new chemistry that delivers… continuous … · 2014. 9. 5. · create innovate inspire chemistry...

8
www.chemmedchem.org A Journal of BOOK OF ABSTRACTS

Upload: others

Post on 18-Oct-2020

0 views

Category:

Documents


0 download

TRANSCRIPT

  • CreateInnovateInspire

    Chemistry that delivers…Continuous product innovation

    Constant product innovationincludes new products andsolutions to drive betterlearning and speed upyour research.

    6496630414_bu

    www.chemmedchem.org

    A Journal of

    BOOK OFABSTRACTS

  • Highly attractive 2015 Rates*for members ofChemPubSoc Europe societies*(without local VAT)

    PSJ-

    14-6

    8258

    _gu

    www.chempubsoc.eu

    CEUJED 20 (29) 8809–9140 (2014) · ISSN 0947-6539 · Vol. 20 · No. 29 · 2014

    Supported by

    www.chemeurj.org

    A Journal of

    2014-20/29

    ConceptSynthesis of Heterocycles through Transition-Metal-Catalyzed Isomerization ReactionsM. Ishoey and T. E. Nielsen

    EJOCFK (12) 2401–2616 (2014) · ISSN 1434-193X · No. 12/2014

    EurJOCEuropean Journal ofOrganic Chemistry

    12/20143rd April Issue

    D 6093

    www.eurjoc.org

    A Journal of

    A sister journal of Asian Journal of Organic Chemistry

    Supported by

    Cover Picture/ Microreview

    Thierry Billard et at.Direct Trifluoromethylthiolation Reactions

    ChemPlusChem 79 (7) 879–1064 (2014) · ISSN 2192-6506 · Vol. 79 · No. 7 · July 2014

    www.chempluschem.org

    A Journal ofCover Picture: Carbocatalyst for Polymerization of 1-Naphthylamine(L. Tan, H.-X. Feng et al.)

    Minireview: Self-Organization of Polar Porphyrinoids(S. S. Babu and D. Bonifazi)

    Communication: Silver Arrays Inside DNA Duplexes(F. Seela et al.)

    7/2014

    EurJIC

    EJICFK (11) 1851–2010 (2014) · ISSN 1099-0682 · No. 11/2014

    European Journal ofInorganic Chemistry

    11/20142nd April Issue

    www.eurjic.org

    Cover Picture

    Li-Cheng Song et al.CO Substitution Reactions of Diiron Complexes

    & Printe

    d onDemandFully

    Electronic

    A Journal of

    3/2014

    A Journal of

    Open 2014 · 77–123 · Online ISSN 2191-1363 · Vol. 3 · No. 3 · June 2014

    Full Papers:Magnetic Resonance for Transient Protein Complex Detection

    (R. Konrat)Mass Spectrometry for Protein Unfolding Monitoring

    (M. Sharon)

    CHEMGX 9 (2) 241–412 (2014) · ISSN 1860-7179 · Vol. 9 · No. 2 · February, 2014

    2/2014Review: Structure-/Fragment-Based GPCR Drug Discovery

    (J. A. Christopher)Full Paper: Selective Orexin 2 Receptor Antagonists

    (A. J. Roecker)

    A Journal of

    www.chemmedchem.org

    CBCHFX 15 (11) 1529–1688 (2014) · ISSN 1439-4227 · Vol. 15 · No. 11 · July 2014 D55712

    11/2014

    www.chembiochem.org

    Minireviews: Using Chemistry to Investigatethe Molecular Consequences of Protein Ubiquitylation (M. R. Pratt)

    The Chemistry and Biology of 6-Hydroxyceramide,the Youngest Member of the Human Sphingolipid Family (K. Vávrová)

    A Journal of

    1/22000011111144444ireviews: UsinUsing Cg CheChemhememimismististstryryry ty toto Io Invest

    lecular Consequenuences oes oooff Pf ProProProtroteoteieinein Un UbUbibiquitylatThe Chemistemistryy andand Bnd Biod BioloBioloologologyogygy oy ofofof 66-H6-Hydroxyce

    the Youngest Mungest Membermber ofer of thof thethe Hhe He HHumumumaumanman Sn SphSphingolipid Fa

    Minirevthethe Molecula

    111111/Mi

    A Journal ofl of

    Online:€ 98,-

    Print: €198,-

    IF 2013: 5.696

    overy

    sts

    2014144444cture-/Fragment-Based GPCR Drug Disco

    (J. A. Christopher)F

    rug Disco(J. A. Christopher)

    Full Paper: Selective Orexin 2 Receptor Antagonis(A. J. Roecker)

    RevReview:ew: Structure

    222/2/2/2/20ReReviewview:

    A Journal of

    Online:€ 98,-

    Print: €198,-

    alyst for Polymerization of 1-Napht(L. Tan, H.-X. Feng et al.)

    eview: Self-Organization of Polar Porphyrinoid(S. S. Babu and D. Bonifazi)

    Communication: Silver Arrays Inside DNA Duplexe(F. Seela et al.)

