignant 1
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1Histiocytic Sarcoma X 1Lymphoma Malignant X 3Plasma Cell Tumor Malignant 1
Thymus + + + + + + + + + + + + + + M + + + + + + + + + + 46Histiocytic Sarcoma 1Lymphoma Malignant X 2
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma X 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 69
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0733
0733
0733
0733
0733
0733
0732
0732
0732
0732
0683
0731
0731
0731
0731
0731
0733
0700
0580
0246
0733
0 MG/KGANIMAL ID
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300 * TOTALS
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Fibrosarcoma 2Subcutaneous Tissue, Hemangiosarcoma 1Subcutaneous Tissue, Sarcoma 1Subcutaneous Tissue, Schwannoma Malignant X 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skeletal Muscle + + 3Rhabdomyosarcoma X 1Schwannoma Malignant, Metastatic, Skin X 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Cranial Nerve, Schwannoma Malignant X 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X 2Alveolar/Bronchiolar Adenoma, Multiple X 1Alveolar/Bronchiolar Carcinoma 1Fibrosarcoma, Metastatic, Skin 1Histiocytic Sarcoma 1Lymphoma Malignant 1Plasma Cell Tumor Malignant 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 70
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0733
0733
0733
0733
0733
0733
0732
0732
0732
0732
0683
0731
0731
0731
0731
0731
0733
0700
0580
0246
0733
0 MG/KGANIMAL ID
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300 * TOTALS
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X X X X 5Carcinoma 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 1Plasma Cell Tumor Malignant 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50Plasma Cell Tumor Malignant 1
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 2Lymphoma Malignant X X 6
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 71
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0677
0732
0733
0733
0733
0554
0004
0732
0732
0732
0732
0732
0732
0003
0704
0732
0732
0694
0733
0003
0005
0733
0719
3 MG/KGANIMAL ID
00301
00302
00303
00304
00306
00307
00308
00309
00310
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325
00326
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + M + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + + A + + + + + + A + + + A + I + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + A + I + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + A + + + A + + + + +Leiomyosarcoma
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + A + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + A + + + + +LeiomyosarcomaLymphoma Malignant X
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocellular AdenomaHepatocellular Adenoma, MultipleHepatocellular Carcinoma X X X X X XHistiocytic Sarcoma XLymphoma Malignant X
Mesentery + + +
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 72
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0677
0732
0733
0733
0733
0554
0004
0732
0732
0732
0732
0732
0732
0003
0704
0732
0732
0694
0733
0003
0005
0733
0719
3 MG/KGANIMAL ID
00301
00302
00303
00304
00306
00307
00308
00309
00310
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325
00326
females(cont...)
Lymphoma Malignant XSarcoma, Metastatic, Skin X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + I + +Pheochromocytoma Benign X
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X
Parathyroid Gland + + + + M + M + + + + + + + + + + + + + + + M + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 73
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0677
0732
0733
0733
0733
0554
0004
0732
0732
0732
0732
0732
0732
0003
0704
0732
0732
0694
0733
0003
0005
0733
0719
3 MG/KGANIMAL ID
00301
00302
00303
00304
00306
00307
00308
00309
00310
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325
00326
females(cont...)
Pituitary Gland + + + + + + + + + + + + + M + + + + + + + + + + +Pars Distalis, Adenoma X X X
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + I + + + + +Lymphoma Malignant X
Ovary + + + + + + + + + + M + + + + + + + + + + + I + +Granulosa Cell Tumor BenignHistiocytic Sarcoma XLymphoma Malignant X
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLeiomyosarcoma XLymphoma Malignant XPolyp StromalSarcoma Stromal X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 74
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0677
0732
0733
0733
0733
0554
0004
0732
0732
0732
0732
0732
0732
0003
0704
0732
0732
0694
0733
0003
0005
0733
0719
3 MG/KGANIMAL ID
00301
00302
00303
00304
00306
00307
00308
00309
00310
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325
00326
females(cont...)
