neuropsychological medicine, madness, & mythsaz-ns.org/presentations/medical_marijuana.pdf ·...
TRANSCRIPT
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Scott Sindelar, Ph.D.
Neuropsychology and Addictions
Neuropsychological Medicine,
Madness, & Myths
Neuropsychological Medicine,
Madness, & Myths
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Outline
• Marijuana Chemistry
• Research Complications
• Dependence
• Negative Effects
Biopsychosocial
• Medicinal Effects
• Recreational
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Marijuana Chemistry
The chemistry of Cannabis is quite complex,
and the isolation and extraction of the active ingredients is difficult, even today.
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Marijuana Chemistry
There are 486 chemicals in
marijuana, but only 85 of them
are unique to the Cannabis plant
-- these are called Cannabinoids.
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Cannabinoids Identified in Marijuana
Mohamed M. Radwan, Mahmoud A. ElSohly, et al., researchers at the University of
Mississippi, reported in their Apr. 3, 2009
study titled "Biologically Active Cannabinoids from High-Potency Cannabis Sativa,“
the discovery of nine (9) new
cannabinoids
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Cannabinoids Identified in MarijuanaCannabinoid Group Abbreviation Variants
1 ∆9-Tetrahydrocannabinol ∆9-THC 92 ∆8-Tetrahydrocannabinol 8-THC 2
3 Cannabichromene CBC 5
4 Cannabicyclol CBL 3
5 Cannabidiol CBD 7
6 Cannabielsoin CBE 5
7 Cannabigerol CBG 6
8 Cannabinidiol CBND 2
9 Cannabinol CBN 7
10 Cannabitriol CBT 9
11 Miscellaneous types 30
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What other pharmaceutical “medication” contains 85 active ingredients?
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Cannabinoids Identified in Marijuana
85 Cannabinoids discovered
Beware of research that states: “THC is the psychoactive ingredient in marijuana”
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Other constituents of the cannabis plant are:
nitrogenous compounds (27 known), amino acids (18), proteins (3), glycoproteins (6), enzymes (2), sugars and related compounds (34), hydrocarbons (50), simple alcohols (7), aldehydes (13), ketones (13), simple acids (21), fatty acids (22), simple esters (12), lactones (1), steroids (11), terpenes (120), non-cannabinoid phenols (25), flavonoids(21), vitamins (1) Vitamin A, pigments (2), and elements (9).
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Marijuana smoke contains
50 percent to 70 percent more
carcinogenic hydrocarbons than does
tobacco smoke
and has the potential to cause cancer
of the lungs and respiratory tractMayo Clinic
Donald P. Tashkin, MD, Director of the Pulmonary Function
Laboratories at the University of California, Los Angeles,
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Main Modes of Marijuana Use
Smoking – 2000+ chemicalsJoints, Bongs, Pipes, Blunts
Vaporizing – unknown # of chemicals
Volcano, Arizer, Silver Surfer, Hot Box, da Buddha, Easy Vape
Ingestion- 486 chemicalsBaked goods, brownies
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Vaporizing
Little research, reportedly fewer chemicals, expensive.
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Vaporizing
Da Buddha
Silver SurferVolcano Arizer
Herbalaire
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Vaporizing
Easy VapeVapire-One
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Dalek
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tetrahydrocannabivarin (THCV)Flash Point: 137.6 °C (279.68 °F)
delta-8-tetrahydrocannabinol (delta-8-THC)Flash Point: 144.5 °C (292.10 °F)
delta-9-tetrahydrocannabinol (THC)Flash Point: 149.3 °C (300.74 °F)
cannabichromene (CBC)Flash Point: 174.2 °C (345.56 °F)
cannabidiol (CBD)Flash Point: 206.3 °C (403.34 °F)
cannabigerol (CBG)Flash Point: 207.2 °C (404.96 °F)
cannabinol (CBN)Flash Point: 212.7 °C (414.86 °F)
Flash Points of some Cannabinoids
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Cannabinoids
Fat soluble and, therefore, easily stored and laterreleased into the bloodstream
Have a long half-life and can be detected in urine from 1 day to 90 days
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Cannabinoids are oily.