    2014144401444arbocatalyst

    (LMiMinireview

    CoverCover Pictver Pictureicture:re: CCarCarboCarbocatalyst

    7/207/27/7/7/7777/7/7//2/220Online:

    € 98,-

    www.eurjic.org

    CCovover Picture

    i-Cheng SonLi- g et al.COO SubstitutC ion Reactions of Diiron ComplexesexesOnline:

    € 98,-

    EJOCFK ( ) 6 6 ( ) ISSN X N /

    A sister journal ofA sister journal of l f hAsian Journal of Organic Chemistry

    Cover Picture/ Microreview

    Thierry Billard et at.Direct Trifluoromethylthiolation Reactions

    Online:€ 98,-

    Print: €398,-

    Transition-Metal-Catalyzed Isomerization ReactioM. Ishoey and T. E. Nielsen

    CEUJED 20 (29) 8809–CEUJED 20 (29) 8809 9140 (2014) · ISSN 0SSN 0947-6539 · Vol 20 ·947-6539 · Vol. 20 · No 29 2014No. 29 · 2014

    s of Heterocycleserocycles throes through TransitM. IshoeM. Ishoey and T.and T. E NiE. Nielsen

    ConceptConceptSynthesis of HetSynthesis of HeteroerocyM

    Online:€ 98,-

    Print: €398,-

    EJOCFK (12) 2401–261J ( ) 4 6 (2014) · ISSN 1434( 4) 434-193X · No. 12/201493 / 4

    IF 2013: 3.154

    14) · ISSN 1099-0682 · No. 11/2014

    j gEJICFK (11) 1851–2010 (20

    IF 2013: 2.965

    www.chempluschem.orggg

    IF 2013: 3.242 IF 2013: 2.938

    wwwwww.chembiochem.wwww.chembiochem.org

    IF 2013: 3.060

    www chemmedchwww.chemmedchwww.chemmedchem.orgem.orgg

    IF 2013: 3.046

    CHEMK3 6 (1) 1–362 (2014) · ISSN 1867-3880 · Vol. 6 · No. 1 · January, 2014

    1/2014Editorial: Innovation and Communication Drives Catalysis Research!

    (M. Rowan)Cover Profile: Direct Energy Extraction from Alginate

    by Gold Nanoparticles on Functionalized Carbon Nanotubes(L. Q. Hoa, E. Tamiya et al.)

    Supported by:

    www.chemcatchem.org

    01444municmmunicaCommunicatuniCommunication Drives Catalysis Re

    (M. Rowan)(M. Row(M. Ro(M. RoM. RProfilele:e:: Direct EneDirect Energrect Enect En y Extraction fExtraction faction from Algirom Alginateomrom Alginate

    by Gold Nanopby Gold Nanopby Gold Nanopaoparticles onrticles on Fucles oncles o Funno ctictionalized Carbon Nanotu(L. Q. Ho(L. Q(L. Q.(L. Q Hoa,Hoa, E. Tamiya et al.)

    wwwww.chemcatchem.orgorg

    n and Com

    CoCover Profilby Gol

    1/1/1/21/21/21/2/201EditoEditorial:torial: IInnoInnovanovatiovationon and Com

    Online:€ 98,-

    IF 2013: 5.044

    CPCHFT 15 (9) 1713–1900 (2014) · ISSN 1439-4235 · Vol. 15 · No. 9 · June 2014

    9/2014Concepts: Coherent Magnetic Resonance of Nanocrystal Quantum-Dot

    Luminescence (J. Lupton et al.), Magnetic Resonance Imagingof Electrochemical Cells (M. Britton)

    Original Contributions: Long-Lasting Oscillations in Electro-OxidationReaction on Intermetallic Surfaces (H. Varela et al.)

    www.chemphyschem.org

    A Journal of 201144444t Magnetic Resonesonancancecee oofof Nof NNaNananoanonococryrystal Qu

    escence (J. Lupton eton et al.),l.), Ma, MagMagnagnegnetnetieticticicc ReResResosonance Imof Electroectrochemhemmicaicalical Cal CeCellCellsells (ls (Ms (M.M.. BBritBritton)

    Original ContrOriginal Contribuibutions:ons: LLongLong-Long-Lag-LastLastinastingtingngg OOOscOscilscillatlations in ElectrReactioReaction onction on Inon InIntertermetermetrmetalmetallitallicllic Suc SuSurfrfacrfaces (H. Varela et al

    wwwww.www.chew.chemphyschem.org

    onceptsepts: CohCoherent MagLumLuminescence

    999/9/9/9/20ConConcepConcepts:s CCoh

    A Journal of

    Online:€ 98,-

    Print: €198,-

    IF 2013: 3.360

    7/2014Cover Picture: Graft Co-polymer Templates for Multifunctional TiO2 Films (J. H. Kim)Back Cover: Peapod-Like Composite as Li-Ion-Battery Anode (Q. Liu, K. Wu, Y. Wang)

