neonatal jaundice
DESCRIPTION
neonatal jaundiceTRANSCRIPT
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Jaundice
Manaen
Neonatal
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Framework
• The definition of Neonatal Jaundice• Billirubin Metabolism• Special characteristic in neonates• Dangerous of the Hyperbillirubinemia• The diseases in relation with Neonatal
Jaundice
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What is the Neonatal Jaundice?
• Neonatal Jaundice(also called Newborn jaundice) is a condition marked by high levels of bilirubin in the blood.
The increased bilirubin cause the infant's skin and whites of the eyes (sclera) to look yellow.
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Billirubin Metabolism
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Special characteristic in neonates
• 1.More billirubin produced• Much more Hemolysis• The life-length of hemolysis(70~80)
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Special characteristic in neonates
• 2.The low capability of albumin on unconjugated billirubin transportation
• acid intoxication• Less albumin in neonates
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Special characteristic in neonates
• 3.The low capability of heptatocyte• Less Y protein and Z protein• The primary development of Hepato-
enzyme system• Easy-broken hepato-enzyme system• After-born, the blood glucose level is very low.
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Special characteristic in neonates
• 4.High workload of the hepato-enteric circulation
• Less bacterial• Low enzymatic activity in intestine• High level of billirubin in meconium
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A little examIncreased rbc’sIncreased rbc’s
Shortened rbc lifespanShortened rbc lifespan
Immature hepatic uptake & conjugationImmature hepatic uptake & conjugation
Increased enterohepaticCirculationIncreased enterohepaticCirculation
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The general symptom of neonatal jaundice
• Yellow skin • Yellow eyes(sclera)• Sleepiness• Poor feeding in infants• Brown urine• Fever• High-pitch cry• Vomiting
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Brown urine
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Grading of extent of jaundice 1
Area of body Billirubin levelsmg/dl (*17=umol)
Face 4-8Upper trunk 5-12Lower trunk & thighs 8-16Arms and lower legs 11-18Palms & soles > 15
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Grading of extent of jaundice 2
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Hemolytic disease of newborn
This condition occurs when there is an incompatibility between the blood types of the mother and baby.
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Are they use the same circulation system?
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Placental barrier
• ..
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The blood types(A, B, O, AB)
• Although it is not as common (especially in a first pregnancy), a similar problem of incompatibility may happen between the blood types (A, B, O, AB) of the mother and baby in the following situations:
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The blood types(A, B, O, AB)
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The blood types (Rh)
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Kernicterus• Kernicterus is damage to the brain centers of
infants caused by increased levels of unconjugated-indirect bilirubin which is free (not bound to albumin).
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Blood-brain barrier
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The symptoms
• Eye movement obstacles
• Hearing disorder