new molecular diagnostics of cancer - … molecular diagnostics of cancer. glycan microchip designed...
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NEW MOLECULARDIAGNOSTICSOF CANCER
Glycan microchip designedfor molecular diagnosticsof 4 cancers:
• breast, • ovarian, • colorectal, • mesothelioma
The array consists of 600 ligands – mostly glycans and glycopeptides.Each ligand is represented at 6 replicates for better accuracy.Sensitivefluorescentdetection.
Glycan array is a plastic chip (1’ x 3’) where 600 ligands are displayed
PRODUCT
PRINCIPLE OF THE DIAGNOSTICSDetection of diagnostic-valuable anti-glycan antibodies in serum/plasma
Diagnostic value - combinations of 8 - 10 antibodies-markers (“signatures”),specificforeachdisease
Cell membraneGlycoprotein
Glycolipid
Proteoglycan Cancer cell
Antibodies
THE GLYCAN MICROCHIP
MICROCHIP BENEFITS
Surface stabilizing nano-barrier addlayer
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Glycan immobilization
A Anchor group
Hydrophilic group
Glycan
Cancer-specific human antibody
Fluorescently labeled antibody
Serum incubation
Plastic support
Surface active 3D nano-layer
• High accuracy due to inclusion of several versions of the same ligand in composition of microchip.
• Multiplexity due to wide range of immobilized ligands;
• Lowbackgroundandwidedynamicrangeduetofluorescentdetectionand newly developed friendly surface architecture;
• DetectionofhighaffinityantibodieswhichknowntohavethebestDxva-lue (whereas ELISA detects full range of Abs);
• Low cost enables mass-diagnostics.
CONTACTS
semiotik-array.com/en/Surface & Nano-technologywww.plasmachem.com
Semiotik LLC,Miklukho-Maklaya str., 16/10, 117437, Moscow, RussiaTel. +7 (903) 537 75 [email protected] http://semiotik-array.com/en/
Plasmachem GmbHSchwarzschildstr. 10, 12489 Berlin, GermanyTel.: +49-30-63926313 [email protected] www.plasmachem.com