    Inside Cover: Chitosan Microreactors for Organic Synthesis in Microfluidics (D.-P. Kim)Review: Catalysis and the Challenges of Powering the Planet (J. M. Thomas)

    ISSN 1864-5631 · Vol. 7 · No. 7 · July, 2014

    Supported by

    A Journal of www.chemsuschem.org2014444

    olymer Templates for Multifunctionad-Like Composite as Li-Ion-Battery Anode (Q

    : Chitosan Microreactors for Organic Synthesis in MReview: Catalysis and the Challenges of Powering the Plan

    Supported bypp y

    araft Co-polymBack Coverk Cover:er: PePeapod-Like

    IInside Cside Cover: ChitoRev

    77/7/7/27/27/27/20CCover PicCover PicturePicture:re: GGrafGraft Caft Co-polyBBack CoBack Cove

    A Journal ofOnline:

    € 98,-

    IF 2013: 7.117

    Online ordering:Simply visit thejournal’s homepage at

    n Complex Detection

    otein Unfolding Monitoring(M. Sharon)

    7–123 · Online ISSN 2191-1363 · Vol. 3 · No. 3 · June 2014Open 2014 · 77

    R. Konrat)(R. Kss Spectromectromeettry fotry for Protein

    (M

    Full PaFull PapePapersapers:ers:s:Magnetic Resonance for Tance for Trane for TransTransansienientient Prnt Protein C

    (R(R. K(R. KonKonrat)Mass SMass SpectroMass Spectrome

    first society

    owned open-

    access chemistry

    journal

    GET ACCESSSubscribe / Renew

    www.onlinelibrary.wiley.com

    Chooseon the left-hand menu andcomplete your order.

    A Journal of

    6/2014

    www.chemelectrochem.org

    959–1086 (2014) · ISSN 2196-0216 · Vol. 1 · No. 6 · June, 2014

    Reviews: Three-Dimensional Structural Engineeringfor Energy-Storage Devices (D. Chen, D. Li, G. Shen et al.)

    Original Contributions: Effective Separation of Lithium Anode andSulfur Cathode in Lithium–Sulfur Batteries (R. Dominko et al.),

    MnO2 Nanoflower Arrays with High Rate Capability for FlexibleSupercapacitors (R. Zou, J. Hu et al.)

    A Journal of

    6/202000111414141444444

    www.chemelectrochem.org

    Reviews: Three-Dimensional Structural Engineerifor Energy-Storage Devices (D. Chen, D. Li, G. Shen e

    Original Contributions: Effective Separation of Lithium ASulfur Cathode in Lithium–Sulfur Batteries (R. Dominko

    MnO2 Nanoflower Arrays with High Rate Capability forSupercapacitors (R. Zou, J. Hu et al.)

    A Journalal of

    6/6/

    Online:€ 98,-

    g

    NEW to the familyPS

    J-14

    -624

    95_g

    u

    EJOCFK (33) 7437–7636 (2013) · ISSN 1434-193X · No. 33/2013

    EurJOCEuropean Journal ofOrganic Chemistry

    33/20133rd November Issue

    D 6093

    www.eurjoc.org

    A sister journal of Asian Journal of Organic Chemistry

    Cover Picture

    Clara Baldoli, Emanuela Licandro et al.Tetra(2-thienyl)ethylene Derivatives

    Microreviews

    Rachel M. Lanigan and Tom D. SheppardRecent Developments in Amide Synthesis

    EurJIC

    EJICFK (25) 4353–4525 (2013) · ISSN 1099-0682 · No. 25/2013

    European Journal ofInorganic Chemistry

    25/20131st September Issue

    www.eurjic.org

    Cover PictureJun Lin et al.White-Emitting Ca9MgNa(PO4)7:Ce3+/Tb3+/Mn2+ Phosphors

    MicroreviewSrinivasa Budagumpi et al.Biologically Relevant Silver(I)–N-Heterocyclic Carbene Complexes

    CBCHFX 14 (17) 2221–2376 (2013) · ISSN 1439-4227 · Vol. 14 · No. 17 · November 2013 D55712 CHEMGX 8 (8) 1229–1420 (2013) · ISSN 1860-7179 · Vol. 8 · No. 8 · August, 2013

    ChemPubSoc Europe Owners Meeting 1999, Madrid ChemPubSoc Europe Owners Meeting 2004, LisbonChemPubSoc Europe Owners Meeting 2000, Athens

