new products 2013 version 4
TRANSCRIPT
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EMD Millipore—with the expertise of Calbiochem ®, Chemicon®, and Upstate®
EMD Millipore is a division of Merck KGaA, Darmstadt, Germany
Epigenetic Regulators Panel - AcetylationCat. No. 324893
Histone acetylation/deacetylation has been implicated in
many biological processes, such as cell differentiation and
survival, double-strand DNA repair, cell cycle progression,
malignant transformation, tumor cell proliferation, cardiac
function and remodeling, and plant acclimation to cold
stress. EMD Millipore’s new Epigenetic Regulators Panel
contains 18 potent and selective small molecules and
enables a coordinated study of the interplay between
acetylation and deacetylation processes.
Epigenetic Regulators Panel - MethylationCat. No. 324894
DNA methylation is an important epigenetic marker of gene
repression. It plays important roles in heterochromatin
formation, long-term silencing of repetitive elements,
X-chromosome inactivation, differentiation of embryonic
stem cells and the establishment and maintenance of
imprinted genes. EMD Millipore’s new Epigenetic Regulators
Panel contains 12 potent and selective molecules and is
an ideal starting point for probing DNA methylation using
chemical genetics.
Small but powerful: regulating gene expressionwith small molecule epigenetic modulatorsGiven the emerging importance of epigenetic regulation and
dysregulation in disease states, it is not surprising that over
a dozen small molecule epigenetic modulators have been
reported in the literature as effective epigenetic modulators
and are either in preclinical or clinical trials1. A few are
already on the market. These small molecules span three
categories of modulators: “readers”, “writers”, and “erasers”
of epigenetic marks. The affected marks include histone
methylation, histone acetylation, and DNA methylation.
In addition to their therapeutic utility, these molecules are
also valuable for elucidating signaling networks and activity
of various enzymes involved in epigenetic regulation. Unlike
genetic perturbations, these small molecules enable dynamic
assays and precise dosing. EMD Millipore is offering these
valuable reagents, with full characterization of purity and
potency, to advance studies of gene regulation.
NeuroscienceCancerSignaling Cell Structure Stem Cell
ANTIBODIES, ASSAYS, SMALL MOLECULES, INHIBITORS, AND PROTEINSNew VOLUME 4 I 2013
products
Epigenetics &
Gene Regulation
1. Lu Q, Quinn AM, Patel MP, Semus SF, Graves AP, Bandyopadhyay D, Pope AJ, Thrall
SH. Perspectives on the discovery of small-molecule modulators for epigenetic
processes. J Biomol Screen. 2012 Jun;17(5):555-71.
HAT
Silenced Genes Gene Expression
HDAC
Hyperacetylation
Apoptosis
Inhibitors
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EMD Millipore is a division of Merck KGaA, Darmstadt, Germany
We’re validated.
We’re guaranteed.We’re published.We create the antibodiesmost cited by the research community.
Reput(Ab)leAntibodies
Researchers trust our antibodies because we are a thoughtful
antibody producer, not a reseller. We’re selective about offering
the best antibodies based on the expertise of Chemicon® andUpstate®, internal R&D teams and collaborations with leading
institutions. We guarantee our antibodies because of a stringent
validation process that produces the highest quality antibodies on
the market today.
We provide the most reliable, defensible, and publishable antibody
performance, because, ultimately, it’s not about our reputation.
It’s about yours.
Put the most reputable antibodies to work for you.
www.emdmillipore.com/Ab
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VOLUME 4 I 2013
Description Host Species Reactivity Key Applications Cat. No.