Lymph Node + +Lymphoma Malignant XBronchial, Alveolar/Bronchiolar Carcinoma,
Metastatic, LungDeep Cervical, Lymphoma Malignant XIliac, Lymphoma Malignant XMediastinal, Lymphoma Malignant XRenal, Lymphoma Malignant X
Lymph Node, Mandibular + + + + + + + + + + + + + M + + + + + M + + + + +Lymphoma Malignant X
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X X X X
Thymus + + + + + + + + + + + + + + + + + + + M + + + + +Lymphoma Malignant X X X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Leiomyosarcoma, Metastatic, Intestine Small,
JejunumLymphoma Malignant X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 75
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0677
0732
0733
0733
0733
0554
0004
0732
0732
0732
0732
0732
0732
0003
0704
0732
0732
0694
0733
0003
0005
0733
0719
3 MG/KGANIMAL ID
00301
00302
00303
00304
00306
00307
00308
00309
00310
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325
00326
females(cont...)
Subcutaneous Tissue, FibrosarcomaSubcutaneous Tissue, Sarcoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle + +Sarcoma X X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar AdenomaAlveolar/Bronchiolar Carcinoma X XHistiocytic Sarcoma XLymphoma Malignant X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 76
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0677
0732
0733
0733
0733
0554
0004
0732
0732
0732
0732
0732
0732
0003
0704
0732
0732
0694
0733
0003
0005
0733
0719
3 MG/KGANIMAL ID
00301
00302
00303
00304
00306
00307
00308
00309
00310
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325
00326
females(cont...)
AdenomaCarcinoma XLymphoma Malignant X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X X X X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 77
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0006
0733
0524
0733
0733
0732
0732
0732
0732
0732
0677
0732
0566
0669
0585
0732
0005
0732
0732
0732
3 MG/KGANIMAL ID
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + 48
Gallbladder + + + + A + I + + + + + + + A + A + + + A + + M 39
Intestine Large, Cecum + + + + + + + + + + + + + + + + A + + + + + + + 46
Intestine Large, Colon + + + + + + + + + + + + + + + + A + + + + + + + 48
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + 49
Intestine Small, Duodenum M + + + + + A + + + + + + + + + + + A + + + + + 44Leiomyosarcoma X 1
Intestine Small, Ileum + + + + + + + + + + + + + + + + A + + + + + + + 47
Intestine Small, Jejunum + + + + + + + + + + + + + + + + A + + + + + + + 47Leiomyosarcoma X 1Lymphoma Malignant 1
Liver + + + + + + + + + + + + + + + + + + + + + + + + 49Hepatocellular Adenoma X X X 3Hepatocellular Adenoma, Multiple X 1Hepatocellular Carcinoma X 7Histiocytic Sarcoma 1Lymphoma Malignant X X 3
Mesentery + + + 6
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + 49
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 78
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0006
0733
0524
0733
0733
0732
0732
0732
0732
0732
0677
0732
0566
0669
0585
0732
0005
0732
0732
0732
3 MG/KGANIMAL ID
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350 * TOTALS
Lymphoma Malignant 1Sarcoma, Metastatic, Skin 1
Salivary Glands + + + + + + + + + + + + + + + + + + M + + + + + 48Lymphoma Malignant 1
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + 49Lymphoma Malignant 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + 49Lymphoma Malignant 1
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + 49Lymphoma Malignant 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + 49Histiocytic Sarcoma 1Lymphoma Malignant 1
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + M + + 47Pheochromocytoma Benign 1
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + 49Adenoma 1
Parathyroid Gland + + M M M + + + + + + + + + + + + + M + + + + + 42
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 79
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0006
0733
0524
0733
0733
0732
0732
0732
0732
0732
0677
0732
0566
0669
0585
0732
0005
0732
0732
0732
3 MG/KGANIMAL ID
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350 * TOTALS
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + 48Pars Distalis, Adenoma 3
Thyroid Gland + + + + M + + + + + + + + + + + + + + + + + + + 48
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + I + + + M + + + + + + + + + + + 46Lymphoma Malignant 1