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Oily Cannabinoids
Complicates research on effects
Reduces withdrawal symptoms
Illusion of “non-addicting”
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Major Research Complications
� Which Chemicals ?� 1? 85? 486? 2000?� What Concentration(s) ?� Cannabinoid Interactions� Pre-natal exposure ?� Age of initiating use ?� Frequency of use ?� Other drug use
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Major Research Complications
Research Publications
Most are in the non-psychological
literature
Botany, Chemistry, Pulmonology, Oncology,
Neurology, Urology, Reproductive Medicine,
Pharmacology, Medical, Transportation, Aviation,
Toxicology, etc
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The Endocannabinoid System (video)
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Prevalence, Abuse, Addiction
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Prevalence of Marijuana Use
Most widely used illicit substance
Usage rates increasing dramatically
Monthly Pot Use Up 80 % Among
Teens 2008 - 2012
Nearly 1 in 10 teens said they
smoke marijuana at least 20 or more
times a month.
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The “harmless herb”
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Prevalence of Marijuana Use
10% become daily users
Marijuana Dependence: 7-9%Alcohol Dependence: 5-7%Cocaine Dependence: 12%
Weekly users: rate of
dependence est. 30%
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Prevalence of Marijuana Use
Among those seeking treatment for psychosis: 23% are currently using
Among those seeking substance abuse treatment:25% treated for marijuana dependence
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Cycles of marijuana growing
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Marijuana Dependence
� Difficulty controlling use� Despite negative consequences� Tolerance � Withdrawal symptoms
90 day rule (unofficial)
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Cannabinoids
8 nanograms activate receptors
Nanogram = 1 billionth of a gram
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New study claims 40% of adolescents
show withdrawal symptoms
when they give up the drug
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Teens who exhibited withdrawal
symptoms were more likely to
experience negative consequences
of using marijuana such as
� trouble at school � or on the job � or financial problems� or relationship problems
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Treatment Participants who :Reported both withdrawal symptoms, and Recognized having a problem had a small but steady improvement in abstinence through the entire study period.
Those who reported withdrawal symptoms but did not recognize a substance use problem had a slight increase in abstinence in the first 3 months But then had an increase in cannabis use during the subsequent 9 months This pattern that was also seen in participants not experiencing withdrawal.
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The effects of sativa are well known for its cerebral high, hence used more in daytime
Indica is well known for its sedative effects and is preferred for night time
Ruderalis – not used recreationally, low cannabinoid content
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Starting to bud -indoors
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Dried buds
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It’s natural
Pretty buds
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Poison Ivy
Poison Sumac
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It grows in nature
Looks harmless
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Poison Oak
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Marijuana and the Brain
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1986: discovery of the first Cannabinoid receptor (CB1) Primarily localized in the central nervous system.
1992: a second receptor (CB2)
The CB1 receptor system is widely
distributed in the body. The highest
concentrations are found in deep brain
structures, the cerebellum, spine
The CB2 receptor appears to beprimarily localized in the liver, spleen and immune cells
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Acute Effects Studies
Researchers first began studying
the acute effects of cannabis on
neuropsychological functioning in the
1970s and
consistently found disruptions in
learning and memory functions.
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Acute Neuropsychological Effects
Dose dependent relationship
Perceptual distortions (hallucinatory)Déjà vu, Jamais vu, Presque vu,
Relaxation
Anxiety, Paranoia
Deficits in complex psychomotor tasks
Munchie vu
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Meta-Analytic Studies (Grant et al)
Strict inclusion/exclusion criteria
Out of 1,014 studies retrieved using
a thorough search strategy, only 11
studies met essential a priori
inclusion criteria, providing data for a
total of 623 cannabis users and 409
non- or minimal users.
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Meta-Analytic Studies (Grant et al)
Strict inclusion/exclusion criteria
Examined the 8 Neuropsychological
Domains
Primary Deficits
Learning
Forgetting (failure to recall or
recognize)
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Domain Acute Effects
0-6 hours
Residual Effects
7 hrs -20 days
Long-Term Effects
3 weeks +Attention/Concentration Impaired – light users
Normal –Heavy usersMixed findings Largely normal
Decision making and
risk taking
Mixed Impaired Impaired
Inhibition/Impulsivity Impaired Mixed findings Mixed Findings
Working Memory Impaired Normal Normal
Verbal Fluency Normal Mixed Findings Mixed Findings
A Summary of Research Findings on the
Effects of Cannabis on NP Functions
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Researchers have discovered how marijuana disrupts short-term memory.