Antibodies
Anti-BANF1, clone EPR7669 Rabbit Hu WB, IHC MABE537
Anti-Bmi-1, clone EPR3745(2) Rabbit Hu WB, IHC MABE480
Anti-Bonzo Rabbit Hu WB, IHC ABE604
Anti-Centrin-2 Rabbit Hu, Ms, Rt WB, IC, IHC, IP ABE480
Anti-Centrin-3 Rabbit Hu, Ms, Rt WB, IP, IC, IHC ABE481Anti-CHD-4, clone 3F2/4 Mouse Hu, Ms WB, IHC, ChIP, IF MABE455
Anti-dimethyl G9a (Lys185) Rabbit Hu WB, PIA, IP ABE489
Anti-dimethyl Histone H3 (Arg17),
symmetric
Mouse Hu WB, DB, IC MABE246
Anti-dimethyl Histone H3 (Lys36) Rabbit Hu WB, DB, ChIP 07-369-I
Anti-FOXO4, clone EPR5442 Rabbit Hu WB, FC MABE539
Anti-H2A.Z.2.2, clone 1H11-11 Rat Hu WB MABE347
Anti-HIRA, clone EPR7416 Rabbit Hu WB, IF MABE565
Anti-Histone Deacetylase 6,
clone EPR1698(2)
Rabbit Hu WB, IHC MABE546
Anti-Histone H1°, clone 34 Mouse Hu, Ms, Rt, Bov, Xenopus WB, IC, IHC, FC MABE446
Anti-Histone H3.3, K27M mutant Rabbit Ms, Hu WB, ChIP ABE419
Anti-hMCM2, clone 2-40 Mouse Hu, Ms, Rt WB MABE203
Anti-IDH Rabbit Hu WB, IHC(P) ABE454
Anti-JMJD2D Rabbit Hu, Chimp WB, IHC, IP ABE499
Anti-KDM1B Rabbit Hu, Ms WB ABE495
Anti-LSD1, clone EPR6825 Rabbit Hu, Ms, Rt WB, IHC MABE545
Anti-Mad1, clone BB3-8 Mouse Hu WB, IF MABE867
Anti-Mad2, clone AS55-A12 Mouse Hu WB, IF MABE866
Anti-monoubiquitin H2A (Lys119) Rabbit Hu, Ms WB, ChIP, IC ABE569
Anti-Myb Binding Protein 1A Rabbit Hu WB, IC, ChIP ABE577
Anti-PERP Rabbit Hu WB, IC ABE606
Anti-PHF19 Rabbit Hu WB, IP, ChIP ABE992
Anti-phospho-FOXO4 (Ser262),
clone EPR2315(2)
Rabbit Hu WB MABE555
Anti-PTBP2 Rabbit Hu, Ms, Rt WB, IP ABE431
Anti-RAG-1 Rabbit Hu WB, IC, IP ABE440
Anti-Sirt1(Sir2), clone 3-10 Rabbit Ms WB, IHC MABE426
Anti-Ski, clone G8 Mouse Hu WB, IHC MABE442
Anti-SPT5 Rabbit Hu WB, IP ABE443
Anti-SUV39H1, clone EPR4960(2) Rabbit Hu WB MABE552
Anti-TCF-4, clone 5F9.1 Mouse Hu WB, IHC MABE361
Anti-TET2 Rabbit Hu WB ABE595
Anti-TET2, clone hT2H 21F11 Mouse Hu, Ms WB, IP MABE462
Anti-THAP11 Rabbit Hu, Ms, Rt WB, IP, ChIP, IHC ABE567
Anti-THRAP3 Rabbit Hu IP, IC, WB ABE487
Anti-TIF1-α Rabbit Hu, Ms WB, IC ABE434
Anti-TIP60, clone 3F9 Mouse Hu WB, IHC MABE430
Anti-UBE2I, clone 1B10 Mouse Hu, Mky WB, IF, IHC, FC MABE429
Anti-USP9X, clone 3H11.1 Mouse Hu, Ms, Rt WB, IHC MABE352
Anti-UTX Rabbit Hu, Ms WB, IC ABE409
Anti-WBP-7 Rabbit Hu, Ms, Rt WB ABE500
Anti-WDR5, clone 7B11 Mouse Hu WB MABE428
Anti-ZEB1 Rabbit Hu WB, IC, IF ABE596
ChIPAb+™ Acetyl Histone H3 (Lys56) Rabbit Hu WB, DB, ChIP 17-10259
Milli-Mark® Anti-acetyl-Histone H4-PE Rabbit Hu FC FCABS326PE
Epigenetics & Nuclear Function
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine,Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque,Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry,IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation,
WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=PeptideInhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,CC=Cell Culture, BM=Bisulfite Modification
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
Anti-Histone H3.3,K27M mutant(Cat. No. ABE419)
In a recent Science paper titled:Inhibition of PRC2 activity by a gain-of-
function H3 mutation found in pediatric
glioblastoma* the Allis laboratory and
colleagues (representing Rockefeller,
Princeton, Duke and the University of
Pennsylvania) used EMD Millipore’s newly
released anti-Histone H3.3 K27 mutant,
rabbit polyclonal antibody (Cat. No.