Ovary + + + + + + + + + + + + + + + + + + + + + + + + 47Granulosa Cell Tumor Benign X 1Histiocytic Sarcoma 1Lymphoma Malignant 1
Uterus + + + + + + + + + + + + + + + + + + + + + + + + 49Histiocytic Sarcoma X 2Leiomyosarcoma 1Lymphoma Malignant 1Polyp Stromal X 1Sarcoma Stromal 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + 49Lymphoma Malignant 2
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 80
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0006
0733
0524
0733
0733
0732
0732
0732
0732
0732
0677
0732
0566
0669
0585
0732
0005
0732
0732
0732
3 MG/KGANIMAL ID
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350 * TOTALS
Lymph Node + 3Lymphoma Malignant 1Bronchial, Alveolar/Bronchiolar Carcinoma,
Metastatic, LungX 1
Deep Cervical, Lymphoma Malignant 1Iliac, Lymphoma Malignant 1Mediastinal, Lymphoma Malignant 1Renal, Lymphoma Malignant 1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + M + + + + + 46Lymphoma Malignant X X 3
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + 49Histiocytic Sarcoma 1Lymphoma Malignant X 4
Spleen + + + + + + + + + + + + + + + + + + + + + + + + 49Lymphoma Malignant X X X 8
Thymus + + + + + + + + + + M + + + + + M + + + M + + + 45Lymphoma Malignant X 4
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + 49Carcinoma X 1
Skin + + + + + + + + + + + + + + + + + + + + + + + + 49Leiomyosarcoma, Metastatic, Intestine Small,
JejunumX 1
Lymphoma Malignant 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 81
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0006
0733
0524
0733
0733
0732
0732
0732
0732
0732
0677
0732
0566
0669
0585
0732
0005
0732
0732
0732
3 MG/KGANIMAL ID
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350 * TOTALS
Subcutaneous Tissue, Fibrosarcoma X X X X 4Subcutaneous Tissue, Sarcoma 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + 49
Skeletal Muscle 2Sarcoma 2
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + 49
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + 49Alveolar/Bronchiolar Adenoma X X X X 4Alveolar/Bronchiolar Carcinoma X 3Histiocytic Sarcoma 1Lymphoma Malignant 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + 49Lymphoma Malignant 1
Trachea + + + + + + + + + + + + + + + + + + + + + + + + 49
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + 49
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + 49
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 82
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0733
0006
0733
0524
0733
0733
0732
0732
0732
0732
0732
0677
0732
0566
0669
0585
0732
0005
0732
0732
0732
3 MG/KGANIMAL ID
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350 * TOTALS
Adenoma X 1Carcinoma X 2Lymphoma Malignant 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + 49Histiocytic Sarcoma 1Lymphoma Malignant X 2
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + 49Histiocytic Sarcoma 1Lymphoma Malignant 1
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + 49Histiocytic Sarcoma X 2Lymphoma Malignant X X X 9
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 83
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0483
0733
0733
0682
0733
0733
0732
0646
0732
0732
0732
0731
0691
0731
0731
0731
0733
0733
0733
0733
0733
6 MG/KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + A + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + A + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + A + + + + + + + + + + + + + + M + + + + +
Intestine Small, Jejunum + + + + A + + M + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +HemangiosarcomaHepatocellular Adenoma X X X XHepatocellular Adenoma, MultipleHepatocellular Carcinoma XLymphoma Malignant X X X
Mesentery + + +HemangiomaHemangiosarcoma X
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 84
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0483
0733
0733
0682
0733
0733
0732
0646
0732
0732
0732
0731
0691
0731
0731
0731
0733
0733
0733
0733
0733
6 MG/KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
Mesothelioma Malignant X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Hemangioma
Stomach, Glandular + + + + A + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Pheochromocytoma Benign X
