neutron filter design for bnct - jan leen kloosterman, tu … · · 2009-09-16neutron filter...
TRANSCRIPT
![Page 1: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/1.jpg)
Neutron filter design for BNCT
Jan Leen KloostermanInterfaculty Reactor Institute
Delft University of Technology
![Page 2: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/2.jpg)
Boron Neutron Capture Therapy
BNCT is a form ofradiotherapy for treatingcertain types of malignanttumours.
BNCT is based on the abilityof the isotope 10B to capturelow energy neutrons toproduce two highly energeticparticles. If the reaction occursnext to or within each cancercell, only the cancer cells aredestroyed.
![Page 3: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/3.jpg)
![Page 4: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/4.jpg)
![Page 5: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/5.jpg)
![Page 6: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/6.jpg)
History of BNCT1936 G.L.Locher (USA) proposes neutron
capture reactions should be applied toradiation therapy:
“In particular, there exist the possibilities of introducing smallquantities of strong neutron absorbers into the region where itis desired to liberate ionization energy (a simple illustrationwould be the injection of a soluble non-toxic compound ofboron, lithium, gadolinium, or gold into a superficial cancer,followed by bombardment with slow neutrons)”.
1951-61 (USA) First trials of BNCT-effective failure.
late 1980’s Re-start of US and European efforts
1994 New US trials at Brookhaven and MIT
1997 Start of first European trial (Petten)
1999 Finnish BNCT consortium
1968 – 1980’s Professor Hatanaka (Japan) – impressive results.
![Page 7: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/7.jpg)
Epithermal neutron beams
![Page 8: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/8.jpg)
Current developments in beam design•Kim and Kim, “Conceptual design of a Cf-based epithermal neutron beam forBNCT using a subcritical multiplying assembly”, Nucl. Techn. 124 (1998).
•Kiger III, Sakamoto, and Harling, “Neutronic design of a fission converter-basedepithermal neutron beam for neutron capture therapy”, Nucl. Sci. Eng. 131(1999).
•Powell, Ludewig, Todosow, and Reich, “Target and filter concepts foraccelerator-driven BNCT applications”, Nucl. Techn. 125 (1999).
•Verbeke, Vujic, and Leung, “Neutron beam optimization for BNCT using the D-Dand D-T High-Energy neutron sources”, Nucl. Techn. 129 (2000).
•Kobayashi, Sakurai, Kanda, Fujita, and Ono, “The remodeling and basiccharacteristics of the heavy water neutron irradiation facility of the Kyotouniversity research reactor, mainly for NCT”, Nucl. Techn. 131 (2000).
•Maucec, “Conceptual design of a clinical BNCT beam in an adjacent dry cell ofthe Jozef Stefan institute TRIGA reactor”, Nucl. Techn. 132 (2000).
![Page 9: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/9.jpg)
European BNCT group
Phase I Clinical Trial - Participating CentresUniversity of Essen D Prinicipal Clinical Investigator/Study Coordinator
University of Bremen D EU Project Coordinator
University Hospital Graz A Neurosurgery/patients
University Hospital Munich D Neurosurgery/patients
University Hospital Lausanne CH Neurosurgery/patients
University Hospital Nice FR Neurosurgery/patients
Central Hospital Bremen D Neurosurgery/patients
Vrije Universiteit Ziekenhuis Amsterdam NL Neurosurgery/patients – care of patients
JRC Petten CEC Facility Management - Technical support –Treatment Planning
ECN Petten NL Facility Operation – Dosimetry -Boron measurements
![Page 10: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/10.jpg)
Petten High Flux Reactor
![Page 11: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/11.jpg)
Petten High Flux Reactor
![Page 12: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/12.jpg)
BNCT facility at the Petten HFR
![Page 13: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/13.jpg)
Current neutron filter design
leadheavyconcrete polybor
main beamshutter
Secondary(or gamma)
shutter
on-line beam monitors
shutter
beam filterCd, Al, Ti, S, Ar
2 x ionisationchambers
2 x fissionchambers ( U)
2 x GMcounters
Irradiationroom
water
Removablecollimator
steelbeams
235
Free beammeasuring
position
![Page 14: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/14.jpg)
Current neutron filter design
![Page 15: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/15.jpg)
![Page 16: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/16.jpg)
![Page 17: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/17.jpg)
In-phantom Figures of Merit (FOM)
•Advantage Depth (AD): Depth in the tissue atwhich the dose to the tumor equals themaximum dose delivered to the normal tissue.
•Advantage Ratio (AR): Ratio of the dose tothe tumor and the dose to the normal tissueintegrated from the body surface to theAdvantage Depth.
•Advantage Depth Dose Rate (ADDR): Doserate to the tumor at the Advantage Depth (AD).
![Page 18: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/18.jpg)
MITR-II M67 Beam
![Page 19: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/19.jpg)
![Page 20: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/20.jpg)
In-air Figures of Merit (FOM)
•Epithermal neutron flux �epi (n.cm-2.s-1).
•Ratio of the fast neutron dose rate to theepithermal neutron flux Ďfn/�epi (Gy.cm2/n).
•Ratio of the gamma dose rate to theepithermal neutron flux Ď
�/�epi (Gy.cm2/n).
![Page 21: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/21.jpg)
Beam characteristics
Facility Power(MW)
�epi(cm-2.s-1)
Ďfn/�epi(Gy.cm2/n)
�/�epi(Gy.cm2/n)
HFR 45 3.3E8 8.6E-13 1.0E-12
BMRR 3 1.8E9 4.3E-13 1.3E-13
BMRR (FCB) 3 1.2E10 2.8E-13 1.0E-13
MITR-II 5 2.1E8 8.6E-13 1.3E-12
MITR (FCB) 5 1.7E10 1.3E-13 1.0E-13
![Page 22: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/22.jpg)
Criteria neutron filter materials
•Material should not undergo phase changes.
•Material should not decompose or emit toxicsubstances.
•Material should not accumulate high long-term activity.
•Material should not contain impurities ormoisture.
•Low cost of material, component fabricationand maintenance.
![Page 23: Neutron filter design for BNCT - Jan Leen Kloosterman, TU … · · 2009-09-16Neutron filter design for BNCT Jan Leen Kloosterman Interfaculty Reactor Institute Delft University](https://reader031.vdocument.in/reader031/viewer/2022022008/5ae40c817f8b9a90138e66a5/html5/thumbnails/23.jpg)
Calculation techniques
•Midway Monte Carlo technique.
•Differential sampling in Monte Carlo codes.