ABE419) to explore epigenetic control in
pediatric glioma and other pathologies.
The authors discovered that certain
human gliomas containing the missense
mutation Lys27Met (K27M) in histone
H3.3 displayed lower overall amounts of
H3K27me3 both in vivo and in vitro . The
Histone H3K27 mutant-specific antibody
from EMD Millipore was used in Western
blotting, immunohistochemistry and ChIP
analysis to reveal the expression of the
gain-of-function mutation and correlate it
to the disease state. The researchers propose
that K-to-M substitutions may represent a
mechanism to alter epigenetic states in a
range of pathologies.
NOTE: To help you extend and complement
these studies we have also just released arecombinant H3K27M recombinant protein.
See the the Proteins, Enzymes and Reagents
Section on the next page.
*Lewis PW et al. Science. 2013 May 17;340(6134):857-61.
PUBLICATION HIGHLIGHT
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VOLUME 4 I 2013
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,
ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,CC=Cell Culture, BM=Bisulfite Modification
Description Host Species Reactivity Key Applications Cat. No.
Antibodies - Trial Size
Anti-acetyl-Histone H3 (Lys14),
clone EP964Y, Trial Size
Rabbit Hu, Rt WB, IHC(P), IC,
IP, DB
04-1044-S
Anti-acetyl-Histone H3 (Lys56), Trial Size Rabbit Hu WB, DB, ChIP 07-677-IS
Anti-Histone H3, (Unmodified Lys4),
clone CMA301, Trial Size
Mouse Hu, VertebRtes WB, IC, ELISA, IP,
FC, DB
05-1341-S
Anti-monomethyl-Histone H3 (Lys9),
Trial Size
Rabbit Hu, Ms, Chk DB, IC, PIA, WB 07-450-S
Anti-monomethyl-Histone H3 (Lys9),
Trial Size
Rabbit Hu WB, IC, PIA, DB ABE101-S
Anti-trimethyl Histone H3 (Lys4),
clone CMA304, Trial Size
Mouse Hu, VertebRtes ELISA, IC, IP, WB,
Multiplexing, DB
05-1339-S
Anti-trimethyl-Histone H4 (Lys20),
Trial Size
Rabbit Hu, Ms, Rt IP, WB, ChIP, DB 07-463-S
Kits & Assays
CpGenome™ Direct Prep Bisulfite
Modification Kit (200 Reactions)
BM 17-10452
CpGenome™ Direct Prep Bisulfite
Modification Kit (50 Reactions)
BM 17-10451
Proteins, Enzymes, & ReagentsHuman Recombinant Histone H3.3 E. Coli ChIP, Activity
Assay
14-1063
Human Recombinant Histone H3.3 K27M E. Coli ChIP, Activity
Assay
14-1064
Epigenetics & Nuclear Function (continued)
Description Details Cat. No.
Small Molecules & Inhibitors
5-Azacytidine A cell-permeable ribonucleoside analog of cytidine that is reported to readily
incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA
methyltransferases depletion, DNA hypomethylation and DNA damage.
