new division!of!orthopaedic!surgery! mcgill!university! … · 2016. 8. 11. ·...

DIVISION OF ORTHOPAEDIC SURGERY

MCGILL UNIVERSITY

Annual Report

For the period

January 1, 2014 to December 31, 2014

Table of contents CHAIR’S REMARKS: ............................................................................................................................. 5

RECRUITMENT: ................................................................................................................................... 6

RESIDENTS, FELLOWS AND GRADUATE STUDENTS .............................................................................. 7 RESIDENTS: ................................................................................................................................................ 7 FELLOWS: .................................................................................................................................................. 8 QUALIFYING POSTGRADUATES 2014 .............................................................................................................. 8 QUALIFYING RESIDENTS 2014 ....................................................................................................................... 8

GRANTS .............................................................................................................................................. 9 ANTONIOU ............................................................................................................................................ 10 BARRALET ............................................................................................................................................. 10 BERGERON ............................................................................................................................................ 11 GLORIEUX ............................................................................................................................................. 11 HAGLUND ............................................................................................................................................. 11 HAMDY ................................................................................................................................................. 12 HARVEY ................................................................................................................................................. 12 HENDERSON ......................................................................................................................................... 13 MARTINEAU .......................................................................................................................................... 13 MORIN .................................................................................................................................................. 13 MWALE ................................................................................................................................................. 15 OUELLET ................................................................................................................................................ 15 RAUCH .................................................................................................................................................. 16 ROUGHLEY ............................................................................................................................................ 17 SEGUIN .................................................................................................................................................. 17 ST ARNAULD .......................................................................................................................................... 17 TANZER ................................................................................................................................................. 18 TURCOTTE ............................................................................................................................................. 18 WEBER .................................................................................................................................................. 18 ZUKOR ................................................................................................................................................... 18

PEER REVIEWED PUBLICATIONS ........................................................................................................ 19 ANTONIOU ............................................................................................................................................ 20 BARRALET ............................................................................................................................................. 20 BENAROCH ............................................................................................................................................ 21 BERGERON ............................................................................................................................................ 21 BURMAN ............................................................................................................................................... 22 FREEMAN .............................................................................................................................................. 22 GLORIEUX ............................................................................................................................................. 22 GOULDING ............................................................................................................................................ 23 HAGLUND ............................................................................................................................................. 23 HAMDY ................................................................................................................................................. 24

HARVEY ................................................................................................................................................. 25 HENDERSON ......................................................................................................................................... 26 HUK ....................................................................................................................................................... 26 JANELLE ................................................................................................................................................. 26 JARZEM ................................................................................................................................................. 26 MARTINEAU .......................................................................................................................................... 27 MORIN .................................................................................................................................................. 28 MORT .................................................................................................................................................... 29 MWALE ................................................................................................................................................. 29 OUELLET ................................................................................................................................................ 29 RAUCH .................................................................................................................................................. 30 REINDL .................................................................................................................................................. 32 ROUGHLEY ............................................................................................................................................ 32 SARAN ................................................................................................................................................... 33 SEGUIN .................................................................................................................................................. 33 ST. ARNAUD .......................................................................................................................................... 34 STEFFEN ................................................................................................................................................ 34 TANZER ................................................................................................................................................. 34 TURCOTTE ............................................................................................................................................. 35 WEBER .................................................................................................................................................. 35 ZUKOR ................................................................................................................................................... 35

HONOURS / AWARDS ....................................................................................................................... 37 ANTONIOU ............................................................................................................................................ 38 BARRALET ............................................................................................................................................. 38 BERGERON ............................................................................................................................................ 39 GLORIEUX ............................................................................................................................................. 39 GOULDING ............................................................................................................................................ 39 HAGLUND ............................................................................................................................................. 39 HAMDY ................................................................................................................................................. 40 HARVEY ................................................................................................................................................. 40 MARTINEAU .......................................................................................................................................... 40 MORIN .................................................................................................................................................. 40 MWALE ................................................................................................................................................. 41 OUELLET ................................................................................................................................................ 41 RAUCH .................................................................................................................................................. 41 SARAN ................................................................................................................................................... 41 TANZER ................................................................................................................................................. 41 WEBER .................................................................................................................................................. 42

DIVISION FACULTY AND STAFF .......................................................................................................... 43 CLINICAL FACULTY ................................................................................................................................. 44 AFFILIATED CLINICAL ............................................................................................................................. 45 RESEARCH FACULTY .............................................................................................................................. 45

ADMINISTRATION ................................................................................................................................. 45 RESEARCH COORDINATORS .................................................................................................................. 46 CLINICAL COORDINATORS .................................................................................................................... 46

OTHER SCHOLARLY ACTIVITIES & SERVICES TO THE PROFESSION AND COMMUNITY ........................ 47 ANTONIOU ............................................................................................................................................ 48 BARRALET ............................................................................................................................................. 49 BENAROCH ............................................................................................................................................ 50 BERGERON ............................................................................................................................................ 50 BURMAN ............................................................................................................................................... 51 GLORIEUX ............................................................................................................................................. 51 GOULDING ............................................................................................................................................ 51 HAGLUND ............................................................................................................................................. 52 HAMDY ................................................................................................................................................. 52 HARVEY ................................................................................................................................................. 53 HUK ....................................................................................................................................................... 54 JANELLE ................................................................................................................................................. 54 JARZEM ................................................................................................................................................. 55 LENCZNER ............................................................................................................................................. 55 MARTINEAU .......................................................................................................................................... 55 MORIN .................................................................................................................................................. 56 MORT .................................................................................................................................................... 57 MWALE ................................................................................................................................................. 57 OUELLET ................................................................................................................................................ 58 RAUCH .................................................................................................................................................. 59 REINDL .................................................................................................................................................. 59 ROUGHLEY ............................................................................................................................................ 59 SARAN ................................................................................................................................................... 60 SEGUIN .................................................................................................................................................. 60 ST-‐ARNAUD ........................................................................................................................................... 60 TALBOT ................................................................................................................................................. 60 TANZER ................................................................................................................................................. 61 TURCOTTE ............................................................................................................................................. 62 WEBER .................................................................................................................................................. 62 ZUKOR ................................................................................................................................................... 63

Chair’s Remarks: We began the year with a challenge and also an opportunity to reflect upon the changing nature of Resident training and optimising and improving the training program. This was the main topic of February’s retreat and we have all worked hard to address areas for improvement. Nonetheless 2014 has been a successful year, one of our first notable achievements being Thierry Pauyo and Stephane Bergeron winning first place at the AAOS Annual meeting in New Orleans with their work "Changes in Orthopaedic job market demand in the United States over the last decade".

Adam Hart and Adriana Martinez also won 2nd and 3rd prize in the Rocke Robertson Visiting Professor Day for their projects on Distal Radius Fractures and Compartment Syndrome.

Asim Makhdom took 1st place for the New Investigator Research Award at the annual ACPOC meeting for his project "The Accordion maneuver and The Effect of Compression Loading on Delayed Regenerate Bone Formation in cases of Limb Lengthening"

You will doubtless recall Drs. Harvey and Van Lancker were ahead of the curve and in the media with pioneering work on Google Glasses.

Our Visiting Professor, Professor Alain Charles Masquelet from Hôpital Avicenne, Paris provided a stimulating two days providing us with his insights into the now renowned ‘Masquelet Technique’ and membrane regeneration.

The Jo Miller Orthopaedic Research Fund made awards totalling $100,000 to

Drs. Jarzem, Ouellet, Weber and Haglund, Infection as the etiology of degenerative disc disease in adults Dr. Martineau, Anterior cruciate ligament (ACL) graft failure Dr. Tanzer, Tissue response and validation of a novel porous material Drs. Morin and Harvey, Quebec registry for atypical femur fractures Drs. Martineau and Henderson, Mast Cells and Bone Regeneration Dr. Steffen, A Self-‐Setting Poly-‐Vinylalcohol (PVA) Gel for Minimally Invasive (MI) Repair of Focal Articular Cartilage Defects Dr. Sato and Barralet, Soft tissue distraction The fall saw another remarkable success for Adriana Martinez winning the QOA Benoit-‐Morin 2014 Resident competition and the awarding of the 2014 Current Concepts in Joint Replacement Scholarship to Anthony Albers.

As a Division we enhanced the orthopaedics literature with over 200 peer reviewed papers in 2014, we were awarded 8 CIHR grants, a CIHR Proof of Principle Grant and 2 CHRP wards as well as considerable awards from NIH, Canadian Cancer Research Society and the Dairy Farmers of Canada and the AO Foundation together with numerous other grants totaling over $7.5M for 2014 alone.

It was with some regrets that we saw Francine Lemay, the Division secretary since 1986 take a well-‐deserved rest in her retirement and I formally acknowledge her hard work over the years in keeping the Division running so efficiently. I also at the same time welcome Italia Gagliani who I am sure will soon be filling the big shoes of her predecessor.

We were fortunate to gain the skills and enthusiasm of Krista Goulding who joins me in Ortho Oncology and we have begun a search for a tenure track position to be filled in 2015.

Good luck to division members facing a move in 2015 and I look forward to the ORL joining us here at the MGH. Thanks to you all for making 2014 a successful year and best wishes for 2015.

RT

Recruitment: Dr. Krista Goulding – Full-‐time Assistant Professor (Clinical) joined the division in August 2014. Krista obtained her MD degree at McMaster and completed her residency training at University of Ottawa. She went on fellowship in Ottawa and at the Royal Orthopaedic Hospital in Birmingham UK, both in Orthopedic Oncology. She then did a 6 months fellowship in Reconstructive Arthroplasty/Oncology at the Mayo Clinic in Phoenix AZ. She also started in 2013 a Master of Public Health at the Johns Hopkins Bloomberg School of Public Health in Baltimore MD.

Residents, Fellows and Graduate Students Residents: RESIDENTS R5 R4 ABATZOGLOU, Sarantis ALKHELAIFI, Khalid ABDULJABBAR, Fahad BEAUMONT COURTEAU, Maxime ALBERS, Anthony COUGHLIN, Ryan AL-‐JURAYYAN, Abdulaziz CRAPSER, Andrew AL-‐QAHTANI, Saad MAKHDOM, Asim DE JESUS, Christopher MOUSSEAU, Isabelle KUMAR, Abhishek PAUYO, Thierry VAN LANCKER, Hans SUTTON, Carl COTA, Adam WALY, Feras YOUNG, Diana R3 R2 ALBISHIi, Waleed AOUDE, Ahmed ALZAHRANI, Mohammad CASTANO, Daniel BALUKI, Wafa DRAGER, Justin CRAPSER, Andrew CORNELIS KRUIJT, Jan HART, Adam ALDEBEYAN, Sultan HUSSEINI, Abdallah ALI ALHAMZAH, Hamzah JIANG, Fan ALNUSIF, Naser S. Martinez Gomez, Adriana ALASEEM, Abdulrahman QUTUB, Ammar Mohammed WAHEED WAHBA MORCOS, Mina R1 MUWANIS, Mashael ALAQEEL, Motaz ALRAIYES, Thamer DOWNEY, Emilie-‐Ann PEDNEAULT, Christopher

Fellows: FELLOWS Sub Specialty Location AL SOBEAI, Mohammed Arthroplasty JGH ALATTAS, Mohammed Sports Medicine SMH ALSULAIMANI, Saleh Oncology MGH ALTURKISTANY, Ahmed Pediatric Orthopaedics Clinical Fellow -‐ BAROUDI, Maher Sports & Arthroscopy Clinical -‐ DUBOIS-‐FERRIERE, Victor Foot & Ankle JGH LIODAKIS, Emmanouill Arthroplasty JGH SCHNEIDER, Prism Steorra Trauma Fellowship -‐ SIMOES, Leonard Scoliosis & Spine -‐

Qualifying Postgraduates 2014 Congratulations to:

STUDENT THESIS TITLE MSc /PhD

SUPERVISOR

JennyAnne Pura Implant-delivered alendronate enhances net bone formation around porous titanium implants

MSc Dr. M. Tanzer

Qualifying Residents 2014 Congratulations to:

ALDEBEYAN, Wassim ABDULAZIZ, Al-‐Maawi AL-‐SHEIKH, Khalid AMITAI, Ari David CARLI, Alberto COTA, Adam PAGÉ, Alexandre SARDAR, Zeeshan YOUNG, Diana Starr

APPENDIX 1

GRANTS 2014

Division of Orthopaedic Surgery

Department of Surgery

FACULTY OF MEDICINE

ANTONIOU 2011 -‐ 2014 Biological Repair of Intervertebral Disc Degeneration. Principal Investigator John

Antoniou, Co-‐investigators Fackson Mwale. AO/ASIF Foundation (Hansjörg Wyss Award 2011), $370,000.

2011-‐2014 Tissue engineering of intervertebral discs. Principal Investigator John Antoniou, Co-‐

investigators Fackson Mwale. Canadian Institute of Health Research (CIHR) $328,000. 2012 – 2016 The efficacy of Link N as a mediator of repair in intervertebral disc degeneration.

Principal Investigator Fackson Mwale, Co-‐investigators John Antoniou. Canadian Institute of Health Research (CIHR), $564,800.

BARRALET 2011 -‐2016 Structural Bioinorganic, Principal Investigator Jake Barralet NSERC Discovery,

$ 200,000 Funding for reporting year $40,000.

2013-‐2015 Injectable Osteoconductives for Enhancement of Bone Formation During Distraction Osteogenesis, Principal Investigator Jake Barralet, Co-‐investigators Hamdy. Robert Matthys Institute $50,000.

2014 Localised bisphosphonate delivery. Principal Investigator: Weber, Co-‐investigators: Siegel/ Barralet. Townshend Lamarre Award, Faculty of Medicine $20,000.

2014 Axial Vascularization of Bioceramic Scaffolds in a Rat Model. Principal Investigator

Makhoul, Co-‐investigators Jake Barralet James Hayward Grant, $15,000.

2014 Local in situ Controlled Delivery of Biphosphonates in Bone Metastasis. Principal Investigator: Jake Barralet, Co-‐investigators Weber/Ouellet MITAC, $80,000.

CFI, $1MTools for minimally invasive surgery, Infrastructure award 2014 NSERC Engage Grant, Graphite exfoliation, $25k, 6mo. 2014 Canadian Cancer Research Society Principal Investigators I Dr. M Weber, CI Dr. P Siegel,

200k, 2 yrBone scaffolds as delivery systems for local and controlled release of anti-‐resorptive in one metastasis treatment.

2014-‐2017 NSERC Strategic Grant Nanoparticles to superparticles: new materials for clean energy.

Principal Investigator Barralet, Co-‐investigators Dr. J Gostick 3yr NSERC $500,000.

Training grants 2014-‐2015 Mimicking Autograft Biology: The Potential of Hypoxia Mimics in Bone Regeneration.

Investigators Justin Drager, Edward Harvey, Jake Barralet. AO Trauma North American Resident Research Grant $10,000.

2014-‐2015 Hypoxic Mimicking Agents to Augment Synthetic Scaffold Bone Regeneration. Primary

author of Grant, Principle Investigator Investigators Justin Drager, Jake Barralet, Edward Harvey Orthopaedic Trauma Association Resident Research Grant $20,000.

BERGERON 2014 Royal College of Physicians and Surgeons of Canada (RCPSC) Professional Development

Grant (Personal Support Grant) 4000$. GLORIEUX 2011-‐2014 Kirin Anti-‐FGF23 in familial hypophosphatemic rickets (PI) US $325,337 . 2009-‐2015 Zoledronic Acid Treatment in babies with severe Osteogenesis Imperfecta (PI) US $285,510. HAGLUND 2014-‐2015 Jo Miller Research Fund Award, Infection as the etiology of degenerative disc disease in

adults has been awarded at a level of $16,700, (role Co Investigator, Principle Investigator Peter Jarzem, Co-‐Investigator Jean Ouellet), budget spent on student under my supervision.

2013-‐2014 McGill Collaborative Research Fund, Hydrogels for Cartilage and Bone Regeneration: A

Prototype for a New Generation of Bio-‐Materials Able to Both Talk and Listen to The Body, $15 000, (role, Co-‐ Investigator, Principle Investigator, Marta Cerruti) budget spent on student under Dr Cerruti's and my supervision.

2012-‐2014 MITACS, Local delivery of biologically active peptides to correct curve progression in a mouse model of EOS, $ 80 000, Training awards, (role, Co-‐Investigator, with Dr Janet Henderson and Dr. Neil Saran), 44K spent on student under my supervision.

2012-‐2014 AO Foundation start-‐up grant, CHAD Fragmentation in Respon to Mechanica Loading,

$120 000 CHF ($148 000 CAD) (role, Principle Investigator, Co-‐Investigators, Dr. Jean Ouellet and Dr. Peter Roughley). 100 LH lab.

2012-‐2015 CIHR operating grant, Intervertebral Disc Degeneration and P 325 959 (role, Principle Investigator, Co-‐Investigators, Dr. Laura Stone and Jean Ouellet). 100% in LH lab.

2011-‐2016 AOSpine Research Network, Biological Repair of the Degenera Intervertebral Disc, $740 000 CHF ($900 000 CAD) (role, Principle Investig Co-‐ Investigators, Dr Thomas Steffen, Dr. Peter Roughley and Dr. Jean Ouell 90% in LH lab.

HAMDY 2014-‐2015 CIHR $160,000/yr P.I.: Maryam Tabrizian Co-‐PI: R. Hamdy A novel injectable chitosan

sponge containing BMP-‐7 as a therapeutic intervention for accelerated bone formation in a critical size defect rat model Proof of Principle – Phase 1 grant.

2014-‐2018 CIHR $678,974/5 yrs P I: U. Narayanan Co-‐PI: R. Hamdy & al. Title: Outcomes of hip

interventions for children with cerebral palsy – an international multi-‐centre prospective comparative cohort study.

