new developments in the dietary management of diabetes nicola guess.pdf · the look ahead research...
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NEW DEVELOPMENTS IN THE
DIETARY MANAGEMENT OF
DIABETES
BACPR Annual Conference 6-7th October 2016
‘Applying Evidence to Practice’
Nicola Guess, RD MPH PhD
Lecturer in Nutrition & Dietetics, King’s College London
Honorary Researcher, Imperial College London
Slides by Dr Louise Goff, Senior Lecturer, KCL, except where noted.
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Overview
Aims of dietary management of diabetes
Effectiveness of dietary management
Current guidelines – the evidence and the application
Current controversies
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Aims of diabetes dietary management
Your average diabetes
patient…
- Type 2 diabetes
- Hyperlipidemia
- Hypertension
- Overweight
AIMS OF DIETARY MANAGEMENT
[1.] Optimise blood glucose control
[2.] Manage & minimise cardiovascular
risk factors
[3.] Prevent chronic complications
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Diabetes dietary management is highly effective
Effects of dietetic counselling, n=2906 newly
diagnosed T2D
Monthly appointments, 3 months duration
Individualised advice, BDA guidelines
-4.61
kg
-2.03
%
-0.28
mmol
/l
-0.23
mmol
/l
-0.41
mmol
/l
Body weightHbA1cT-Cholesterol LDL-C Triglycerides
Manley SE et al. Diab Med 2000; 17: 518-523
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RCT of 6 months intensive
individualised dietary advice
(EASD), n=93
8 dietitian appts in 6 mths
Diabetes dietary management is highly effective
Coppell KJ et al. BMJ 2010; 341: c3337
-1.3
kg
-0.4
%
-0.5
kg/m2
-1.6
cm
Body weightHbA1cBMI Waist
Difference between
intervention and
control at 6 months
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Effectiveness in a ‘real world’ setting
221 T2D patients, referred for nutrition education & counselling
Diabetes dietary management is highly effective
Lemon CC et al. J Am Diet Assoc 2004; 104: 1805-1815.
Weight
Glycaemic control
Cardiovascular
risk factors
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Current guidelines for dietary advice
What type?How much?
- sugar-free, ‘diabetic foods’
- low carbohydrate
- 50% carbohydrate
A SHIFT
IN FOCUS
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Obesity is responsible for 80% of the population attributable risk for
diabetes (Laaksonen MA et al. 2010. Eur J Epidemiol)
7-fold greater risk of diabetes in obesity (BMI ≥30 kg/m2) and 3-fold
in overweight (BMI >25 and ≤30 kg/m2) (Abdullah A et al. 2010. Diab Res Clin
Prac)
4.5-9% relative increase in T2D risk for every 1 kg weight gain(Mokdad et al. 2000 Diabetes Care 23(9);1278-83)
60% to 90% of T2D appears related to weight gain (Anderson et al.
2003 AJCN 22(5);331-339)
Current guidelines for dietary advice
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Weight loss of 10% of initial body weight dramatically improves glycaemic control and reduces lipids and BP
BMI <25 kg/m2 is recommended for persons with T2D
Effects of weight loss with very low energy diets on fasting plasma glucose
values for obese persons with type 2 diabetes.
Mean values from 10 studies (see text) including 152 subjects.
Anderson et al. (2003) Importance of weight management in Type 2
Diabetes: Review with Meta-Analysis of Clinical Studies. J Am Coll Nutr
22(5);331-339.