5.04317.0001
CRM1 Inhibitor IV,
KPT-251
A cell-permeable, irreversible, triazole-containing heterotricyclic CRM1 inhibitor
that effectively blocks CRM1-mediated nuclear export (4 h 1µM in U2OS cells)
via covalent interaction with CRM1 NES- (nuclear export signal) binding groove
cysteine (Cys528 in human).
5.00505.0001
Ezh2 Inhibitor II, EI1 A cell-permeable indolocarboxamide compound that acts as a potent and selective
inhibitor against Ezh2/PRC2 (Polycomb repressive complex 2; Ezh2/SUZ12/EED/
AEBP2/RbAP48) HMTase activity (IC50
/substrate = 15 nM/H3K27me021-44 and
13 nM/H3K27me221-44, respectively, against human wt or Y641F Ezh2-containing
PRC2; [SAM] = 1 µM) in a cofactor SAM-competitive manner.
5.00561.0001
Histone Lysine
Demethylase
Inhibitor VII, GSK-J1
A pyridinyl-pyrimidinylaminopropanoic acid that effectively inhibits KDM6 family
H3K27m3 demethylases JMJD3 and UTX (IC50
= 18 and 56 µM, respectively, by
MALDI Mass detection) in an α-ketoglutarate-competitive, peptide
substrate-non-competitive manner. Recommended for cell-free assays only.
420204-10MG
JQ1 Enantiomers Set A cell-permeable I-BET (Cat. No. 401010) class of thienodiazepine derivative whose
(S)-(+), but not (R)-(-), enantiomer is shown to target both bromodomains
(BD1 & BD2) of BET family members BRD2, BRD3, BRD4, and BRD6/BRDT in a
Kac- (ε-N-acetylated lysine) competitive manner.
500586-1SET
L3MBTL3 MBT
Domain Blocker,UNC1215
A cell-permeable pyrrolidinyl-piperidinyl-benzamide that effectively competes
against H4K20Me2 peptide for L3MBTL3 binding by targeting the first two L3MBTL3MBT domains (K
d = 120 nM in binding studies using recombinant 3MBT fragment).
5.00557.0001
Ezh2 Inhibitor II, EI1(Cat. No. 5.00561.0001)
EMD Millipore has recently introduced
a new inhibitor of Ezh2/PRC2 (Enhancer
of zeste homolog 2/Polycomb repressivecomplex 2) methyltransferase activity.
In a 2012 PNAS paper titled:
Selective inhibition of Ezh2 by a small
molecule inhibitor blocks tumor cell
proliferation*
Qi and colleagues showed that this inhibitor
exhibited about 142-fold greater selectivity
over Ezh1 and >10,000-fold selectivity over
several other histone methyltransferases
(G9a, Suv39H2, Set7/9, CARM1, SmyD2,
SETD8, NSD3, SETD2, MLL, and Dot1L).
They also report that this Ezh2 inhibitor
blocked the growth of diffuse large B cell
lymphoma cells carrying Ezh2 mutations
and diminished H3K27me3 and H3K27me2
levels without affecting H3K27me1.
* Qi, W. et al. 2012. Proc. Natl. Acad. Sci, USA 109,
21360-21365.
Perform intricate in vitro manipulations of
histones, nucleosomes, and chromatin with
our portfolio of purified recombinant histones,
native nucleosomes, highly active histone-
modifying enzymes, and broad range of
modified peptide substrates. To see more, visit:www.emdmillipore.com/epiproteins
PUBLICATION HIGHLIGHTON SMALL MOLECULES:
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VOLUME 4 I 2013
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
Cancer
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,
ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,CC=Cell Culture, BM=Bisulfite Modification
Description Host Species Reactivity Key Applications Cat. No.
