neuro radiology schwanoma
DESCRIPTION
Neuro radiology of SchwanomaTRANSCRIPT
![Page 1: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/1.jpg)
Neuro Radiology - Schwannoma
Dr.Roopchand PSSenior resident Neurology
![Page 2: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/2.jpg)
Introduction:
• WHO grade I tumours.• Peaks in the 4th or 5th decade of life.• Adolescent age – NF2• Mostly occur in 8th nerve• Other CN can be involved.• 30% of Intra spinal tumours.• 7-8% of all primary intracranial tumours and
75-90% of cerebellopontine angle masses.
![Page 3: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/3.jpg)
• Bilateral vestibular schwannomas are highly suggestive of neurofibromatosis type 2 (NF2).
Clinical presentation• sensorineural hearing loss or tinnitus.• Facial Palsy• Cerebellar symptoms• Pressure effect, hydrocephalus.
![Page 4: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/4.jpg)
Pathology:• Arise from the intracanalicular segment of the
vestibular portion of the vestibulocochlear nerve – Near the transition point between glial and
Schwann cells (Obersteiner-Redlich zone) .• In over 90% of cases these tumours arise from
the inferior division of the vestibular nerve . • They are well circumscribed encapsulated masses .• Bony erosion of internal auditory meatus can occur.• Usually never invades in to adjacent structures.
![Page 5: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/5.jpg)
• They can display two types of growth pattern:• Antoni A– elongated cells with cytoplasmic processes arranged in
fascicles – little stromal matrix– Verocay bodies : nuclear free zones of processes lying
between regions of nuclear palisading• Antoni B– loose meshwork of cells– less densely cellular– microcysts and myxoid change
![Page 6: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/6.jpg)
Radiographic features:
• Most vestibular schwannomas have an intracanalicular component.
• Widening of the porus acousticus resulting in the trumpeted IAM sign.– present in up to 90% of cases .– Helps in differentiating it from meningoma.
• Extracanalicular extension into cerebellopontine angle can lead to "ice cream cone" appearnace
![Page 7: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/7.jpg)
• Tumours tend to be solid.• Cystic degeneration seen commonly in larger
tumours.• Haemorrhagic areas may also be seen.• Calcification is typically not present
![Page 8: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/8.jpg)
CT:
• Erosion and widening of the internal acoustic meatus.
• Variable density.• Hard to identify due to adjacent bone artefact.• Contrast enhancing.– Variable
![Page 9: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/9.jpg)
Normal SideTrumpeted IAM
![Page 10: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/10.jpg)
ContrastPlain
![Page 11: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/11.jpg)
MRI:• T1– slightly hypo-intense c.f. adjacent brain - 63%– iso intense c.f adjacent brain - 37%– may contain hypo intense cystic areas
• T2– heterogeneously hyper intense c.f to adjacent brain – cystic areas fluid intensity– may have associated peri-tumoural arachnoid cysts
• T1 C+ (Gd)– contrast enhancement is vivid– but heterogeneous in larger tumours
![Page 12: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/12.jpg)
T1+CT1
![Page 13: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/13.jpg)
![Page 14: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/14.jpg)
Differentials:• meningioma
– more homogeneous in appearance . – meningiomas tend to have a broad dural base– usually lack trumpet IAM sign– calcification more common
• epidermoid– no enhancing component– very high signal on DWI– does not widen the IAM
• metastasis– uncommon– usually does not remodel the IAM as metastases are usually present for only
a short time• ependymoma
– centered on the fourth ventricle– does not extend into the IAM– usually younger patients
![Page 15: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/15.jpg)
Spinal Schwanoma:
• Spinal schwannomas usually arise from the dorsal sensory roots.
• Radicular pain.• Myelopathy if large.• NF2 association seen.
![Page 16: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/16.jpg)
Radiographic features:
• Appear as rounded lesions.• Often with associated adjacent bony
remodelling.• Large tumors– Either align themselves with the long axis of the
cord forming sausage shaped masses– Can extend over several levels– May protrude out of the neural exit foramen
forming a dumb-bell shaped mass.
![Page 17: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/17.jpg)
MRI:
• Neuromas and schwannomas looks identical• Haemorrhage, intrinsic vascular changes
(thrombosis; sinusoidal dilatation), cyst formation and fatty degeneration – Schwannoma.
• T1 - 75% are isointense, 25% are hypointense• T2 - more than 95% are hyperintense, often
with mixed signal • T1 C+ (Gd) - virtually 100% enhance
![Page 18: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/18.jpg)
T2
![Page 19: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/19.jpg)
T2T1
![Page 20: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/20.jpg)
T1C FatSatT2
![Page 21: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/21.jpg)
![Page 22: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/22.jpg)
Differentials:
• neurofibroma• meningioma• paraganglioma• myxopapillary ependymoma• intradural extra medullary metastases
![Page 23: Neuro radiology schwanoma](https://reader036.vdocument.in/reader036/viewer/2022062513/556b9d79d8b42ada358b5453/html5/thumbnails/23.jpg)
Thank You