Current guidelines for dietary advice
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Shifting the focus to weight loss
The Look AHEAD study
…‘provide a definitive assessment of the long-term health consequences of intentional weight loss’
5,145 overweight men and women with type 2 diabetes
16 US centres
Standard care vs intensive lifestyle
12 years follow-up
Outcome: cardiovascular morbidity &
mortality
Management of Diabetes
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Intensive lifestyle intervention goals:
1. Achieve mean weight loss of 7% of initial weight
2. Increase physical activity to ≥ 175 minutes a week
Management of Diabetes
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Intensive lifestyle intervention goals:
1. Achieve mean weight loss of 7% of initial weight
2. Increase physical activity to ≥ 175 minutes a week
Management of Diabetes
Frequency Format of sessions Weight loss goal Activity goal
PHASE I
Months 1-6
Months 7-12
Weekly
3 per month
3 group, 1 individual
2 group, 1 individual
Lose ≥ 10% of initial weight
Continued loss or weight
maintenance
Exercise ≥ 175 min/wk by mo. 6
Increase min/wk; 10,000
steps/day goal
PHASE II
Years 2-4 Min. 1 per
month
1 individual + min. 1
contact by phone/email
Weight maintenance, reverse
weight gain as it occurs
Maintain high levels of physical
activity
PHASE III
Year 5+ Monthly Individual Prevention of weight gain Prevention of inactivity
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Management of Diabetes
Group Education:
-cost effective
-social support
-healthy competitiveness
Individual Counselling:
-individual tailoring e.g. culture, ethnicity
-creates a stronger bond, share more personal details
-safety net for participants who stop group attendance
-continuity of care
Dietary Intervention:
-energy prescription
-portion control
-meal replacements
-low fat, low saturated fat
Physical Activity:
-walking
-steadily increase
-lifestyle activity e.g. stairs
rather than escalators
-supervised activity classes
Behaviour Modification:
-recording food intake &
activity
-weight measurements
-education
-homework assignments
FORMAT
CONTENT
The Look AHEAD Research Group. Obesity. 2006 May; 14(5): 737-752
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Management of Diabetes
The Look AHEAD Research Group. N Engl J Med
2013; 369: 145-54
• 8.6% weight loss in the intervention
group vs 0.7% in the control at 1 year
• 6.0 vs 3.5% weight loss at trial end
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Management of Diabetes
Usual care Intensive dietary interventionIntensive dietary intervention
+ increased physical activity
593 newly diagnosed type 2
diabetes patients
vs vs
5-10% weight loss & maintenance
Reduced calories, fat & glycaemic index
Individual goal setting & motivational interviewing
Individual appts with dietitian every 3 months, nurse appts every 6 wks
Standard diet & exercise
advice
Doctor and nurse reviews at 6
& 12 months
30 mins brisk walking, 5
days/wk + pedometer
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Management of Diabetes
Between group differences at 6
months (95% CI)
p Between group differences at 12
months (95% CI)
p
Weight (kg)
Diet vs usual care -2.28 (-3.08 to -1.48) <0.001 -2.41 (-3.49 to -1.32) <0.001
Diet & activity vs usual care -2.21 (-3.01 to -1.40) <0.001 -2.25 (-3.35 to -1.16) <0.001
Diet & activity vs diet 0.08 (-0.53 to 0.68) 0.81 0.15 (-0.65 to 0.95) 0.71
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Management of Diabetes
Between group differences at 6
months (95% CI)
p Between group differences at 12
months (95% CI)
p
HbA1c (%)
Diet vs usual care -0.28 (-0.46 to -0.10) 0.0049 -0.26 (-0.44 to -0.08) 0.005
Diet & activity vs usual care -0.33 (-0.51 to -0.14) 0.0009 -0.21 (-0.39 to -0.02) 0.027
Diet & activity vs diet -0.05 (-0.18 to 0.09) 0.51 0.06 (-0.08 to 0.19) 0.43
Baseline HbA1c 6.7%
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How to achieve weight loss in diabetes
Low
carbohydrate
diets
Very low carbohydrate
diets
Meal
replacement
diets
Commercial diet
groups
Very low calorie
diets
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How to achieve weight loss in diabetes
Low
carbohydrate
diets
Very low carbohydrate
diets
Meal
replacement
diets
Commercial diet
groups
Very low calorie
diets
THEY ARE ALL
EFFECTIVE BUT NOT
FOR EVERYONE
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Low-Carbohydrate Diets
Definition? Covers a diverse range of diets, with food choices
changing as degree of CHO restriction changes
Rationale? CHO is the only nutrient that has direct effect on blood
glucose concentrations – reducing it will improve blood glucose control
Food choices? grains, starch, sugar and fat and protein
Effective? Can be effective in short-term studies (<6mo) but as
degree of restriction increases, adherence declines
Evidence? Meta-analyses suggest “superiority” of LCHO over low-fat
over 1 year: BUT mean difference modest; drop-outs high.
Larsen RN et al. Diabetologia 2011;54: 731-740. Krebs JD et al. Diabetologia 2012;55: 905-914. Mansoor N,
Vinknes KJ et al. Br J Nutr. 2016;115(3):466-79.
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Low-Carbohydrate Diets in Practice
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Very Low Carbohydrate Diets
Definition? <50g/d CHO (250-300g/d in average diet)
Rationale? CHO affect blood glucose AND CHO weight
Food choices? NO grains, starch, sugar and fat & protein
Effective? Significant weight loss (12kg in 24 wks), BP, LDL-C and
glucose improvements but not different to low-fat diet. Significantly
better improvements in TG, HDL and HbA1c in low-CHO diet.
Independent of weight loss: Improvement in TG, HDL and HbA1c
Tay J. et al. Diabetes Care 2014; 169: 344-351. Mansoor N. et al. Br J Nutr. 2016;115(12):2264-6. Nuttal FQ. et
al. Nutr Metab. 2012;9(1):43. Comparison of low- and high-carbohydrate diets for type 2 diabetes management: a
randomized trial. Tay J et al. Am J Clin Nutr. 2015;102(4):780-90.
