2nd International Conference

Bioengineering and Cell Therapy

WEBINAR - 9th October 2020

International ConferenceBioengineering and Cell Therapy

21st September 2018University of Brescia - School of Medicine

Main Lecture Hall - Viale Europa 11-Brescia

8:30 Registration9:00 Welcome of the Authorities

- Rector of the University of Brescia Prof. M. Tira- Director General of ASST Spedali Civili di Brescia Dott. E. Belleri- Director General of the Italian National Transplant Centre (CNT) Dott. A. Nanni Costa- President of Fondazione Comunità Bresciana Dott. P. L. Streparava

Welcome on behalf of GITMO and SIES and Introduction D. Russo

First SessionChairman: F. Magni, M. Pizzi, E. Mariani9:30 Scaffold Universe – Engineering the cellular microenvironment with materials and growth factors M.S. Sanchez10:00 The potential of MSCs in regenerative medicine K. Le Blanc10:30 Lab-on-a-tissue: Using Mass Spectrometry Imaging in clinical research B.P.A.M. Heijs11:00 Re-engineering developmental process for cartilage and bone regeneration I. Martin

11:30 -12:00 Coffee break

Second SessionChairman: M. Castellano, R. Faglia, D. Russo12:00 High performance Gelatin/Chitosan-based Hydrogels as Scaffolds for Tissue Engineering Applications L. Sartore12:20 Human Platelet Lysate production for h-MSCs expansion C. Almici12:40 Hydrogel Polymeric Scaffolds (HyPSs) bioengineered with Human Mesenchymal Stem Cells (hMSCs)

for regenerative medicine employment: a pilot study F. Re13:00 Development of artificial cartilage on chitosan-based scaffolds: critical points and preliminary data G. Lisignoli13:20 The role of proteomics for molecular and cellular characterization of human platelet lysate and scaffolds C. Chinello

13:45 -14:30 Light Lunch

Third sessionChairman: P. Guizzi, E. Sardini, P. Nicolai14:30 Skull base reconstructions after expanded endoscopic approaches: state of the art F. Doglietto14:50 3-D printing of biocompatible engineered polymers for personalized skull base reconstruction in

endoscopic skull base surgery: preliminary results and future directions. the e-Bones Project D. Mattavelli15:10 Sensing scaffolds for cell monitoring in tissue engineering S. Tonello15:30 Research Activities in the Tissue Engineering Laboratory at the University of Brescia M. Serpelloni

Fourth sessionChairman: G. De Petro, S. Sozzani, E. Monti15:50 A multidisciplinary approach to build an engineered heart tissue P. Dell’Era16:10 iPS-derived dopaminergic neurons: a new tool to model neurodegenerative disorders M.C. Missale16:30 Extracellular vesicles in regenerative medicine A. Radeghieri

SCIEnTIFIC PROGRAM

Organizing SecretariatStudioProgress SncVia Cattaneo 51 - 25121 Brescia (Italy)Tel. +39(0)30290326www.studioprogress.itinfo@studioprogress.it

Registration is free but must be finalized accessing the Organizing Secretariat website www.studioprogress.it NEXT MEETINGS.The Organizing Secretarial will send anacceptance e-mail to confirm registration.

Scientific Secretariat: D. Russo, P. Nicolai,E. Sardini, L. Sartore, C. Paganelli, P. Guizzi, C. Almicion behalf of– DPT of Clinical and Experimental Sciences– DPT of Medical and Surgical Specialities,

Radiological Sciences and Public Health– DPT of Information Engineering– DPT of Mechanical and Industrial Engineering– DPT of Orthopaedic Surgery– School of Dentistry– DPT of Laboratory MedicineOfficial scientific language: English

Under the Patronage of:

International ConferenceBioengineering and Cell Therapy

21st September 2018University of Brescia - School of Medicine

Main Lecture Hall - Viale Europa 11-Brescia

8:30 Registration9:00 Welcome of the Authorities

- Rector of the University of Brescia Prof. M. Tira- Director General of ASST Spedali Civili di Brescia Dott. E. Belleri- Director General of the Italian National Transplant Centre (CNT) Dott. A. Nanni Costa- President of Fondazione Comunità Bresciana Dott. P. L. Streparava

