networking event wednesday december 9, 2015 · 21/01/2016 · networking event wednesday december...
TRANSCRIPT
Networking Event
Wednesday
December 9, 2015
12 Humanities and Social Science Departments 354 Tenured/Tenure Track Faculty
“How people process and document the human experience”
College of Liberal Arts Research
December, 2015
• Neurobiology of learning and memory; affective modulation of brain systems
• Normative and atypical human development
• Health and race
• Media’s influence on health behavior
HEALTH Related Researcher Activities
Director: Dr. Charles D. Johnson
(Psychology)
Director: Dr. Mark Fossett (Sociology)
Established in 2011, multi-university consortium (including Baylor, UT, Rice, UTSA), five colleges Examples of data sets: National Center for Health Statistics, the Agency for Healthcare Research, and Quality
Healthy Aging in the College of Education and Human Development
Program on
Healthy Aging Texas A&M Health Science Center
School of Public Health Marcia G. Ory, PhD, MPH, Director
Vision: to be a recognized Center of Excellence for promoting successful aging throughout the life-course that will improve the lives of Texans and others throughout the nation and world.
Mission: to promote successful aging through innovations in research, education and practice that examine social, behavioral, environmental, and technological solutions linking academic and real-world settings.
Areas of interest: promoting evidence-based practices for chronic disease prevention and management; building healthy communities; exploring interactions between health, aging and technology; enhancing geriatric care; and growing the pipeline of experts in gerontology and geriatrics.
What We Do: Current Foci
• Infrastructure & Training
• Evidence-Based Disease Prevention Programs for
Seniors
• Population & Disease Specific Programs
• Childhood & Family Programs
AGING :Energy (900 MJ/kg) vs Entropy Generation (11,000 kJ/kg K) Over Life Span.
• Kalyan’s research on Combustion of Coal, , Oil and gas, oxygen deficient combustion in liquid fuel sprays and coal suspensions and Thermodynamics
• Track i) energy consumption ( kJ/kg) from birth to death using CDC data on food intake, ii) estimate entropy generation ( kJ/kg K) from birth to death;
• Women reach 10,000 kJ/kg over 78 yrs while men reach this # within 74 yrs; ants will reach it in a few days!
By Kalyan Annamalai, Paul Pepper Professor of Mech Engineering , [email protected]
Death Limit for all species
Men Women
J. of Thermodynamics, 2009; J.of Entropy, 100-123, 2008; J.of Entropy, 2012
ORGAN STRESS: Which Organ has the highest Entropy generation per unit mass over life
Thermo, 2nd Ed(2012)
HLKN Bone Biology Laboratory (PI: S. Bloomfield, [email protected])
Hip fracture: • Most serious consequence of aging-related
bone loss
• Over 50% with reduced mobility; mortality
as high as 20% within 2 yr
• Loss of bone strength accelerated by
periods of bed rest or muscle paralysis
Lab Objective: Understand how adaptations
of bone cell activity (& bone structural
integrity) to exercise or disuse is modified by: • Nutrition (calories, iron, omega-3)
• Osteoporosis medications
• Radiation exposure
• Changes in blood flow
• Estrogen status
Lisa Geraci
Department of Psychology
Explicit Implicit
Younger
Older
Me
mo
ry P
erf
orm
an
ce
Aging and cognition:
the role of test type and personal expectations
.30
.40
.45
.55
.35
Success
Pro
po
rtio
n r
ec
all
ed
Control
.50
.60
*
Younger
Older
3
3.5
4
4.5
5
5.5
25 45 65 85
Me
mo
ry B
eli
efs
Healthy Brain Aging William H. Griffith, Ph.D.
Neuroscience & Experimental Therapeutics
How do we keep our brains healthy ? How do we protect,
restore or enhance the functioning of our brains as we age?