Antibodies
Anti-ACVR1 Rabbit Hu IHC ABC330
Anti-Ambra1 Rabbit Hu, Ms WB ABC131
Anti-Atg13 Rabbit Hu WB ABC130
Anti-CLEC2A Rabbit Hu WB ABC328
Anti-CRK Mouse Hu, Ms, Rt WB MABC172Anti-CRKL Rabbit Hu, Ms, Rt WB, IP ABC242
Anti-CRTC1, clone 1B5 Mouse Hu WB, IC, FC MABC691
Anti-DHODH Rabbit Hu WB, IHC(P) ABC138
Anti-EIF4B, clone 1F5 Mouse Hu, Ms WB, IC, FC, IHC MABC666
Anti-ENC1, clone EPR5406(B) Rabbit Hu WB, IHC MABC685
Anti-EPB41L3 (DAL1), clone 12D12.1 Mouse Hu WB, IHC MABC156
Anti-EPHB4 Rabbit Hu WB ABC257
Anti-ETV4, clone 1A2G3 Mouse Hu WB MABC681
Anti-FLI1 Rabbit Hu, Ms WB ABC219
Anti-GLI1 Rabbit Hu, Rt WB, IHC(P) ABC217
Anti-Gli-1, clone EPR4523 Rabbit Hu WB, IHC MABC678
Anti-GPC3, clone 9C2 Mouse Hu, Ms WB, IF, IHC, FC MABC667
Anti-IRF-5, clone EPR6094 Rabbit Hu WB, FC MABC686
Anti-KLF4, clone 1E6 Mouse Hu IHC, WB MABC631
Anti-KPNA2 Rabbit Hu, Rt WB, IHC ABC342
Anti-LPL, clone 2C5 Mouse Hu WB MABC674
Anti-MATK, clone 9D7 Mouse Hu WB, FC MABC682
Anti-MUM1, clone 4G10 Mouse Hu WB, IHC MABC640
Anti-Napsin A, clone EPR6252 Rabbit Hu WB, IHC MABC643
Anti-NLRP10, clone 8H2 Rat Hu WB, FC, IC MABC293
Anti-NPC1 Rabbit Rt, Ms WB ABC133
Anti-nSMase1, clone EPR6718 Rabbit Hu WB, IF MABC687
Anti-Nucleostemin, clone 5C3.1 Mouse Hu WB, IC MABD97
Anti-NUP96, clone EPR6678 Rabbit Hu WB, IHC MABC689
Anti-OTUD7B, clone 90-46-126 Mouse Hu WB MABC281
Anti-PALB2 Rabbit Hu WB, IHC ABC331
Anti-PDCD1LG2 Rabbit Hu WB, FC ABC221
Anti-phospho AMBRA1 (Ser52) Rabbit Hu WB, PIA ABC80
Anti-phospho MLKL (Thr357) Rabbit Hu WB, PIA ABC234
Anti-phospho ULK1 (Thr574) Rabbit Hu WB, PIA ABC212
Anti-PIDD, clone 1511.1 Mouse Hu, Ms, Rt WB, IC MABC189
Anti-PLAP, clone EPR6141 Rabbit Hu WB, IHC MABC644
Anti-PLK-4, clone 6H5 Mouse Hu WB, IC, IP MABC544
Anti-PSP94, clone EPR7345 Rabbit Hu WB, IHC MABC645
Anti-PTGFR, clone EPR5844 Rabbit Hu WB MABC642
Anti-RIP, clone EPR4689 Rabbit Hu WB MABC688
Anti-RRM2, clone 4D1.2 Mouse Hu WB, IC MABC154Anti-RUNX1, clone 2B5 Mouse Hu WB MABC679
Anti-SCARB1 Rabbit Hu WB, IHC, IF ABC326
Anti-SCCA, clone EPR5157 Rabbit Hu WB, IHC MABC646
Anti-SDF-1 Rabbit Hu, Ms, Rt, Mky WB ABC96
Anti-SFRP1, clone EPR7003 Rabbit Hu WB, IHC MABC647
Anti-SFTPC Rabbit Hu, Rt, Ms WB, IHC(P) ABC99
Anti-phospho AMBRA1(Ser52)(Cat. No. ABC80)
EMD Millipore’s newly released anti-
phospho AMBRA1 (Ser52) rabbit polyclonal
antibody (Cat. No. ABC80) was recently
published in an important study identifying
a new target for mTOR and a key new
positive regulation loop in autophagy in a
Nature Cell Biology paper titled:
mTOR inhibits autophagy by controlling
ULK1 ubiquitylation, self-association and
