Bipolar Disorder is a common, severe, and sometimes disabling condition characterized by a dynamic course of illness in which affective, cognitive and neurovegetative symptoms wax and wane. The illness has been well-recognized by clinicians for decades, if not cen-turies, yet the causes of bipolar disorder are not completely understood. Only recently with significant technological advances in both neuroimaging and genetic research, have clues that underlie the neurophysiology of the illness been discovered. The Bipolar Brain is the first focused look at these advances that have greatly enhanced our understanding of the development and course of the disorder.

Well organized in its presentation of empirical evidence, this volume concludes by vividly expounding a neurophysiological model that will not only help to guide research on bipo-lar disorder but also lead to a new framework for understanding the illness, developing improved therapies, and preventing its onset. This book is a must have for psychiatrists, neuroscientists, and practitioners who want the definitive reference on the bipolar brain.

Key Features:-Includes all known imaging modalities: MRI, CT, fMRI, DTI, PET, MRS, and SPECT-Analyzes common and distinct neuroimaging and genetic evidence between bipolar disorder and schizophrenia-Provides strategies for investigating the neurobiological differences between bipolar and unipolar depression

New fromOXFORD UNIVERSITY PRESS

Edited by Stephen M. Strakowski

The bipolar brainintegrating neuroimaging and genetics

June 2012 | 296 pages | 9780199797608 | $99.99/$74.99

Save 25% with promo code 30840!

"The Bipolar Brain is an outstanding compendium and synthesis summarizing the substantial advances to date in understanding the genetics, brain structures and function involved in the clinical manifestations of bipolar disorder. Highly readable and clinically relevant, with contributors who have led the fields of clinical neuroscience in bipolar disorder, this volume in itself advances the field." -- Paul E. Keck, Jr., MD, President-CEO Lindner Center of HOPE and Professor & Executive Vice Chair, Department of Psychiatry, University of Cincinnati College of Medicine

"The Bipolar Brain is an excellent, comprehensive, thoughtful, and cutting edge overview of what we know about the intersecting worlds of genetic and neuroimaging research in bipolar illness. It is also a first-rate gateway into the future." -- Kay Redfield Jamison, PhD, The Dalio Family Professor in Mood Disorders and Professor of Psychiatry, Johns Hopkins School of Medicine

"Strakowski and a stellar group of colleagues have produced a volume much awaited by the field. They provide us with an integrated neurophysiological model of bipolar disorder by focusing on neuroimaging and genetic findings -- no doubt the most robust biomarkers on the pathophysiology of this devastating condition. This volume achieves its goal of providing us with a neurophysiological paradigm of bipolar disorder -- a volume that will be of great value not only to investigators in the field but also to clinicians treating patients with bipolar disorder who wish to better understand its pathophysiology. This book gives me hope that with a better understanding of the condition, our patients will benefit from better treatments. The goal of developing treatments tailored to neuroimaging and genetic finding may not be that far away after all."-- Mauricio Tohen MD, DrPH, MBA, President, International Society for Bipolar Disorders

"The Bipolar Brain provides an abundance of readily accessible information on ways that brain imaging methods can aid in understanding the psychopathology, illness course, and interrelationships between brain structure and functions and other fundamental areas of investigation about bipolar disorders. For persons interested in incorporating brain imaging methodologies, an excellent overview addresses the principles, particular strengths and limitations of the several primary techniques available in the field. Much of the book focuses on multi-system studies. In particular, a section on interrelationships between mitochondrial functions and its impact on brain structure and function, as well as the unique genetic underpinnings of mitochondrial systems, is worth reading even by scientists working solely outside the field of brain imaging studies." -- Charles L. Bowden, MD, Professor of Clinical Psychiatry, The University of Texas Health Science Center at San Antonio

Section I: How neuroimaging informs models of bipolar disorder.Chapter 1. Brain imaging techniques and their application to bipolar disorder.by Caleb M. Adler and Michael Cerullo

Chapter 2. Structural brain abnormalities in bipolar disorder.by Koji Matsuo, Marsal Sanches, Paolo Brambilla, and Jair C. Soares

Chapter 3. Functional brain imaging in bipolar disorderby Lori L. Altshuler and Jennifer Townsend

Chapter 4. Neurochemical and metabolic imaging in bipolar disorderby Jieun E. Kim, In Kyoon Lyoo, and Perry F. Renshaw

Chapter 5. Neuroimaging studies of bipolar disorder in youth.by Manpreet K. Singh, Melissa P. DelBello, and Kiki D. Chang

Chapter 6. Neuroimaging studies of bipolar and unipolar depression.by Amelia Versace, Jorge R.C. Almeida, and Mary L. Phillips

Chapter 7. Neuroimaging in bipolar disorder and schizophrenia.by Heather Whalley, Jessika Sussman, and Andrew M. McIntosh

Section II: How genetic research informs models of bipolar disorder.Chapter 8. Genetic techniques and their application to bipolar disorder.by Aaron C. Vederman and Melvin G. McInnis

Chapter 9. General genetics of bipolar disorder.by John I. Nurnberger, Jr.

Chapter 10. Genetics of bipolar disorder and schizophrenia.by Michael E. Talkowski, Kodavali V. Chowdari, Hader Mansour, K. M. Prasad, Joel Wood, and Vishwajit L. Nimgaonkar

Chapter 11. Mitochondrial genetics and bipolar disorder.by Hayley B. Clay, Satoshi Fuke, Tadafumi Kato, and Christine Konradi

Section III: Integration and future directions.Chapter 12. Integrating imaging and genetic research: toward personalized medicineby Roy H. Perlis and Hilary P. Blumberg

Chapter 13. Integration and consolidation: a neurophysiological model of bipolar disorder.by Stephen M. Strakowski

Table of Contents

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The bipolar brainintegrating neuroimaging and genetics

edited by stephen m. strakowski

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