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland + M + + + + + + + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + I + + + + + + + + + + +Pars Distalis, Adenoma XPars Intermedia, Adenoma
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 85
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0483
0733
0733
0682
0733
0733
0732
0646
0732
0732
0732
0731
0691
0731
0731
0731
0733
0733
0733
0733
0733
6 MG/KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Follicular Cell, Adenoma X
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + M + + + + + + + + + + + + + + + + + + + +
Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Cystadenoma X XHemangiosarcomaLuteoma X X
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant XPolyp Stromal X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +HemangiosarcomaLymphoma Malignant X
Lymph NodeIliac, Lymphoma MalignantMediastinal, Lymphoma MalignantRenal, Lymphoma Malignant
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 86
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0483
0733
0733
0682
0733
0733
0732
0646
0732
0732
0732
0731
0691
0731
0731
0731
0733
0733
0733
0733
0733
6 MG/KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + M + + + + + + +Lymphoma Malignant X
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + I + + +Lymphoma Malignant X X
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +HemangiosarcomaLymphoma Malignant X X X
Thymus M + + + + + M + + + + + + + + + + + M + + + + + +Fibrosarcoma, Metastatic, SkinLymphoma Malignant
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, FibrosarcomaSubcutaneous Tissue, HemangiosarcomaSubcutaneous Tissue, Sarcoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 87
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0483
0733
0733
0682
0733
0733
0732
0646
0732
0732
0732
0731
0691
0731
0731
0731
0733
0733
0733
0733
0733
6 MG/KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma XAlveolar/Bronchiolar Carcinoma X XAlveolar/Bronchiolar Carcinoma, Multiple XCarcinoma, Metastatic, Harderian GlandFibrosarcoma, Metastatic, SkinLymphoma Malignant X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Harderian Gland
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X X X XCarcinomaLymphoma Malignant X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 88
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0483
0733
0733
0682
0733
0733
0732
0646
0732
0732
0732
0731
0691
0731
0731
0731
0733
0733
0733
0733
0733
6 MG/KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
Lymphoma Malignant
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X X XMesothelioma Malignant X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 89
DAY ON TEST
B6C3F1 MICE FEMALE
0698
0732
0652
0732
0732
0732
0732
0638
0624
0732
0733
0733
0609
0732
0733
0733
0733
0617
0733
0733
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + I + + + + + + + + + + + + + + + + 49
Gallbladder + + A + + + + A A + M + + + + + M + + + M + + + + 43
Intestine Large, Cecum + + A + + + + + A + + M + + + + + A + + + + + + + 46
Intestine Large, Colon + + + + + + + + A + + + + + + + + A + + + + + + + 48
Intestine Large, Rectum + + + + + + + + A + + + + + + + + + + + + + + + + 49
Intestine Small, Duodenum + + A + + + + A A + + + + + + + + A + + + + + + + 45
Intestine Small, Ileum + + A + + + + + A + + + + + + + + A + + + + + + + 45
Intestine Small, Jejunum + + A + + + + + A + + + + + + + + A + + + + + + + 45
Liver + + + + + + + + A + + + + + + + + + + + + + + + + 49Hemangiosarcoma X 1Hepatocellular Adenoma X X X X X 9Hepatocellular Adenoma, Multiple X X 2Hepatocellular Carcinoma X X 3Lymphoma Malignant X 4
Mesentery + + 5Hemangioma X 1Hemangiosarcoma 1
Pancreas + + A + + + + + A + + + + + + + + + + + + + + + + 48Lymphoma Malignant X 2
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 90
DAY ON TEST
B6C3F1 MICE FEMALE
0698
0732
0652
0732
0732
0732
0732
0638
0624
0732
0733
0733
0609
0732
0733
0733
0733
0617
0733
0733
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400 * TOTALS
Mesothelioma Malignant 1
Salivary Glands + + M + + + + + + + + + + + + + + + + + + + + + + 49Lymphoma Malignant X X 2
Stomach, Forestomach + + + + + + + + A + + + + + + + + + + + + + + M + 48Hemangioma X 1
Stomach, Glandular + + + + + + + + A + + + + + + + + + + + + + + M + 47Lymphoma Malignant X 1