Welcome on behalf of GITMO and SIES and Introduction D. Russo

First SessionChairman: F. Magni, M. Pizzi, E. Mariani9:30 Scaffold Universe – Engineering the cellular microenvironment with materials and growth factors M.S. Sanchez10:00 The potential of MSCs in regenerative medicine K. Le Blanc10:30 Lab-on-a-tissue: Using Mass Spectrometry Imaging in clinical research B.P.A.M. Heijs11:00 Re-engineering developmental process for cartilage and bone regeneration I. Martin

11:30 -12:00 Coffee break

Second SessionChairman: M. Castellano, R. Faglia, D. Russo12:00 High performance Gelatin/Chitosan-based Hydrogels as Scaffolds for Tissue Engineering Applications L. Sartore12:20 Human Platelet Lysate production for h-MSCs expansion C. Almici12:40 Hydrogel Polymeric Scaffolds (HyPSs) bioengineered with Human Mesenchymal Stem Cells (hMSCs)

for regenerative medicine employment: a pilot study F. Re13:00 Development of artificial cartilage on chitosan-based scaffolds: critical points and preliminary data G. Lisignoli13:20 The role of proteomics for molecular and cellular characterization of human platelet lysate and scaffolds C. Chinello

13:45 -14:30 Light Lunch

Third sessionChairman: P. Guizzi, E. Sardini, P. Nicolai14:30 Skull base reconstructions after expanded endoscopic approaches: state of the art F. Doglietto14:50 3-D printing of biocompatible engineered polymers for personalized skull base reconstruction in

endoscopic skull base surgery: preliminary results and future directions. the e-Bones Project D. Mattavelli15:10 Sensing scaffolds for cell monitoring in tissue engineering S. Tonello15:30 Research Activities in the Tissue Engineering Laboratory at the University of Brescia M. Serpelloni

Fourth sessionChairman: G. De Petro, S. Sozzani, E. Monti15:50 A multidisciplinary approach to build an engineered heart tissue P. Dell’Era16:10 iPS-derived dopaminergic neurons: a new tool to model neurodegenerative disorders M.C. Missale16:30 Extracellular vesicles in regenerative medicine A. Radeghieri

SCIEnTIFIC PROGRAM

Organizing SecretariatStudioProgress SncVia Cattaneo 51 - 25121 Brescia (Italy)Tel. +39(0)30290326www.studioprogress.itinfo@studioprogress.it

Registration is free but must be finalized accessing the Organizing Secretariat website www.studioprogress.it NEXT MEETINGS.The Organizing Secretarial will send anacceptance e-mail to confirm registration.

Scientific Secretariat: D. Russo, P. Nicolai,E. Sardini, L. Sartore, C. Paganelli, P. Guizzi, C. Almicion behalf of– DPT of Clinical and Experimental Sciences– DPT of Medical and Surgical Specialities,

Radiological Sciences and Public Health– DPT of Information Engineering– DPT of Mechanical and Industrial Engineering– DPT of Orthopaedic Surgery– School of Dentistry– DPT of Laboratory MedicineOfficial scientific language: English

Under the Patronage of:

ASSOCIAZIONE ITALIANACONTRO LE LEUCEMIE-LINFOMI E MIELOMA

SEZIONE DI BRESCIA - O D V

International ConferenceBioengineering and Cell Therapy

21st September 2018University of Brescia - School of Medicine

Main Lecture Hall - Viale Europa 11-Brescia

8:30 Registration9:00 Welcome of the Authorities

- Rector of the University of Brescia Prof. M. Tira- Director General of ASST Spedali Civili di Brescia Dott. E. Belleri- Director General of the Italian National Transplant Centre (CNT) Dott. A. Nanni Costa- President of Fondazione Comunità Bresciana Dott. P. L. Streparava

Welcome on behalf of GITMO and SIES and Introduction D. Russo

First SessionChairman: F. Magni, M. Pizzi, E. Mariani9:30 Scaffold Universe – Engineering the cellular microenvironment with materials and growth factors M.S. Sanchez10:00 The potential of MSCs in regenerative medicine K. Le Blanc10:30 Lab-on-a-tissue: Using Mass Spectrometry Imaging in clinical research B.P.A.M. Heijs11:00 Re-engineering developmental process for cartilage and bone regeneration I. Martin