It impairs users’ working memory — the ability to retain and use information over short periods of time. Mariscano & Zhang Cell 2012
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Researchers have discovered how marijuana disrupts short-term memory.
Cannabinoids weaken the connections, or synapses, between neurons in the hippocampus, a structure that is crucial for memory formation. Mariscano & Zhang, Cell 2012
But wait! There’s more!
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Astrocytes
The star-shaped astrocytes have long been considered nothing more than support cells that protect neurons.
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Researchers have discovered how marijuana disrupts short-term memory.
Found compelling evidence that astrocytes control neurons and memory. Mariscano & Zhang
Cell 2012
“The supporting actor has become the leading actor”
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1 Marijuana users activate less within the normal
attention network, especially in the dorsal parietal
regions, right dorsal and inferior lateral PFC and the
medial cerebellum (red regions).
2 Marijuana users activate more than non-drug users
in several small brain regions outside the normal
attention network (blue)
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Historically, marijuana has been viewed by some as a “less severe” or “soft” drug.
In contrast, scientific study has provided a corpus of empirical evidence that marijuana use and its disorders are associated with a number of clinically significant problems.
These negative effects are evident in physical,social, interpersonal, and, more recently, psychological realms.
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Feb 2015, Journal of Developmental and Behavioral Pediatrics:
Review: Links cannabis to “long-term and potentially irreversible physical, neurocognitive, psychiatric and psychosocial adverse outcomes.”
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Frequent marijuana use is associated
with increased risk of severe respiratory
illnesses, especially chronic bronchitis.
Br Med J 295; CHEST, 112
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Compared with individuals who do not use marijuana or tobacco, or with tobacco smokers who have no marijuana use history,
the lung functions of those who use marijuana regularly is significantly poorer
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Some investigations suggest that there is an increased risk of lung cancer among more frequent users of marijuana.
But there are few controlled studies in this area.
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Smoking one cannabis cigarette a day
for a year increases the risk of lung
cancer by 8%, according to the BLF
report.
By comparison, smoking 20 tobacco
cigarettes a day for a year increases
the risk of lung cancer by 7%.
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The average puff on a cannabis joint
is two-thirds larger and is held for
four times longer than the average
puff on a tobacco cigarette.
As a result, someone smoking a
cannabis joint inhales four times as
much tar as from a tobacco
cigarette, and five times as much
carbon monoxide.
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Some research suggests that
marijuana use may be related to
impaired immune system
functioning,
but these investigations have not
been consistently replicated.
The risk of testicular cancer in
young pot users appears to double
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In a survey of nine epidemiological
studies, the National Cancer Institute said:
among pot smokers,
• throat cancers seemed to increase• while tongue cancers decreased.
"Cannabinoids could provide advantages
compared to current antitumoral therapies''
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“No known overdoses from cannabis”
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A case report 08/04/2014 links MJ to the deaths of two
young men in Germany
"After exclusion of other causes of death, we assume
that the young men died from cardiovascular
complications evoked by smoking cannabis"
"The potential cardiotoxicity of cannabis has been reported
in peer-reviewed abstracts as well as scientific
proceedings.
Institute of Legal Medicine, University Hospital Duesseldorf , Germany
Cardiotoxicity & Death
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Journal of the American Heart Association, 04/2014
researchers examined data on health complications
following marijuana use.
They found that among the 2,000 cases of reported
complications, 35 cases involved heart problems.
Among those were 20 people who had heart attacks,
including nine who died.
The risk of cardiovascular effects of marijuana use in the
general population is low, but it is higher in people who
have cardiovascular issues
Forensic Science International journal 04/2014
Cardiotoxicity & Death
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Effects on Reproduction
Non-human research suggests
that heavier marijuana use is
related to impaired reproduction
capacity,
but controlled evidence among
humans is currently lacking.
Any Volunteers?