function through AMBRA1 and TRAF6*
The authors demonstrated that mTORinhibits AMBRA1 by phosphorylation
under non-autophagic conditions. Upon
induction of autophagy, AMBRA1 enhances
ULK1 kinase activity and stability through
its Lys-63-linked ubiquitination and
interaction with TRAF6, thus detaching
from the anchoring dynein complex. The
authors used the anti-phospho AMBRA1
(Ser52) antibody in Western blotting
and immunocytochemistry to identify
AMBRA1 phosphorylation in the complex
during autophagic induction. Elucidating
the interactions in this autophagosome-
related protein complex may reveal apositive feedback mechanism for sustaining
autophagy in a continuous loop and may
have significant therapeutic implications.
*Nazio F et al. Nat Cell Biol. 2013 Apr;15(4):406-16.
PUBLICATION HIGHLIGHT
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Description Details Cat. No.
Small Molecules & Inhibitors
Akt Inhibitor XVI,
AT7867
A cell-permeable pyrazolo compound that acts as a potent inhibitor against Akt
(IC50
= 32, 17, and 47 nM against Akt1, Akt2, and Akt3, respectively), PKA (IC50
= 20
nM), and p70S6K (IC50
= 85 nM) in an ATP-competitive manner (Ki = 18 nM using
AKT2), with much reduced potency toward RSK1 (IC50
>100 nM) and a panel of
13 other cellular kinases (IC50 >1 µM).
124033-10MG
Bcr-abl Inhibitor IV,
Imatinib
A cell-permeable, orally bioavailable 2-phenylaminopyrimidine derived compound
that competitively binds to ATP-binding site of Abl and stabilizes the inactive
conformation, and acts as a highly potent and reversible inhibitor of Abl (IC50
= 38,
25 and 25 nM for v-Abl, Bcr-Abl, and c-Abl, respectively). Also shown to block the
activity of PDGFR and c-kit (IC50
= 50 and 100 nM).
5.04595.0001
CXCR4 Antagonist
IV, TF14016
A 14-aa internally disulfide-bonded peptide that potently competes against SDF-
1α/CXCL12 for CXCR4 binding (IC50
= 0.91 nM; [SDF-1] = 100 nM) and protects
MT-4 cells against X4-HIV strain HIV-1IIIB infection (EC50
= 4 nM in 5 d;
MOI = 0.01) with no significant cytotoxicity (CC50
= 56 µM; 5 d).
5.00507.0001
ERK Inhibitor VIII A cell-permeable pyrimidylpyrrole compound that acts as an active site-targeting,
highly potent and selective ERK1/2 inhibitor (KI <2 nM against Erk2; [ATP] = 65 µM).
Orally available in both mice and rats in vivo .
328011-10MG
Gemcitabine, HCl A bioavailable, moderately toxic, deoxyctytidine analog with anti-metabolite and
anti-tumor properties. Shown to be effective against a variety of tumors and blocks
the growth of cancer cells in culture (IC 50 = 8.7, 57, 3.7, and 36 nM for L1210,
CEM, Caco2, and HeLa cells, respectively).