2013 – 2015 Robert Matthys $25,000 Co-‐PI. R. Hamdy (PI: Jake Barralet) Foundation Swiss franc

Title: Injectable Osteoconductives for per year Enhancement of Bone Formation During Distraction Osteogenesis.

2012 – 2015 CIHR $146,822.00 yearly P.I. R. Hamdy (Co P.I.: M. Tabrizian & P. Moffatt) (3 years)

Title: The Effect of a Hybrid and Injectable Nanoparticulate BMP Delivery System on Bone Regeneration during Distraction Osteogenesis.

2012 -‐ 2016 International Shriners $819,257.00 Co P.I. R. Hamdy (P.I. René St-‐Arnaud) Organization

Title: Blocking FGFR3 Signaling to Accelerate Distraction Osteogenesis. HARVEY 2012-‐2014 Principal Investigator – EJ Harvey Co-‐Investigators -‐S Morin MD (McGill) S Laverty

(UofM) Que.TraumaNet-‐ Quebec trauma network FRQ-‐S Intersectorial Grant -‐Ref No 26756 $189 250 per annum x 2 years.

2013-‐2014 Principal Investigators-‐ J Drager, EJ Harvey, J Barralet Hypoxic Mimicking Agents to

Augment Synthetic Scaffold Bone Regeneration Orthopedic Trauma Association $20 000.

2013-‐2014 Principal Investigators-‐ J Drager EJ Harvey, J Barralet Mimicking Autograft Biology: The

Potential of Hypoxia Mimics in Bone Regeneration AO North America Resident Trauma Research Support Grant $5000 /year-‐ $10,000.

2014-‐2016 Principal Investigator-‐ Stephane Bergeron Supervisor -‐ EJ Harvey Royal College

Education Grant (MPH Studies).

2014-‐2018 Principal Investigator-‐ EJ Harvey JE Henderson Co-‐Investigator-‐ R Mongrain Implantable Micro-‐Device to Monitor Muscle Compartment Pressure in Trauma Victims, CIHR-‐NSERC CHRP Program.

2014-‐2018 Sponsor: Canadian Institutes of Health Research – CIHR Agency No.: CPG 134738 OSR

Tracking No.: 64410 2014-‐ 2015, $44,596. 2014-‐2017 Sponsor: Natural Sciences and Engineering Research Council – NSERC Agency No.:

CHRP 462278-‐2014 OSR Tracking No.: 64569 2014-‐2015, $44,596.

2013-‐2014 Principal Investigators-‐ J Drager, EJ Harvey, J Barralet Hypoxia Mimicking Agents for Bone Regeneration FRQ-‐S Junior Investigator Award, $23 000.

2014 Principal Investigators -‐ S Morin E Harvey Quebec Registry for Atypical Femur Fractures

McGill Orthopaedic Research Fund $13,500. HENDERSON 2014-‐2017 Operating Co-‐PI implant micro-‐device tissue 04/2014-‐03/2017 $361,137. 2012-‐2015 Team Co-‐PI pFrQesRsN. T/bioactive biomaterials for implants 07/2012-‐ 06/2015

$234,000 Network Coapplicant FRSQ/Oral & bone health network. 2011-‐2015 $1,850,000. 2013-‐ 2015 Train/Operate PI MITACS/therapeutics mouse model of 09/2013-‐08/2015

$80,000 FRSQ-‐RSBO scoliosis. 2013-‐2015 Support for major infrastructure 09/2013-‐08/2015 $40,000 2014-‐2015 RI-‐MUHC/Surgery Mast cell function in bone repair.

09/2014-‐08/2015 $50,000. MARTINEAU 2012-‐2015 Subvention Établissement jeunes chercheurs Fonds de recherche en santé Québec,

Martineau Principal Investigator 30 000$. 2014-‐2015 Gait Differences between Patients with Primary and Secondary Knee Osteoarthritis and

the Impact on Disease Progression PI: S. Robbins CIHR-‐ Institute of Musculoskeletal Health and Arthritis – 100000$ Martineau Co-‐Investigator.

2012-‐2014 Transport properties of contrast agents for cartilage imaging PI: T.M. Quinn, Martineau Co-‐Investigator AO Foundation -‐ 117500$ over 2 yrs.

2014 Anterior cruciate ligament graft failure – internal award PI: Martineau PA 13300$.

2014 Mast cells and bone regeneration – internal award PI: Martineau PA 16700$.

2013-‐present Porous compression screw for fracture fixation. Part II: Preclinical in vivo testing in a large animal model PI: P.A. Martineau, Financial partner – Amorchem LLD – 975000$.

MORIN 2014-‐2015 CIHR Planning and Dissemination Grant – Institute Community Support, “Developing

consensus recommendations for atypical femur fracture care in Canada”, Co-‐Principal Investigator; Nominated Principal Investigator: Angela Cheung ($10,000).

2013-‐ 2018 CIHR Operating Grant (Winter 2013), “The effect of dietary calcium intake as compared to calcium supplementation on vascular and bone health in postmenopausal women”, Nominated Principal Investigator, Co-‐Principal Investigator: S. Daskalopoulou ($483,339).

2014-‐2017 Dairy Farmers of Canada, “FAmily MILk product two-‐Year dose-‐response study to

enhance bone health (FAMILY)”, Co-‐Investigator; Principal Investigator: H. Weiler ($1,066,161).

2014-‐2017 CIHR Operating Grant, “Evaluating the 48-‐hour Benchmark for Surgery: The Canadian

Collaborative Study of Hip Fractures”, Co-‐Investigator, Nominated Principal Investigator: B. Sobolev, ($685,608).

2013-‐2015 Physicians Services Incorporated Foundation (PSI), Health Research Grant, “Effect of

teriparatide in fracture healing in patients with incomplete Atypical Femur Fractures: A randomized controlled trial (the TAFF Trial)”, Co-‐Investigator, Co-‐Principal Investigators: A. Cheung (Nom-‐PI) and L. Tile ($170,000).

2012-‐ 2014 McGill University Health Centre, in partnership with the Québec Blue Cross, Challenge

Q+, “Improving PAIN control following FRactures; towards an Elder-‐friendly Emergency department (PAINFREE)”, Principal Investigator ($150,000).

2013-‐2014 CIHR Knowledge Synthesis Grant, "The Management of Bone Disease in Chronic

Kidney Disease: A Systematic Review", Co-‐Principal Investigator, Nominated Principal Investigator: A Jamal ($98,763).

2013-‐ 2014 Technology Evaluation in the Elderly Network (TVN) 2013 Knowledge Synthesis Grant

Program, “Hip fracture quality indicators: A scoping review”, Co-‐Investigator, Principal Investigator: SB Jaglal ($48,465).

2012-‐2014 FRSQ Operating Grant, “Mise sur pied d’un réseau pancanadien en traumatologie

orthopédique par le biais de son antenne au Québec (QUE-‐TraumaNet)”, Co-‐Principal Investigator with E. Harvey ($379,500).

2011-‐2015 FRSQ Subvention d'établissement de jeune chercheur clinicien, « Ostéoporose et

fractures de la hanche ; stratégies de traitement », Principal Investigator ($30,000). 2011-‐2014 CIHR Operating Grant, “A Knowledge to Action Intervention for Long-‐term Care: A

Feasibility Study Focusing on the Uptake of Osteoporosis and Fracture Prevention Best Practices”, Co-‐Investigator, Principal Investigator: A. Papaioannou ($288,980).

2011-‐ 2015 CIHR Operating Grant, “Safety and effectiveness of Oral Bisphosphonates in Older

Adults”, Principal Investigator ($178,232). 2013-‐2014 CIHR Planning Grant (Fall 2012), “Creating and Implementing a National Reporting

System of Quality Indicators for Hip Fracture Care”, Co-‐Investigator, Principal Investigator: L. Beaupre ($25,000).

2014-‐2019 Amgen Canada Inc., “Quebec Registry for Atypical Femur Fractures”, Principal investigator ($25,000).

2014-‐2019 Merck Canada Inc., “Quebec Registry for Atypical Femur Fractures”, Principal

Investigator ($25,000). 2008-‐2015 Amgen Canada Inc., “Epidemiology of Osteoporosis in Manitoba”, Co-‐ Investigator;

Principal Investigator WD Leslie ($214,000). MWALE 2012-‐2016 The efficacy of Link N as a mediator of repair in intervertebral disc degeneration

(ongoing). Principal Investigator Fackson Mwale, Co-‐investigators John Antoniou Canadian Institute of Health Research (CIHR), $564,800.

2011 – 2014 Biological Repair of Intervertebral Disc Degeneration (ongoing). Principal Investigator

John Antoniou, Co-‐investigators: Fackson Mwale. AO/ASIF Foundation (Hansjörg Wyss Award 2011), $370,000.

2011-‐2014 Tissue engineering of intervertebral discs (ongoing) Principal Investigator John

Antoniou, Co-‐investigators Fackson Mwale. Canadian Institute of Health Research (CIHR) $328,000.

2011 – 2016 Model of human disc regeneration in the spectrum of degenerative disc disease

(ongoing). Principal Investigator James Iatridis, Co-‐investigators: Fackson Mwale National Institutes of Health (NIH), $2, 368,138.

OUELLET

2007– 2014 Shriners Organization Peer Review Local P.I. $26,120 PI: Matthew Dobbs

BRAIST(Bracing Study in Adolescent Idiopathic Scoliosis) Multicenter NIH co funded pan American; McGill Scoliosis & Spinal Research.

2012 – 2014 AO Spine Peer Reviewed Co P.I. $74,000 X 2 yrs PI: Lisbet Haglund; CoPI: Peter

Roughley CHAD Fragmentation in response to mechanical load as indicator of DDD Ortho Research Lab; McGill Scoliosis & Spinal Research.

2014 -‐2015 Jo Miller Research Award, Peer reviewed Co-‐PI $16,700.00 Infection as the etiology

of degenerative disc disease in adults Principle Investigator Peter Jarzem, Lisbet Hadlung.

2014 – 2017 Shriners International Salary Support for Post Graduat Co P.I. 62,500.00 X 3yrs

Biomarkers Optimization of post-‐operative pain management in children.

2014 – 2017 AO Foundation P.I. $169,402.33 x 3yrs Evaluation of the modern Luqué Trolley growth gliding system vs. conventional treatment of early onset scoliosis patients: A prospective, non-‐randomized multi-‐center cohort study with a historical control. CRO – AOCID.

2013 – 2015 FRSQ Salary support for Post Doc Co P.I. $20,000.00 X 3yrs P.I.: Astrid Brousselle La prioritisation des patients: le cas d’une Clinique multidispinaire en orthopédie pédiatrique.

2012 -‐ 2015 CIHR Peer reviewed Co P.I. $108 653.00 X3yrs PI: Lisbet Haglund Co. PI: Laura

Stone Bioreactor Research: Intervertebral disc degeneration and pain Ortho Research Lab; McGill Scoliosis & Spinal Research; Stone Lab.

2011 – 2016 AO Foundation Foundation Co P.I. $185,000.00 X5yrs P.I.: Lisbet Haglung Co.PI:

Peter Roughley Development of a novel bioreactor for human intervertebral disc allowing the characterization of the pathophysiology of the mechanically loaded disc to develop a regenerative approach for degenerative disc disease.

2010 -‐ 2015 CIHR Peer reviewed Accreditation Co P.I. $144 000.00 X 5yrs PI: Jill Chorney Pain at

Home in Children following Major Surgery:Physical, Psych, $ Consequences. Multicenter Pan Canadian. PI for Optimism Section.

2012 -‐ 2014 DePuySPINE Educational Grant P.I. $60 000.00 X 2 yrs McGill Minimal Invasive Spine

Anesthesia Fellowship. 2005 – 2015 AONA SPINE Peer review Accreditation P.I. $80 000.00 X 10 yrs AONorth American Spine Fellowship accreditation and funding. RAUCH 2014 -‐ 2022 Muscle-‐bone interactions in Canadians: a national, population-‐based study. Principal

Investigator Frank Rauch. Canadian Institutes of Health Research $1,334,440. 2014 -‐ 2019 Brittle bone disorders consortium of the rare disease clinical research network.

Principal Investigator Lee, Co-‐Investigator Frank Rauch. National Institutes of Health 2014 – 2019 The role of BRIL in the pathogenesis of osteogenesis imperfect type V. Principal

Investigator Moffatt, Co-‐Investigator Frank Rauch. Canadian Institutes of Health Research

2012 -‐2016 Causes and treatments of heritable osteoporosis in childhood and adolescence.

Principal Investigator Frank Rauch. FRQS Checheur-‐boursier 2012-‐2016 Genomic determinants of common long-‐term treatment effects in childhood acute

lymphoblastic leukemia survivors. Principal Investigator Sinnet, Co-‐Investigator Frank Rauch. Canadian Institutes of Health Research

2013-‐2014 Metaphyseal dysplasia with maxillary hypoplasia and rachydactyly – studies on the

phenotype of a Quebec orphan disease. Principal Investigator Frank Rauch. GDPL $25,000.

2012 -‐2014 Effect of High-‐Dose Vitamin D on Bone Density in Osteogenesis Imperfecta. Principal

Investigator Frank Rauch. Shriners of North America $242,000.

ROUGHLEY 2011-‐ 2016 AO -‐ Biological repair of the degenerate intervertebral disc. $105,000pa Co-‐PI with Dr

Lisbet Haglund. 2012-‐17 CIHR -‐ The role of hyaluronan in the growth and function of the skeletal system.

$110,283pa Co-‐PI with Dr Pierre Moffatt. SEGUIN 2012-‐2017 Genomic determinants of common long-‐term treatment effects in childhood acute

lymphoblastic leukemia survivors Co-‐investigator: Séguin, Chantal, Co-‐applicant: Caroline Laverdiere; Principal Investigator: Sinnett, Daniel Canadian Institutes of Health Research (CIHR) CIHR Team Grant: Childhood Cancer Late Effects of Treatment Total Funding -‐ 2,445,054 (Canadian dollar).

2010 – 2015 Osteonecrosis as a Complication of ALL and Lymphoma treatment Principal

investigator: Séguin, Chantal Co-‐investigator: Dr Edward J. Harvey; Janet E. Henderson Leukemia and Lymphoma Society Operating grant (USA) Total Funding -‐ 600,000 (Canadian dollar).

2010 – 2015 In vitro, Ex Vivo and In Vivo Analysis of the Molecular and Cellular Mechanisms

Implicated in the Development of Avascular Necrosis of the Femoral Head: an Endothelium-‐Based Approach. Principal investigator: Séguin, Chantal. Montreal General Hospital Foundation (Can) Wallace Denver Donation Total Funding -‐ 500,000 (Canadian dollar).

2011 – 2014 Biomarqueur permettant le dépistage précoce de l'ostéonécrose induite par les

glucocorticoïdes. Principal investigator: Séguin, Chantal Fonds de la Recherche en Santé du Québec (FRSQ) Chercheur-‐boursier clinicien, Junior 2 -‐ Volet clinique Total Funding -‐ 112,613 (Canadian dollar).

ST ARNAULD 2012-‐2017 86400 St-‐Arnaud (PI) $240,142/yr Shriners Hospitals for Children Title: Gene

expression in bone cells. 2012-‐2017 85300 St-‐Arnaud (PI) $156,556/yr Shriners Hospitals for ChildrenTitle: Blocking FGFR3

signalling to accelerate Distraction Osteogenesis. 2011-‐2017 MOP-‐119306 St-‐Arnaud (PI) $125,439/yr CIHRTitle: The alphaNAC transcriptional

coregulator as a downstream effector of PTH action in bone. 2013-‐2016 85600 St-‐Arnaud (PI) $231,184/yr Shriners Hospitals for ChildrenTitle: Vitamin D

synthesis in bone: molecular genetics analysis. 2014-‐2016 85210 St-‐Arnaud (PI) $57,918/yr Shriners Hospitals for Children Title: Inhibition of

transcriptional coregulator phosphorylation in vivo.

2014-‐2017 ERA-‐RARE2 Jones (PI) $41,666/yr E-‐rare 2 JTC 2013 Title: IIH-‐ECC: Idiopathic Infantile Hypercalcemia: European-‐Canadian Consortium.

2014-‐2015 NIST Jones (PI) $15,000/yr $15,000/yr Title: Physiological role of 3-‐epi-‐1, 25(OH) 2D. TANZER 2014-‐2017 Development of a mechanically biomcompatible hip replacement implant with Ti-‐6Al-‐

4V open-‐cell microlattice architecture. Pasini,D and Co Investigator Tanzer, M. Canadian Institutes of Health Research. $158,665 April 2014 – September 2017.

2014 Unrestricted research grant, $90,000, Zimmer Inc. Principal Investigator Tanzer M. January 2014.

TURCOTTE 2014 Hybrid Image Analysis for Radiotherapy Primary Inst:. IM.EL NAQA C. Freeman, I.

Poon, J. Seuntjens, R. Turcotte CIHR $134,809\yr X 4 yrs. 2014-‐2019 Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Canadian Institutes of

Health Research Operating Grant Grant period: 01/10/2014 -‐ 30/09/2019 Funding amount: Total funding: $1,248,043.19 (CIHR, PSI Foundation, MSTS) Principal Investigator: Michelle Ghert Co -‐ Principal Investigator: Mohit Bhandari Co -‐ Investigators: M Anderson, T Balach, A Baptista, T Beckinsale, E Carmody,P Clarkson, M Clayer, J Cummings, B Deheshi, Y Doung, P Ferguson, M Galliserra, M Gebhardt, D Geller, M Goodman, Y Gortzak, R Grimer, G Guyatt, J Healey, W Hettwer, G Holt, M Isler, M Laitinen, B Miller, S Mottard, L Nystrom, T O’Shea, A Puri, L Randall, N Reimer, J Schwab, L Thabane, R Turcotte, K Weiss, J Werier, J Wunde.