    Speakers ChemBioChem / ChemPhysChemSymposium 2010, Paris

    ChemPubSoc Europe Owners Meeting 2013, Gothenburg

    We are

    2/2013

    Open 2013 · 39–76 · Online ISSN 2191-1363 · Vol. 2 · No. 2 · April 2013

    Communication:Enantioselective Artificial Metalloenzymes

    (J. Eppinger)Full Paper:

    Nanoparticle Agglomeration(K. Tschulik, R. G. Compton)

    www.chempubsoc.eu

    ChemPlusChem 78 (8) 749–884 (2013) · ISSN 2192-6506 · Vol. 78 · No. 8 · August 2013

    www.chempluschem.org

    A Journal ofCover Picture: Nanodiamond–TiO2 Composites for Photocatalysis (A. M. T. Silva et al.)

    Minireview: The Piers–Rubinsztajn Reaction (R. Wakabayashi and K. Kuroda)Full Paper: Energy-Transfer Mechanisms in IrIII–EuIII Complexes (Z. Bian et al.)

    8/2013

    CEUJED 20 (2) 337–612 (2014) · ISSN 0947-6539 · Vol. 20 · No. 2 · 2014

    ConceptHydrogen-Bonding in Aminocatalysis: From Proline and BeyondK. A. Jørgensen et al.

    www.chemeurj.org

    A Journal of

    2014-20/2

    CPCHFT 14 (9) 1749 –2004 (2013) · ISSN 1439-4235 · Vol. 14 · No. 9 · June 2013

    CHEMK3 6 (1) 1–362 (2014) · ISSN 1867-3880 · Vol. 6 · No. 1 · January, 2014

    Launched2010

    Launched1995

    Launched2000

    Launched2014

    Launched2009

    Launched2008

    Launched2000

    Launched2005

    Launched1998

    Launched1998

    Launched2012

    Launched2012

    Speakers Chemistry – A European JournalSymposium 2005, Strasbourg

    Conference on Coordination Chemistry, Organometal-lic Chemistry and Catalysis 2012, Métabief Mont d’Or

    Poster Awards ChemBioChem / ChemPhysChemSymposium 2010, Paris

    Wissenschaftsforum Chemie 2013, DarmstadtChemPubSoc Europe SigningChemistryOpen 2011, Warsaw

  • Editorial Board

    ChairmenGiorgio Tarzia (Italy)Rainer Metternich (Germany)

    MembersKarl-Heinz Altmann (Switzerland)Paul A. Bartlett (USA)Maria Laura Bolognesi (Italy)Maurizio Botta (Italy)Paul J. Coleman (USA)Harren Jhoti (UK)

    Gerhard Klebe (Germany)Martin Stahl (Switzerland)Hans Ulrich Stilz (Denmark)Renxiao Wang (China)Yasuyoshi Watanabe (Japan)David A. Winkler (Australia)

    MED

    International Advisory Board

    Christopher Abell (UK)Yves P. Auberson (Switzerland)Annette G. Beck-Sickinger

    (Germany)William R. Bishai (USA)Maria José Camarasa (Spain)Girolamo Cirrincione (Italy)Bernd Clement (Germany)Seth M. Cohen (USA)Angel de Lera (Spain)Carlo De Micheli (Italy)Manoj C. Desai (USA)FranÅois Diederich

    (Switzerland)Beat Ernst (Switzerland)Arun K. Ghosh (USA)Sylviane Giorgi-Renault

    (France)Ernest Giralt (Spain)Peter Gmeiner (Germany)Concepción Gonz�lez-Bello

    (Spain)Gilles Gosselin (France)Ronald Gust (Austria)Michael M. Hann (UK)Adriaan P. IJzerman (The

    Netherlands)Zhi-Hong Jiang (China)Jesus Jim�nez-Barbero (Spain)Ahmed Kamal (India)Kazunori Kataoka (Japan)

    Thomas Keller (Singapore)Alan P. Kozikowski (USA)Karen Lackey (USA)Dominique Lesuisse (France)Craig W. Lindsley (USA)Antonello Mai (Italy)Filippo Minutolo (Italy)Marco Mor (Italy)Stefano Moro (Italy)Heinz Moser (USA)Sylviane Muller (France)Christa E. M�ller (Germany)Klaus M�ller (Switzerland)Peter Nussbaumer (Germany)Paul M. O'Neill (UK)Tudor I. Oprea (USA)Eckhard Ottow (Germany)Antti Poso (Finland)Barry V. L. Potter (UK)Laurent Provins (Belgium)Michael Rowley (Switzerland)Thomas Ryckmans

    (Switzerland)Henning Steinhagen

    (Germany)Serge Van Calenbergh

    (Belgium)Hanno Wild (Germany)Paul Wyatt (UK)Xin-Shan Ye (China)