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + A + + + + + + + + + + + + + + + + 49Lymphoma Malignant X 2
Adrenal Medulla M + + + + + + + A + + + M I + + + + + + + + + + + 46Pheochromocytoma Benign 1
Islets, Pancreatic + + A + + + + + A + + + + + + + + + + + + + + + + 48
Parathyroid Gland + + + + M + + + + + + + + + + + M + + + M + + + + 46
Pituitary Gland + + + + + + + + M + + + + + + + + + + + + + + + + 48Pars Distalis, Adenoma X X 3Pars Intermedia, Adenoma X 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 91
DAY ON TEST
B6C3F1 MICE FEMALE
0698
0732
0652
0732
0732
0732
0732
0638
0624
0732
0733
0733
0609
0732
0733
0733
0733
0617
0733
0733
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400 * TOTALS
Thyroid Gland + + + + + + + + A + + + + + + + + + I + + + + + + 48Follicular Cell, Adenoma 1
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + M + + + + + + + + + + + + + + + + 48
Ovary + + + + + + + + A + + + + + + + + + + + + + + + + 49Cystadenoma X X 4Hemangiosarcoma X 1Luteoma 2
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 1Polyp Stromal 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + A + + + + + + + + + + + + + + + + 49Hemangiosarcoma X 1Lymphoma Malignant X 2
Lymph Node + + + 3Iliac, Lymphoma Malignant X 1Mediastinal, Lymphoma Malignant X X 2Renal, Lymphoma Malignant X X 2
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 92
DAY ON TEST
B6C3F1 MICE FEMALE
0698
0732
0652
0732
0732
0732
0732
0638
0624
0732
0733
0733
0609
0732
0733
0733
0733
0617
0733
0733
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400 * TOTALS
Lymph Node, Mandibular + + M + + + + + A + I + + M + + + + + + + + + + + 45Lymphoma Malignant X X 3
Lymph Node, Mesenteric + + + + + + + + A + + + + M + + + M + + + + + + + 46Lymphoma Malignant X X X 5
Spleen + + A + + + + + A + + + + + + + + + + + + + + + + 48Hemangiosarcoma X X 2Lymphoma Malignant X X X X 7
Thymus + + + + + + + + + + + M + + + + + + + + + + + + + 46Fibrosarcoma, Metastatic, Skin X 1Lymphoma Malignant X X X X 4
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Fibrosarcoma X 1Subcutaneous Tissue, Hemangiosarcoma X 1Subcutaneous Tissue, Sarcoma 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 93
DAY ON TEST
B6C3F1 MICE FEMALE
0698
0732
0652
0732
0732
0732
0732
0638
0624
0732
0733
0733
0609
0732
0733
0733
0733
0617
0733
0733
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400 * TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X 2Alveolar/Bronchiolar Carcinoma 2Alveolar/Bronchiolar Carcinoma, Multiple 1Carcinoma, Metastatic, Harderian Gland X 1Fibrosarcoma, Metastatic, Skin X 1Lymphoma Malignant X 2
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma, Metastatic, Harderian Gland X 1
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 5Carcinoma X X X X 4Lymphoma Malignant 1
URINARY SYSTEM
Kidney + + + + + + + + A + + + + + + + + + + + + + + + + 49Lymphoma Malignant X X 3
Urinary Bladder + + + + + + + + A + + + + + + + + + + + + + + + + 49
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 94
DAY ON TEST
B6C3F1 MICE FEMALE
0698
0732
0652
0732
0732
0732
0732
0638
0624
0732
0733
0733
0609
0732
0733
0733
0733
0617
0733
0733
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400 * TOTALS
Lymphoma Malignant X 1
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X X X X X X X X X 13Mesothelioma Malignant 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 95
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0668
0733
0732
0732
0732
0732
0732
0733
0733
0710
0733
0733
0691
0729
0729
0729
0729
0733
0733
0733
0733
0733
12 MG/KGANIMAL ID
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + M + I + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + I + + A + + + + + + + + +Adenoma
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + A + + + + + + + + + + + +LeiomyosarcomaLymphoma Malignant
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocellular Adenoma X X XHepatocellular Adenoma, Multiple X XHistiocytic Sarcoma XLymphoma Malignant X X X
Mesentery + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 96
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0668
0733
0732
0732
0732
0732
0732
0733
0733
0710
0733
0733
0691
0729
0729
0729
0729
0733
0733
0733
0733
0733
12 MG/KGANIMAL ID
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
females(cont...)