11:30 -12:00 Coffee break

Second SessionChairman: M. Castellano, R. Faglia, D. Russo12:00 High performance Gelatin/Chitosan-based Hydrogels as Scaffolds for Tissue Engineering Applications L. Sartore12:20 Human Platelet Lysate production for h-MSCs expansion C. Almici12:40 Hydrogel Polymeric Scaffolds (HyPSs) bioengineered with Human Mesenchymal Stem Cells (hMSCs)

for regenerative medicine employment: a pilot study F. Re13:00 Development of artificial cartilage on chitosan-based scaffolds: critical points and preliminary data G. Lisignoli13:20 The role of proteomics for molecular and cellular characterization of human platelet lysate and scaffolds C. Chinello

13:45 -14:30 Light Lunch

Third sessionChairman: P. Guizzi, E. Sardini, P. Nicolai14:30 Skull base reconstructions after expanded endoscopic approaches: state of the art F. Doglietto14:50 3-D printing of biocompatible engineered polymers for personalized skull base reconstruction in

endoscopic skull base surgery: preliminary results and future directions. the e-Bones Project D. Mattavelli15:10 Sensing scaffolds for cell monitoring in tissue engineering S. Tonello15:30 Research Activities in the Tissue Engineering Laboratory at the University of Brescia M. Serpelloni

Fourth sessionChairman: G. De Petro, S. Sozzani, E. Monti15:50 A multidisciplinary approach to build an engineered heart tissue P. Dell’Era16:10 iPS-derived dopaminergic neurons: a new tool to model neurodegenerative disorders M.C. Missale16:30 Extracellular vesicles in regenerative medicine A. Radeghieri

SCIEnTIFIC PROGRAM

Organizing SecretariatStudioProgress SncVia Cattaneo 51 - 25121 Brescia (Italy)Tel. +39(0)30290326www.studioprogress.itinfo@studioprogress.it

Registration is free but must be finalized accessing the Organizing Secretariat website www.studioprogress.it NEXT MEETINGS.The Organizing Secretarial will send anacceptance e-mail to confirm registration.

Scientific Secretariat: D. Russo, P. Nicolai,E. Sardini, L. Sartore, C. Paganelli, P. Guizzi, C. Almicion behalf of– DPT of Clinical and Experimental Sciences– DPT of Medical and Surgical Specialities,

Radiological Sciences and Public Health– DPT of Information Engineering– DPT of Mechanical and Industrial Engineering– DPT of Orthopaedic Surgery– School of Dentistry– DPT of Laboratory MedicineOfficial scientific language: English

Under the Patronage of:

International ConferenceBioengineering and Cell Therapy

21st September 2018University of Brescia - School of Medicine

Main Lecture Hall - Viale Europa 11-Brescia

8:30 Registration9:00 Welcome of the Authorities

- Rector of the University of Brescia Prof. M. Tira- Director General of ASST Spedali Civili di Brescia Dott. E. Belleri- Director General of the Italian National Transplant Centre (CNT) Dott. A. Nanni Costa- President of Fondazione Comunità Bresciana Dott. P. L. Streparava

Welcome on behalf of GITMO and SIES and Introduction D. Russo

First SessionChairman: F. Magni, M. Pizzi, E. Mariani9:30 Scaffold Universe – Engineering the cellular microenvironment with materials and growth factors M.S. Sanchez10:00 The potential of MSCs in regenerative medicine K. Le Blanc10:30 Lab-on-a-tissue: Using Mass Spectrometry Imaging in clinical research B.P.A.M. Heijs11:00 Re-engineering developmental process for cartilage and bone regeneration I. Martin

11:30 -12:00 Coffee break

Second SessionChairman: M. Castellano, R. Faglia, D. Russo12:00 High performance Gelatin/Chitosan-based Hydrogels as Scaffolds for Tissue Engineering Applications L. Sartore12:20 Human Platelet Lysate production for h-MSCs expansion C. Almici12:40 Hydrogel Polymeric Scaffolds (HyPSs) bioengineered with Human Mesenchymal Stem Cells (hMSCs)

for regenerative medicine employment: a pilot study F. Re13:00 Development of artificial cartilage on chitosan-based scaffolds: critical points and preliminary data G. Lisignoli13:20 The role of proteomics for molecular and cellular characterization of human platelet lysate and scaffolds C. Chinello