WEBER 2014-‐2016 Research Institute of the McGill University Health Centre & Merck 2014 Research

Competition -‐ Translational approaches to injectable, cell based therapeutics towards curbing degenerative disc disease of the spine Principal Applicant $25,000 year 1 & 2 = $50,000 CAD September 2014-‐September 2016.

2014-‐2016 Canadian Cancer Society – Bone scaffolds as delivery systems for local controlled

release of anti-‐resorptive in bone metastasis treatment Principal Applicant $99,745 x 1 year, $99,965 x 1 year = $200,000 CAD February 2014-‐February 2016.

ZUKOR 2012-‐2016 CHIR Extended venous thromboembolism prophylaxis comparing Rivaroxaban to

aspirin following total hip and knee arthroplasty (EPCAT II)/ co-‐applicant.

APPENDIX 2

PEER REVIEWED PUBLICATIONS 2014



FACULTY OF MEDICINE

ANTONIOU

A. Hart, J.A. Khalil, A. Carli, O. Huk, D. Zukor, J. Antoniou. Blood Transfusion in Primary Total Hip and Knee Arthroplasty: Incidence, Risk Factors, and 30-‐Day Complication Rates. J Bone Joint Surg Am. 96(23):1945-‐51, 2014.

Carli A, Aoude A, Reuven A, Matache B, Antoniou J, Zukor DJ. Inconsistencies between navigation data

and radiographs in total knee arthroplasty are system-‐ dependent and affect coronal alignment. Can J Surg. 57(5):305-‐13, 2014.

Gerarduzzi C, He Q, Antoniou J, Di Battista JA. Quantitative phosphoproteomic analysis of signaling

downstream of the prostaglandin e2/g-‐protein coupled receptor in human synovial fibroblasts: potential antifibrotic networks. J Proteome Res. 13(11):5262-‐80, 2014.

Gerarduzzi C, He Q, Antoniou J, Di Battista JA. Prostaglandin E(2)-‐dependent blockade of actomyosin and

stress fibre formation is mediated through S1379 phosphorylation of ROCK2. J Cell Biochem. 115(9):1516-‐27, 2014.

Alaseem A, Madiraju P, Aldebeyan S, Noorwali H, Antoniou J, Mwale F. Naproxen induces type X

collagen expression in human bone marrow derived mesenchymal stem cells through the upregulation of 5-‐lipoxygenase. Tissue Eng Part A. 2014, On line.

Salem O, Wang HT, Alaseem AM, Ciobanu O, Hadjab I, Gawri R, Antoniou J, Mwale F. Naproxen affects

osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules. Arthritis Res Ther. 17;16(4):R152, 2014.

Nikolaou VS, Petit A, Khoury V, Blain-‐Pare E, Zukor DJ, Huk OL, Antoniou J. Magnetic resonance imaging

of painful metal-‐on-‐metal total hip replacement. Eur J Orthop Surg Traumatol. 2014. On line. R Gawri, P Önnerfjord, J Antoniou, J Ouellet, PJ Roughley, D Heinegard, F Mwale, L Haglund. Link-‐N is

cleaved by annulus fibrosus cells generating a product with retained biological activity. J Orthop Res. 2014. 32(9):1189-‐97, 2014.

Mwale F, Wang H, Roughley P, Antoniou J, Haglund L. Link N and MSCs can induce regeneration of the

early degenerate intervertebral disc. Tissue Eng. Part A. 20(21-‐22):2942-‐9, 2014. BARRALET B. Marelli, S.N. Nazhat, J.E. Barralet, Newly identified interfibrillar collagen crosslinking suppresses cell proliferation and remodeling, acccepted in Biomaterials. J. Drager , E.J. Harvey, J.E. Barralet, Hypoxia Signalling Manipulation for Bone Regeneration, accepted in Expert Reviews in Molecular Medicine. B. Marelli, C.E. Ghezzi, Y. L. Zhang, I. Rouiller, J.E. Barralet, S.N. Nazhat, Fibril Formation pH Controls Intrafibrillar Collagen Biomineralization In Vitro and In Vivo’, Biomaterials, 37C:252-‐ 259, 2014. Xu J, Strandman S, Barralet J, Cerruti M, Genipin-‐crosslinked catechol-‐chitosan mucoadhesive hydrogels for buccal drug delivery, Biomaterials, 37C:395-‐404, 2014.

Soliman G, Xu J, Zhang Y, Merle G, Cerruti M Barralet J, Hydrocaffeic acid-‐chitosan nanoparticles with enhanced stability, mucoadhesion and permeation properties, European Journal of Pharmaceutics and Biopharmaceutics, 88, 1026-‐1037, 2014. Tresguerres IF, Tamimi F, Eimar H, Barralet J, Torres J, Blanco L, Fernández-‐Tresguerres JA. Resveratrol as anti-‐aging therapy for age-‐related bone loss. Rejuvenation Res. 17, 5, 439-‐445, 2014. Tresguerres IF, Tamimi F, Eimar H, Barralet J, Torres J, Blanco L, Fernández-‐Tresguerres JA. Melatonin Dietary Supplement as an Anti-‐Aging Therapy for Age-‐Related Bone Loss, Rejuvenation Res. 17, 5, 341-‐346, 2014. Maria SM, Prukner C, Sheikh Z, Mueller F, Barralet JE, Komarova SV. Reproducible quantification of osteoclastic activity: Characterization of a biomimetic calcium phosphate assay. J Biomed Mater Res B Appl Biomater. 2014, 102(5):903-‐12. Bassett DC, Meszaros R, Orzol D, Woy M, Ling Zhang Y, Tiedemann K, Wondraczek L, Komarova S, Barralet JE. A new class of bioactive glasses: Calcium-‐magnesium sulfophosphates. J Biomed Mater Res A. 2014, 102(8):2842-‐8. Merle G, Fradette S, Madore E, Barralet JE Electropolymerized carbonic anhydrase immobilization for carbon dioxide capture. Langmuir. 2014; 30 (23):6915-‐9. G. Merle, D. C. Bassett, J. A. Finch, G. Demopoulos and J. E. Barralet Self-‐assembled photoactive heterojunction phase gradient, J. Mater. Chem. A, 2, 23, 8868-‐8874, 2014. G. Merle, M. Seon-‐Lutz, J H Lopes, J E. Barralet Hierarchical stable enzyme micro-‐environments for high temperature stability in amine solvents, Particle & Particle Systems Characterization, 31, 10, 1091-‐1096 2014. F. Tamimi, J. Torres, K. Al-‐Abedalla, E. Lopez-‐Cabarcos, M. H. Alkhraisat, D. C. Bassett, U. Gbureck, J. E. Barralet Osseointegration of dental implants in 3D-‐printed synthetic onlay grafts customized according to bone metabolic activity in recipient site Biomaterials, 35(21), 5436-‐5445, 2014. Geffers M, Barralet JE, Groll J, Gbureck U. Dual-‐setting brushite-‐silica gel cements, accepted in Acta Biomater. BENAROCH Makhdom AM, Jiang F, Hamdy RC, Benaroch TE, Lavigne M, Saran N. Hip joint osteochondroma: systematic review of the literature and report of three further cases. Adv Orthop. : Epub 2014 May 20, 2014 BERGERON Toussaint RJ, Bergeron SG, Weaver MJ, Tornetta P 3rd, Vrahas MS, Harris MB. The Effect of the Massachusetts Healthcare Reform on the Uninsured Rate of the Orthopaedic Trauma Population. The Journal of Bone & Joint Surgery, American Volume. 96(16): e141, 2014 Aug 20.

Research collaboration with Mitchel B. Harris, Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA. BURMAN Gohil,S., Martineau,P., Burman,M. : Anterior Cruciate Ligament reconstruction using an out to in femoral tunnel with flexible reamers -‐ A technical note. Techniques in Orthopedics (IN PRESS)

FREEMAN Evans MD, Hudon C, Podgorsak EB, Freeman CR. Institutional experience with a rotational total skin electron irradiation (RTSEI) technique-‐A three decade review (1981-‐2012). Rep Pract Oncol Radiother. 19(2): 120-‐34, 2014. Nguyen NTA, Roberge D, Freeman CR, Wong C, Hines J, Turcotte RE. Skin Elasticity as a Measure of Radiation Fibrosis: Is it Reproducible and Does it Correlate with Patient and Physician-‐reported Measures? Technology in Cancer Research & Treatment. 13(5): 469-‐76, 2014. Sarfehnia A, Poon E, Davis SD, Fleming A, Mitchell D, Freeman CR. A novel approach to total skin irradiation using helical TomoTherapy. Pract Radiat Oncol. 4(5): 330-‐5, 2014. Skamene S, Mitchell D, Abish S, Freeman CR. SHOULD FRACTIONATED FULL DOSE RADIOTHERAPY REMAIN THE STANDARD FOR TREATMENT OF METASTATIC SITES IN RHABDOMYOSARCOMA? Pediatric Blood & Cancer. 61: S224-‐S, 2014. Vallieres M, Freeman CR, Skamene S, El Naqa I. Early Assessment of Tumor Aggressiveness Using Joint FDG-‐PET/MR Textural Features. International Journal of Radiation Oncology Biology Physics. 90: S6-‐S7, 2014. GLORIEUX Veilleux LN, Lemay M, Pouliot-‐Laforte A, Cheung MS, Glorieux FH, Rauch F. Muscle Anatomy and Dynamic Muscle Function in Osteogenesis Imperfecta Type I. J Clin Endocrinol Metab. 99:E356-‐62, 2014. Fratzl-‐Zelman N, Schmidt I, Roschger P, Glorieux FH, Klaushofer K, Fratzl P, Rauch F, Wagermaier W. Mineral particle size in children with osteogenesis imperfecta type I is not increased independently of specific collagen mutations. Bone. 60:122-‐8, 2014. Palomo T, Glorieux FH, Rauch F. Circulating Sclerostin in Children and Young Adults with Heritable Bone Disorders. J Clin Endocrinol Metab. 99:E920-‐5, 2014. Farber CR, Reich A, Barnes AM, Becerra P, Rauch F, Cabral WA, Bae A, Quinlan A, Glorieux FH, Clemens TL, Marini JC. A Novel IFITM5 Mutation in Severe Atypical Osteogenesis Imperfecta Type VI Impairs Osteoblast Production of Pigment Epithelium-‐Derived Factor. J Bone Miner Res 29:1402-‐11, 2014. Fahiminiya S, Majewski J, Al-‐Jallad H, Moffatt P, Mort J, Glorieux FH, Roschger P, Klaushofer K, Rauch F. Osteoporosis Caused by Mutations in PLS3 -‐ Clinical and Bone Tissue Characteristics. J Bone Miner Res. 29:1805-‐14, 2014.

Glorieux FH, Pettifor JM. Vitamin D/dietary calcium deficiency rickets and pseudo-‐vitamin D deficiency rickets. Bonekey Rep. Mar 19; 3:524, 2014. Dogba MJ, Rauch F, Tre G, Glorieux FH, Bedos C. Shaping and managing the course of a child's disease: Parental experiences with osteogenesis imperfecta. Disabil Health J. 3:343-‐9, 2014. Takeyari S, Yamamoto T, Kinoshita Y, Fukumoto S, Glorieux FH, Michigami T, Hasegawa K, Kitaoka T, Kubota T, Imanishi Y, Shimotsuji T, Ozono K. Hypophosphatemic osteomalacia and bone sclerosis caused by a novel homozygous mutation of the FAM20C gene in an elderly man with a mild variant of Raine syndrome. Bone. 67:56-‐62, 2014. Palomo T, Al-‐Jallad H, Moffatt P, Glorieux FH, Lentle B, Roschger P, Klaushofer K, Rauch F. Skeletal Characteristics Associated with Homozygous and Heterozygous WNT1 Mutations. Bone. 67:63-‐70, 2014. Rauch F, Lalic L, Glorieux FH, Moffatt P, Roughley P. Targeted Sequencing of a Pediatric Metabolic Bone Gene Panel Using a Desktop Semiconductor Next-‐Generation Sequencer. Calcif Tissue Int. 95:323-‐31, 2014. Al-‐Jallad H, Palomo T, Moffatt P, Roughley P, Glorieux FH, Rauch F. Normal Bone Density and Fat Mass in Heterozygous SERPINF1 Mutation Carriers. J Clin Endocrinol Metab. 99: E2446-‐50, 2014. Gamsjaeger S, Hofstetter B, Fratzl-‐Zelman N, Roschger P, Roschger A, Fratzl P, Brozek W, Masic A, Misof BM, Glorieux FH, Klaushofer K, Rauch F, Paschalis EP. Pediatric reference Raman data for material characteristics of iliac trabecular bone. Bone. 69C:89-‐97, 2014. Dogba M, Rauch F, Wong T, Ruck J, Glorieux FH, Bedos C. From pediatric to adult care: strategic evaluation of a transition program for patients with osteogenesis imperfecta. BMC Serv Res. 14(1):489, 2014. Fratzl-‐Zelman N, Schmidt I, Roschger P, Roschger A, Glorieux FH, Klaushofer K, Wagermaier W, Rauch F, Fratzl P. Unique micro-‐ and nano-‐scale mineralization pattern of human osteogenesis imperfecta type VI bone. Bone. 73C:233-‐41, 2014. GOULDING Goulding KA Lopez Gaston CL, Grimer R.Outcomes and options for prosthetic reconstruction after tumour resection about the knee. Curr Surg Reports (2014) 2:42. Lopez Gaston CL, Goulding KA, Grimer R. The use of endoprostheses in musculoskeletal oncology Oper Tech (2014) 6. HAGLUND Rosenzweig DH, Quinn T, Haglund L. Low frequency high magnitude mechanical strain of articular chondrocytes activates p38 MAPK and induces phenotypic changes associated with osteoarthritis and pain, Int. J. Mol. Sci. 2014, 15, 14427-‐14441; doi:10.3390. Alkhatib B, Rosenzweig D, Krock E, Ouellet J, Weber M, Beckman L, Roughley P, Steffen T, and Haglund L, Loading of the IVD: Link to Degeneration and Pain, 19-‐Aug-‐2014, European Cells and Material.

Mulligan KR, Gawri R, SteffenT, Pike GB, Jarzem P, Borthakur A Haglund L and Ouellet J, Axial T1ρ MRI as a diagnostic imaging modality to quantify proteoglycan concentration in degenerative disc disease, June 2014, European Spine. Gawri R, Moir J, Ouellet J, Beckman L, AL Thukair R, Steffen T, Roughley P and Haglund L, Physiological loading can restore the proteoglycan content in Research a model of early IVD degeneration, Accepted June 2014 PLOS ONE. Gawri R, Ouellet J, Onnerfjord P, Alkhatib B, Heinegard D, Steffen T, Antoniou J, Mwale F Haglund L, Link N is cleaved by annulus fibrosus cells generating a product with retained biological activity, Journal of Orthopaedic Research, 2014, May 3. DOI 10.1002/jor.22653. Mwale F, Wang HT, Roughley P, Antoniou J, Haglund L, Link N and MSCs can induce regeneration of the early degenerate intervertebral disc., Tissue Engineering Part A, 2014 Apr, 30. Krock E, Rosenzweig DH, Chabot-‐Dore A-‐J, Jarzem P, Ouellet J, Stone LS, Haglund L, Degenerating and Painful Intervertebral Discs Secrete Pro-‐ inflammatory and Pro-‐nociceptive Factors that Stimulate PC12 Cells and Mouse DRG Neurons, Journal of Cell and Molecular Medicine, 2014 Mar 20. Gawri R, Rosenzweig DH, Krock E, Ouellet L, Stone LS, Quinn TM and Haglund L, High Mechanical Loading of Primary Intervertebral Disc Cells Initiates Secretion of Inflammatory Factors Associated with Disc Degeneration and Pain, Arthritis Research and Therapy. 2014 Jan 23; 16(1):R21. HAMDY Alzahrani MM, Anam EA, Makhdom AM, Villemure I, Hamdy RC 2014. The effect of altering the mechanical loading environment on the expression of bone regenerating molecules in cases of distraction osteogenesis. Front Endocrinol (Lausanne). 2014 Dec 10; 5:214. Hamdy RC. 2014 CORR Insights®: How Do Different Anterior Tibial Tendon Transfer Techniques Influence Forefoot and Hindfoot Motion? Clin Orthop Relat Res. 2014 Dec 13. Nayef L., Rendon J. S., Matthys R., Hamdy R., Tabrizian M., 2014 Liposome-‐Encapsulated Quantum Dots for Imaging of a Rat Model of Distraction Osteogenesis Journal of Nanopharmaceutics and Drug Delivery. In Press. Parent A, Pouliot-‐Laforte A, Laberge M, Hamdy R, Rochelle R, Ballaz L. 2014 Articulated vs. fixed carbon-‐fibre prosthesis after transmetatarsial amputation: a case study. Comput Methods Biomech Biomed Engin. 2014 Aug; 17 Suppl 1:106-‐7. Reggie Hamdy, Montpetit Kathleen, Aiona Michael,William MacKenzie, vanBosse JP Harold, 2014 Unni Narayanan, Ellen M Raney, Ross Chafetz, Susan Sienko Thomas,Shannon Weir, Shelley Gregory, Petya Yorgova, Susan Takahashi, Mario Rinaldi, Xun Zhang,Noémi Dahan-‐Oliel: Safety and efficacy of botulinum toxin A in children undergoing lower limb lengthening and deformity correction: results of a double-‐blind, multicenter, randomized controlled trial"J Paediatr Orthop. Accepted. In Press.

