natural selection in human populations natural selection and disease the ccr5 gene gene is...
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![Page 1: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/1.jpg)
Natural Selection in Human Populations
• Natural Selection and Disease• The CCR5 gene• Gene is transcribed and translated to a surface
protein of T-helper cells. • Related to HIV (human immunodeficiency virus• Virus acquired from chimpanzees ca. 1930• Does no harm in chimpanzees.• Related to AIDS (acquired immune deficiency
syndrome)
![Page 2: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/2.jpg)
Prevalence of HIV infection, ages 15-45
![Page 3: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/3.jpg)
Increase over time in HIV prevalence in adults
![Page 4: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/4.jpg)
Life cycle of HIV
![Page 5: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/5.jpg)
Azidothymidine (AZT)treatment
![Page 6: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/6.jpg)
Fast acquisition of resistance toAZT
![Page 7: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/7.jpg)
• Some people are resistance to HIV
• CCR5 – delta 32 allele
![Page 8: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/8.jpg)
![Page 9: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/9.jpg)
• Sickle cell anemia and malaria
• Global incidence of malaria: 300-500 cases/year
• 1-3 million deaths/year
• Hemoglobin
• HbA HbS
• HbA/HbS = heterozygote advantage
![Page 10: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/10.jpg)
HbA/HbS
sickle cell trait
HbS/HbS
sickle cell anemia
![Page 11: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/11.jpg)
Frequency of HbS
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Prevalence ofmalaria
![Page 13: Natural Selection in Human Populations Natural Selection and Disease The CCR5 gene Gene is transcribed and translated to a surface protein of T-helper](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d425503460f94a1d31b/html5/thumbnails/13.jpg)
Relationship between HbS and malarial impact