Leiomyosarcoma, Metastatic, Intestine Small,Jejunum
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Glandular + + + + + + + + + + + + I + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adrenal Medulla M + + + + + + + + + + + M + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland + + + + + + + + + + + + M + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pars Intermedia, Carcinoma
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 97
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0668
0733
0732
0732
0732
0732
0732
0733
0733
0710
0733
0733
0691
0729
0729
0729
0729
0733
0733
0733
0733
0733
12 MG/KGANIMAL ID
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
females(cont...)
Thyroid Gland + + + + + + + + + + + + M + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Ovary + + + + + + + + + I + + + + + + + + + + + + + + +Cystadenoma X XLuteoma
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic SarcomaLeiomyosarcoma
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic SarcomaLymphoma Malignant XMast Cell Tumor Benign X
Lymph Node +Mediastinal, Lymphoma Malignant X
Lymph Node, Mandibular + + + + + + + + + + M + + + + + M + + + + + + + +Lymphoma Malignant X X X X X X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 98
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0668
0733
0732
0732
0732
0732
0732
0733
0733
0710
0733
0733
0691
0729
0729
0729
0729
0733
0733
0733
0733
0733
12 MG/KGANIMAL ID
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
females(cont...)
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X X X X X X X
Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X X X X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Sarcoma XSubcutaneous Tissue, Schwannoma Malignant
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland
RESPIRATORY SYSTEM
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 99
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0668
0733
0732
0732
0732
0732
0732
0733
0733
0710
0733
0733
0691
0729
0729
0729
0729
0733
0733
0733
0733
0733
12 MG/KGANIMAL ID
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
females(cont...)
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma XAlveolar/Bronchiolar Carcinoma XCarcinoma, Metastatic, Harderian Gland XCarcinoma, Metastatic, Uncertain Primary Site XHistiocytic Sarcoma XLymphoma Malignant X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Harderian Gland X
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X X X X X X XCarcinoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic SarcomaLymphoma Malignant X X X X
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 100
DAY ON TEST
B6C3F1 MICE FEMALE
0733
0733
0733
0668
0733
0732
0732
0732
0732
0732
0733
0733
0710
0733
0733
0691
0729
0729
0729
0729
0733
0733
0733
0733
0733
12 MG/KGANIMAL ID
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
females(cont...)
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X X X X X X X X X
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 101
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0732
0732
0719
0732
0732
0732
0729
0579
0729
0729
0729
0711
0733
0647
0694
0733
0731
0543
0731
0731
0731
12 MG/KGANIMAL ID
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + A + + + A + + + 46Lymphoma Malignant 1
Intestine Large, Cecum + + + + + + + + + + + + + + + A + + + + + + + + + 49
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + A + + + + + M + + + 46Adenoma X 1
Intestine Small, Ileum + + + + + + + + + + + + + + + A + + + + + + + + + 49
Intestine Small, Jejunum + + + + + + + + + + + + + + + A + + + + + + + + + 48Leiomyosarcoma X 1Lymphoma Malignant X 1
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocellular Adenoma X X 5Hepatocellular Adenoma, Multiple X 3Histiocytic Sarcoma X X X 4Lymphoma Malignant X 4
Mesentery + + + 6
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 102
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0732
0732
0719
0732
0732
0732
0729
0579
0729
0729
0729
0711
0733
0647
0694
0733
0731
0543
0731
0731
0731
12 MG/KGANIMAL ID
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450 * TOTALS
Leiomyosarcoma, Metastatic, Intestine Small,Jejunum
X 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 2Lymphoma Malignant 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 2
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Glandular + + + + + + + + + + + + + + + A + + + + + + + + + 48
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 48
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Parathyroid Gland + + + + + + + + + + + + + + + M + + + M + + + + + 47