(Institute of Medicine : Grand Challenges of 21st Century)
Big Questions
Electrophysiology Optogenetics Molecular Biology Immunohistochemistry Behavior
In Vitro: • Brain slices • Single isolated neurons
Young – unimpaired Aged – impaired Aged – unimpaired
Techniques
Program: Neurological function and brain aging • Calcium homeostasis and aging (>25 yrs) • Reproductive aging & estrogens (R01 AG041360)
• Optogenetic transgenic mice (R01 AG047652)
Ca 2+
extracellular
intracellular
Ca 2+
Ca 2+
Rapid buffering Aging
only
HEALTH PROMOTION FOR AGING AFRICAN
AMERICAN
Investigator: Dr. I. Shevon Harvey
Expertise:
Qualitative Research Methodology
Community-based Participatory Research
Chronically ill Population (i.e., co-morbidities such as diabetes,
arthritis, & blood pressure; overweight & obesity)
Interest in Healthy Aging:
Self-care management research,
Racial / ethnic health disparities,
Qualitative research,
Health protective behaviors among aging women,
Dissemination and implementation of research projects to
understand the complexity of health interventions (i.e., including
individuals with multiple health conditions & traditionally
underrepresented populations in research)
TTI – Center for Transportation Safety
• Driver safety research
– In-vehicle technologies
– Driver stress and workload
– Comprehension and decision making
• Older driver research
– Driving feedback
– Driving data for driver assessment
Human Rehabilitation Group Dr. Pilwon Hur at Mechanical Engineering, http://hurgroup.net
Research Interests
1. Human movement is optimal
2. Learn from Human movement
3. Neurological impairments affects optimality
4. Rehabilitate for optimal sensorimotor behavior
Public Policy Research Institute
Created in 1983 – 30 Projects Annually - $140 Million since 1986
Capabilities: Surveys – Large Datasets – Statistical Analysis
Illustrative Projects
Department of Aging and Disability Services Mandated Surveys
1.3 Million Served - PES Survey
Aging Texas Well
Texas Co-op Extension – Plan for boomer aging – Concept-mapping
AARP Survey
Evaluation Health & Wellness events – 3,000 Interviews – Ohio, Pennsylvania, Arizona
Design Research for Active Living Center for Health Systems and Design
Chanam Lee, PhD, Professor
Landscape Architecture and Urban Planning http://research.arch.tamu.edu/activeliving
[email protected] Health Active
Living
Built
Environment
The Biological Control of Physical Activity J. Timothy Lightfoot, HLKN
• It is well known that Physical Activity is key to the attainment and maintenance of health (and cognitive ability), especially as one ages. • The literature is clear that Activity level is controlled by heredity, but this heritable control diminishes as individuals age. • Our work focuses on the Biological and Genetic mechanisms that regulate daily activity. - Sex hormones - Dopaminergic systems • Our hope is to better understand these mechanisms so that treatments/interventions can be developed to aid in the adoption & maintenance of a physically active lifestyle.
Create physical environments for
long-term care residents to
Walk & Roll
Zhipeng Lu, Ph.D., LEED AP BD+C
Associate Director, Center for Health Systems & Design
• Safe and convenient indoor & outdoor environments for walking or rolling wheelchairs
• Collaborate with administrators to modify the environment and develop activity programs
Director: Michael L. Madigan, PhD Director: Michael Madigan, Ph.D. Email: [email protected]
GOAL: to help prevent injuries through an improved understanding of the biomechanics and neuromuscular control of human motion.
FOCUS: 1) understand factors that affect balance and contribute to falls 2) develop fall prevention interventions
Before training
After training
Slipping
Tripping
BMI/obesity
Aging
The NeuroErgonomics Lab
Brain-Behavior Assessments Brain (and muscle) imaging: Functional near infrared spectroscopy
Strength measurement: Isokinetic and handgrip dynamometers
Ambulatory sensors: Physical activity monitors, ECG sensors, electromyography (EMG) sensors, Balance board
Lab-based: Vicon Motion Capture, Force Plates, EMG, Neuromuscular Electrical Stimulation
Research Interests NeuroErgonomic evaluation of stress/fatigue
Obesity and the Aging Brain
Depression and motor function
Promoting brain health for falls prevention and improving mobility
Collaborations SPH PHA, University at Buffalo, Motor
Neuroscience TAMU, Psychology TAMU
Funding NIH, Hogg Foundation, CDC NIOSH, Huffines
Institute, SPH
Ranjana Mehta, PhD [email protected]
979-436-9327
Steve Liu: [email protected]
Adam Pickens: [email protected]
Hearing, Movement and Balance
• Sensing and holistic modeling of functional levels
• Pattern modeling and feedback systems
• Use of pattern classification techniques to reconstruct individual function models
• Potential applications: functional level change detection to reduce the risk of falls
Upper/Lower Extremity Movements
Position and Balance Sensors
Low-Level Signal Processing
Low-Level Execution
High-Level Decision Making
Interactive Art Making for Social Connectedness and Empowerment
Interactive Plants: Soft/Organic Interfaces for Tangiable Reminiscing
Jinsil Hwaryoung Seo Ph.D. assistant professor
department of visualization, soft interaction lab
Klemens Meyer, MD; Duane Steward, DVM, MSIE, PhD
Role of SOLOMON* in Healthcare
SOLOMON
Personal
Health Preference
Model
Personal
Health Preference
Model
Depersonalized
Health Preference
Model
Healthcare Policy and Research
Insurance, HMO, Employer Health Plan
Internet
Web TV
Home
Software
Waiting Room
Software
Medical Care Delivery
*Systematic Obtainer of Language Overtly Multidimensional and Operational in Nature
Contact me to Collaborate
SAMUEL D. TOWNE JR., PHD, MPH, CPH
SCHOOL OF PUBLIC HEALTH
Vascular Aging
• Aging is associated with increased stiffening of the large arteries which is a primary contributing factor to other pathologies such as stroke and heart failure
• We have focused on the mechanisms contributing to increased stiffness including elastin fiber degradation and altered extracellular matrix production.
• We use a variety of techniques that range from cell culture to whole animal studies. We use genetic models to manipulate changes in particular genes that are associated with the process.