Makhdom A, Jiang F, Hamdy R, Benaroch T, Lavigne M, Saran N 2014 Hip Joint Osteochondroma; Systematic Review of The Literature and Report of Three Further Cases, Advances in Orthopaedics. 2014: 180254. Hamdy, C.R., Makdom,A., Saran, N., Birch,J.: 2014 Congenital Fibular Deficiency Journal of the American Academy of Orthopaedic Surgeons Apr; 22(4): 246-‐55. Carli, A., Leblanc, E., Amitai,A., Hamdy, R.C. : 2014 The Evaluation and Management of Pediatric Tarsal CoalitionsJ Bone Joint Surg : Reviews, August issue, Vol. 2, Issue 8. Makhdom, AM, Rauch, F., Lauzier D, Hamdy, RC. : The Effect of Systemic Administration of Sclerostin Antibody in a mouse 2014 Model of Distraction Osteogenesis Journal of Musculoskeletal and Neuronal Interactions. March 14 (1), 124-‐130. HARVEY Distal ulna fractures: A biomechanical comparison of locking versus non-‐locking constructs. Collins M*, Hart A*, Hines J*, Steffen T, Harvey EJ, Martineau PA. J Orthop Trauma. August 2014 -‐ Volume 28 -‐ Issue 8: 470-‐75. PMID: 24121982 / doi: 10.1097/BOT.0000000000000021. Scapula fractures: interobserver reliability of classification and treatment. Neuhaus V, et al J Orthop Trauma. 2014 Mar; 28(3):124-‐9. doi: 10.1097/BOT.0b013e31829673e2. The Medical and Surgical Management of ARCO Stage I and II Osteonecrosis of the Femoral Head. Carli A*, Albers A*, Seguin C, Harvey EJ#. JBJS Reviews. 2014 Feb; 2 (2): e2. Radiographic Loss of Contact Between Radial Head Fracture Fragments Is Moderately Reliable. Bruinsma WE et al Clin Orthop Relat Res. 2014 Apr 8. [Epub ahead of print]. Factors Affecting Relative Age Effect in NHL Athletes CI Parent-‐Harvey#, C Desjardins#, EJ Harvey* Can J Surgery, 2014 June; 57(3): 157-‐61 PMID: 24869606. Attempting primary closure for all open fractures: the effectiveness of an institutional protocol. Moola F*, Carli A*, Berry GK, Reindl R, Jacks D*, Harvey EJ#. Can J Surg. 2014 Jun; 57(3): E82-‐E88. PMID: 24869621. Can the Use of Variable-‐Angle Volar Locking Plates Compensate for Suboptimal Plate Positioning in Unstable Distal Radius Fractures? A Biomechanical Study. Hart A*, Collins M*, DC Forum, Steffen T, Harvey EJ, Martineau PA. J Orthop Trauma. 2014 [Epub ahead of print] PMID: 24786734. Management of femoral neck fractures in the young patient: A critical analysis review. Pauyo T*, Drager J*, Albers A*, Harvey EJ#. World J Orthop 2014; 5(3): 204-‐217 DOI: http://dx.doi.org/10.5312/wjo.v5.i3.204. Interobserver Variability in the Treatment of Little Finger Metacarpal Neck Fractures Tosti R, et al J Hand Surg Am. Sep; 39 (9): 1722-‐7. doi: 10.1016/j.jhsa.2014.05.023. Burn Management in Orthopaedic Trauma-‐A Critical Analysis Review SM AlQahtani, MD, MSc; MM Alzahrani, MD, MSc; A Carli, MD, MSc; EJ Harvey, MD, MSc JBJS Reviews, 2014 Oct;2(10):e4. http://dx.doi.org/10.2106/JBJS.RVW.N.00010.

Treatment with Acetylsalicylic Acid (Aspirin) Prevents Short-‐To-‐Mid Term Radiographic Progression of Non-‐Traumatic Osteonecrosis of the Femoral Head B. Routy, A. Albers, A. Carli, E.J. Harvey, C. Seguin Thrombosis Research 05/2014; 133:S51-‐S52. DOI: 10.1016/S0049-‐ 3848(14)50171-‐5. HENDERSON Z. Jabbour, M. El-‐Hakim, J.E. Henderson, R. F de Albuquerque Jr 2014 Bisphosphonates inhibit bone remodeling in the jaw bones of rats and delay healing following tooth extractions Oral Oncology v50, p485-‐490 (RSBO). S. Salem, C. Gao, A. Li, H. Wang, L. Nguyen-‐Yamamoto, D. Goltzman, J.E. Henderson, P Gros 2014 A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism J Cell Mol Med (online June 2014) (CIHR). D.A. Behrends, L. Cheng, M.B. Sullivan, M.H. Wang, G.B. Roby, N. Zayed, C. Gao, J.E. Henderson and P.A. Martineau 2014 Defective bone repair in mast cell deficient mice with c-‐ Kit loss of function. E. Cells & Materials v28, p209-‐222 (CIHR, RSBO). Sachs AJ, Babu H, Su YF, Miller KJ, Henderson JM. 2014; 17(4):303-‐10; discussion 10-‐1. Lack of efficacy of motor cortex stimulation for the treatment of neuropathic pain in 14 patients. Neuromodulation. 174: 303-‐10; discussion 10-‐1., 2014. HUK A. Hart, J.A. Khalil, A. Carli, O. Huk, D. Zukor, J. Antoniou. Blood Transfusion in Primary Total Hip and Knee Arthroplasty: Incidence, Risk Factors, and 30-‐Day Complication Rates. J Bone Joint Surg Am. 96(23):1945-‐51, 2014. Carli A, Politis A, Zukor D, Huk O, Antoniou J. Clinically significant corrosion at the head-‐neck taper interface in total hip arthroplasty: a systematic review and case series. Hip Int. Oct., 2014 Nikolaou VS, Petit A, Khoury V, Blain-‐Pare E, Zukor DJ, Huk OL, Antoniou J. Magnetic resonance imaging of painful metal-‐on-‐metal total hip replacement. Eur J Orthop Surg Traumatol. 2014. On line. A Reuven, GN Manoudis, A Aoude, OL Huk, D Zukor, J Antoniou. Clinical and Radiological Outcome of the Newest Generation of Ceramic-‐on-‐Ceramic Hip Arthroplasty in Young Patients. Advances in Orthopedic Surgery, 2014, Article ID 863748, 6 pages, 2014. JANELLE Saad Mohammed Al Qahtani, Anthony Bozzo, Reggie Hamdy, Chantal Janelle. Slipped Capital Femoral Epiphysis in a Healthy 5-‐year-‐old child: A Case Report with 3 year follow-‐up and literature review. Saudi Journal of Medicine & Medical Sciences. Vol 2 – Issue 2 -‐ ; 117-‐119. 2014. JARZEM Richard Assaker*†, Karsten Ritter-‐Lang*, Dominique Vardon, Stéphane Litrico, Stéphane Fuentes, Michael Putzier, Jörg Franke, Peter Jarzem, Pierre Guigui, Gérard Nakach, Jean-‐Charles Le Huec,

Maverick Total Disc Replacement in a real-‐world patient population: A prospective, multicentre, observational study, European Spine Journal, June 2014. Krock E, Rosenzweig D, Chabot-‐Dore A, Jarzem P, Weber M, Ouellet J, et al. Painful, degenerating intervertebral discs up-‐regulate neurite sprouting and CGRP. J Cell Mol Med. 19(6): 1213-‐25, 2014. Waleed Awwad, Mahdi Bassi, Peter Barriga, Ian Shrier .Peter F Jarzem, Mitigating the Spinal Cord Distraction Injury: The In-‐Vitro effect of durotomy in decreasing Cord Interstitial pressure, European J of Orthopedic Surgery and Traumatology, 2014 MARTINEAU Mellema JJ, Doornberg JN, Guitton TG, Ring D, Martineau PA et al. * Biomechanical Studies: Science (f) or Common Sense? * As part of Science of Variation Group. Injury, 2014, 45(12): 2035-‐9. Behrends DA, Cheng L, Sullivan MB, Wang MH, Roby GB, Zayed N, Gao C, Henderson JE, Martineau PA. Defective Bone Repair in Mast Cell Deficient Mice with c-‐Kit Loss of Function. Eur Cell Mater, 2014, 28(10): 209-‐221. Doring AC, Hageman MG, Mulder FJ, Guitton TG, Ring D, Martineau PA et al. * Trigger Finger: Assessment of Surgeon and Patient Preferences and Priorities for Decision Making. * As part of Science of Variation Group. Journal of Hand Surgery Am., 2014, 39(10): 1152-‐6. Hageman MG, Kinaci A, Ju K, Guitton TG, Mudgal CS, Ring D, Martineau PA et al. * Carpal Tunnel Syndrome: Assessment of Surgeon and Patient Preferences and Priorities for Decision-‐ making. * As part of Science of Variation Group. Journal of Hand Surgery Am., 2014, 39(9): 1799-‐1804. Tosti R, Ilyas AM, Mellema JJ, Guitton TG, Ring D, Martineau PA et al. * Interobserver Variability in the Treatment of Little Finger Metacarpal Neck Fractures. * As part of Science of Variation Group. Journal of Hand Surgery Am., 2014, 39(9): 1722-‐7. Han Y, Hart A, Martineau PA. Is the Clock Face an Accurate, Reliable and Precise Measuring Tool for ACL Reconstruction? Journal of Arthroscopy, 2014, 30(7): 849-‐55. Hart A, Collins M, Chaatwal D, Steffen T, Harvey EJ, Martineau PA. Can the use of variable angle volar locking plates compensate for suboptimal plate positioning in unstable distal radius fractures? Journal of Orthopaedic Trauma, 2014 [Epub ahead of print]. AlSheihk K, Behrends D, Cota A, Martineau PA. A cadaveric analysis of flexible versus rigid instrumentation in a single-‐incision distal biceps tendon repair. Journal of Arthroscopy, 2014, 30(5): 561-‐567. Neuhaus V, Bot AG, Guitton TG, Ring D, Martineau PA, et al.* Scapula Fractures: Interobserver Reliability of Classification and Treatment. * As part of Science of Variation Group. Journal of Orthopaedic Trauma, 2014, 38(5): 856-‐62.

MORIN Pitzul KB, Munce SE, Perrier L, Beaupre L, Morin SN, McGlasson R, Jaglal SB. Quality indicators for hip fracture patients: a scoping review protocol. BMJ Open. 2014 Oct 21; 4(10):e006543. PMID: 25335964. Leslie WD, Morin SN, Lix LM, Majumdar SR. Does diabetes modify the effect of FRAX risk factors for major osteoporotic and hip fracture prediction? Osteoporos Int. Dec 2014; 25(12): 2817-‐2824. Leslie WD, Aubry-‐Rozier B, Lix LM, Morin SN, Majumdar SR, Hans D, Spine Bone Texture Assessed by Trabecular Bone Score (TBS) Predicts Osteoporotic Fractures in Men: The Manitoba Bone Density Program. Bone 2014 Oct; 67: 10-‐14. Kennedy CC, Thabane L, Ioannidis G, Adachi R, Papaioannou A, on behalf of the ViDOS Investigators. Implementing a Knowledge Translation Intervention in Long-‐term Care: Feasibility Results from the Vitamin D and Osteoporosis Study (ViDOS). J Am Med Dir Assoc. Dec 2014; 15(12): 943-‐945. PMID: 24953541. Leslie WD, Morin SN. Osteoporosis Epidemiology 2013: Implications for Diagnosis, Risk Assessment and Treatment. Curr Opin Rheumatol. Jul 2014; 26(4): 440-‐446. PMID: 24807402. Leslie WD, Orwoll ES, Nielson CM, Morin SN, Majumdar SR, Johansson H, Odén A, McCloskey EV, Kanis JA. Lean Mass and Fat Mass Differentially Affect Femoral Bone Density and Strength Index in Women and Men But Are Not FRAX Independent Risk Factors for Fracture. J Bone Miner Res. Nov 2014; 29(11): 2511-‐2519. PMID: 24825359. Leslie WD, Majumdar SR, Lix LM, Morin SN, Johansson H, Oden A, McCloskey E, Kanis JA. Can Change in FRAX Score Be Used to “Treat-‐to-‐Target”? A Clinical Feasibility Study. J Bone Miner Res. May 2014; 29(5):1074-‐1080. PMID: 24877235. Brown JP, Morin S, Leslie WD, Papaioannou A, Cheung AM, Davison KS, Goltzman D, Hanley DA, Hodsman AB, Josse RG, Jovaisas A, Juby AG, Kaiser SM, Karaplis A, Kendler DL, Khan AA, Ngui D, Olszynski WP, Ste-‐Marie LG, Adachi JD. Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms and drug holidays. Can Fam Physician. Apr 2014; 60(4):324-‐333. PMID: 24733321. Riverin B, Dewailly E, Côté S, Johnson-‐Down L, Morin S, Dodin S. Prevalence of vitamin D insufficiency in healthy school-‐age Cree children. Paediatr Child Health. 2014 Mar; 19(3):e15-‐9. PMID: 24665228. Morin SN, Lix LM, Leslie WD. The Importance of Previous Fracture Site on Osteoporosis Diagnosis and Incident Fractures in Women. J Bone Miner Res. 2014 Jul; 29(7):1675-‐80. PMID: 24535832. Lam A, Leslie WD, Lix LM, Yogendran M, Morin SN, Majumdar SR. Major Osteoporotic to Hip Fracture Ratios in Canadian Men and Women with Swedish Comparisons: A Population Based Analysis. J Bone Miner Res. May 2014; 29(5): 1067-‐1073. PMID: 24243719. Leslie WD, Lix LM, Yogendran M, Morin SN, Metge CJ, Majumdar SR. Temporal Trends in Obesity, Osteoporosis Treatment, Bone Mineral Density and Fracture Rates: A Population-‐Based historical cohort study. J Bone Miner Res. 2014 Apr; 29(4):952-‐9. PMID: 24115100.

MORT Roughley, P.J., Geng, Y. and Mort, J.S. (2014). The non-‐aggregating aggrecan in the human intervertebral disc can arise by a non-‐proteolytic mechanism. Eur. Cell. Mater. 28, 129-‐136. Fahiminiya, S., Majewski, J., Al-‐Jallad, H., Moffatt, P., Mort, J., Glorieux, F.H., Roschger, P., Klaushofer, K. and Rauch, F. (2014) Heritable bone fragility caused by mutations in PLS3 -‐ clinical and bone tissue characteristics. J. Bone Miner. Res. 29, 1805-‐1814. Ho, Y.Y., Baron, M., Recklies, A.D., Roughley, P.J. and Mort, J.S. (2014) Cells from the skin of patients with systemic sclerosis secrete chitinase-‐like protein 1. BBA Clinical 1, 2-‐11. MWALE Risbud MV, Schoepflin ZR, Mwale F, Kandel RA, Grad S, Iatridis JC, Sakai D, Hoyland JA. Defining the Phenotype of Young Healthy Nucleus Pulposus Cells: Recommendations of the Spine Research Interest Group at the 2014 Annual ORS Meeting. J Orthop Res. 2014 Nov 20. [Epub ahead of print]. Tchetina EV, Mwale F, Poole AR. Changes in gene expression associated with matrix turnover, chondrocyte proliferation and hypertrophy in the bovine growth plate. Acta Naturae. 6(3):89-‐97, 2014. Mwale F. Syndecan-‐4 Signaling and Intervertebral Disc Degeneration. Am J Pathol. 184(9):2371-‐3, 2014. Salem O, Wang HT, Alaseem AM, Ciobanu O, Hadjab I, Gawri R, Antoniou J, Mwale F. Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules. Arthritis Res Ther. 16(4):R152, 2014. R Gawri, P Önnerfjord, J Antoniou, J Ouellet, PJ Roughley, D Heinegard, F Mwale, L Haglund. Link-‐N is cleaved by annulus fibrosus cells generating a product with retained biological activity. J Orthop Res. 32(9):1189-‐97, 2014. Mwale F, Wang H, Roughley P, Antoniou J, Haglund L. Link N and MSCs can induce regeneration of the early degenerate intervertebral disc. Tissue Eng. Part A. 20(21-‐22):2942-‐9, 2014. OUELLET Krock E*., Rosenzweig D.H., Chabot-‐Dore A.J., Jarzem P., Weber M.H., Ouellet J.A., Stone L.S. Haglund L. Degenerating and painful human intervertebral discs release pronociceptive factors and increase neurite sprouting and CGRP via nerve growth factor. Global Spine Journal 4.S01:or2-‐04. 2014 DOI: 10.1055/s-‐0034-‐1376539. Alkhatib B*., Rosenzweig D.H., Krock E., Roughley P.J., Beckman L., Steffen T., Weber M.H., Ouellet J.A., Haglund L. Acute mechanical injury of the human intervertebral disc link to degeneration and pain. Eur Cell Mater. Sep 12;28:98-‐111, 2014. PMID: 25214017. Mulligan K.R*., Ferland C.E., Gawri R., Borthakur A., Haglund L., Ouellet J.A. Axital T1p MRI as a diagnostic imaging modality to quantify proteoglycan concentration in degenerative disc disease. Eur. Spine J. Sept 19 (Epub ahead of print) 2014. PMID: 25236594.