Pituitary Gland + + + + + + + + + + + + M + + + + + + + + + + + + 49Pars Intermedia, Carcinoma X 1
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 103
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0732
0732
0719
0732
0732
0732
0729
0579
0729
0729
0729
0711
0733
0647
0694
0733
0731
0543
0731
0731
0731
12 MG/KGANIMAL ID
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450 * TOTALS
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + M + + + + + + + 49
Ovary + + + + + + + + + + + + + + + M + + + + + + + + + 48Cystadenoma X 3Luteoma X 1
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 1Leiomyosarcoma X 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 1Lymphoma Malignant 1Mast Cell Tumor Benign 1
Lymph Node 1Mediastinal, Lymphoma Malignant 1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 48Lymphoma Malignant X 7
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 104
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0732
0732
0719
0732
0732
0732
0729
0579
0729
0729
0729
0711
0733
0647
0694
0733
0731
0543
0731
0731
0731
12 MG/KGANIMAL ID
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450 * TOTALS
Lymph Node, Mesenteric + + + + M + + + + + + + + + + + + + + + I + + + + 48Histiocytic Sarcoma 1Lymphoma Malignant X X 5
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X X 3Lymphoma Malignant X 10
Thymus + + + + + + + + + + + M + + + M + + + + + + + + + 48Lymphoma Malignant X 6
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Sarcoma 1Subcutaneous Tissue, Schwannoma Malignant X 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma, Metastatic, Pituitary Gland X 1
RESPIRATORY SYSTEM
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 105
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0732
0732
0719
0732
0732
0732
0729
0579
0729
0729
0729
0711
0733
0647
0694
0733
0731
0543
0731
0731
0731
12 MG/KGANIMAL ID
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450 * TOTALS
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X 2Alveolar/Bronchiolar Carcinoma 1Carcinoma, Metastatic, Harderian Gland 1Carcinoma, Metastatic, Uncertain Primary Site 1Histiocytic Sarcoma X 2Lymphoma Malignant 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma, Metastatic, Harderian Gland 1
Harderian Gland + + + + + + + + + + + M + + + + + + + + + + + + + 49Adenoma X X 9Carcinoma X X 3
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 1Lymphoma Malignant 4
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 106
DAY ON TEST
B6C3F1 MICE FEMALE
0732
0732
0732
0732
0732
0732
0719
0732
0732
0732
0729
0579
0729
0729
0729
0711
0733
0647
0694
0733
0731
0543
0731
0731
0731
12 MG/KGANIMAL ID
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450 * TOTALS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X X X 4Lymphoma Malignant X X 13
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 107
DAY ON TEST
B6C3F1 MICE FEMALE
0138
0169
0316
0282
0239
0316
0282
0239
0232
0316
0004
0292
0134
0197
0285
0274
0296
0250
0309
0288
0136
0149
0248
0276
0316
25 MG/KGANIMAL ID
00451
00452
00453
00454
00455
00456
00457
00458
00459
00460
00461
00462
00463
00464
00465
00466
00467
00468
00469
00470
00471
00472
00473
00474
00475
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + + + + A + I + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + A + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + A + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
Tongue
CARDIOVASCULAR SYSTEM
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 108
DAY ON TEST
B6C3F1 MICE FEMALE
0138
0169
0316
0282
0239
0316
0282
0239
0232
0316
0004
0292
0134
0197
0285
0274
0296
0250
0309
0288
0136
0149
0248
0276
0316
25 MG/KGANIMAL ID
00451
00452
00453
00454
00455
00456
00457
00458
00459
00460
00461
00462
00463
00464
00465
00466
00467
00468
00469
00470
00471
00472
00473
00474
00475
females(cont...)
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland + + M + + + + + + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + M + + + + + + + + +
Thyroid Gland + + M + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Ovary + + + + + + + + + + + + + + + + + + + + + + + + +
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 109
DAY ON TEST
B6C3F1 MICE FEMALE
0138
0169
0316
0282
0239
0316
0282
0239
0232
0316
0004
0292
0134
0197
0285
0274
0296
0250
0309
0288
0136
0149
0248
0276
0316
25 MG/KGANIMAL ID
00451
00452
00453
00454
00455
00456
00457
00458
00459
00460
00461
00462
00463
00464
00465
00466
00467
00468
00469
00470
00471
00472
00473
00474
00475
females(cont...)