13:45 -14:30 Light Lunch

Third sessionChairman: P. Guizzi, E. Sardini, P. Nicolai14:30 Skull base reconstructions after expanded endoscopic approaches: state of the art F. Doglietto14:50 3-D printing of biocompatible engineered polymers for personalized skull base reconstruction in

endoscopic skull base surgery: preliminary results and future directions. the e-Bones Project D. Mattavelli15:10 Sensing scaffolds for cell monitoring in tissue engineering S. Tonello15:30 Research Activities in the Tissue Engineering Laboratory at the University of Brescia M. Serpelloni

Fourth sessionChairman: G. De Petro, S. Sozzani, E. Monti15:50 A multidisciplinary approach to build an engineered heart tissue P. Dell’Era16:10 iPS-derived dopaminergic neurons: a new tool to model neurodegenerative disorders M.C. Missale16:30 Extracellular vesicles in regenerative medicine A. Radeghieri

SCIEnTIFIC PROGRAM

Organizing SecretariatStudioProgress SncVia Cattaneo 51 - 25121 Brescia (Italy)Tel. +39(0)30290326www.studioprogress.itinfo@studioprogress.it

Registration is free but must be finalized accessing the Organizing Secretariat website www.studioprogress.it NEXT MEETINGS.The Organizing Secretarial will send anacceptance e-mail to confirm registration.

Scientific Secretariat: D. Russo, P. Nicolai,E. Sardini, L. Sartore, C. Paganelli, P. Guizzi, C. Almicion behalf of– DPT of Clinical and Experimental Sciences– DPT of Medical and Surgical Specialities,

Radiological Sciences and Public Health– DPT of Information Engineering– DPT of Mechanical and Industrial Engineering– DPT of Orthopaedic Surgery– School of Dentistry– DPT of Laboratory MedicineOfficial scientific language: English

Under the Patronage of:

SIESocietà Italiana di Ematologia

SCIENTIFIC PROGRAMOpening Webinar: 13.15 Welcome and Introduction: M. Pizzi - C. Rossi - D. Russo

First Session: Regenerative Medicine (ReMed-NetWorK)

13.25 Lecture: Application of Raman imaging to molecular medicine - G. Pezzotti (Kyoto - JAPAN time 20:30)

I Part Chairs: L. Sartore - G. Lisignoli - P. Guizzi - D. Russo

13.45 Polymeric scaffolds for bone and cartilage regeneration - L. Sartore & S. Pandini (Brescia)14.00 Advances in highly performing polysaccharides, bio-engineered scaffolds, hydrogels for bone regeneration - F. Re (Brescia)14.15 Generation of new artificial cartilage - G. Lisignoli (Bologna)14.30 Overview of mesenchymal stromal cell biology: regenerative vs. immunomodulatory properties - S. Viswanathan (Toronto)

14.45-15.00: Questions and General Discussion

II Part Chairs: J. Irish - R. Gilbert - P. Nicolai - D. Russo

15.00 Molecular analysis of osteogenic differentiation pathways activation: the role played by the scaffolds - S. Bernardi (Brescia)15.15 3D-mapping of mesenchymal stem cells growth on bioengineered scaffolds - S. Taboni (Brescia - Toronto) 15.30 Preliminary experience with in vivo bone regeneration through bio-engineered poly-hydrogel scaffolds - M. Ferrari (Brescia-Toronto)

15.45-16.00: Questions and General Discussion

Second Session: CAR-T cell therapy

Chairs: F. Ciceri – P. Corradini – F. Porta – D. Russo

16.00 What are CAR-T and how they work - A. Turra (Brescia)16.15 The pediatric experience - F. Locatelli (Roma)16.30 Results and new strategies in ALL - A. Rambaldi (Bergamo)16.45 Results and new strategies in DLBCL - NHL - C. Jacobson (Boston - USA time 10:45)17.00 CAR-T Therapy in AML - F. Ciceri (HSR Milano)17.15 The MSKCC experience - MA Perales (NY - USA time 11:15)17.30 MoAb target therapies in ALL and BLBCL: integrative or competitive vs CAR-T - A. Tucci (Brescia)17.45 CAR-T cell therapy in Head and Neck Oncology - N. Muhanna (Tel Aviv)

18.00-18.15: Questions and General Discussion

Third Session: Artificial Intelligence in Medicine and Innovation in Clinical Research and Methodology (PhD UniBS) 18.15 Lecture: What can MedTech learn from lessons from FinTech - R. Stein (NY-USA time 12:15)