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Prenatal – Pre-Pregnancy
Mothers who use marijuana as
teens—long before having children—
may put their future children at a
higher risk of drug abuse.
Journal of Psychopharmocology 2012
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Prenatal – Pre-Pregnancy
Cannabinoid exposure during
pregnancy (in rats, monkeys and
humans) can affect offspring
development,
including impairment of cognitive
function, increased impulsivity, and
increased risk of depression and
anxiety.
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4-20
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Health Benefits
Anecdotal vs. Empirical
vs. Placebo Effect
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Synthetic Cannabinoid Research
Nachshon Korem and Irit Akirav
Neuropsychopharmacology (5 June 2014)
(PTSD in Rats)WIN55,212-2 prevented the effects of the shock and SRs on extinction, plasticity, and startle response.
WIN 55,212-2 is a potent cannabinoid receptor agonist that has been found to be a potent analgesic in a rat model of neuropathic pain.
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Synthetic Cannabinoid Research
WIN 55,212-2, along with HU-210 and JWH-133, may prevent the inflammation caused by amyloidbeta proteins involved in Alzheimer’s disease, in addition to preventing cognitive impairment and loss of neuronal markers.
They prevent microglial activation that elicits the inflammation. Additionally, these cannabinoids completely abolish neurotoxicity related to microglialactivation in rat models
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Synthetic Cannabinoid Research
WIN 55,212-2 is a full agonist at the CB1 cannabionoid receptor (1.9 nM) and has much higher affinity than THC
It produces effects similar to those of cannabinoids such as THC but has an entirely different chemical structure
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Synthetic Cannabinoid Research
WIN 55,212-2 reduces voluntary wheel running in laboratory mice
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Synthetic Cannabinoid Research
Peer-reviewed studies in several countries show that
cannabinoids are effective not only for cancer-symptom
management (nausea, pain, loss of appetite,
fatigue), they also confer a direct antitumoral effect.
Certain cannabinoids selectively target and destroy
tumor cells while leaving healthy cells unscathed.Reviews in Medicinal Chemistry
Cannabidiol (CBD), a nonpsychoactive component of the
marijuana plant, is a potent inhibitor of breast cancer cell
proliferation, metastasis, and tumor growth.McAllister – NIH Grant 2007
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Breast cancer cells killed by CBD
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The Miami Cannibal
Rudy Eugene -2012
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Social Functioning Evidence
Marijuana use was a contributing
factor to impaired educational
attainment. (Zvolensky et al 2011)
Others have found that marijuana
use leads to reduced workplace
productivity, as well as impaired
judgmentLehman, et al; Leirer ,et al
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The general users fared worse on all behavior and academic measures than the students who had no history of marijuana use.
This was even more pronounced in the students who were in-school users. In particular, the students with in-school use had the lowest levels of academic integrity, attendance, and classroom involvement.
High School PerformanceFinn, K. V. (2012). Marijuana use at school and achievement-linked behaviors.The High School Journal, 95.3, 2-13.
N =1112, 11 schools
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Results from neuroimaging studies show astonishing similarities between
the areas of damage due to heavy cannabis use and the areas undergoing normal development during late adolescence.
Vulnerability of adolescent brain
growth to cannabis Ashtari-Handbook of Growth and Growth Monitoring in Health and
Disease 2012
The hippocampal formation, which undergoes
neurogenesis (the birth of new neurons) during
adolescence, is reported to be significantly affected
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The Journal of Neuroscience April 16, 2014
The size and shape of two brain regions involved in
emotion and motivation may differ in young adults who
smoke marijuana at least once a week
CNS Structural Changes
The more the marijuana users reported consuming,
the greater the abnormalities in the
nucleus accumbens (reward processing) and the
amygdala (fight/flight emotion)
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Heavy use of MJ linked to changes in hippocampus, poor memory for life events
• Study links oddly shaped hippocampus to poor long-term
memory in former marijuana users
• The longer teens used cannabis, the more abnormal
the hippocampus as adults
• Former users perform 18 percent worse
on long-term memory test
•Cannabis affects short and long-term memory
Csernansky, J., Hippocampus (Journal) 03/2015
2 years after stopping use
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Previous research by the same Northwestern team showed: • poor short-term and working
memory performance and • abnormal shapes of brain
structures in the sub-cortex including the striatum, globuspallidus and thalamus
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Loss of some of our peripheral vision
Driving Issues
It affects the passage of time, or the idea of how rapidly time is passing
It can affect our ability to make decisions
It can make it hard to multitask
Interferes with drivers' ability to hold the vehicle in the middle of the traffic lane
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Marijuana use has recently been linked to fatal traffic accidents and general driving impairment
even after statistically controlling for the variance accounted for by alcohol use.(Everett et al; Meta Analysis- BMJ 2012
Video 2:34
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In all of these studies, a consistent pattern emerges:
The greater the amount of use
(measured in frequency of use),
the greater the impairment.