Gawri R*., Ouellet J., Onnerfjord P., Heinegard D., Steffen T., Antoniou J., Mwali F, Haglund L. Link N is Cleaved by Human annulus fibrosus cells generating a fragment with Retained Biological activity. J Orthop. Res. Sep; 32(9):1189-‐97 2014. PMID: 24861010. Gawri R*., Moir J., Ouellet J., Beckman L., Steffen T., Roughley P., Haglund L. Physiological loading can restore the proteoglycan content in a model of early IVD degeneration. PLoS One. Jul 3:9(7):e101233 2014. PMID: 24861010. Alkhatib B*., Rosenzweig D.H., Krock E., Roughley P.J., Beckman L., Steffen T., Weber M.H., Ouellet J.A., Haglund L. Acute mechanical injury of the human intervertebral disc: link to degeneration and pain. European Cells and Materials. July-‐December 2014 Vol 28;(1):98-‐111. Awwad W, Al-‐Ahaideb A*, Jiang L, Algarni AD, Ouellet J, Harold MU, Arlet V. Correction of severe pelvic obliquity using maximum-‐width segmental sacropelvic screw fixation: an analysis of 20 neuromuscular scoliosis patients. Eur J Orthop Surg Traumatol. May 6, 2014. PMID: 24799089. Krock E.*, Rosenzweig D.H., Chabot-‐Doré A.J., Jarzem P., Weber M.H., Ouellet J.A., Stone L.S., Haglund L. Painful, degenerative intervertebral discs up-‐regulate neurite sprouting and CGRP through nociceptive factors. J Cell Mol Med. Mar; 20: 2014. PMID 24650225. Gawri R.*, Rosenzweig D.H., Ouellet J.A., Stone L.S., Quinn T.M., Haglund L. High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain. Arthritis Res. Ther., Jan; 16(2) R21:2014. PMID 24457003. RAUCH Maman Dogba, Frank Rauch, Erin Douglas, Christophe Bedos (2014) Impact of three genetic musculoskeletal diseases: a comparative synthesis of achondroplasia, Duchenne muscular dystrophy and osteogenesis imperfecta. Health and quality of life outcomes 12: 1. Oct. Cristina Avela, Heljä Hirvinen, Mouna Ben Amor, Frank Rauch (2014) Metaphyseal dysplasia with maxillary hypoplasia and brachydactyly in a Finnish woman: first confirmation of a duplication in RUNX2 as pathogenic variant. European journal of medical genetics 57: 11-‐12. 617-‐620 Nov/Dec. S Gamsjaeger, B Hofstetter, N Fratzl-‐Zelman, P Roschger, A Roschger, P Fratzl, W Brozek, A Masic, B M Misof, F H Glorieux, K Klaushofer, F Rauch, E P Paschalis (2014) Pediatric reference Raman data for material characteristics of iliac trabecular bone. Bone 69: 89-‐97 Dec. Hadil Al-‐Jallad, Telma Palomo, Pierre Moffatt, Peter Roughley, Francis H Glorieux, Frank Rauch (2014) Normal bone density and fat mass in heterozygous SERPINF1 mutation carriers. The Journal of clinical endocrinology and metabolism 99: 11. E2446-‐E2450 Nov. Maman Joyce Dogba, Frank Rauch, Trudy Wong, Joanne Ruck, Francis H Glorieux, Christophe Bedos (2014) From pediatric to adult care: strategic evaluation of a transition program for patients with osteogenesis imperfecta. BMC health services research 14: 10. Frank Rauch, Liljana Lalic, Francis H Glorieux, Pierre Moffatt, Peter Roughley (2014) Targeted sequencing of a pediatric metabolic bone gene panel using a desktop semiconductor next-‐generation sequencer. Calcified tissue international 95: 4. 323-‐331 Oct.

Telma Palomo, Hadil Al-‐Jallad, Pierre Moffatt, Francis H Glorieux, Brian Lentle, Paul Roschger, Klaus Klaushofer, Frank Rauch (2014). Skeletal characteristics associated with homozygous and heterozygous WNT1 mutations. Bone 67: 63-‐70 Oct. Andreas Roschger, Paul Roschger, Petra Keplingter, Klaus Klaushofer, Sami Abdullah, Michaela Kneissel, Frank Rauch (2014) Effect of sclerostin antibody treatment in a mouse model of severe osteogenesis imperfecta. Bone 66: 182-‐188 Sep. Maman Joyce Dogba, Frank Rauch, Ghislaine Tre, Francis H Glorieux, Christophe Bedos (2014) Shaping and managing the course of a child's disease: Parental experiences with osteogenesis imperfecta. Disability and health journal 7: 3. 343-‐349 Jul. A Pouliot-‐Laforte, L N Veilleux, F Rauch, M Lemay (2014) Validity of an accelerometer as a vertical ground reaction force measuring device in healthy children and adolescents and in children and adolescents with osteogenesis imperfecta type I. Journal of musculoskeletal & neuronal interactions 14: 2. 155-‐161 Jun. C Caouette, F Rauch, I Villemure, P -‐ J Arnoux, M Gdalevitch, L -‐ N Veilleux, J L Heng, C -‐ E Aubin (2014) Biomechanical analysis of fracture risk associated with tibia deformity in children with osteogenesis imperfecta: a finite element analysis. Journal of musculoskeletal & neuronal interactions 14: 2. 205-‐212 Jun. Telma Palomo, Francis H Glorieux, Frank Rauch (2014). Circulating sclerostin in children and young adults with heritable bone disorders. The Journal of clinical endocrinology and metabolism 99: 5. E920-‐E925 May. V Phan, T Blydt-‐Hansen, J Feber, N Alos, S Arora, S Atkinson, L Bell, C Clarson, R Couch, E A Cummings, G Filler, R M Grant, J Grimmer, D Hebert, B Lentle, J Ma, M Matzinger, J Midgley, M Pinsk, C Rodd, N Shenouda, R Stein, D Stephure, S Taback, K Williams, F Rauch, K Siminoski, L M Ward (2014) Skeletal findings in the first 12 months following initiation of glucocorticoid therapy for pediatric nephrotic syndrome. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 25: 2. 627-‐637 Feb. Louis-‐Nicolas Veilleux, Martin Lemay, Annie Pouliot-‐Laforte, Moira S Cheung, Francis H Glorieux, Frank Rauch (2014) Muscle anatomy and dynamic muscle function in osteogenesis imperfecta type I. The Journal of clinical endocrinology and metabolism 99: 2. E356-‐E362 Feb. Nadja Fratzl-‐Zelman, Ingo Schmidt, Paul Roschger, Francis H Glorieux, Klaus Klaushofer, Peter Fratzl, Frank Rauch, Wolfgang Wagermaier (2014) Mineral particle size in children with osteogenesis imperfecta type I is not increased independently of specific collagen mutations. Bone 60: 122-‐128 Mar. A M Makhdom, F Rauch, D Lauzier, R C Hamdy (2014) The effect of systemic administration of sclerostin antibody in a mouse model of distraction osteogenesis. Journal of musculoskeletal & neuronal interactions 14: 1. 124-‐130 Mar. Charles R Farber, Adi Reich, Aileen M Barnes, Patricia Becerra, Frank Rauch, Wayne A Cabral, Alison Bae, Aaron Quinlan, Francis H Glorieux, Thomas L Clemens, Joan C Marini (2014) A novel IFITM5 mutation in severe atypical osteogenesis imperfecta type VI impairs osteoblast production of pigment epithelium-‐

derived factor. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 29: 6. 1402-‐1411 Jun. Alexa Patoine, Marie-‐Hélène Gaumond, Prashant K Jaiswal, François Fassier, Frank Rauch, Pierre Moffatt (2014) Topological mapping of BRIL reveals a type II orientation and effects of osteogenesis imperfecta mutations on its cellular destination. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 29: 9. 2004-‐2016 Sep. Somayyeh Fahiminiya, Jacek Majewski, Hadil Al-‐Jallad, Pierre Moffatt, John Mort, Francis H Glorieux, Paul Roschger, Klaus Klaushofer, Frank Rauch (2014) Osteoporosis caused by mutations in PLS3: clinical and bone tissue characteristics. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 29: 8. 1805-‐1814 Aug. REINDL A Pilot Evaluation of the Role of Bracing in Stable Thoracolumbar Burst Fractures Without Neurological Deficit, Shamji, MF; Roffey, DM.; Young, DK; Reindl, R; Wai, EK, Journal of Spinal Disorders & Techniques: October 2014 -‐ Volume 27 -‐ Issue 7 -‐ p 370 – 375. Circumferential Casting of Distal Radius Fractures Drager J,Carli A, Matache B, Berry G,Reindl R, MD,Harvey E, J Orthop Trauma 2014. ROUGHLEY Al-‐Jallad H, Palomo T, Moffatt P, Roughley P, Glorieux FH, Rauch F. Normal bone density and fat mass in heterozygous SERPINF1 mutation carriers. J Clin Endocrinol Metab. 99(11): E2446-‐50, 2014. Alkhatib B, Rosenzweig DH, Krock E, Roughley PJ, Beckman L, Steffen T, et al. Acute mechanical injury of the human intervertebral disc: link to degeneration and pain. Eur Cell Mater. 28: 98-‐110; discussion -‐1, 2014. Gawri R, Moir J, Ouellet J, Beckman L, Steffen T, Roughley P, et al. Physiological loading can restore the proteoglycan content in a model of early IVD degeneration. PLoS One. 97: e101233, 2014. Illien-‐Junger S, Lu Y, Purmessur D, Mayer JE, Walter BA, Roughley PJ, et al. Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model. Spine J. 14(11): 2724-‐32, 2014. Mwale F, Wang HT, Roughley P, Antoniou J, Haglund L. Link N and mesenchymal stem cells can induce regeneration of the early degenerate intervertebral disc. Tissue Eng Part A. 20(21-‐22): 2942-‐9, 2014. Nasto LA, Ngo K, Leme AS, Robinson AR, Dong Q, Roughley P, et al. Investigating the role of DNA damage in tobacco smoking-‐induced spine degeneration. Spine J 14(3): 416-‐23, 2014. Rauch F, Lalic L, Glorieux FH, Moffatt P, Roughley P. Targeted sequencing of a pediatric metabolic bone gene panel using a desktop semiconductor next-‐generation sequencer. Calcif Tissue Int. 95(4): 323-‐31, 2014.

Roughley PJ, Geng Y, Mort JS. The non-‐aggregated aggrecan in the human intervertebral disc can arise by a non-‐proteolytic mechanism. Eur Cell Mater. 28: 129-‐36, 2014. Sivan SS, Wachtel E, Roughley P. Structure, function, aging and turnover of aggrecan in the intervertebral disc. Biochim Biophys Acta. 1840(10): 3181-‐9, 2014. Tio L, Martel-‐Pelletier J, Pelletier JP, Bishop PN, Roughley P, Farran A, et al. Characterization of opticin digestion by proteases involved in osteoarthritis development. Joint Bone Spine. 81(2): 137-‐41, 2014. Gawri, R., Ouellet, J., Onnerfjord, P., Alkhatib, B., Steffen, T., Heinegård, D., Roughley, P., Antoniou, J., Mwale, F. and Haglund, L. Link N is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity. J. Orthop. Res., 32, 1189-‐1197, 2014. Ho, Y.Y., Baron, M., Recklies, A.D., Roughley, P.J. and Mort, J.S. Cells from the skin of patients with systemic sclerosis secrete chitinase 3-‐like protein 1. Biochim. Biophys. Acta Clin., 1, 2-‐ 11, 2014. Roughley, P.J. and Mort, J.S. The role of aggrecan in normal and osteoarthritic cartilage. J. Exp. Orthop., 1, 8, 2014. Zhang, Y., Vasheghani, F., Li, Y.H., Blati, M., Simeone, K., Fahmi, H., Lussie,r B., Roughley, P., Lagares, D., Pelletier, J.P., Martel-‐Pelletier, J. and Kapoor, M. Cartilage-‐specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. Ann. Rheum. Dis., in press, 2014. [doi: 10.1136/annrheumdis-‐2013-‐204599]. SARAN Ferland C, Bote S, Mac-‐Thiong J, Saran N, Stone L, Ouellet J, et al. Identification of pen-‐operative pain-‐related biomarkers for adolescent spine surgery. Journal of Pain. 15(4): S94-‐S, 2014. Hamdy RC, Makhdom AM, Saran N, Birch J. Congenital Fibular Deficiency. Journal of the American Academy of Orthopaedic Surgeons. 22(4): 246-‐55, 2014. Makhdom AM, Jiang F, Hamdy RC, Benaroch TE, Lavigne M, Saran N. Hip joint osteochondroma: systematic review of the literature and report of three further cases. Adv Orthop. : Epub 2014 May 20, 2014. Makhdom AM, Khishta W, Saran N, Azouz M, Fassier F, “Are Fassier-‐Duval Rods at Risk of Migration in Patients Undergoing Spine Magnetic Resonance Imaging? J. Pediatr Orthop. 2014 Jul 29 [Epub ahead of print]. SEGUIN Damlaj M, Séguin C. Refractory Autoimmune haemolytic Anemia in a Patient with Di George Syndrome Treated Successfully with Plasma Exchange: A case report and review of the literature. IJH, 2014 Nov; 100(5): 494-‐7. Carli A, Albers A, Séguin C, Harvey EJ. The Medical and Surgical Management of ARCO Stage I and II Osteonecrosis of the Femoral Head. JBJS Reviews, 2014 (Feb); 2(2); 1-‐10.

ST. ARNAUD Hekmatnejad, B., V. Mandic, V.W.C. Yu, O. Akhouayri, A. Arabian, and R. St-‐Arnaud. 2014. Altered gene dosage confirms the genetic interaction between FIAT and NAC. Gene 538: 328-‐333. Pellicelli, M., J.A. Miller, A. Arabian, C. Gauthier, O. Akhouayri, J.Y. Wu, H.M. Kronenberg, and R. St-‐Arnaud. 2014 The PTH-‐Gs-‐PKA cascade controls NAC localization to regulate bone mass. Mol. Cell. Biol. 34: 1622-‐ 1633. Kaufmann, M., C. Gallagher, M. Peacock, K.-‐P. Schlingmann, M. Konrad, H.F. DeLuca, R. Sigueiro, B. Lopez, A. Mourino, M. Maestro, R. St-‐Arnaud, J. Finkelstein, D.P. Cooper, and G. Jones. 2014. Clinical utility of simultaneous quantification of 25-‐hydroxyvitamin D & 24, 25-‐ dihydroxyvitamin D by LC-‐MS/MS involving derivatization with DMEQ-‐TAD. J. Clin. Endocrinol. Metab. 99: 2567-‐2574. Choudhury, S., S. Bae, Q. Ke, J.Y. Lee, S.S. Singh, R. St-‐Arnaud, F. del Monte, and P.M. Kang. 2014. Abnormal calcium handling and exaggerated cardiac dysfunction in mice with defective vitamin D signaling. PLoS ONE 9(9): e108382. doi:10.1371/journal.pone.0108382. El-‐Hoss J, Arabian A, Dedhar S, St-‐Arnaud R. Inactivation of the Integrin-‐Linked Kinase (ILK) in osteoblasts increases mineralization. Gene 533(1): 246-‐52, 2014. Hekmatnejad B, Akhouayri O, Jafarov T, St-‐Arnaud R. Journal of Cellular Biochemistry. SUMOylated alpha NAC Potentiates Transcriptional Repression by FIAT. Journal of Cellular Biochemistry. 115(5): 866-‐73, 2014. Jones G, Kaufmann M, Schlingmann KP, St-‐Arnaud R, Rodd C. THE DELICATE BALANCE OF CYP27B1 AND CYP24A1 IN ENSURING OPTIMAL 1,25-‐(OH)(2)D-‐3 CONCENTRATIONS FOR HUMAN HEALTH. Anticancer Research. 34(4): 2044-‐, 2014. STEFFEN Alkhatib B, Rosenzweig DH, Krock E, Roughley PJ, Beckman L, Steffen T, et al. Acute mechanical injury of the human intervertebral disc: link to degeneration and pain. Eur Cell Mater. 28: 98-‐110; discussion -‐1, 2014. Gawri R, Moir J, Ouellet J, Beckman L, Steffen T, Roughley P, et al. Physiological loading can restore the proteoglycan content in a model of early IVD degeneration. PLoS One. 97: e101233, 2014. Gawri R, Ouellet J, Onnerfjord P, Alkhatib B, Steffen T, Heinegard D, et al. Link N is Cleaved by Human Annulus Fibrosus Cells Generating a Fragment With Retained Biological Activity. Journal of Orthopaedic Research 32(9): 1189-‐97, 2014. TANZER Bobyn JD, Thompson R, Lim L, Pura JA, Bobyn K, Tanzer M.: Local Alendronic Acid Elution Increases Net Peri-‐implant Bone Formation. A Micro-‐CT Analysis. Clin Orthop Relat Res. 2014 Feb; 472(2):687-‐94. Erratum in: Clin Orthop Relat Res. 2014 Feb; 472(2):772.

Yakobov, E., Scott, W., Tanzer, M., Stanish, W., Dunbar, M., Richardson, G., Sullivan, MJL. Validation of the Injustice Experiences Questionnaire adapted for Use with Patients with Severe Osteoarthritis of the Knee. J Arthritis 2014, 3: 130. doi:10.4172/2167-‐7921.1000130. TURCOTTE Mak IW, Singh S, Turcotte R, Ghert M. The epigenetic regulation of SOX9 by miR-‐145 in human chondrosarcoma. J Cell Biochem. 2014 Aug 21. doi: 10.1002/jcb.24940. [Epub ahead of print]. Baroudi MR, Ferguson PC, Wunder JS, Isler MH, Mottard S, Werier JA, Turcotte RE. Forearm soft tissue sarcoma: Tumors characteristics and oncologic outcomes following limb salvage surger y. J Surg Oncol. 2014 Jun 9. doi: 10.1002/jso.23686. [Epub ahead of print]. WEBER F. Abduljabbar, A. Aljurayyan, S. Alqahtani, Z. Sardar, Rajeet S. Saluja, J. Ouellet, Weber MH, T. Steffen, L.Beckman, P. Jarzem. What is safer in Osteoporotic Vertebral Compression Fractures, Kyphoplasty or Vertebroplasty? A study in Vertebral Analogs.Eur Spine J (2014) 23 (Suppl 5):P593 DOI 10.1007/s00586-‐014-‐3515-‐4.

