natural resources for our healthy and prosperous generation subagus wahyuono faculty of pharmacy,...
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Natural Resources for our Healthy Natural Resources for our Healthy and Prosperous Generationand Prosperous Generation
Subagus WahyuonoSubagus WahyuonoFaculty of Pharmacy, Universitas
Gadjah Mada, Yogyakarta, Indonesia
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IndonesiaIndonesia
Indonesia is an archipelago comprising of approximately 17,508 islands. It encompasses 37 provinces with about 250 million people, making Indonesia is the world's fourth most populous country
West CentralEast
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We are blessed by the richnest of biodiversity on We are blessed by the richnest of biodiversity on the world. This is one of Biodiversity Hot spots in the world. This is one of Biodiversity Hot spots in
IndonesiaIndonesia
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Papaver somniverum
Salix alba
Nicotiana tabacum
Taxus brevifolia
Garlic
Diospyros kaki
(kesemek)
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Traditional Medicine has been Traditional Medicine has been Practiced in IndonesiaPracticed in Indonesia
TRM practiceTRM practice Raw materials Raw materials traditionally usedtraditionally used
Jamu Godog Jamu Godog
Registered Jamu Registered Jamu preparationpreparation
1st lady1st lady
Herbal Herbal Product Product
SymbolsSymbols
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INTEGRATEDINTEGRATED MEDICINEMEDICINE
TRADITIONALTRADITIONAL
MEDICINEMEDICINE
WESTERN MODERN WESTERN MODERN MEDICINEMEDICINE
HARMONIZATIONHARMONIZATION
STANDARDIZATIONSTANDARDIZATION
Way to “Health for All ”
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• 105 species were collected according to local Medicine Man, consisting of:– 3 families
(Lycopodiaceae, Gleicheniaceae, Polypodiaceae) of Pteridophyte
– 42 families of Spermatophyte
Searching Potential Searching Potential Biodiversity from Central Biodiversity from Central Kalimantan, guided by Kalimantan, guided by local medicine manlocal medicine man
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• Yellow roots (Male)• Arcangelisia flava (L.) Merr.
(Fam. Menispermaceae)• Cure Liver deseases
• Yellow roots (Female)• Fibraurea chloroleuca
Miers. (Fam. Menispermaceae)
• Cure Liver deseases
N O
O
O
OCH3
OCH3
8-oxoprotoberberineHeLa Cells (20.08%)
inhibited in vitro by this compound (500 µg/ml).
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• Renta (Local name) • Combretum acuminatum
Roxb. (Fam. Combretaceae)• Protection for pregnant
woman from Magic.
• Sinduk (Local name) (Garlic odor when the leaves craushed)
• Scorodocarpus borneensis Becc. (Fam. Olacaceae)
• Stomachache, antiflatullent
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• Saluang belong Male (local Name)
• Dictamnus albus L. (Fam. Rutaceae)
• Sexual enhancement for Men
• Pasak bumi/Tongkat Ali• Eurycoma longifolia
Jack. (Fam. Simaroubaceae)
• Sexual enhancement for men
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• Serai hutan (Local name)• Celtis cinnamomea Lindl.
ex Plancho (Fam. Ulmaceae)
• Smell likes Lemon Grass (Gramineae)
• Tapak barito (Local Name)
• Ficus deltoidea Jack. (Fam. Moraceae)
• Habitus : epifit• Sexual enhancement for
women
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Principal Active Compounds
THE ROLES OF THE ROLES OF NATURAL RESOURCESNATURAL RESOURCES FOR FOR HUMAN HEALTH AND PROSPERITYHUMAN HEALTH AND PROSPERITYFlora, Animals
MicroorganismsMarine chemistry
Human biochemistry
DRUGSDRUGS(Curative)(Curative)
PHYTOPHARMAKA (Plants)
(Curative)
Chemopreventive, Chemoprotective
(Prevention)
Methyl gallateMethyl gallate
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CurativeCurative v/s v/s PPreventireventiveve
Secretion
Procarcinogen
Metabolic activation
Ultimate Carcinogen
Normal cells
Initiation (1-2 days)
Initiated cells
Promotion (> 10 thn)
Preneoplastic cells
Neoplastic cells
Progression (> 1 thn)
Multi-stage of Multi-stage of carcinogenesiscarcinogenesis
Detoxification
KuratifKuratif
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PRO-TECTPRO-TECT : : A product provides A product provides aa broad spectrum flavonoid complex broad spectrum flavonoid complex
Pro-tectPro-tect : Provides broad spectrum antioxidant nutrition of flavonoid.
Pro-tectPro-tect : Provides flavonoids present in the 8 standardized-qualified extracts
FlavonoidFlavonoid : a phenolic type of compound present in plants, responsible for the bright colors of fruits, vegetables, useful for health promotion.
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Pro-Tect contains :Pro-Tect contains : Pycnogenol dan grape seed extract Redbilberry extract Grape skin extract Green tea extract Ginkgo biloba extract Milk thistle (Sylibum marianum) extract Citrus bioflavonoids
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Red Billberry
Gyngko biloba
Silibum marianum
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Silimarin
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Lutein (a carrotenoid type of compound)
Utilize the waste of carrot (Daucus carota) leaves
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Proton NMR
Lutein
Scientific data is Scientific data is a must a must
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OPTIMATION OF KESEMEK (Diospyros kaki Thunb.) LEAVES AS SUPPLEMEN PRODUCT TO PROMOTE
HEALTH
• This sp. grows well in the northern of TNGM (Merapi Mt National Park)• The fruits have economic values for people• The leaves are discarded• How to optimize economic values of the plant benefit for people surrondings
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Similarity Index 79,2 %
Similarity index 20,8 %
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Herbs Garden
Herbal Medicine Products
Modern Medicine, Taxol
But please not this kind But please not this kind of product.....of product.....
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Thank you for your attention
Research LaboratoryDept. of Pharmaceutical Biology
Faculty of Pharmacy, GMUUnit-2, 1st floor
E-mail: [email protected]