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There is evidence indicating that
cannabis impairment can be at its
peak
despite low measurements of
tetrahydrocannabinol in the blood.
Harder, et al, Int Clin Pharmacol Ther1997
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Acute cannabis consumption nearly doubles the risk of a collision resulting in serious injury or death. BMJ 2012;344:e536
The influence of cannabis use on the risk of “minor” collisions remains unclear
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DENVER – 08/19/2014A study found the number of people Killed in marijuana-related accidents increased 100 percent over five yearswhere the state legalized marijuana.
There were 78 fatalities where a driver, bike rider or pedestrian tested positive for marijuana. In 2007, the number was 39.
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When subjected to the effects of 17 mg THC, regular
marijuana smokers hit the walls more often on the
virtual maze task than without THC.
Effects of marijuana on visuospatial working memory: fMRI Smith, et al, Psychopharmacology 2010
fMRI- reduced metabolism in areas that are related to
visual integration of motion in the occipital lobes.
ConclusionThese findings suggest that in regular marijuana users, the
immediate effects of marijuana may impact cognitive–
motor skills and brain mechanisms that modulate
coordinated movement and driving.
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A study of postal workers found that employees who tested positive for marijuana had
55% more accidents,
85% more injuries,
75% increase in being absent from work.
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Numerous lines of empirical evidence have provided robust evidence of an association between marijuana use and psychotic-spectrum disorders.
Marijuana and Psychosis
Edvard Munch (1863–
1944)
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Acute effects of marijuana use have
been found to contribute to the
elicitation of psychotic episodes
and exacerbations of such symptoms
among previously afflicted persons
Mathers, et al BMJ 161
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Among those medicated with
antipsychotics, (schizophrenics vs.
normal controls)
marijuana use exacerbated positive
schizophrenic symptoms
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Cannabis Risk Factor over time
Jauhar et al, BMJ 2011; 342:d738 N =1923
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Neuroimaging studies also have found similarities between neural networks impaired by marijuana
and those known to be implicated in the etiology of schizophrenia.
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In a meta-analytic review of the existing empirical literature, Semple and colleagues concluded that: The early use of marijuana increased risk of schizophrenia or a schizophrenia-like psychotic illness by approximately three-fold.
Semple et al, J Psychopharmaco 2005
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Scientific activity has been focused on addressing marijuana’s relationship to depressive symptoms or problems.
Marijuana and Depression
Marijuana users often reported a “lack of motivation” for completing day-to-day activities (e.g., going to school)
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The depression-marijuana literature has sometimes identified statistically significantrelations between marijuana use and depressive symptoms and disorders
Marijuana and Depression
Recent work in this domain has indicated that the strength of such marijuana-depressive associations may be relatively weak.
Chen, et al Soc Psychiatry
Psychiatric epidemiology 2002
Zvolensky, 2011
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When a person is intoxicated from using marijuana, they may experience acute paranoia, escalating anxiety symptoms, and perhaps a panic attack.
Marijuana and Anxiety
Among weekly users of marijuana, approximately 40% reported having had at least one panic attack related to such use.
Thomas, Drug & Alcohol
Dependency 1996
Hathaway, Addiction Res &
Theory 2003
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A representative sample (n = 4,745) found that a lifetime history of marijuana dependence, but not use or abuse, was related to an increased risk of panic attacks
(after covarying the effects of polysubstance use, alcohol abuse, and demographic variables).