    ChemMedChem succeeds IL FARMACO,a journal of the Società Chimica Italiana

    Editor:Natalia Ortúzar

    Senior Associate Editor:Scott D. Williams

    Associate Editor:Saskia Neubacher

    Managing Editor:Lisa Abel

    Editorial Assistant:Jean-Pierre Parks

    Production:Stefanie Klein, Denis Ott

    Secretary:Luisa Prieto

    Telephone:(+ 49) 6201-606-142

    Fax:(+ 49) 6201-606-331 or -328

    E-mail:[email protected]

    Courier Services:Boschstraße 1269469 Weinheim (Germany)

    Regular Mail:Postfach 10 11 6169451 Weinheim (Germany)

    Homepage:http://www.chemmedchem.org

    Manuscript Submission System:

    http://www.editorialmanager.com/cmdc

    Subscriptions:Customer Services([email protected])

    Marketing:Monika Silz (ext. 458, fax: ext. 100,e-mail : [email protected])

    Advertising:Marion Schulz (ext. 565, fax: ext. 550,e-mail : [email protected], [email protected])

    Copyright Permissions:Bettina Loycke (ext. 280, fax: ext. 447,e-mail : [email protected])

    Reprints, e-prints, posters:Carmen Leitner (fax: ext. 226)e-mail : [email protected]

    Publishers:WILEY-VCH Verlag GmbH & Co. KGaA,Postfach 10 11 6169451 Weinheim (Germany)http://www.wiley-vch.de/

    Founding Editor:Peter Gçlitz

    Coordinating Managing Editor:Karen J. Hindson

    Publication:12 issues in 2014

    � 2014 WILEY-VCH Verlag GmbH & Co. KGaA,Weinheim.

    Further masthead information follows directlyafter the Table of Contents.

  • ChemMedChem is indexed in Biological Abstracts (Thomson ISI), BIOSIS Previews (Thomson ISI), Cambridge Structural Database(CSA/CIG), CAS: Chemical Abstracts Services (ACS), Chemical Abstracts Service/SciFinder (ACS), ChemInform (Wiley-VCH), COMPENDEX(Elsevier), Current Contents/Life Sciences (Thomson ISI), EMBASE (Elsevier), EMCare (Elsevier), GEOBASE/Geographical & GeologicalAbstracts (Elsevier), IBIDS : International Bibliographic Information on Dietary Supplements, Index Medicus/MEDLINE/PubMed (NLM),International Pharmaceutical Abstracts (Thomson ISI), Journal Citation Reports/Science Edition (Thomson ISI), MEDLINE/PubMed(NLM), Mosby Yearbooks (Elsevier), Science Citation Index (Thomson ISI), Science Citation Index Expanded (aka SciSearch) (Thomson ISI),SCOPUS (Elsevier), VINITI (All-Russian Institute of Science & Technological Information) and Web of Science (Thomson ISI).

    When citing work presented herein, please ensure the abbreviation ChemMedChem is used.

    MEDSubscription rates for 2014

    In 2007 a new, tiered pricing model was introduced for new journals. The appro-

    priate rate for an institutional subscription is based on the number of Full Time

    Equivalents (FTE) at the institution purchasing the journal.

    Customer Type* Institutional Rates for ChemMedChem in 2014

    small medium large

    FTE Academic Customer � 10 000 � 40 000 40 000+FTE Corporate/Government

    Customer

    � 1 000 � 10 000 10 000+

    Subscription Rate (print & electronic / print only or electronic only)

    Europe E 2937 / 2552 3906 / 3396 5412 / 4706

    Switzerland SFr 4575 / 3978 6091 / 5296 8472 / 7366

    Rest of the World US$ 3768 / 3277 5120 / 4452 6967 / 6058

    *Rates for hospitals upon request.

    Personal rates for members of a national chemical society, print only(including postage and handling charges):Europe : E 198.00.Individual subscription rates are available on request. All Wiley-VCH pricesare exclusive of VAT. Postage and handling charges included. Prices aresubject to change. Individual rate subscriptions may not be resold or usedas library copies.

    Ordersmay be placed through your book-seller or directly at the publishers ;

    for readers in Germany, Switzerland,and Austria :WILEY-VCH,Customer Service Journals,Postfach 101161,69451 Weinheim (Germany);Fax: (+49) 6201-606-184;E-mail : [email protected] readers in the rest of the world:John Wiley and Sons Ltd. ,Journals Administration Dept. ,1 Oldlands Way, Bognor Regis,West Sussex,PO22 9SA (England);Tel. : (+44) 1234-779-777;Fax: (+44) 1234-843-232;E-mail : [email protected]

    Delivery:By direct mail (printed matter) orthrough book-sellers.* Change of address:

    Please notify your bookseller orthe publishers immediately.

    * Cancellation of subscriptions:The publishers must be notifiednot later than three months be-fore the end of the calendaryear.