18.35 Lecture: Health economics: a compass to guide innovation in the health care? - R. Levaggi (Brescia)

19.00 End of the Meeting

Under the Patronage of:

Scientific Secretariat: Simona Bernardi, Federica Re, Marco Ferrari, Stefano Taboni, Luciana Sartore, Domenico Russoon behalf of

- Board ReMed Network

- DPT of Clinical and Experimental Sciences - Brescia University Domenico Russo Fabrizio Luigi Rodella Elisa Borsani Simona Bernardi Federica Re

- DPT of Medical and Surgical Specialties, Radiological Sciences and Public Health - Brescia University Francesco Doglietto Davide Mattavelli Marco Ferrari Stefano Taboni Tommaso Gualtieri Corrado Paganelli Fabio Savoldi Piero Nicolai (Padova University)

- DPT of Mechanical and Industrial Engineering - Brescia University Luciana Sartore Stefano Pandini Kamol Dey Silvia Agnelli

- DPT of Information Engineering - Brescia University Emilio Sardini Francesco Nicola Lopomo Sarah Tonello Mauro Serpelloni Guido Faglia Matteo Ferroni Camilla Baratto

- DPT of Orthopaedic Surgery - ASST Spedali Civili - Brescia Pierangelo Guizzi

- DPT of Laboratory Medicine - ASST Spedali Civili - Brescia Camillo Almici Andea Bianchetti

- Laboratory of Tissue Regeneration - Istituto Ortopedico Rizzoli - Bologna University Gina Lisignoli Erminia Mariani

- Laboratory of Proteomics and Metabolomics - Milano Bicocca University Fulvio Magni Clizia Chinello Andrew James Smith

- DPT of Biomedical Engineering, School of Engineering - University of Glasgow Manuel Salmeron-Sanchez Marco Cantini Vladimira Moulisova

- DPT of Otolaryngology, Head and Neck Surgery - University Health Network of Toronto Jonathan Irish Ralph Gilbert

- Krembil Research Institute - University Health Network of Toronto Sowmya Viswanathan

FACULTYSimona Bernardi (Università di Brescia)Fabio Ciceri (IRCSS Ospedale San Raffaele Milano)Paolo Corradini (Istituto Nazionale dei Tumori di Milano, Università di Milano)Marco Ferrari (Università di Brescia)Ralph Gilbert (University Health Network of Toronto, Canada)Pierangelo Guizzi (ASST Spedali Civili Brescia)Jonathan Irish (University Health Network of Toronto, Canada)Caron Jacobson (Brigham and Women’s Hospital, Dana-Farber Cancer Institute – Boston, USA)Rosella Levaggi (Università di Brescia)Gina Lisignoli (Istituto Ortopedico Rizzoli - Università Bologna)Franco Locatelli (Ospedale Bambin Gesù - Roma)Nidal Muhanna (Tel Aviv Sourasky Medical Center - Israel)Piero Nicolai (Università di Padova)Stefano Pandini (Università di Brescia)Miguel-Angel Perales (MSKC Center - NY, USA)Giuseppe Pezzotti (Kyoto University, Japan)Marina Pizzi (Delegato alla Ricerca Università di Brescia)Fulvio Porta (ASST Spedali Civili - Brescia)Alessandro Rambaldi (Università di Milano, Ospedale Papa Giovanni XXIII - Bergamo)Federica Re (Università di Brescia)Camillo Rossi (Direttore Sanitario - ASST Spedali Civili di Brescia)Domenico Russo (Università di Brescia - ASST Spedali Civili Brescia)Luciana Sartore (Università di Brescia)Alessandra Tucci (ASST Spedali Civili Brescia)Alessandro Turra (ASST Spedali Civili Brescia)Roger Stein (Stern School of Business - New York, USA) Stefano Taboni (ASST Spedali Civili Brescia)Sowmya Viswanathan (Krembil Research Institute - University Health Network of Toronto, Canada)

RegistrationRegistration is free but must be finalized accessing the Organizing Secretariat website www.studioprogress.it NEXT MEETINGS.The Organizing Secretarial will send an acceptance e-mail to confirm registration.

Organizing Secretariat StudioProgress SncVia Cattaneo 51 - 25121 Brescia (Italy)Tel. +39(0)30290326www.studioprogress.itinfo@studioprogress.it

UniBS WEB-e-Learning AssistanceTechnical ManagerSilvestro Nevola

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