Melich GJ, Weber MH, Stein B, Minutolo V, Arena M, Arena GO. Total sacrectomy for recurrent rectal cancer – A case report featuring technical details and potential pitfalls. International Journal of Surgery Case Reports 5/7 (2014), pp. 403-‐407. PMID24879330. Weber MH, Hong CH, Schairer WW, Takemoto S, Hu SS. The concomitance of cervical spondylosis and adult thoracolumbar spinal deformity. Evid Based Spine Care J. 2014 Apr; 5(1):6-‐11. PMID24715867. Weber MH, Mathew JE, Takemoto SK, Na LH, Berven S, Spinal Deformity Study Group. Postoperative Recovery Outcomes in Adult Scoliosis: A Prospective Multicenter Database with Five-‐Year Follow-‐Up, Spine Deformity, 2, 226-‐232, 2014. Krock E, Rosenzweig D, Chabot-‐Dore AJ, Jarzem P, Weber MH, Ouellet J, Laura Stone L, Haglund L; Painful Degenerating Intervertebral Discs Upregulate Neurite Sprouting and CGRP Through Nociceptive Factors. Journal of Cellular and Molecular Medicine 2014 Jun; 18(6):1213-‐25 PMID24650225. Alkhatib B, Rosenzweig DH, Krock E Roughley PJ, Beckman L, Steffen T, Weber MH. Ouellet JA, Haglund L, Acute mechanical injury of the human intervention disc:Link to Degeneration and Pain. European Cells and Materials, accepted 00. Acute mechanical injury of the human intervertebral disc: Link to Degeneration and Pain. 2014 Sep 12; 28:98-‐111. PMID25214017. ZUKOR Carli A, Aoude A, Reuven A, Matache B, Antoniou J, Zukor DJ. Inconsistencies between navigation data and radiographs in total knee arthroplasty are system-‐dependent and affect coronal alignment. Can J Surg. 57(5): 305-‐13, 2014. Carli A, Politis A, Zukor D, Huk O, Antoniou J. Clinically significant corrosion at the head-‐neck taper interface in total hip arthroplasty: a systematic review and case series. Hip Int. Oct 27: 2014.

Hart A, Khalil JA, Carli A, Huk O, Zukor D, Antoniou J. Blood transfusion in primary total hip and knee arthroplasty. Incidence, risk factors, and thirty-‐day complication rates. J Bone Joint Surg Am. 96(23): 1945-‐51, 2014. Nikolaou VS, Petit A, Khoury V, Blain-‐Pare E, Zukor DJ, Huk OL, et al. Magnetic resonance imaging of painful metal-‐on-‐metal total hip replacement. Eur J Orthop Surg Traumatol. : Jun 7 [Epub ahead of print], 2014. A.Reuven, GN Manoudis, A Aoude, OL Huk, D Zukor, J Antoniou. Clinical and Radiological Outcome of the Newest Generation of Ceramic-‐on-‐Ceramic Hip Arthroplasty in Young Patients. Advances in Orthopaedic Surgery, 2014, Article ID 863748, 6 PAGES, 2014.

APPENDIX 3

HONOURS / AWARDS 2014



FACULTY OF MEDICINE

ANTONIOU Annual Experimental Surgery Research Day – 2nd place TED talk presentation. McGill Orthopaedics. January 23, 2014. The extracellular calcium sensing receptor as a regulator of cartilaginous endplate intervertebral disc degeneration (co-‐author). Second International Philadelphia Spine Research Symposium. Philadelphia, PA, 2014 (2nd best poster award) for Mechanism of proteoglycan synthesis by bovine and human Link N (co-‐author). Chercheur national. Funding agency/source: Fonds de la recherche en santé du Québec (FRSQ) Term of grant: 07/2013-‐2017. Total dollar amount of grant: $180,000. Funding for reporting year (plus any additional one-‐time funding): $45,000. BARRALET Alan Thompson chair in surgical research. Student Award Huaifa Zhang Great travel award ($500) 2014 Canadian Chapter of the Controlled Release Society travel award ($250).

Zeeshan Sheikh Dentistry Graduate Studentship Award (McGill University, Faculty of Dentistry). $4000. April, 2014. Jinke Xu CC-‐CRS travel award. Harshdeep Mangat, best oral presentation Conference Name: Oral and Maxillofacial Surgery Research Day 2014 Location: Montreal, Canada.

Justin Drager Third Prize Presentation Winner, “Local Delivery of Iron Cheltators on Osteoclast Mediated Bone Resorption”, (Drager J, Sheikh Z, Harvey EJ, Barralet J) Canadian Pharmaceutical Society and Controlled Release Society combined meeting, Montreal, Qc, June 2014. BERGERON Salary Award Royal College of Physicians and Surgeons of Canada (RCPSC) Professional Development Grant (Personal Support Grant) 4000$.

Best Poster Award in the Practice Management/ Rehabilitation category at the 2014 American Academy of Orthopaedic Surgeons Annual Meeting, New Orleans “ Changes in Orthopaedic Job Market Demand in the United States Over the Last Decade.” Pauyo T, Scheffler P, Harris MB, Bergeron S. 2nd Place McGill University Orthopaedic Annual Research Day 2014, Division of Orthopaedic Surgery, McGill University“ Validated Orthopaedic Surgical Simulation Model for Training and Evaluation of Basic Arthroscopic Skills.” Coughlin R, Pauyo T, Sutton JC, Coughlin L, Bergeron S.

Teacher of the Year Award (2014), Division of Orthopaedic Surgery, McGill University. Outstanding Teacher of the Year Award (2014), Surgical Teaching Award, Post Graduate Education Department of Surgery, McGill University.

GLORIEUX Arabella I. Leet Memorial Lecture, Johns Hopkins University, Baltimore, MD. William F Neuman Award, American Society for Bone and Mineral Research for outstanding and major scientific contributions in the area of bone and mineral research and for contributions to associates and trainees in teaching, research and administration. Humanitarian Award, Osteogenesis Imperfecta Foundation, USA for outstanding commitment to people with Osteogenesis Imperfecta. GOULDING Tomlinson award, Henry &Margaret Johnson Oncology Award, MGH Foundation Award. HAGLUND Research Award, the Auxiliary of the MGH Research Award.

HAMDY Teacher of the Year award, Department of Paediatric Surgery, McGill University. New Investigator Research Award Paper for Dr.Asim Makhdom, Annual ACPOC meeting, Anaheim, California, March 2014 Title: The Accordion Maneuver And The Effects Of Compression Loading On Delayed Regenerate Bone Formation In Cases Of Limb Lengthening Authors : Asim Makhdom, Reggie C. Hamdy. HARVEY Salary award Hornstein Chair in Surgical Excellence. 2014 H. Rocke Robertson 19th Annual Trauma Research Day 2nd place Fixation Methods of Ulna Fractures A Hart, M Collins, L Beckman, T Steffen, EJ Harvey, PA Martineau. 2014 Canadian Pharmaceutical Society and Controlled Release Society combined meeting, Montreal, Qc, June 2014 Third Prize Presentation Winner, “Local Delivery of Iron Cheltators on Osteoclast Mediated Bone Resorption” Drager J, Sheikh Z, Harvey EJ, Barralet J. 2014 AAOS (American Academy of Orthopaedic Surgery) Achievement Award-‐ presented to AAOS members who have supported the orthopaedic community through volunteerism. MARTINEAU Hart A, Martineau PA. Can Variable Axis Locking Plates Compensate for Suboptimal Plate Position in Distal Radius Fractures. 2014 McGill Rocke Roberts on Visiting Professor Research Competition. 2nd prize. Behrends D, Henderson JE, Martineau PA. Defective Bone Repair in Mast Cell Deficient Mice. 2014 McGill Experimental Surgery Research Day. 1st prize. Chari B, Chong J, Martineau PA, Powell T. Dynamic Assessment of Engaging Hill-‐Sachs Lesions using 3D Animation Techniques. 2014, 41st Annual Meeting and Musculoskeletal Imaging Course of the International Skeletal Society. Best technical report. Salary Award, FRSQ chercheur clinician boursier junior 1 (2012-‐2016). MORIN

FRSQ – Chercheur-‐boursier clinicien, Junior 1 -‐ Volet clinique et épidémiologique. “Ostéoporose et fractures de la hanche; stratégies de traitement.” ($163,328) Ranked 1st among applicants Apr 2011-‐2015. Vice-‐Chair, Scientific Advisory Council, Osteoporosis Canada Sep 2012-‐present. Chair, Guidelines Committee, Osteoporosis Canada Jun 2009-‐present. Jo Miller Research Fund Award, “Quebec Registry for Atypical Femur Fractures”, Principal Investigator ($13,330) 2014-‐ 2016. McGill University Health Centre, The Patient Education Committee Grant Award, Bone’ing up on skeletal health”, Principal Investigator ($2,500) 2014-‐ 2015. MWALE Annual Experimental Surgery Research Day – 2nd place TED talk presentation. McGill Orthopaedics. January 23, 2014. The extracellular calcium sensing receptor as a regulator of cartilaginous endplate intervertebral disc degeneration (co-‐author). OUELLET Surgeon Scientist – Shriners Hospital for Children 2012 – 2015. Recipient of McGill Scoliosis & Spinal Research Chair (differed) 2007 – 2015. Platinum Member of AOSpine North America 2012 – 2015. RAUCH Salary Support Award; Fonds de la Recherche en Santé du Québec, Senior 2012. SARAN Personalité de la Semaine, La Presse Newspaper, Montreal, QC, July 7th, 2014. TANZER Tissue response and validation of a novel porous material. Tanzer M. Jo Miller Research Fund Award $13,330, 2014.

WEBER The Cedars Cancer Institute – Henry R. Shibata Fellowship Award (2014) $20,000. Montreal General Hospital Foundation Award (2014) $10,000. Student Awards Octavian Dobrescu, Summer 2014, Supervised his project: Cervical Muscle Morphology in Cervical Spondylotic Myelopathy. Awarded McGill Fall research bursary 2014 in the amount of $2,000. Corrado De Marco, Summer 2014, Supervisor for his project: Bioceramic Bone Grafts for the In Situ Controlled Release of Biphosphonate in a Bone Defect Following Tumour Resection.

APPENDIX 4

Division Faculty and Staff 2014

Division of Orthopaedics


FACULTY OF MEDICINE

CLINICAL FACULTY Core Clinical Rank Sub-‐Specialty Location ANTONIOU, John Assistant Professor Arthroplasty SMBD -‐ JGH BENAROCH, Thierry Assistant Professor Paediatrics Shriners-‐MCH BERGERON, Stéphane Assistant Professor Sports/Trauma SMBD-‐JGH BERRY, Gregory Assistant Professor Trauma MUHC-‐MGH BURMAN, Mark Assistant Professor Sports MUHC-‐MGH CHAYTOR, Ruth Assistant Professor Foot & Ankle SMBD-‐JGH COUGHLIN, Larry Associate Professor Sports St Mary’s DIMENTBERG, Ronald Assistant Professor Sports St Mary’s FASSIER, François Associate Professor Paediatrics Shriners-‐MCH FISHER, William Associate Professor Arthroplasty MUHC-‐MGH GDALEVITCH, Marie Assistant Professor Paediatrics Shriners-‐MCH GOULDING, Krista Assistant Professor HAMDY, Reggie Professor Paediatrics Shriners-‐MCH HARVEY, Edward Professor Trauma MUHC-‐MGH HUK, Olga Assistant Professor Arthroplasty SMBD-‐JGH JANELLE, Chantal Assistant Professor Paediatrics Shriners-‐MCH JARZEM, Peter Assistant Professor Spine MUHC-‐MGH JOHANSSON, Joyce Faculty Lecturer Arthroplasty St Mary’s LENCZNER, Eric Assistant Professor Sports MUHC-‐MGH LINCOLN , Larry Faculty Lecturer Sports St Mary’s MARIEN, Robert Assistant Professor Sports MUHC-‐MGH MARTINEAU, Paul Assistant Professor Sports MUHC-‐MGH MORELLI, Moreno Faculty Lecturer Sports St Mary’s OUELLET, Jean Associate Professor Spine Shriners-‐MCH REINDL, Rudy Assistant Professor Trauma MUHC-‐MGH ROSEN, Leonard Faculty Lecturer Arthroplasty SMBD-‐JGH SARAN, Neil Assistant Professor Paediatrics Shriners-‐MCH STEPHENSON, Paul Faculty Lecturer Arthroplasty St Mary’s SULLIVAN, James Post Retirement SUTTON, John Faculty Lecturer Arthroplasty St Mary’s TALBOT, Maxime Assistant Professor Trauma MUHC-‐MGH TANZER, Michael Professor Arthroplasty MUHC-‐MGH TURCOTTE, Robert Professor Oncology MUHC-‐MGH VOLESKY, Monika Assistant Professor Foot & Ankle SMBD-‐JGH WEBER, Michael Assistant Professor Spine MUHC-‐MGH ZUKOR, David Associate Professor Arthroplasty SMBD-‐JGH

AFFILIATED CLINICAL AFFILIATED CLINICAL Rank Sub-‐Specialty Location BAYLIS, Penny Assistant Professor Sports medicine McGill DOULAS, Bill Sports medicine FREEMAN, Carolyn Professor Oncology MUHC-‐MGH GLORIEUX, Francis Professor Paediatrics Shriners-‐MCH HUDSON, Marie Assistant Professor Rheumatology SMBD-‐JGH LACROIX, Vincent Assistant Professor Family Medicine McGill MORIN, Suzanne Associate Professor Internal Medicine MUHC-‐MGH RADHAKHRISHNA, Mohan Assistant Professor Physiatry/Rehab MUHC-‐MGH RAUCH, Frank Associate Professor Paediatrics Shriners-‐MCH SEGUIN, Chantal Assistant Professor Hematology MUHC-‐MGH SUN, Kathryn Assistant Professor Sports McGill WILTSHIRE, David Faculty Lecturer Arthroplasty Lakeshore

RESEARCH FACULTY

RESEARCH Rank Laboratory Location BARRALET, Jake Professor C9 MUHC-‐MGH HAGLUND, Lisbet Assistant Professor C9 MUHC-‐RVH HENDERSON, Janet Professor C9 740 Penfield MORT, John Professor Joint Disease Shriners MWALE, Fackson Associate Professor ORL-‐LDI ORL-‐LDI RECKLIES, Anneliese Professor Joint Disease Shriners ROUGHLEY, Peter Professor Genetics Unit Shriners ST-‐ARNAUD, René Professor Genetics Unit Shriners STEFFEN, Thomas Associate Professor ORL-‐RVH MUHC-‐RVH

ADMINISTRATION

ADMINISTRATION GAGLIANI, Italia Robert Turcotte MGH LIS, Rona David Zukor SMBD-JGH DEBELLIS, Paula Jean Ouellet MCH DELISLE, Sharon Thierry Benaroch Shriners KERR, Catherine John Sutton St Mary's WALL, Paula Reggie Hamdy Shriners

RESEARCH COORDINATORS RESEARCH COORDINATORS ALIMINIANA, Maricar Arthroplasty SMBD-JGH AMADEO, Mary Trauma MUHC-MGH BARKER, Joy Spine MUHC-MGH CARTALEANU, Adrien Trauma MUHC-MGH DANDACHLI, Firas Oncology MUHC-MGH FAITH, Janet Sports MUHC-MGH HOUGHTON, Fiona Trauma MUHC-MGH NAYLOR, Dee Anne Spine MUHC-MGH SINCLAIR, Joan Arthroplasty MUHC-MGH SMITH, Karen Arthroplasty MUHC-MGH

CLINICAL COORDINATORS CLINICAL COORDINATORS ALEVISATOS, Maria Arthroplasty SMBD-JGH BARBIERI, Filomena Foot & ankle SMBD-JGH BALZAMO, Louise Sports MUHC-MGH BUENO-ARAUJO, Fernando Ortho clinic MUHC-MGH CIAMPINI, Melanie Arthroplasty SMBD-JGH COLAGIACOMO, Francis Ortho clinic and Oncology MUHC-MGH DE CRESCENTIS, Silvana Trauma MUHC-MGH DUKE, Diane Arthroplasty MUHC-MGH GAGLIANI, Italia Ortho clinic MUHC-MGH GAGNE, Francine Sports MUHC-MGH IZZI, Sonia Sports MUHC-MGH LIS, Rona Arthroplasty SMBD-JGH LONGO, Carla Ortho clinic MUHC-MGH PAMPENA, Mary Spine MUHC-MGH

APPENDIX 5

Other Scholarly Activities & Services to the Profession and Community

2014



FACULTY OF MEDICINE

ANTONIOU Community Service Canadian Orthopaedic Research Society -‐ President. Orthopaedic Research Society– Co-‐chair International Committee. American Academy of Orthopaedic Surgeons, Member of Adult. Reconstruction; Hip Program Committee Member. Canadian Orthopaedic Association -‐ Board Member. Canadian Arthritis Society – Orthopaedic expert for the Scientific Advisory Committee. Presentation Corrosion at the Head-‐Neck Taper Interface Affects the prognosis of Hip Revision Surgery – ASTM – Symposium on Modularity and Tapers in Total Joint Replacement Devices -‐ New Orleans, LA, November 10, 2014. – invited. Work-‐Up for the Painful Metal on Metal Hip. Technology for the Treatment of Adult Hip and Knee Disorders 8th Annual Hip Joint Course. Baltimore, MD, August 14-‐16, 2014. – invited. Ceramic-‐on-‐Ceramic: Better than We Thought. Technology for the Treatment of Adult Hip and Knee Disorders. 8th Annual Hip Joint Course. Baltimore, MD, August 14-‐16, 2014. – invited. MoM hip resurfacing should be banned. 6th Advanced Resurfacing Course, Ghent, Belgium. May 28-‐31, 2014. – invited. Editorial Activity Journal of Bone and Joint Surgery – Orthopaedic Highlights (Knee Surgery) – editorial board member. Journal of Arthroplasty – editorial board elite reviewer. European Spine Journal – editorial board member. Spine – editorial board member. Refereed Research eCM XlV 2014, Davos, Switzerland. June 16-‐18, 2014 MP Grant LM Epure, J Antoniou, F Mwale. Human cartilaginous endplate degeneration is regulated by the extracellular calcium-‐sensing receptor. MP Grant, LM Epure, O Salem, O Ciobanu, M Alaqeel, J Antoniou, F Mwale. Development of a whole bovine long-‐term organ culture system that retains vertebral bone for intervertebral disc repair and biomechanical studies. F Mwale, R Gawri, J Ouellet, P Önnerfjord, B Alkhatib, T Steffen, D Heinegård, PJ Roughley, J Antoniou, L Haglund. The Link to regeneration of human intervertebral discs. M Alaqeel, MP Grant, LM Epure, O Salem, OL Huk, J Antoniou, F Mwale. Link N suppresses Interleukin-‐1β induced human osteoarthritic cartilage degradation through down-‐regulation of NF-‐κB signalling. World Forum for Spine Research Xi'an, China. May 15-‐17, 2014. H Noorwali, P Madiraju, L Epure, J Antoniou, F Mwale. Effect of Link N treatment on pain associated with intervertebral disc degeneration. I Hadjab, LM Epure, J Antoniou, L’H Yahia, F Mwale. Fourier transform infrared spectral analysis of degenerative human intervertebral discs.