    Registered names, trademarks, etc. ,used in this journal, even when notmarked as such, are not to beconsidered unprotected by law.

    Responsibility: This journal wascarefully produced in all its parts. Nev-ertheless, the Publisher, Editors andAuthors cannot be held responsiblefor errors or any consequences arisingfrom the use of information containedin this journal; the views and opinionsexpressed do not necessarily reflectthose of the Publisher, and Editorsneither does the publication of adver-tisements constitute any endorsementby the Publisher, and Editors of theproducts advertised.

    Copyright and PhotocopyingCopyright � 2014 Wiley-VCH VerlagGmbH & Co. KGaA. All rights reserved.No part of this publication may be re-produced, stored or transmitted inany form or by any means withoutthe prior permission in writing fromthe copyright holder. Authorization tophotocopy items for internal and per-sonal use is granted by the copyrightholder for libraries and other users

    registered with their local Reproduc-tion Rights Organisation (RRO), e.g.Copyright Clearance Center (CCC),222 Rosewood Drive, Danvers, MA01923, USA (www.copyright.com),provided the appropriate fee is paiddirectly to the RRO. This consent doesnot extend to other kinds of copyingsuch as copying for general distribu-tion, for advertising or promotionalpurposes, for creating new collectiveworks or for resale. Special requestsshould be addressed to:[email protected]

    Delivery Terms and Legal TitleWhere the subscription price includesprint issues and delivery is to the re-cipient’s address, delivery terms areDelivered at Place (DAP); the recipientis responsible for paying any importduty or taxes. Title to all issues trans-fers FOB our shipping point, freightprepaid. We will endeavour to fulfilclaims for missing or damaged copieswithin six months of publication,within our reasonable discretion andsubject to availability.

    For the USA and Canada:ChemMedChem (ISSN 1860-7179) ispublished monthly by Wiley-VCH,PO Box 191161, 69451 Weinheim,Germany. Periodical postage pendingat Jamaica, NY 11431. Air freight andmailing in the USA by Publications Ex-pediting Services Inc. , 200 MeachamAve., Elmont, NY 11003.US POSTMASTER: Sendaddress changes to ChemBioChem,John Wiley & Sons Inc. , C/O TheSheridan Press, PO Box 465,Hanover, PA 17331.Wiley’s Corporate Citizenship initiativeseeks to address the environmental,social, economic, and ethical chal-lenges faced in our business andwhich are important to our diversestakeholder groups. We have madea long-term commitment to standard-ize and improve our efforts aroundthe world to reduce our carbon foot-print. Follow our progress atwww.wiley.com/go/citizenship

    Open Access:ChemMedChem accepts articlesfor Open Access publication.Please see www.chemmedchem.org and select Online Open.

    Access ChemMedChem fromyour desktop. The journal isavailable through Wiley OnlineLibrary at

    wileyonlinelibrary.com

    Articles are published onlinedays or even weeks before theprinted issues are mailed,through the Wiley OnlineLibrary service. A full-rate sub-scription entitles users toonline access to full text plusaccess to the tables of con-tents and abstracts of hun-dreds of other Wiley journals.Speak to your librarian or visitthe site for full details.

    wileyonlinelibrary.com

    Typesetting, Printing andBinding:

    Johannes-Gutenberg-Strasse 1–397199 Ochsenfurt-Hohestadtwww.triltsch.de

    Paper: acid-freePrinted in theFederal Republic of Germany

    Authors who wish to publish in ChemMedChem should consult the current “Notice to Authors”,which appears on the ChemMedChem homepage at http://www.chemmedchem.org, before theydraft their manuscript.

    ISSN 1860-7179 (Print)ISSN 1860-7187 (Online)

    � 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

    www.chemmedchem.orgmailto:[email protected]:[email protected]

  • Lisbon, PortugalSeptember 7-11, 2014www.efmc-ismc.org

    All information in this book ofabstracts is accurate at the time of printing

  • SILVER SPONSORS

    GOLD SPONSORS

    WITH THE SUPPORT OF

    ORGANISED BY

    ON BEHALF OF

    SPONSORS

    Wiley Online Library www.chemmedchem.org EFMC-ISMC 2014 │

    EFMC International Symposium on Medicinal Chemistry MED

    6

  • AWARDS SPONSORS

    CONCERT SPONSOR

    TRAVEL GRANTS SPONSORS

    MEDIA PARTNERS

    SPONSOR OF THE LANYARDS SPONSOR OF THE NOTEPADS

    BRONZE SPONSORS

    Wiley Online Library www.chemmedchem.org EFMC-ISMC 2014 │

    EFMC International Symposium on Medicinal Chemistry MED

    7

  • LOCAL ORGANISING COMMITTEE

    J. Cavaleiro (University of Aveiro, Portugal) P. S. Da Silva (Bial, Portugal) W. Heggie (Hovione, Portugal) A. M. Lobo (New University of Lisbon - FCT, Portugal) M. Marques (Technical University of Lisbon, Portugal) R. Moreira (University of Lisbon, Portugal)