Marijuana and Anxiety
Zvolensky, J Psychiatric Res 2006
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Adolescent-onset marijuana use and dependence, especially among tobacco users, were both associated with the development of later panic attacks and panic disorder.
Marijuana and Anxiety
Zvolensky, et al J Psychiatric Res 2008
Adolescents (n = 1,709) with a mean age of 16.6 and were reassessed 1 year later and then again as young adults age = 24.2 years.
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August 20, 2014
A long-term study of Swedish men finds that
those who smoked marijuana 50 times before age 18,
were more likely to end up on the
nation’s disability rolls by age 59.
N=50,000 Men born between 1947-51
Chronic Use
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N = 1,100
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2011 Colorado Study74% of adolescents in substance abuse treatment had used someone else’s medical marijuana.
They reported using “diverted” medical marijuana a median of 50 times.
Diverted Medical Marijuana
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Edibles
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“Medical” Marijuana?
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Research Hurdles
Schedule 1 Drug
Need approval from
FDA
DEA
HHS
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Research Hurdles
Marinol –Schedule III
Synthetic THC
Nausea –Chemotherapy
Appetite enhancer
Cesamet –Schedule II
Nausea –Chemotherapy
Can cause A/V Hallucinations
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Cannabinoids
THC, THC-A, CBD, THC-V
CBG, CBC,
And Terpenes
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Cannabinoids
THC and THC-a
Video 5:14
Chemical analysis complications
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Cannabinoids
THC and THC-a,
GC vs. HPLC (video)
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THC Metabolism
THC - 3-5 hours
OH-THC 6-8 hours
C-THC 1 – 7 Days
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Cannabinoids
THC –V
tetrahydrocannabinolvarin
Video 2:54
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Cannabinoids
THC –V
tetrahydrocannabinolvarin
video
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Cannabinoids
CBD
Cannabidiol
Video 5:00
Anti-InflammatoryAnti-ConvulsantApoptosis-Cancer cellsProtect NeuronsProtect Damaged CellsStimulant -> Sedative
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Cannabinoids
CBD
Cannabidiol
video
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Cannabinoids
CBC
Cannabichromeme
Video 3:00
Anti-Inflammatory
Analgesic
Anti-Fungal
Anti-Bacterial
Anti-Tumoral
Anti-Depressant
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Cannabinoids
CBC
Cannabichromeme
video
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Cannabinoids
CBG
Cannabigerol
Video 3:59
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Cannabinoids
CBG
Cannabigerol
video
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Terpenes
Video 2:13
Aromatic CompoundsAnti-InflammatoryAnti-DepressantPsychoactive
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Terpenes
video
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Health BenefitsComplicated
The strongest evidence of possible health benefits for marijuana use appears to be on
+/- appetite, decreasing nausea and vomiting (not any better than Rx), preventing systemic weight loss, Auto-Immune Disorders, Cancer, anti-convulsant, anti-inflammatory, and possibly improving pain tolerance.
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(1) Acquired immune deficiency syndrome (AIDS).
(2) Anorexia.
(3) Arthritis.
(4) Cachexia.
(5) Cancers
(6) Chronic pain.
(7) Glaucoma.**
(8) Migraine.
(9) Persistent muscle spasms, including, but not limited to, spasms associated
with multiple sclerosis.
(10) Seizures, including, but not limited to, seizures associated with epilepsy.
(11) Severe nausea.
(12) PTSD
(13) Anxiety
(14) Depression (14B) ADD
(15) Any other chronic or persistent medical symptom that either:
(A) Substantially limits the ability of the person to conduct one or more major life
activities as defined in the Americans with Disabilities Act of 1990 (Alcoholism)
(B) If not alleviated, may cause serious harm to the patient’s safety or physical or
mental health.
Brief List of Ailments “treated” with Medical Marijuana
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Health Benefits
Anecdotal vs. Empirical
vs. Placebo Effect
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Synthetic Cannabinoid Research
Nachshon Korem and Irit Akirav
Neuropsychopharmacology (5 June 2014)
(PTSD in Rats)WIN55,212-2 prevented the effects of the shock and SRs on extinction, plasticity, and startle response.