The NLD is an initiative within the department of Educational Psychology that promotes the use of biometrics (EEG, Psychophysiology, Eye tracking) to better understand human learning and development throughout the lifespan. • Research mission
• Educational mission
• Community Outreach mission
Director: Dr. Steven Woltering
Website: nld.tamu.edu
Vascular Biology Laboratory
A. Vascular Aging B. Isolated Arteries
C. Cell Signaling D. Exercise
Design for Active Living
and Healthy Aging
Active Living &
Healthy Aging
Built Environment
Buildings… Communities…. Cities…
Xuemei Zhu, Ph.D., Associate Professor, College of Architecture, TAMU
Mission CTRAL The Center for Translational Research in Aging and Longevity is
engaged on ongoing translational research on nutrition, exercise, and
metabolism in relation to aging and the common diseases of our
aging population. Translation of knowledge from basic and applied
sciences to care and clinical practice for older adults is the overall
goal of CTRAL.
We particularly investigate the role of (protein, specific amino acids
and fat) metabolism on muscle mass and functional performance of
the muscle, gut and brain in the pursuit of healthy aging.
Furthermore, we examine how changes in nutrition can affect certain
metabolic pathways and improve outcomes in disease and aging.
Besides using advanced state-of the art stable isotope methodology,
functional performance is measured by a battery of tests and
questionnaires.
CTRAL facilities at Research Park - Clinical research unit with 9 beds and 3RN’s
- Large function area: body composition, bone density,
endurance and strength, and cognition testing.
Workout area.
- Mass Spectroscopy and blood / tissue processing Lab
Types of research projects Diseased populations:
Observational and human clinical trials in
- Cancer
- COPD
- Chronic Heart failure
- Obstructive Sleep Apnea
- Mild Cognitive Impairment and Dementia
- Autism
Healthy population:
- Older adults: 10 days of bedrest and nutrition
intervention
- Morbid obese: Effect bariatric surgery
- Methionine toxicity
Human Clinical Research Facility New building (12 bed, 23,000 sqrt)
Groundbreaking Jan 21, 2016.
Houses CTRAL and ESNL
CENTER FOR HEALTH
SYSTEMS & DESIGN
DO Older People Need Nature?
o OUTDOOR USAGE/ PREFERENCES: Survey, Interview, Focus group, Photographic comparison
o HEALTH BENEFITS: Anxiety, Cortisol level, Positive and Negative Mood after being outdoors
Environment Influences Usage
o Multiregional study confirmed most important features
o Shade, seating, walkways, and doorways often poorly-designed, discouraging outdoor usage
Translate Research to Design
o “Access to Nature” video series (www.accesstonature.org)
o Seniors Outdoor Survey (SOS Tool) validated (The Gerontologist, 2014)
Susan Rodiek, Ph.D.
Design-Based
Research:
The Value of
Nature for
Older Adults
Photos courtesy of the Norwegian Center for Dementia Research and Nishino Hospital, Kitakyushu, Japan
CENTER FOR HEALTH
SYSTEMS & DESIGN
SOS Tool Goals o Designed to evaluate how well outdoor
spaces at long-term care facilities support aging residents
o Addresses both therapeutic and psychosocial needs
o Uses as a design and decision-making tool
Structure & Development
o 60 ratable items on a seven-point scale o Organized into Five Literature-Based Domains o Affordance theory based o Differential weighting emphasizes greater
effects of some items. o Intuitive 100-Base scoring system
Testing Scoring & Translations o Validity: Items supported by resident
preferences and subject matter experts, and associated with walking and outdoor activity outcomes
o Reliability: Inter-Rater =.91, Test-Retest= .92 o Translations in Italian, Japanese, Mandarin
Eric Bardenhagen, Ph.D.
Assessing Successful Spaces with the SOS Tool
(Seniors Outdoor Survey)
Giulio Senes
Photos Courtesy of Access to Nature
CENTER FOR HEALTH
SYSTEMS & DESIGN
“Aging in Place” means healthcare elsewhere
o Most people want to (and will) “age in place”
o Gardens in HCFs must accommodate everyone
“Design for the Most Vulnerable”
o Key HC design tenet o Often includes the elderly o “Universal Design” – Design for
all abilities
Design Examples o Safety; Comfort; “Escape”; Nature
Distraction; Exercise; Social Support o Easy physical & visual access; safe &
comfortable seating; choice of sun or shade.
Naomi A. Sachs, PhD(c)
Healthcare Design with
Aging in Mind
δ β
Υ α
α
β
β1
Dystrophin
Dystrophin
Glycoprotein
Complex Caveolin-3
α1
F-actin
Laminin
John Lawler, Redox Biology Lab
Ang II Growth
Factors
Nox-2
ROS Protein turnover, auto(mito)phagy
nNOS
SS-31
ET
muscle atrophy, cardiac remodeling
gp91 ds-tat, HMB
nNOSµ,
dystrophin
transfection
ET CR
aging
Losartan
ET
ROS
cytokines
fibrosis
ET, gene Tg HSPs
Aox enzymes
SIRT-1/PGC-1
ET
ECM (Collagen/Fibronectin) ET = Exercise Training