MP Grant, LM Epure, J Antoniou, F Mwale. Activation of the extracellular calcium-‐sensing receptor as a contributor in human cartilaginous endplate degeneration. 48th Annual Meeting of the Canadian Orthopaedic Research Society. Montreal, QC. June 18-‐21, 2014 R Gawri, J Ouellet, P Önnerfjord, B Alkhatib, T Steffen, D Heinegård, P Roughley, J Antoniou, F Mwale, L Haglund. Link-‐N is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity. A Alaseem, P Madiraju, S Aldebeyan, J Antoniou, F Mwale. Mechanism of Naproxen induced type X collagen expression in mesenchymal stem cells. H Noorwali, P Madiraju, J Antoniou, F Mwale. Link-‐N as a therapeutic agent for pain associated with intervertebral disc degeneration. M Alaqeel, MP Grant, LM Epure, O Salem, OL Huk, J Antoniou, F Mwale. Effect of Link N on the synthesis and degradation of matrix proteins in human articular osteoarthritic cartilage. F Mwale, HT Wang, P Roughley, J Antoniou, L Haglund. Link N and stem cell therapy for the repair of intervertebral disc degeneration. F Mwale, S Aldebeyan, LM Epure, MP Grant, S Rampersad, J. Antoniou. Mechanism of human and bovine Link N -‐ induced proteoglycan synthesis in the intervertebral disc. MP Grant, LM Epure, M Alaqeel, O Salem, OL Huk, J Antoniou, F Mwale. The calcium-‐sensing receptor in health and osteoarthritis. MP Grant, LM Epure, J Antoniou, F Mwale. Regulation of the Calcium-‐Sensing Receptor by Link N in the cartilaginous endplates of human intervertebral discs. SY Brin, LM Epure, AS Cartaleanu, OL Huk, DJ Zukor, J Antoniou. TKA and THA procedure duration affect the rate of wound complications and length of hospital stay. Patent US 61975329/ In progress/ Filling date: 2014-‐04-‐04/ Patent Title: “Link N for treatment of inflammatory pain”. PCT/CA2014/000656/ In progress/ Filling date: 2014-‐08-‐27/ Patent Title: “Methods and Compositions for Treatment of Cartilage and Disc Tissue Pathologies”.

BARRALET Presentation 28th-‐29th August, 2014, International Forum on 3D printing: Fundamentals and Biomedical Applications, Xi’an, Shannxi, China. Materials Research Society. Self-‐assembled anatase-‐rutile heterojunction for dye-‐sensitized solar cell. San Francisco, USA. 24th April 2014. Materials Research Society. Hierarchical stable enzyme micro-‐environments for improved CO2 capture. San Francisco, USA. 22th April 2014.

Organized Conferences/Symposia Canadian Society for Pharmaceutical Sciences 2014 Annual Meeting. Fraser Gurd Surgical Research Day-‐2014. Editorial Board Journal of Biomaterials Applications 2004-‐Present Journal of Biomedical Materials Research (B) 2006-‐ Present Journal of Biomedical Materials Research (A) 2007-‐ Present Acta Biomaterialia 2011-‐ Present

BENAROCH Presentation Benaroch, T. E., “Painful Valgus Foot Deformity”, Presented at the 11th Annual Fall Orthopaedic Symposium: Pediatric Orthopaedics: A Thirty-‐Year Experience (Times Two), October 24, 2104, The University of Texas Southwestern Medical Center, Texas Scottish Rite Hospital for Children, Dallas, Texas, USA. Professional Development April 2, 2014 Program Director Workshop, Montreal, Quebec, Canada. April 10, 2014 New Program Director Workshop, McGill University, Montreal, Quebec, Canada.

BERGERON

Editorial Activity Clinical Orthopaedic and Related Research. Arthroscopy: The Journal of Arthroscopic and Related Surgery. Invitation Course Faculty, Canadian Orthopaedic Resident Forum (CORF) -‐-‐ trauma section, Calgary, April 4 -‐ 7, 2014. Continuing Professional Development Activity Master in Public Health summer semester (6 weeks), Harvard School of Public Health Completion of practicum for MPH degree. Presentation Changes in Orthopaedic Job Market Demand in the United States Over the Last Decade. Pauyo T, Scheffler P, Harris MB, Bergeron SG. (Trainees: Pauyo T and Scheffler P).

Refereed Presentation American Academy of Orthopaedic Surgeons, Annual Meeting, New Orleans, 2014 Poster Presentation Changes in Orthopaedic Job Market Demand in the United States Over the Last Decade. Pauyo T, Scheffler P, Harris MB, Bergeron SG. (Trainees: Pauyo T and Scheffler P). Local, national, international research collaborations Research collaboration with Mitchel B. Harris, Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA.

BURMAN Community Involvement Head Orthopedic Surgeon / Team Physician Montreal Impact FC. Orthopedic Surgeon / Team Physician Montreal Alouettes Football Team. Orthopedic Surgeon McGill Redmen/Martlets Varsity Athletics. Soccer Coach – Girls Intercity Soccer. Orthopedic Consultant / Surgeon for Nunavik Communities. Editorial Activity Manuscript reviewer: J. Arthroscopy, International J. Sports Medicine, KSSTA Journal, CJS. COA 70 th Annual Meeting -‐ Sport s Medicine Section Abstract Reviewer. Invitation Invited faculty Canadian Orthopedic Residents Forum – Calgary, AB. Professional Development Canadian Orthopedic Association (COA/AOA) Combined Meeting. AANA 33rd Annual Meeting. McGill / UdeM Shoulder Arthroscopy Course.

GLORIEUX Visiting Professorship March 2014 Johns Hopkins University, Baltimore, MD.

GOULDING Invitation Association Orthopédique du Quebec (2 lectures, Sept 2014/May2015). Professional Development Finishing of clinical fellowship – Mayo Clinic (August'2014).

Master of Public Health – Johns Hopkins University. Editorial activity European Orthopaedic Surgery&Traumatology. Local, national, international research collaborations PARITY trial (international RCT – antibiotic prophylaxis in bone sarcoma)-‐ McMaster Compress endoprostheses (in collaboration with Mayo clinic) Golf Ball project – evaluating an education intervention to family physicians in soft tissue sarcoma (Royal Orthopaedic Hospital, Birmingham, UK)

HAGLUND Editorial activity Reviewer: Arthritis and Rheumatology, Arthritis Research & Therapy, BMC, Musculoskeletal Disorders, Bio Medical Engineering OnLine, Connective Tissue Research, European Spine, European Cells and Material, European Journal of Pain, Histochemistry & Cell Biology, Journal of Biological Chemistry, Journal of Cellular Biochemistry, Journal of the Royal Society, Osteoarthritis and Cartilage, PLOS ONE, Tissue Engineering, Tissue and Cell Journal. Invitation Invited Speaker -‐ Anatomy and Cell Biology Retreat McGill University, Mont Saint Gabriel, May 2014, Title: Intervertebral Disc Degeneration and Pain. Invited Speaker -‐ World Forum for Spine Research, Xi'an China May 2014 Title: Bioreactors; How good are they. Speaker World Forum for Spine Research, Xi'an China May 2014 Title: The Abillity of Physiological Load to Restore Disc Function. Scientific or Specialty Society Contribution 2014—Present Vice President, Canadian Connective Tissue Society (CCTS). 2012 – Present Board member, Canadian Connective Tissue Society (CCTS). 2011 – Present Executive Board Member, AOSpine Research Network (AOSRN). 2009 – Present Member, Orthopaedic Research Society (ORS). 2008 – Present Member, McGill Scoliosis and Spine Research Group. 2007 – Present Member, AOSpine. HAMDY Conference, Seminar Workshops XXVI SICOT Triennial World Congress combined with 46th SBOT Annual Meeting 2014 Rio de Janeiro, Brazil, November 20-‐23 Invited Speaker. COA Basic Science Course (Post-‐Graduate Course) 2014 Ottawa, October 27. MCH Telehealth Distance Teaching & Learning Center, January 15 2014.

HARVEY Editorial activity Journals Editor in Chief -‐ Canadian Journal of Surgery. Editorial Board -‐ Journal of Orthopaedic Trauma Reviewer. Reviewer: Journal of Bone and Joint Surgery (American), Journal of Trauma, Journal of Orthopaedic Trauma, Bone, Rheumatology, Journal of Biomaterials Applications, Clinical Anatomy, Clinical Medicine Research and Review, Disease Models and Mechanisms, Arthritis Research and Therapy, Journal of Musculoskeletal Pain, Journal of Zhejiang University, Medical Practice and Reviews, Journal of Bone and Joint Surgery -‐ Case Connector, e-‐Cells and Materials. Invitation June 2014 Combined BOA -‐ EFFORT meeting June 2014 “Orthopaedic Trauma Processes in Canada” Panel Member: Upper Extremity Trauma. Chairman of COA-‐AOA combined meeting 2014. Co -‐ Chairman of McGill Medicine Class of ’89 Medical Seminar-‐ 2014 “New Perspectives, Old Problems” Speaker -‐ Avascular Necrosis of The Hip: Not your Father's Oldsmobile Anymore. Refereed Presentation Aegean conference: Osteoimmunology meeting, Helona Kos, Greece June 2014 Podium Presentation Identification of a novel mutation in heritable osteonecrosis of the femoral head 80 T Wang, W Mah, EJ Harvey, J Majewski, DS Rosenblatt, C Séguin. MLTD Thrombosis Meeting Valencia Spain 2014: Poster presentation Treatment with acetylsalicylic acid (aspirin) prevents short to mid-‐term radiographic progressionof non-‐traumatic osteonecrosis of the femoral head, B. Routy, A. Albers, A. Carli, E.J. Harvey, C. Séguin. European Orthopaedic Research Society (EORS 2014), July 2014 Nantes, France Podium Presentation Identification of a novel mutation in heritable osteonecrosis of the femoral head 80 T Wang, W Mah, EJ Harvey, J Majewski, DS Rosenblatt, C Séguin. 5th International Conference on Osteoimmunology Kos, Greece June 2014 Poster Presentation Identification of a novel mutation in heritable osteonecrosis of the femoral head, T Wang, W Mah, EJ Harvey, J Majewski, DS Rosenblatt, C Séguin. European Orthopedics Research Society Nantes, France July, 2014 Podium Presentation Identification of a novel mutation in heritable osteonecrosis of the femoral head T Wang, W Mah, EJ Harvey, J Majewski, DS Rosenblatt, C Séguin. 3rd Annual Canadian Human and Statistical Genetics Meeting, May 2014, Victoria, BC Podium Presentation Identification of a novel mutation in heritable osteonecrosis of the femoral head 80 T Wang, W Mah, EJ Harvey, J Majewski, DS Rosenblatt, C Séguin. 3rd Annual Canadian Human and Statistical Genetics Meeting Victoria, BC May, 2014 Poster Presentation Identification of a novel mutation in heritable osteonecrosis of the femoral head. T Wang, W Mah, EJ Harvey, J Majewski, DS Rosenblatt, C Séguin. Canadian Pharmaceutical and Controlled Release Society combined meeting, Montreal, QC, June 2014 69 Poster Presentation “Local Delivery of Iron Cheltators on Osteoclast Mediated Bone Resorption” Drager J, Sheikh Z, Harvey EJ, Barralet J. Community Service 1997 -‐ present Consultant Physician Montreal Alouettes Professional Football Team. 1997-‐present Consultant Physician McGill University Sports Teams. 2005 -‐ present Consultant Physician Montreal Impact Professional Soccer Team. 2006-‐ present Consultant Physician Toronto Maple Leafs Professional Hockey Team.

2006 -‐ present Consultant physician NHLPA -‐ National Hockey League Players Association. 2009-‐ present Member of the NHL Physicians Group. 2013-‐present Team Physician -‐ Lac-‐St-‐Louis Midget AA Elites – Hockey. Coach of Novice A intercity, High school (Marcelline) and Midget AA hockey. RUIS/Outreach Launched Google glass project in Far North and Haiti. Patent Compartment Pressure Monitoring Device Provisional Patent Application 2010-‐ OTT McGill. Biomarker for Diagnosing Avascular Necrosis Provisional Patent Application US 61/300,636. Wireless Energy Harvesting Capacitive Sensor Device for Biological Compartment Pressure Monitoring Provisional Patent Application 2010-‐ OTT McGill. HUK Invitation Ceramic-‐on-‐ceramic: Better than We Thought. 3rd Annual Canadian Arthroplasty Society Meeting. Totonto, ON. November 27 -‐28, 2014. Refereed Presentation 3rd Annual Canadian Arthroplasty Society Meeting. Totonto, ON. November 27 -‐28, 2014. O Huk, A Aoude, LM Epure, Y Brin, K Smith, DJ Zukor, M Tanzer, J Antoniou. Ceramic-‐on-‐ceramic: Better than We Thought. DJ Zukor, YS Brin, LM Epure, AS Cartaleanu, OL Huk, J Antoniou. Procedure duration of total knee arthroplasty and total hip arthroplasty affects the rate of wound complications and length of hospital stay. J Antoniou, A Hart, S Bergeron, LM Epure, OL Huk, DJ Zukor. Comparison of American and Canadian Perioperative Outcomes in Primary Total Hip and Knee Arthroplasty. eCM XlV 2014, Davos, Switzerland. June 16-‐18, 2014 M Alaqeel, MP Grant, LM Epure, O Salem, OL Huk, J Antoniou, F Mwale. Link N suppresses Interleukin-‐1β induced human osteoarthritic cartilage degradation through down-‐regulation of NF-‐κB signalling. 48th Annual Meeting of the Canadian Orthopaedic Research Society. Montreal, QC. June 18-‐21, 2014 M Alaqeel, MP Grant, LM Epure, O Salem, OL Huk, J Antoniou, F Mwale. Effect of Link N on the synthesis and degradation of matrix proteins in human articular osteoarthritic cartilage. MP Grant, LM Epure, M Alaqeel, O Salem, OL Huk, J Antoniou, F Mwale. The calcium-‐sensing receptor in health and osteoarthritis. SY Brin, LM Epure, AS Cartaleanu, OL Huk, DJ Zukor, J Antoniou. TKA and THA procedure duration affect the rate of wound complications and length of hospital stay. 60th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA. March 15-‐18 2014 MP Grant, LM Epure, M Alaqeel, O Salem, OL Huk, J Antoniou, F Mwale. The role of the extracellular Calcium-‐Sensing Receptor in osteoarthritis. JANELLE Personnel Development Réunion conjointe de l’AOA et L’ACO et SROC. Conférence d’enseignement. Montréal, Qc 21 juin 2014.

JARZEM Invitation When to send patietns for Kyphoplasty and Vertebroplasty, McGill Annual Refressher Course, Montreal, December 3, 2014. Program / Meeting Chair Meeting Chair, REGIONAL PERSPECTIVES ON NETWORKS OF CARE, Montreal Neurological Institute, Jan 10, 2014. Refereed Research Presentation Alturki A, Basamh M, Awwad W, Jarzem P, Multicorporal Abcess Formation due to Esophageal Perforation Post Anterior Cervical Discectomy and Fusion, International Journal of Neurology and Neurosurgery, 6, 27-‐34, 2014.

LENCZNER Professional Development CDA Meeting Montreal 2014.

MARTINEAU Community Service Head Team Orthopaedic Surgeon, Montreal Canadiens. Team Orthopaedic Surgeon, Montreal Alouettes. Orthopaedic Consultant, McGill University Athletics. Orthopaedic Consultant, Concordia University Athletics. Quality of Clinical Contribution Martineau PA: Surgical Innovation. Canadian Orthopaedic Residents Association Annual Meeting, Montreal, Canada (2014). Refereed Research Presentation Behrends D, Cheng M, Gao C, Li A, Wang H, Sullivan M, Wang M, Henderson J, Martineau PA. The Role of Mast Cells in Cortical Bone Regeneration. 2014 Canadian Orthopaedic Research Society Annual Meeting, Montreal, Canada. Hart A, Martineau PA. Can Variable Axis Locking Plates Compensate for Suboptimal Plate Position in Distal Radius Fractures. 2014 McGill Rocke Roberts on Visiting Professor Research Competition. 2nd prize. Behrends D, Henderson JE, Martineau PA. Defective Bone Repair in Mast Cell Deficient Mice. 2014 McGill Experimental Surgery Research Day. 1st prize. Chari B, Chong J, Martineau PA, Powell T. Dynamic Assessment of Engaging Hill-‐Sachs Lesions using 3D Animation Techniques. 2014, 41st Annual Meeting and Musculoskeletal Imaging Course of the International Skeletal Society. Best technical report.