Lymph Node, Mandibular + + + + + + + + + + M + + + + + + + + + + + + + +
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +
Thymus + + + + + + + + + + + + + + + + + + + + + + + + +
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Pleura +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 110
DAY ON TEST
B6C3F1 MICE FEMALE
0138
0169
0316
0282
0239
0316
0282
0239
0232
0316
0004
0292
0134
0197
0285
0274
0296
0250
0309
0288
0136
0149
0248
0276
0316
25 MG/KGANIMAL ID
00451
00452
00453
00454
00455
00456
00457
00458
00459
00460
00461
00462
00463
00464
00465
00466
00467
00468
00469
00470
00471
00472
00473
00474
00475
females(cont...)
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 111
DAY ON TEST
B6C3F1 MICE FEMALE
0316
0177
0316
0284
0292
0004
0215
0284
0257
0184
0006
0290
0253
0159
0166
0249
0227
0316
0316
0131
0234
0275
0205
0156
0003
25 MG/KGANIMAL ID
00476
00477
00478
00479
00480
00481
00482
00483
00484
00485
00486
00487
00488
00489
00490
00491
00492
00493
00494
00495
00496
00497
00498
00499
00500 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + A + + + + + + + + + + + + + A 46
Intestine Large, Cecum + + + + + + + + + + A + + + + + + + + + + + + + + 49
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + A + + + + + + + + + + + + + + 49
Intestine Small, Duodenum + + + + + + + + + + A + + + + + + + + + + + + + A 48
Intestine Small, Ileum + + + + + + + + + + A + + + + + + + + + + + + + + 48
Intestine Small, Jejunum + + + + + + + + + + A + A + + + + + + + + + + + + 47
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Tongue + 1
CARDIOVASCULAR SYSTEM
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 112
DAY ON TEST
B6C3F1 MICE FEMALE
0316
0177
0316
0284
0292
0004
0215
0284
0257
0184
0006
0290
0253
0159
0166
0249
0227
0316
0316
0131
0234
0275
0205
0156
0003
25 MG/KGANIMAL ID
00476
00477
00478
00479
00480
00481
00482
00483
00484
00485
00486
00487
00488
00489
00490
00491
00492
00493
00494
00495
00496
00497
00498
00499
00500 * TOTALS
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adrenal Medulla + + M + + + + + + + + + + + + + + + + + + + + + + 49
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
Pituitary Gland + + + + + + + + + + I + + M + + + + + + + + + + + 47
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + M M + + + + + + + + + + + + + + + + + + M 47
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 113
DAY ON TEST
B6C3F1 MICE FEMALE
0316
0177
0316
0284
0292
0004
0215
0284
0257
0184
0006
0290
0253
0159
0166
0249
0227
0316
0316
0131
0234
0275
0205
0156
0003
25 MG/KGANIMAL ID
00476
00477
00478
00479
00480
00481
00482
00483
00484
00485
00486
00487
00488
00489
00490
00491
00492
00493
00494
00495
00496
00497
00498
00499
00500 * TOTALS
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 49
Lymph Node, Mesenteric + + + + + + + + + + I + + + + + + + + M + M + + + 47
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50
Thymus + + + + + + + + + + M + + + + + + + + + + + + + + 49
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pleura + + + 4
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 114
DAY ON TEST
B6C3F1 MICE FEMALE
0316
0177
0316
0284
0292
0004
0215
0284
0257
0184
0006
0290
0253
0159
0166
0249
0227
0316
0316
0131
0234
0275
0205
0156
0003
25 MG/KGANIMAL ID
00476
00477
00478
00479
00480
00481
00482
00483
00484
00485
00486
00487
00488
00489
00490
00491
00492
00493
00494
00495
00496
00497
00498
00499
00500 * TOTALS
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50
*** END OF REPORT ***
TDMS No. 99037 - 06 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 08/11/2010Test Type: CHRONIC alpha/beta Thujone mixture Time Report Requested: 13:12:57
Route: GAVAGE CAS Number: THUJONEMIXAB First Dose M/F: 06/30/03 / 06/30/03Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 115