neurofeedback in pain management
TRANSCRIPT
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Neurofeedback in Pain Neurofeedback in Pain ManagementManagement
Victoria L. Ibric, MD, PhD, BCIACNeurofeedback & NeuroRehab
Institute, Inc.www.nnrionline.com
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Neurofeedback in Pain Neurofeedback in Pain ManagementManagement
• Definitions:
• Pain is a necessary “evil”.
• or
• “Pain is unquestionably a sensation in a part or parts of body but is always unpleasant and therefore also an emotional experience” (Merskey1986) as defined by the International Association for the Study of Pain (IASP).
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Pain ModelsPain Models
1. Psychological pain associated with physiological conditions.
2. The bio-psycho-social model of pain.
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Psychological pain is associated with Psychological pain is associated with physiological conditionsphysiological conditions
• Melzak & Wall in 1965, “Gate Theory” of pain.
• This theory incorporated the three systems that are involved in pain experience –sensory-discriminative, motivational-affective and cognitive-evaluative.
• This model integrates the notions that pain can be somatic as well as psychogenic.
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Psychological pain is associated with Psychological pain is associated with physiological conditionsphysiological conditions
• The mechanism of pain, incorporating peripheral receptors, pain pathways and cortical and sub-cortical centers where pain is perceived, has brought emphasis to the importance of the corticalization of pain.
• Birbaumer, Flor, Lutzenberger, & Elbert, 1995!
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NF, due to CNS neuroplasticity, NF, due to CNS neuroplasticity, affects pain perceptionaffects pain perception
• CNS neuroplasticity (Ramanchandran & Rogers-Ramanchandran, 2000) may explain why Neurofeedback is such a valuable technique.
• Neurofeedback proposes that by teaching self-regulation, a patient can reduce or even eliminate pain sensations.
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The bio-psycho-social model of pain
• Gatchel & Turk (1996)
• Craig’s statements including the theory on social learning mechanisms (1986).
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Table I Table I -- Etiology of Chronic Pain of Etiology of Chronic Pain of our patientsour patients’’ populationpopulation
• Head Injuries due to different accidents: STBI, MTBI, CVA
• Work related injuries due to repetitive muscle activities
• Post surgery• Post inflammation (ie: post shingles)• Psychological or Idiopathic• Chronic degenerative diseases
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Overview of the complexity of Overview of the complexity of treating chronic paintreating chronic pain
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The usefulness of BF/NF with coThe usefulness of BF/NF with co--morbidities associated with chronic painmorbidities associated with chronic pain
• The co-morbidities include high blood pressure and cognitive dysfunctions (Ibric & Grierson, 1995), and sleep disorders (Ibric, 2001).
• The addictive behaviors associated with chronic pain have been addressed with NF, resulting in remarkable success (Ibric 2002; Guyol, 2006).
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Table II Table II –– Overlapping diagnoses of Overlapping diagnoses of our patientsour patients’’ populationpopulation
• Anxiety and/or Depression• ADHD• Asthma• Cancer – different localizations• Essential Tremor or Parkinson’s• Hypertension• Sleep Disorders• Memory impairment
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Table III Table III –– Factors perpetuating Factors perpetuating and aggravating pain syndromesand aggravating pain syndromes
Osteoarthritis, Rheumatoid arthritis, Systemic Lupus Erythematosus
Rheumatologic Disorders 8
Radiculopathies, Entrapment neuropathies Peripheral neuropathies, Multiple Sclerosis
Neurologic Disorders 7
Sleep Apnea Bruxism Sleep Disorders 6
Bacterial, viral, fungi, etc Immune Deficit Syndromes
Chronic Infections 5
Adjustment Disorder Psychosomatic Disorder Secondary Gain
Secondary Psychosocial Factors 4
Hypothyroidism/ HypoglycemiaHyperuricemia
Metabolic and Endocrinologic abnormalities
3
Avitaminosis, Poor or imbalanced diet Nutritional deficiencies2
Structural asymmetry Poor Posture Mechanical stressors 1
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Comprehensive evaluationComprehensive evaluation