    INTERNATIONAL SCIENTIFIC COMMITTEE

    K.-H. Altmann (ETH Zürich, Switzerland) P. Arturson (University of Uppsala, Sweden) Y. P. Auberson (Novartis Institute for BioMedical Research, Switzerland) S. Bagal (Pfizer Neusentis, United Kingdom) B. Bang-Andersen (H. Lundbeck, Denmark) E. Banoglu (Gazi University, Turkey) E. Barreiro (Federal University of Rio de Janeiro, Brazil) M. Blanco-Pillado (Eli Lilly and Company, United States) M. Brands (Bayer Pharma, Germany) A. Brown (Pfizer Neusentis, United Kingdom) M. J. Camarasa (CSIC, Spain) N. Carruthers ( Johnson & Johnson, United States) G. Cirrincione (University of Palermo, Italy) S. J. Conway (University of Oxford, United Kingdom) B. Cox (Novartis Institutes for Biomedical Research, United Kingdom) P. S. Da Silva (Bial, Portugal) A. Davis (AstraZeneca, Sweden) G. Duburs (Latvian Institute of Organic Synthesis, Latvia) G. Ecker (University of Vienna, Austria) P. Ettmayer (Boehringer Ingelheim, Austria) E. Ferreira (University of Sao Paulo, Brazil) V. Gabelica Markovic (Fidelta, Croatia) C. Garcia-Echeverria (Sanofi, France) C. Genicot (UCB Pharma, Belgium) P. George (Independent Scientific Expert & Adviser, France) M. Hann (GSK Medicines Research Centre, United Kingdom) R. Hartmann (Elexopharm, Germany) T. Hoffmann (Zealand Pharma, Denmark) T. Högberg (Leo Pharma, Denmark) A. P. Ijzerman (University of Leiden, The Netherlands) H. Jhoti (Astex Therapeutics, United Kingdom) K. Jozwiak (Medical University of Lublin, Poland) G. Keseru (Hungarian Academy of Sciences, Hungary) G. Klebe (Philipps-University Marburg, Germany) A. Kourounakis (University of Athens, Greece) A. Levitzki (Hebrew University of Jerusalem, Israel) J. Mack (Boehringer Ingelheim, Germany) M. Marques (Technical University of Lisbon, Portugal) L. Meerpoel ( Janssen R&D, Belgium)

    J. Mestres (IMIM and University Pompeu Fabra, Spain) F. Micheli (Aptuit, Italy) J. Miners (Flinders University School of Medicine, Australia) M. Missbach (Novartis, Switzerland) C. Montanari (University of Sao Paulo, Brazil) G. Müller (Mercachem, The Netherlands) R. Nudelman (Teva Pharmaceutical Industries, Israel) D. Oliver (North-West University, South Africa) T. Oost (Boehringer Ingelheim, Germany) V. A. Palyulin (M.V.Lomonosov Moscow State University, Russia) Z. Pan (Peking University, China) L. Peterlin Masic (University of Ljubljana, Slovenia) M. Pinto (University of Porto, Portugal) A. T. Plowright (Astra Zeneca, Sweden) G. Robertson (Tes Pharma, Italy) I. Rozas (Trinity College Dublin, Ireland) G. Schneider (ETH Zürich, Switzerland) N. Shimma (Syngen Consulting, Japan) S. Simoes (Bluepharma & University of Coimbra, Portugal) H. Steinhagen (Grünenthal, Germany) H. Suga (University of Tokyo, Japan) G. Tamagnan (Institute for Neurodegenerative Disorders and Molecular NeuroImaging, United States) A. Thomas (F. Hoffmann-La Roche, Switzerland) A. Torrens (Esteve, Spain) M. Tozer (Peakdale Molecular, United Kingdom) A. Tsantili-Kakoulidou (University of Athens, Greece) K. Urbahns (Merck, Germany) S. Van Calenbergh (University of Ghent, Belgium) M. Varasi (European Institute of Oncology, Italy) G. L. Verdine (Harvard University, United States) P. Warner (Formerly with AstraZeneca, United Kingdom) A. Williams (Eli Lilly and Co, United Kingdom) A. Wood (Pfizer, United States) J. Yli-Kauhaluoma (University of Helsinki, Finland) A. Yonath (Weizmann Institute of Science, Israel) M.-Q. Zhang (Amgen China, China)

    M. Pinto (University of Porto, Portugal) F. Proença (University of Minho, Portugal) C. Romao (Alfama & ITQB, Portugal) M. L. Sa E Melo (University of Coimbra, Portugal) A. M. Silva (University of Aveiro, Portugal) S. Simoes (Bluepharma & University of Coimbra, Portugal)