Han Y, Hart A, Martineau PA. Evaluation of the Endoscopic Over-‐the-‐top Guide and Proposition of a New Technique for Femoral Tunnel Placement in Anterior Cruciate Ligament Reconstruction. 2014 Combined American Orthopaedic Association/ Canadian Orthopaedic Association Annual Meeting (Montreal, Canada) Hart A, Collins M, Chhatwal D,Steffen T, Harvey EJ, Martineau PA. Can the Use of Variable-‐Angle Volar Locking Plates Compensate for Suboptimal Plate Positioning in Unstable Distal Radius Fractures. 2014 Combined American Orthopaedic Association/ Canadian Orthopaedic Association Annual Meeting and Canadian Orthopaedic Resident Association (Montreal, Canada). Editorial Activity 2013-‐Present Editor The Journal of Bone and Joint. 2011-‐ Present Reviewer Bone & Joint Research. 2009-‐ Present Associate Editor Canadian Journal of Surgery. 2009-‐ Present Reviewer Canadian Journal of Surgery. Invitation Martineau PA: Surgical Innovation. Canadian Orthopaedic Residents Association Annual Meeting, Montreal, Canada (2014). Canadian Orthopaedic Residents Association Meeting, Montreal, Quebec (2014), scientific session moderator. Scientific or Specialty Society Contribution 2014-‐17 American Orthopaedic Society for Sport Medicine -‐ Council of Delegates. Personal Development NHL Hockey Specific Advanced Trauma Life Support Course taken.

MORIN Editorships and Member of Journal Editorial Board July 2014 Guest Editor, Le Médecin du Québec. Ostéoporose: Briser le Cycle des Fractures July 2014, numéro 7, volume 49. Jun 2006-‐present Editorial Board, Canadian Journal of General Internal Medicine. Invited Presentations /Lectures “Vitamin D in 2014: Not so fast?” Plenary, 65th Annual Refresher Course for Family Physicians, McGill University, Montreal, Quebec Dec 2 2014. “Osteoporosis Management”, Workshop, 65th Annual Refresher Course for Family Physicians, McGill University, Montreal, Quebec Dec 2 2014. “Drug holiday and duration of treatment”, Family Medicine Forum, Québec, Québec Nov 13-‐15 2014. “Temporal trends in high-‐ and low-‐trauma hip, femur and pelvic fracture rates and selected quality of care indicators in Québec”, CCDSS Osteoporosis Working Group Meeting, Public Health Agency of Canada, Ottawa, Ontario June 13, 2014.

Keynote Speaker, “Improving PAIN control following FRactures; towards an Elder friendly Emergency department (PAINFREE)”, Combined Annual Research Day 2014: Health Outcomes Axis & McGill Division of Geriatric, Montreal, Quebec June 12, 2014. “Calcium: bon pour les os, dangereux pour le coeur?” 45th Laurentian Conference of Rheumatology, Tremblant, Quebec May 10 2014. “Drug Holiday”, Beyond the Break Inter-‐professional Education Series, Osteoporisis Canada and Women’s College Hospital, Toronto, Ontario (via Telemedicine) May 9 2014. "Women's Health-‐Beyond Bisphosphonates”, 45th Annual Drug Therapy Course (CME), McGill Center for Continuing Medical Education, Montreal, Quebec May 8 2014.

MORT Editorial activity Editorial board member BBA Clinical 2014 -‐Present. Book Chapters and Invited Manuscripts Roughley, P.J. and Mort, J.S. (2014) The role of aggrecan in normal and osteoarthritic cartilage. J. Exp. Orthop. 1, 8. Erickson, A.H., Isidoro, C., Mach, L., and Mort, J.S. (2014) Cathepsins: getting into shape for lysosomal proteolysis. in Proteases -‐ Structure and Function (Brix, K. and Stöcker, W., eds.), pp. 127-‐174, Springer-‐Verlag, Wein.

MWALE Organised Conferences/Symposia Organizer research interest group “The Spine Research Community. 60th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA. March 15-‐18. 2014.

Scientific Peer-‐Review Processes National Institutes of Health (Baltimore, USA): Skeletal Biology Structure & Regeneration (SBSR) Study section (April). Canadian Institute of Health Research, Biomedical Engineering peer review committee (May and December session). Editorial Board 2010-‐present World Journal of Orthopaedics. 2010-‐present Invited editor International Journal of Biomaterials. 2007-‐present The Open Orthopaedics Journal. 2007-‐present The Open Biomedical Engineering Journal. Community-‐relations activity 61 Annual Meeting of the Orthopaedic Research Society. Las Vegas, NV. Abstract reviewer World Forum for Spine Research. Xi'an, China. Abstract reviewer.

Invitation National Institute of Musculoskeletal and skin diseases (NIAMS) round table “The greatest scientific challenges related to understanding pathological changes leading to disc degeneration”. Washington. October 27. 2014. LINK N as a therapeutic agent to treat early intervertebral disc degeneration – ISAET and PSRC International conference. Thailand. December 16-‐17, 2014. The LINK between intervertebral disc degeneration and regeneration – Rush University. Chicago. September 3, 2014. The LINK between intervertebral disc degeneration and regeneration -‐ World Forum for Spine Research Xi'an, China. May 15-‐17, 2014. Patent PCT/CA2014/000656: Methods and Compositions for Treatment of Cartilage and Disc Tissue Pathologies.

OUELLET Invitation and Presentation AOLF Association des Orthopédistes de la Langue Française. Spine. Round Tables and talk: Cyphose Congénitales. St-‐Petersberg – Russia. May 18-‐25, 2014 (Guest) Advances Techniques in Complex Pediatric Spine Surgery. AOSpine Management of congenital scoliosis. Tampa, Florida – USA. May 16-‐17, 2014. Advances Techniques in Complex Pediatric Spine Surgery. AOSpine New Growth Modulation Technology,Tampa, Florida – USA. May 16-‐17, 2014. 14th O.I. Foundation Scientific Meeting. i) Functional Outcomes & Pulmonary Function Following Spinal Fusion Surgery in Children with Osteogenesis Imperfecta. ii) Surgical Treatment Axial Skeleton. . Chicago – Illinois – USA. April 9-‐11, 2014. Round Tables: Chirurgie précoce dans les scolioses évolutives de l’Enfant. GES (Groupe Etude Scoliose) Nice – France March 21-‐22, 2014. (Invited) AOSpine International Course & Symposium – (International Guest Lecture) Idiopathic Scoliosis Deformity in Adolescent. 1. What is New on the Etiology of Scoliosis? 2. Management of AIS Lenke 3. Pearls and Pitfall of Scoliosis Surgery. Sao Paula, Brazil, Oct 2-‐5, 2014 (International Guest Lecture) Visiting Pediatric Orthopedic Surgeon Brian Greenhill. Give 4 Presentations: 1. Biomarker of Pain: Quest for objective qualification of Pain. 2. City Widr Grand Rounds Orthopaedic: Spondylolisthesis, Finding the Balance. 3. Visitng Professor Pediatric Ortho: Management of Congenital scoliosis. 4. Management of Neuromuscular scoliosis. Edmonton, Alberta – Nov 27-‐29, 2014. O.I. Tutorship – Presentation: O.I. & Spine. Shriners Hospital for Children Cda – Oct. 8, 2014 SPORC Ste-‐Justine Paediatric Orthopaedic Review Courses in Association with The Shriners Hospital for Children and The Montreal Children’s Hospital. Since 2002 to 2015 Guest Speaker: Idiopathic Scoliosis: How Efficient is Conservative Treatment? 65th Annual McGill Refresher Course 2014. F11-‐ Spine: Lower Back Pain in Children, Dec 2, 2014 Centre Mont-‐Royal / Montreal Children’s Hospital – McGill Faculty of Medicine Course Title: Annual Specialty Day: It doesn’t have to be so complicated: Demystifying the child with complex medical needs. Practical Problems in Pediatrics (1 hour course for staff, residents and nurses) -‐ Course Topic: Back to Basics: Back Problem in Children.

Presentation at Hôpital Sacré Coeur – Title: Recherche colonne lombaire prélevées sur nos donneurs d’organes. Mtl, Qc. Jan. 9, 2014. Editorial Board 2009 -‐ Present Evidence Base Spine Journal. 2009 -‐ Present Global Spine Journal. Book Chapter Growth Guided Instrumentation: Luque trolley; Ouellet JA, Ferland CE, Mehdian H. Chapter 48: TheGrowing Spine; Management of Spinal Disorders in Young Children, 2nd edition, Edited by Drs. B Akbarnia, M. Yazici & G. Thompson. Springer Science + Business Media. (In Press) 2014.

RAUCH Editorial activity 2009 -‐ Present Editor in Chief, Journal of Musculoskeletal & Neuronal Interactions.

REINDL Refereed Presentation 2014 “Intramedullary Versus Extramedullary Fixation Of Unstable Intertrochanteric Hip Fractures: A Prospective Randomized Control Study,” .R. Reindl, E.J.Harvey, G.K.Berry, E.Rahme, COTS Highlight paper American Academy of Orthopaedic Surgeons meeting, New Orleans. Editorial Activity European Spine Journal. Invitation AO Course Davos Switzerland. Local, national, international research collaborations Canadian Orthopaedic Trauma Society AO Trauma.

ROUGHLEY Editorial Activity Editorial Board member for the following Journals: eCM Journal Osteoarthritis & Cartilage Biochemical Journal. Presentation Intervertebral disc degeneration – Why does it occur and can it be reversed? -‐ Physiatry Rounds, Hopital Notre Dame, Montreal.

Invitation The life of aggrecan -‐ ECM XV Meeting on Cartilage & Disc: Repair and Regeneration, Davos, Switzerland.

SARAN Book Chapter Saran N. Harvey EJ, Ouellet JA, “Torticollis and Sprengel Deformity.” In The Pediatric Upper Extremity (Springer). Submitted. Estimated publication Sept. 2014. Presentation Ferland C, Stone L, Saran N, Ouellet J., “Identification and Validation of pain-‐related biomarkers surrounding spinal surgery in adolescents”. Canadian Spine Society Annual Meeting, Feb. 2014.

SEGUIN Invited Presentation (2014). Potential Role of alpha-‐2-‐Macroglobulin in the pathogenesis of Glucocorticoid-‐induced Osteonecrosis. Pediatric Rheumatology Rounds Montreal Children Hospital, McGill University Health Center, Montreal, Canada

ST-ARNAUD Editorial Activity Managing Editor, GENE; Editorial Board Member, BONE. Invitation Invited speaker: 8th Clare Valley Bone meeting, Adelaide, Australia. Professional Development Manager’s retreat (2), Shriners Hospitals for Children – Canada: Recognition in the workplace; Transition.

TALBOT Personal Development 2014-‐ Present MBA student, John Molson School of Business. Book Chapter Talbot M, Harvey EJ, Berry GK Chapter 9: Polytrauma Care in: Orthopaedic Knowledge Update 11. American Academy of Orthopaedic Surgeons. 2014. (In print).

TANZER Invitations – Lectures & Presentations “Surgical Etiquette”, Montreal Neurologic Hospital, Montreal, Canada, March 21, 2014. McGill Orthopaedic Grand Rounds: “International Consensus on Prosthetic Infections”, Montreal, Canada, April 2014. Fourth Annual Hip & Knee Masterclass-‐Current Trends in Arthroplasty: Treatment of Challenging Patients. Toronto, Canada, April 26, 2014. -‐ “Advancement in Bearing Surface Technology for TKA” -‐ “The Revision Continuum: Techniques and Options” Persona: The Personalized Knee System. Montreal, Canada, June 19, 2014. -‐ “Persona Advanced Bearing Surface” MUHC Radiology Technicians In-‐Service Lecture– “Templating in THA & TKA”, Montreal, Canada, November 6, 2014. Refereed Research Presentation Poster Presentation: Orthopaedic Research Society Sixtieth Annual Meeting, New Orleans, LA, USA. March 2014. Pura,JA; Bobyn, JD; Lim,L; Bobyn, KM; Tanzer, M: Implant-‐Delivered Alendronic Acid Increases Bone Formation Around Porous Titanium Implants. Poster Presentation: Orthopaedic Research Society Sixtieth Annual Meeting, New Orleans, LA, USA. March 2014. Bobyn, JD; Pura,JA; Tanzer, M: Local alendronic acid elution increases implant-‐bone fixation strength. 2014 AOA/COA Combined Meeting: "Locally Delivered Alendronic Acid Increases Net Bone Formation around Porous Titanium Implants" Montreal, Quebec, Canada, June 19, 2014. 2014 AOA/COA Combined Meeting: "Locally Delivered Alendronic Acid Improves Bone Formation and Porous Implant Fixation" Montreal, Quebec, Canada, June 19, 2014. Journal Editorial Boards Elite Reviewer Journal of Arthroplasty 2012 -‐ Present Journal of Arthroplasty 2002-‐ Present Scientific or Specialty Society Contribution J Arthroplasty Editorial Board. Hip Society Membership Committee. American Academy of Orthopaedic Surgery Instructional Course Lecture Committee. Patent International (PCT) Patent Application No. PCT/CA2012/001191 (Publication Number WO2013091085 A1) -‐Title: BONE REPLACEMENT IMPLANTS WITH MECHANICALLY BIOCOMPATIBLE CELLULAR MATERIAL: PASINI, Damiano, KHANOKI, Sajad Arabnejad, TANZER, Michael. United States Provisional Patent ApplicationTitle: BIOCOMPATIBLE, BIODEGRADABLE AND TOUGHENED MULTILAYERED BONE GRAFT SUBSTITUTE MADE FROM CALCIUM PHOSPHATE, GELATIN, AND

collagenapplicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY. Barthelat, Francois and Tanzer, Michael.

TURCOTTE Editorial Activity Editorial Board: World Journal of Orthopaedics (WJO) Current Oncology – Section Editor. Invitation 2014/02 MUHC Dept of Radio Oncology What’s new in bone metastases April 2014 Musculoskeletal oncology to University of Sherbrooke orthopaedic residents. 2014/04 MGH OR nurses weekly rounds Reconstruction following bone tumor resection Quebec Orthopaedic Association annual meeting, Gatineau, Qc, Oct 3rd 2014 Tumor implants for non-‐tumorous condition. Department of Orthopaedic Surgery, Sherbrooke University, April 16th 2014 Benign bone tumors 19th Annual National Canadian Preparatory Course in Clinical and Radiation Oncology Jan 29th 2014, Montreal Soft tissue sarcoma. 3rd Canadian Orthopaedic Resident Review in Joint Reconstruction Course (CORR-‐RECON), Mississauga, Ontario (January 16th to 18th, 2014) Metastatic bone disease Mock Orals. Moderator or discusser June 2014 Moderator, Tumor papers session COA-‐AOA Combined meeting, Montreal, Quebec, Canada. Community Service

Montreal specialized medicine chair table. Musculoskeletal services organization committee 2013-‐ Present. . Clinical sub-‐committee in Orthopaedic surgery APSS-‐CUSM/CRDS-‐Wes. Professional development 2014 Leadership Development Program McGill Faculty of Medicine, Feb 24-‐27th 2014. 2014 Fujitsu Lean.

WEBER Professional Development Attended NASS Nov (San Francisco CA; November 2014). Presentations Fahad Abduljabbar, MBBS ; Jacob Mathew, MBBS ; Asim M. Makhdom, MD, MSc; Mona T. Rajeh DMD, Msc; Weber MH , MD, PhD, FRCSC , Jean Ouellet, MD, FRCSC; Peter Jarzem, MD, FRCSC: The Predictors of

Clinical Outcomes After Lumbar Interbody Fusion with A Porous Nitinol Implant. COA, Montreal, June, 2014. Zeeshan M. Sardar, Ahmed Alghamdi, Mihai Radulescu, Louis-‐Charles Moreau, Weber MH , Rudy Reindl, Jean Ouellet, Peter Jarzem Radiologic outcomes of short segment divergent pedicle screw fixation for unstable thoracolumbar fractures. /American Orthopaedic Association(AOA) / Canadian Orthpaedic Association(COA), June 18-‐21, 2014. Zeeshan M. Sardar, Weber MH. What is safer in incompetent vertebrae with posterior wall defects, Kyphoplasty or Vertebroplasty: A study in vertebral analogs. Canadian Spine Society, March 2014. Weber MH et al. Degenerating and Painful Intervertebral Discs Secrete Pro-‐inflammatory and Pro-‐nociceptive Factors That Stimulate Neurite Growth and Induce CGRP Expression Through Nerve Growth Factor, Orthopaedic Research Society, March 2014.

ZUKOR Invitation Complex knee (valgus knee). Academic half day Teaching Mc Gill Orthopaedic Residents (R1-‐R5). Shriners Hospital Montreal QC April 17, 2014. Procedure duration of total knee arthroplasty and total hip arthroplasty affects the rate of wound complications and length of hospital stay. 3rd annual Canadian Arthroplasty Society Meeting, Toronto, ON November 27-‐28-‐2014. Refereed presentation 3rd annual Canadian Arthroplasty Society Meeting, Toronto, ON November 27-‐28-‐2014. O Huk, A Aoude, LM Epure, Y Brin, K Smith, DJ Zukor, M Tanzer, J Antoniou. Ceramic-‐on-‐ceramic: Better than We Thought. DJ Zukor, YS Brin, LM Epure, AS Cartaleanu, OL Huk, J Antoniou. Procedure duration of total knee arthroplasty and total hip arthroplasty affects the rate of wound complications and length of hospital stay. J Antoniou, A Hart, S Bergeron, LM Epure, OL Huk, DJ Zukor. Comparison of American and Canadian Perioperative Outcomes in Primary Total Hip and Knee Arthroplasty. 48th Annual Meeting of the Canadian Orthopaedic Research Society, Montreal QC. June 18-‐21, 2014. SY Brin, LM Epure, AS Cartaleanu, OL Huk, DJ Zukor, J Antoniou. TKA and THA procedure duration affect the rate of wound complications and length of hospital stay.

new division!of!orthopaedic!surgery! mcgill!university! … · 2016. 8. 11. ·...

Documents