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PsychoPsycho--physiological Profile on physiological Profile on Biocomp InstrumentBiocomp Instrument
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PenfieldPenfield’’s Homunculus, 1958s Homunculus, 1958
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Table IV Table IV ––The Ten cases presented in detailThe Ten cases presented in detail
40NARSD left footF204
82Addiction to pain killers
Neuropathy post TBI & Spinal cord injury due to work accident
M333
145Hypertension,Urinary incontinence
Headaches, Neck Spasticity post meningitis, Gait dysfunction
F672
15Depression,Sleep disorder
RSD Post MVAF521
#NF sessions
CO-MorbiditiesMain DiagnosticSexAgeCase#
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The Ten cases presented in detailThe Ten cases presented in detail
54Rheumatoid ArthritisTMJ/ RSD or Fibromyalgia post MVA
F518
16PTSD, BruxismMyofascial pain,Headaches, TMJ
F357
46Bipolar Depression,Addiction to pain killers
Neuropathy post laminectomy
M626
22HypertensionIdiopathic Neuropathy
M635
#NF sessions
CO-MorbiditiesMain DiagnosticSexAgeCase#
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The Ten cases presented in detailThe Ten cases presented in detail
112Kidney stones, Addiction to Pain Killers
Left inguinal chronic pain post surgery, mTBI
M4210
56Parkinson’s Disease, Colon Cancer, Leukemia
Chronic pain upper/ lower back and legs
F609
#NF sessions
Co-MorbiditiesMain DiagnosticSexAgeCase#
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Case 1Case 1
• Case 1 –A 52 y/o female with reflex sympathetic dystrophy (RSD) post MVA, post neck surgery.
• Symptoms: right side face shoulder/ arm, right eye lid spastic ptosis, depression, sleep disorder
• Etiology: MVA 3 years prior to investigating BF• Other therapies: neck surgery, physical therapy,
electrical stimulator implanted• Medications: Antidepressants, Vicodin
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Case 1Case 1-- TrainingTraining
• NF training - 15 sessions; NF protocols were done mostly at C3 site {where Beta (15-18 Hz) was enhanced while Theta (4-7 Hz) and High Beta (22-30 Hz) suppressed.}
• Neurocybernetics was the instrument used. The C3 site corresponds to the right eye projection, at the sensory-motor area of the homunculus (see figure).
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Case 1 Case 1 –– RSD right face, RSD right face, neck/shoulder, during NF sessionneck/shoulder, during NF session
Before NF training
After 30 minutes NFOn NC
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Case 1Case 1-- ResultsResults
• After the first session, the eye stayed opened for 1 hr. As the NF continued, after each session, the same effect occurred as described as in the first session, except that it was sustained for a longer and longer time.
• After 15 sessions, NF training was terminated, due to her family’s leaving the state.
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Case 2Case 2
• Case 2 – A 67 y/o retired actress (recently widowed) with chronic headaches, neck and low back pain; spasticity post meningitis; and hypertension as co-morbidity.
• Symptoms: headaches, right side neck spasticity, gait dysfunction, depression/ anxiety, sleep disorders, memory and concentration impairments, urinary incontinence.
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Case 2Case 2• Etiology: Three neck surgeries after an MVA,
that occurred 20 years prior investigating BF. Last surgery was done a year before BF and that induced meningitis.
• Other therapies: surgery, psychotherapy, physical therapy, acupuncture,
• Medications: Lorcet, Neurontin, Elavil, Restoril, Depakote, Norvasc, Baclofen, Hydrochlorothyazide, Duragesic patches, Synthroid, Cardura, Norco 10-350, Vitamin B complex, Vitamin E.
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Case 2 Case 2 -- TrainingTraining
• NF training: 145 sessions. Neurocybernetics and ROSHI instruments were used for her NF training. The electrode positioning varied from CZ to C3, or C4, C3-Cz, Cz-C4 and F3/F4, or C3/C4, enhancing either SMR, 15 Hz, or correcting coherence. EEG patterns modified, from a great variability to a more stable activity.
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Case 2 Case 2 -- ResultsResults
• NF results: Pain perception modified and decreased to none, less depressed or anxious, better and more restful sleep, lowered blood pressure, better gait, and better quality of life. Patient was able to enjoy travel, and moved to a new house, since her husband died.
• Able to reduce her meds by half, under her physician’s supervision.