WIN 55,212-2 is a potent cannabinoid receptor agonist that has been found to be a potent analgesic in a rat model of neuropathic pain.
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Synthetic Cannabinoid Research
WIN 55,212-2, along with HU-210 and JWH-133, may prevent the inflammation caused by amyloidbeta proteins involved in Alzheimer’s disease, in addition to preventing cognitive impairment and loss of neuronal markers.
They prevent microglial activation that elicits the inflammation. Additionally, these cannabinoids completely abolish neurotoxicity related to microglialactivation in rat models
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Synthetic Cannabinoid Research
WIN 55,212-2 is a full agonist at the CB1 cannabionoid receptor (1.9 nM) and has much higher affinity than THC
It produces effects similar to those of cannabinoids such as THC but has an entirely different chemical structure
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Synthetic Cannabinoid Research
WIN 55,212-2 reduces voluntary wheel running in laboratory mice
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Synthetic Cannabinoid Research
Peer-reviewed studies in several countries show that
cannabinoids are effective not only for cancer-symptom
management (nausea, pain, loss of appetite,
fatigue), they also confer a direct antitumoral effect.
Certain cannabinoids selectively target and destroy
tumor cells while leaving healthy cells unscathed.Reviews in Medicinal Chemistry
Cannabidiol (CBD), a nonpsychoactive component of the
marijuana plant, is a potent inhibitor of breast cancer cell
proliferation, metastasis, and tumor growth.McAllister – NIH Grant 2007
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CANCER ResearchCannadinoids
AntiproliferativePrevents cancer cells from
reproducing
AntiangiogenicPrevents formation of new blood
vessels needed by the tumor to grow
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CANCER Research
AntimetastaticPrevents cancer cells from spreading to other organs
ApoptoticInduces cancer cell suicide
Video 13:05
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Synthetic Cannabinoid Research
Italian investigators described CBD as “the most
efficacious inducer of apoptosis” in prostate cancer.
Ditto for cannabidiol and colon cancer, according to
British researchers at Lancaster University.
International Cannabinoid Research Society Conference 2014
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Breast cancer cells killed by CBD
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video
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Immune System Research
80 Auto-Immune Diseases
Video 3:39
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video
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Seizure Disorder Research
Anecdotal &Conflicting Results
2014 –American Epilepsy Society
Kevin Chapman MD –Chart Review
75 children -Denver
Parental Bias
“Seizure-Free” but still having Seizures
EEG data showing no improvement
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Seizure Disorder Research
Epidolex - CBD
Phase 2/3 Studies underway
Randomized, double-blind, placebo controlled
NYU Langone Comprehensive Epilepsy Center
Dr. Orrin Devinsky
Gravet and Lennox-Gastaut Syndrome
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2014 study by the American
Academy of Neurology reported
that medical marijuana may be
beneficial in easing some of the
symptoms associated with multiple
sclerosis
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“Medical” Marijuana?
The number of applications for
medical marijuana made by people
saying they have severe arthritis
has jumped 2,400 per cent in a two-
year period.
Severe arthritis is a category that
requires the OK of only one
physician (Canada).
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The marijuana industry’s newest
customers are sick and elderly dogs
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Auntie Dolores’ “Treatables”
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“Medical” Marijuana?
• Which chemicals, • In what concentrations, • In what combinations, • At what dosages, • For what patients?• For what disorders?• Side Effects?
What do YOU think?
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Coming Up: Sunday
Monday: 4/20
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Scott Sindelar, Ph.D.
Clinical Psychology and [email protected]
4921 East Bell RoadSuite 207
Scottsdale AZ 85254
602-482-1487
![Page 157: Neuropsychological Medicine, Madness, & Mythsaz-ns.org/presentations/Medical_Marijuana.pdf · 2015-08-28 · Mohamed M. Radwan, Mahmoud A. ElSohly, et al., researchers at the University](https://reader034.vdocument.in/reader034/viewer/2022042308/5ed462d1764a794afa41f96c/html5/thumbnails/157.jpg)
Scott Sindelar, Ph.D.
Neuropsychology and [email protected]
Neuropsychological Medicine,
Madness, & Myths
Neuropsychological Medicine,
Madness, & Myths