    COMMITTEES

    Symposium ChairmenR. Moreira (University of Lisbon, Portugal)MembersB. Clement (Kiel University, Germany) G. Costantino (University of Parma, Italy) P. Jones (University of Dundee, United Kingdom)

    H. P. Maerki (F. Hoffmann-La Roche, Switzerland) E. Ottow (Bayer Healthcare, Germany) A. M. Silva (University of Aveiro, Portugal) K. B. Simonsen (Lundbeck, Denmark) U. Stilz (EFMC President & Novo Nordisk, Denmark) H. Timmerman (VU University Amsterdam, The Netherlands)

    INTERNATIONAL ORGANISING COMMITTEE

    Wiley Online Library www.chemmedchem.org EFMC-ISMC 2014 │

    EFMC International Symposium on Medicinal Chemistry MED

    8

  • Prinect PDF Report 13.00.025 - 1 - 24.07.2014 15:57:21

    Dokument ÜbersichtDateiname: 1622_U2_CMC.PDFTitel: Masthead 1622..1622Erstellt mit: Arbortext Advanced Print Publisher 9.1.580/WAnwendung: Acrobat Distiller 10.0.0 (Windows)Verfasser: -Erstellt am: 23.07.2014 11:42:03Geändert am: 24.07.2014 15:55:01Dateigröße: 1.5 MByte / 1502.5 KByteTrapped: UnbekanntOutput Intent: -PDF/X Version: -PDF-Version: 1.3Anzahl Seiten: 1Medien-Rahmen: 238.00 x 325.00 mmEndformat-Rahmen: 210.00 x 279.00 mm

    Zusammenfassung Fehler Warnung Repariert InfoDokument - - - -PDF/X - - - -Seiten - - - -Farben - 92 - -Schriften - - - -Bilder - - - -Inhalt - - - -

    FarbenFarbraum: Geräte-RGB #91Maximale Flächendeckung 370% ist oberhalb der 340% Grenze #1

    Sonstige InformationenFarbseparationen: 4

    CMYK

    FarbräumeDeviceCMYKDeviceRGB

    Schriften: 5AdvMYR4 Type1 / Custom / eingebettetAdvMYR4I Type1 / Custom / eingebettetAdvMYR6 Type1 / Custom / eingebettetAdvMYR6I Type1 / Custom / eingebettetMyriad-Bold Type1 / WinAnsi / eingebettet

  • Prinect PDF Report 13.00.025 - 2 - 24.07.2014 15:57:21

    Rastersystem-Informationen: 2Kein Standard-Rastersystem! Name: Unbekannt (Halbton-Typ: 1)Winkel: 45.0 Frequenz: 148.0 Punktform: RoundKein Standard-Rastersystem! Name: Unbekannt (Halbton-Typ: 1)Winkel: 45.0 Frequenz: 74.0 Punktform: Nicht Standard

  • Prinect PDF Report 13.00.030 - 1 - 22.08.2014 13:05:32

    Dokument ÜbersichtDateiname: 003_Masthead_Board_Members.PDFTitel: Masthead 1622..1622Erstellt mit: Arbortext Advanced Print Publisher 9.1.580/WAnwendung: Acrobat Distiller 10.0.0 (Windows)Verfasser: -Erstellt am: 23.07.2014 11:42:03Geändert am: 30.07.2014 11:33:06Dateigröße: 2.9 MByte / 2924.0 KByteTrapped: UnbekanntOutput Intent: ISO Coated v2 (ECI)PDF/X Version: -PDF-Version: 1.3Anzahl Seiten: 1Medien-Rahmen: 216.00 x 286.00 mmEndformat-Rahmen: 210.00 x 279.00 mm

    Zusammenfassung Fehler Warnung Repariert InfoDokument - - - -PDF/X - - - -Seiten - - - -Farben - - - -Schriften - - - -Bilder - - - -Inhalt - - - -

    Sonstige InformationenFarbseparationen: 4

    CMYK

    FarbräumeDeviceCMYK / Separation

    Schriften: 5AdvMYR4 Type1 / Custom / eingebettetAdvMYR4I Type1 / Custom / eingebettetAdvMYR6 Type1 / Custom / eingebettetAdvMYR6I Type1 / Custom / eingebettetMyriad-Bold Type1 / WinAnsi / eingebettet

    Rastersystem-Informationen: 2Kein Standard-Rastersystem! Name: Unbekannt (Halbton-Typ: 1)Winkel: 45.0 Frequenz: 148.0 Punktform: RoundKein Standard-Rastersystem! Name: Unbekannt (Halbton-Typ: 1)Winkel: 45.0 Frequenz: 74.0 Punktform: Nicht Standard