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Case 3Case 3• Case 3 –A 33 y/o retired construction engineer,
Neuropathy post TBI and spinal cord injury• Symptoms: Neck, shoulder, upper/lower back,
arms, legs pain, spasticity, tremor, gait dysfunction, memory problems, depression, panic attacks, sleep deprivation, neuro-vegetative deregulation (temperature fluctuations with profuse sweats, paroxysmal tachycardia, blood pressure with large fluctuations!), which were exacerbated by Elavil(discontinued).
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Case 3Case 3
• Etiology: TBI due to work injury that affected the brain stem (post 16 ft ladder-fall)
• Medications: Zoloft, Mirapex, Baclofen, Buspar, Vicodin, Sonata, Ambien, Elavil,
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Case 3 Case 3 -- TrainingTraining
• NF training: 82 sessions• NF protocols: Number of NC sessions (8)
and ROSHI sessions (74)• Results: decreased pain, tremor and
spasticity reduced, less depression, better sleep, reduced medication
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Case 3 Case 3 -- ProtocolsProtocols• The electrodes were placed over the central sensory
motor area over the vertex at the Cz position. • The ROSHI training was set for complex adaptive
modality (CAM) for the light stimulation, to inhibit high beta frequency over 25 Hz, or HiBeta [I].
• The effect enhanced by using the electromagnetic stimulation, concomitantly.
• The hands tremor ceased when the electrodes were placed over the C3/C4 positions (where the motor control projection of the hands is located on Penfield’s homunculus) and the training was designed to enhance S14 (SMR 14) or SMR, 12-15 Hz (while Theta and HiBeta were discouraged).
• The sessions done on ROSHI I, were monitored and recorded on Neurocybernetics
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Case 3 Case 3 –– EEG recordings on NC, EEG recordings on NC, pre NF and post 32 ROSHI sessionspre NF and post 32 ROSHI sessions
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Case 4Case 4
• Case 4 – A 20 y/o student with RSD left foot • Symptoms: chronic pain of left foot migrating to
the right, headaches, and cognitive dysfunctions due to meds.
• Etiology: A heavy metal object fell on her left foot, 2 years prior to investigating BF.
• Other therapies: Physical therapy, Acupuncture• Medications: Various antidepressants, Vicodin,
Motrin
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Case 4 Case 4 -- Training/ ResultsTraining/ Results
• NF training: 20 sessions. Protocols mostly over the central sensory area at the Cz or Cz/C4 positions using the Neurocybernetics (11) followed by the ROSHI (9) NF instruments.
• NF results: Pain reduced from 8 (0-10 VAS) to 2-1. Able to return to school
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Case 5Case 5
• Case 5 –63 y/o retired engineer with Idiopathic neuropathy; hypertension as co-morbidity
• Symptoms: legs pain, level 9 (0-10 VAS) anxiety, sleep disorder, hypertension
• Other Therapies: Physical Therapy• Medications: Neurontin, Norvasc
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Case 5 Case 5 -- Training/ ResultsTraining/ Results
• NF training: 22 sessions. Protocols on NC Cz SMR (2), and on ROSHI (20) with light and electromag stimulation F3/F4 alpha inhibit.
• Results: Pain reduction down to none, anxiety controlled, better sleep, reduced Neurontin
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Case 6Case 6• Case 6 –62 y/o writer, with Neuropathy post
laminectomy• Symptoms: chronic pain low back and legs, level
8 (0-10 VAS); depression, attempted suicide, addiction to pain meds
• Etiology: laminectomy for chronic low back pain 8 yrs prior to NF
• Other Therapies: surgery, psychotherapy, Palade exercises, Yoga
• Medications: Neurontin, Wellbutrin, Vicodin
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Case 6 Case 6 -- Training/ ResultsTraining/ Results• NF training: 46 sessions. Protocols on NC (4),
Cz SMR and on ROSHI (42), F3/F4 the protocols varied from AO[I] or alpha only inhibit (8), to S14 reward (4), B16 reward (16), B17 (5) and Sync enhance (9). The Complex Adaptive Modality of light stimulation was always used with ROSHI I.
• NF Results: pain reduction down to none, no more depression, reduced meds, no more Vicodin
• After 7 years since the NF training ended, the learned skills continued to benefit the client, enhanced his performance.
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Case 7Case 7• Case 7 - A 35 y/o student with MFPS, chronic
headaches (multiple origins) and (PTSD), Bruxism• Symptoms: Headaches due to dental problems or sinus
infections or allergies, left TMJ, teeth grinding , depression, anxiety, anger, sleep disorders.