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Very Low Carbohydrate Diets in Practice
Very Low Carbohydrate Diet (<50g/d) – 1500 kcals/d,
<10% saturated fat
High Carbohydrate Diet (~200g/d) – 1500 kcals/d,
<10% saturated fat
30g high fibre cereal 40g high fibre cereal
1 crispbread e.g. Ryvita 5 crispbread e.g. Ryvita
250g lean meat ½ cup cooked pasta/rice/potato
40g almonds and 20g pecans 2 slices wholegrain bread
3 cups of low-starch vegetables 80g lean meat, 80g fish
200ml skimmed milk 80g legumes
100g diet yoghurt 3 cups vegetables
20g cheese 400g fruit
30g margarine/oil of monounsaturated variety 250ml semi-skimmed milk
150g reduced fat yoghurt
20g cheese
25g margarine/oil of monounsaturated variety
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Meal Replacement Diets
Definition? calorie-controlled, pre-packaged product in the form of a bar
or beverage (ready to drink or powder), that replaces a regular meal
Rationale? Restrict food choice, portion & calorie control
Food choices? Commercially available products to replace meals
Effective? Greater weight loss than reduced energy diets over the short
term
Weight loss = 7-8%
2.54 kg (P<0.01) and 2.43 kg (P=0.14) greater weight loss in the meal
replacement group for the 3-month and 1-y periods, respectively.
Heymsfield SB et al. 2003. Int J Obes Relat Metab Disord; 27(5):537-49
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Meal Replacement Diets in Practice
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Commercial Weight Loss Programmes
Definition? A range of commercially available weight loss
programmes – provide education & behaviour change techniques e.g.
group support, goal setting, motivational interviewing
Rationale? Support individual behaviour change relating to weight
management
Food choices? Range of approaches aiming to restrict calories, fat
and sugar
Effective? Achieve significantly greater weight loss than
control/education but not evaluated specifically in diabetes
Gudzane KA et al. Ann Intern Med 2015; 162(7): 501-512
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Commercial Weight Loss Programmes in Practice
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Very Low Calorie Diets
Definition? <800 kcals/d (400-800 kcals), provided in fortified liquid meals as sole source of nutrition for 12 weeks
Rationale? Significant, rapid weight loss has been shown to normalise blood glucose concentrations – ‘diabetes remission’
Food choices? NONE!
Effective? Significantly greater weight
loss than low calorie regimens BUT
not always maintained
NB: requires clinical supervision
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Very Low Calorie Diets in Practice
Lighter Life
8 weeks plus 12 weeks
food reintroduction
£66/wk inc. supplements,
counsellors and group
support meetings
Cambridge Plan
Optifast
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Which Diet?
Low
carbohydrate
diets
Very low carbohydrate
diets
Meal
replacement
diets
Commercial diet
groups
Very low calorie
diets
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Which Diet?
Low
carbohydrate
diets
Very low carbohydrate
diets
Meal
replacement
diets
Commercial diet
groups
Very low calorie
diets
THE ONE THAT THE
PATIENT LIKES &
WILL STICK TO!
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Summary – diet & diabetes management
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Current Controversies
SATURATED FAT - should it be restricted or does it not matter?
Diabetes guidelines focus on restricting SF due to increased
cardiovascular risk in diabetes patients
Evidence for the role of saturated fat in cardiovascular disease has
been brought into question
Alongside this activists have focused on carbohydrate as the main
culprit in diabetes
low carbohydrate, high (saturated) fat diets
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Low Carbohydrate, High (Saturated) Fat Diets
The evidence:
Saturated fats should continue to be restricted, and replaced with
monounsaturated fats for the reduction of cardiovascular risk
Low carbohydrate diets, that are not high in fat or saturated fat, are
effective for weight loss
There is no evidence upon which to recommend high fat, high
saturated fat diets in diabetes
Diabetes UK and British Dietetic Association’s Diabetes Specialist Group Policy Statement, 2015
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My Views
Some evidence that in ketogenic diet, SFA does not increase LDL-C.
BUT, above a certain amount of CHO, increase in LDL-C is a concern.
Therefore delivering public health advice challenging.
Need to understand more about what people eat “low-carb”.
BUT – even in ketogenic diet, CVD risk factors IMPROVE more with
foods rich in MUFAs and PUFAs than SFAs.
Tay J et al. Am J Clin Nutr. 2015;102(4):780-90. Fuehrlein BS et al. J Clin Endocrinol Metab. 2004;89(4):1641-5. Volek JS,
et al. 2008;47(5):307-18.
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Summary
Dietetic management is first line therapy in the management of
diabetes
It should focus on optimising glycaemic control, reducing cardiovascular
risk and minimising long-term diabetes complications
The primary goal should be weight management
A number of weight management options are available
Low carbohydrate diets are one option for diabetes management –
they are recommended for weight loss and should not promote
increased fat and saturated fat intakes
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