• Other therapies: chiropractic, massage therapy, sinus surgeries, psychotherapy
• Medications: Neurontin, Depakote, Vicodin, Acetaminophen, Motrin, Relafen, Diazepam, Lorcet, Relafen, Baclofen, Tegretol, Serozone, LidocaineInfusions, Antihistamines (Zyrtec, NavCon-A, Albuterol, as needed)
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Case 7 Case 7 -- Training/ ResultsTraining/ Results• NF training: 15 sessions. Protocols used as
needed at Cz or C4 SMR and C3 Beta (some sessions done with alternation of C3 beta followed by C4 SMR) using Neurocybernetics Instrument.
• NF results: Headache and TMJ pain reduced from 8-9 to 2-1, and emotional correction of depression. Anxiety from 8 to 2 - 0. Improved cognitive functioning with the reduction of the meds. Three months post the 15th session the normalization of the brain wave activity sustained and she was able to resume school.
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Longitudinal case studiesLongitudinal case studies
• Case 8• Case 9• Case 10
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Case 8Case 8• Case 8 - A 51 y/o teacher with chronic neck/
shoulder or N/S pain, and TMJ /RSD; co-morbidity, Rheumatoid Arthritis
• Symptoms: Severe chronic pain (left neck/shoulder, TMJ, ear), numbness of left hand; sleep disorders: insomnia, teeth grinding; fatigue, nervousness
• Etiology: MVA 4 year prior to investigating BF• Medications: Relafen, Plaquenil, Prozac,
Serozone (Elavil, Zoloft, Sinequal in the past) HRT for menopause.
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Case 8 Case 8 -- Training/ ResultsTraining/ Results• NF training: 22 sessions on NC, resumed NF
after a 5 months brake; then continued to session 51 on NC, followed by 3 re-evaluations
• NF training at Cz or C4 - SMR enhanced, and theta and high beta discouraged.
• NF Results: TMJ and neck/ shoulder pain level lowered from 8-9 to 2-4 and gradually was reduced and kept for longer time, even after the NF ended, at acceptable levels of 1-3 on the Visual Analog Scale, or VAS, as reported and presented in Figures 5-9.
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Case 8 - Temporo Mandibular Joint pain
-0.2
0
0.2
0.4
0.6
0.8
1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51
Sessions
Rel
ativ
e VA
S r
educ
tion
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Case 8 - Neck/Shoulder pain
0
0.1
0.2
0.3
0.4
0.5
0.6
1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51
Sessions
Rela
tive
VAS
redu
ctio
n
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Case 8 - NF Treatment Effectiveness in TMJ pain control
0123456789
10
1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52
Number of sessions
Pain
per
cept
ion
(VA
S)
Pre TMJPost TMJ
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Case 8 - NF Treatment Effectiveness in N/S pain control
0
1
2
3
4
5
6
7
8
9
1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52
Number of sessions
Pain
per
cept
ion
(VA
S)
Pre N/SPost N/S
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Case 9Case 9• Case 9 - 60 y/o () Housewife with Chronic pain;
co-morbidities: Parkinson’s Disease (PD), Skin and Colon cancer, Chronic Lymphatic Leukemia (CLL)
• Etiology: 2 years prior BF fell and injured left knee, diagnosed also with CLL and PD. Symptoms: Severe Lower back and left knee pain, level 8-9 (0-10 VAS), spasticity of left foot, numbness of the left hand, tremor, depression, Anxiety, sleep disorder, tinnitus.
• Medications: Cinemet, Trazadone, Zoloft, Lodosyn, HRT, Oscal and multivitamins.
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Case 9 Case 9 -- Training/ ResultsTraining/ Results• NF training: 56 sessions on NC, mostly at Cz
enhance SMR and reduce high beta.• Results: Spasticity lowered form 8-10 to 3 post
20 sessions and reduced to none after 50 sessions; Tremor more controlled and better after each session, imperceptible after 50 sessions;
• Pain reduction to 2-1, anxiety/ depression controlled, better sleep, reduced meds (under physician control). Pain continued to be under control even after 1 year and a half or 2 years and half after the NF training ended (see Figures 10-14)
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Case 9 - Back Pain
0
0.2
0.4
0.6
0.8
1
1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52 55
Session
Rel
ativ
e VA
S R
educ
tion
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Case 9 - Knee Pain
0
0.2
0.4
0.6
0.8
1
1.2
1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55
Session Number
Rel
ativ
e VA
S R
educ
tion
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Case 9 - NF Treatment Effectivness in back pain control
0
2
4
6
8
10
1 5 9 13 17 21 25 29 33 37 41 45 49 53
Number of sessions
Pain
per
cept
ion
(VA
S)
Pre backPost back
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Case 9 - NF Treatment Effectiveness in knee pain control
0
2
4
6
8
10
1 5 9 13 17 21 25 29 33 37 41 45 49 53
Number of sessions
Pain
per
cept
ion
(VA
S)
Pre kneePost knee
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Case 10Case 10
• Case 10 – A 42 y/o carpenter with left inguinal pain post surgery and kidney stones (185 over the years), mTBI, chronic colitis, addictions to pain killers/ marijuana
• Symptoms: Depression/ Anger, Chronic Fatigue; Left inguinal pain, Low back pain
• Etiology: Hernia surgery and epidydimectomy, 4 years prior to investigating BF; work injury (hit with a 2X4 at the posterior right of the head)
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Case 10Case 10
• Other therapies: Acupuncture, chiropractic, herbs
• Medications: Vicodin, Morphin (repeated ER visits), Iboprufen 2400mg, Epinephrine
• NOTE: all the meds stopped after 15 sessions of NF!
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Case 10 Case 10 -- TrainingTraining
• 112 Neurofeedback sessions: Neurocybernetics (9): C4 SMR, C3 Beta, P3 Alpha [E]; ROSHI (103): enhanced NF by light or electromagnetic closed loop EEG: F3/F4 alpha only inhibit, AO[I]; theta only inhibit, TO[I], or theta 4, T4[I]; P3/P4 , alpha only enhanced, AO[E]; C3/C4 or Cz SMR; F3/F7, synchronization inhibit, Sync [I]; Fp1/T3 Sync [I]. When NF was completed, continued the home training with a pROSHI (personal ROSHI entrainer/ disentrainer, non-NF instrument).
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Case 10 Case 10 -- ResultsResults
• Pain reduction from 9-10 immobilizing pain to 3-1 and complete elimination of pain killers.
• Able to go back to work and produced musical CD, due to enhanced mental performance!
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Case 10Case 10
• Progress evaluation• Subjective tests:
– SCL-90R– Stress Test– CES-D, depression test
• Objective tests:– IVA– QEEG pre, during and post NF
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Case 10 Case 10 –– SCLSCL--90R90R
0
5 0
1 0 0
1 5 0
2 0 0
2 5 0
7/23 /0 3 9/24 /0 3 10 /2 8/031/12 /0 4 4/30 /0 4 7/20 /0 51/18 /0 6 8/22 /0 6
M ax =3 60 ; M in =0
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Case 10 Case 10 –– Stress TestStress Test
0
20
40
60
80
100
120
7/23/03 9/24/03 10/28/031/12/04 4/30/04 7/20/051/18/06 8/22/06
0-25 mild;26-50 moderate;51-75 severe;76+very severe
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Case 10 Case 10 -- CESCES--D D ––Depression scaleDepression scale
0
1 0
2 0
3 0
4 0
5 0
6 0
7 /2 1 /03 9 /4 /0 3 1 0 /2 8 /031 /1 2 /04 4 /3 0 /0 4 7 /2 0 /0 51 /1 8 /06 8 /2 0 /0 6
N o te : C E S-D m a x= 6 0 ; ove r 1 6 + d e p res s io n
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Case 10 Case 10 –– HEG evaluation during HEG evaluation during NF training on ROSHINF training on ROSHI
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Case 10 Case 10 –– HEG evaluation during HEG evaluation during NF training on ROSHI NF training on ROSHI (continuation)(continuation)
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Case 10 Case 10 –– QEEG connectivity map QEEG connectivity map pre NF (NeuroRep program)pre NF (NeuroRep program)
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Case 10 Case 10 –– QEEG connectivity map QEEG connectivity map during NF (NeuroRep program)during NF (NeuroRep program)
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Case 10 Case 10 –– QEEG connectivity map QEEG connectivity map post NF (NeuroRep program)post NF (NeuroRep program)
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Statistical Analysis of the NF Statistical Analysis of the NF Efficacy in pain syndromesEfficacy in pain syndromes
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3 /17
Rheumatoid Arthritis (RA) /Other (e.g. Cancer pain)
7Abdominal pain of Different origins
13CRPS type I, II
10MFPS & Fibromyalgia
30Back & Leg Pain
9Neck & Shoulder Pain
Total 58(19)
Headache & Migraines (Headaches only)
No. patientsNo. patientsMain Pain Diagnostics Main Pain Diagnostics and/or localizationsand/or localizations
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Number of NF sessions Number of NF sessions influenced the outcome!influenced the outcome!
70 / 74 or 70 / 74 or 95%95%Success rate of Success rate of positive resultspositive results
68 / 74 or 68 / 74 or 92%92%Success rate CSI*Success rate CSI*
[2A + 68 “CSI”*= 70] 74>19 NF sessions
(3A)2511-19 NF sessions
[1 ameliorated, (A)]332-10 NF sessions
0151 NF sessions afterevaluation
ResultsNo. casesNo. of Patients
(CSI is abbreviation for “Clinical Significant Improvement”)
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Number of NF training sessions on Number of NF training sessions on the Efficacy of the NF in Painthe Efficacy of the NF in Pain
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The differences (Kruskal-Wallis test) between medians 6.0, 18.5, 35.5 are significantare significant (p< 0.001)
25064.535.5272068CSI
342518.51486A
321362173Zero results
MaxUpper QuartileQ3 (75%)
Median Me(50%)
Lower Quartile Q1(25%)
MinNo of Patients
Efficacy Results
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Case control study of the Efficacy of NF training for “more than 19 sessions”
469Not exposed toenough NF raining(1-19 NF sessions)
704Exposed to enough NF training (More than 19 sessions)
Controls –without disease(Positive effect)
Cases –with disease(Zero effect)
NF exposure
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Sex effect on the NF Efficacy in Pain Management
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The differences (based on Kruskal-Wallis test for two groups equivalent to Mann-Whitney test or Wilcox on Two-Sample Test)
between 32 and 46.5 are not significant (H=2.314, DF=1, p = 0.128)
16473.546.531.52028Male
250603224.52040Female
MaxQ3MeQ1MinNo of patients
Sex
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Age effect on NF efficacy in Pain Age effect on NF efficacy in Pain ManagementManagement
0
0.5
1
1.5
2
2.5
3
0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85
Age
log(
NS)
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ConclusionsConclusions
• Pain or Dolor is one of the 5 symptoms present in inflammation! Explain the use of anti-inflammatory drugs
• After 6 month pain becomes “chronic pain”• Co-morbidities are aggravating the pain• “Chronic pain Hurts the Brain, disrupting
the default mode network dynamics (DMN)” Journal of Neuroscience, 2008 p 1398
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ConclusionsConclusions• Baliki et al (2008) showed that chronic pain
patients present a smaller area of deactivation, suggesting the widespread disruptions of the DMN, explaining the cognitive and behavioral impairments.
• Various electrodes positioning in NF training were found useful, e.g. – in acute pain, the area on the homunculus
corresponding to the contra-lateral peripheral localization of pain is desired to be trained.
– in chronic pain, frontal area, corresponding to the unpleasantness of pain is to be trained.
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ConclusionsConclusions
• QEEG evaluations similar to fMRI are guiding NF therapists in choosing the right area of the brain for each individual case.
• The frontal area that deals with the “cumulative memory” in chronic pain syndromes may be modulated through NF.
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• There are no differences between the number of NF sessions needed and the gender of our pain population.
• There is no correlation between the age of our pain population and their response to NF modulation on pain perception.
• The number of NF sessions did influence the outcome.• Twenty NF sessions “were necessary and almost
sufficient” to produce positive effects on pain perception and affect.
• Correction of sleep and emotional dysfunctions have also been noted.
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ConclusionsConclusions
• Research and clinical data presented may attest that Neurofeedback is possible to extend the brain innate self-healing process and perhaps re-establish the “default mode network” needed for optimal brain function.
• QEEG and NF must be integrated in medical care of pain sufferers.
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