5.04594.0001
HIF Inhibitor V A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced
cellular HIF-1α accumulation in a manner similar to LW6 (Cat. No. 400083) by
upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much
higher potency (IC50
= 120 nM vs 2.44 µM, respectively, against hypoxia-induced
HRE reporter activity in HCT116 cells
5.00498.0001
IDH1 Inhibitor, R132
Somatic Mutant-
Specific
A cell-permeable phenyl-glycine analog that acts as an IDH1 (Isocitrate
Dehydrogenase 1) R132 somatic mutant-specific inhibitor (IC50
= 0.07, 0.16, and
>100 µM, respectively, against R132H, R132C, and wt IDH1), potently inhibiting
oncometabolite 2-HG (D-2-hydroxyglutarate) production.
410972-25MG
Mcl-1 Inhibitor,
MIM1
A cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but
not Bcl-XL, antiapoptotic activity, by directly targeting Mcl-1 BH3-binding site,
effectively competing against Bid BH3 sequence interation with Mcl-1
(IC50
= 4.8 µM) without affecting Bcl-XL interaction with Bad or Bid BH3
sequence (IC50
>50 µM).
444130-25MG
mTOR Inhibitor XI,
Torin1
A cell-permeable pyridinonequinoline derivative that acts as a highly potent,
ATP-competitive inhibibitor against mTOR and DNA-PK (IC50
= 4.32 and 6.34 nM,
respectively), while inhibiting PI 3-K only at much higher concentrations
(IC50
=171 to 533 nM).
475991-10MG
mTOR Inhibitor XII,
Torin2
A Torin1 (Cat. No. 475991) structural analog that acts as a cell-permeable, potent,
ATP-competitive inhibitor against DNA-PK and mTOR (IC50
= 0.5 and 2.81 nM,
respectively).
475992-10MG
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,
CC=Cell Culture, BM=Bisulfite Modification
VOLUME 4 I 2013 Cancer (continued)
Description Host Species Reactivity Key Applications Cat. No.
Antibodies (continued)
Anti-SOD1, clone 6F5 Mouse Hu, Ms WB, IC, FC MABC684
Anti-SOX9, clone 1B11 Mouse Hu WB, IF MABC672
Anti-STIP1, clone EPR6606 Rabbit Hu WB, IHC MABC648
Anti-Syntaxin 8 Rabbit Hu WB ABC144
Anti-TSG101, clone EPR7130(B) Rabbit Hu WB, FC MABC649Anti-TSPO Rabbit Hu WB, IHC ABC139
Anti-TXNDC5, clone 2E7/7 Mouse Hu WB, IC MABC546
Anti-VKORC1 Rabbit Hu WB, IHC ABC325
Anti-ZBED1 Rabbit Hu WB, IHC(P) ABC258
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Description Details Cat. No.
Small Molecules & Inhibitors
TLR1/TLR2
Antagonist, CU-
CPT22
A cell-permeable benzotropolone compound that competes against Pam3CSK4-
(Cat. No. 506350) for TLR1/TLR2 heterodimer binding
(Ki = 410 nM) and selectively antagonizes against Pam3CSK4-induced RAW264.7
cellular NO production (IC50
= 580 nM) without apparent cytotoxicity (up to 100
µM and 24 h).
614305-10MG
Description Details Cat. No.
Small Molecules & Inhibitors
p21-Activated
Kinase Inhibitor II,
PF-3758309
A cell-permeable pyrrolopyrazole that acts as a potent inhibitor against
p21-activated kinases (Ki in nM/[ATP] in µM = 13.7/200, 18.7/40, 18.1/80. 17.1/72,
respectively, in PAK1, PAK4, PAK5, PAK6 kinase assays; IC50
= 190 and 99 nM against
PAK1 and PAK3, respectively) by directly targeting the kinase ATP-binding site in a
reversible manner (Kd = 4.5 nM using rhPAK4300-591 kinase domain).
5.00613.0001
Protein DisulfideIsomerase Inhibitor
III, PACMA 31
A cell-permeable propynoic acid carbamoyl methyl amide (PACMA) that is morepotent than PAO (Cat. No. 521000) in inhibiting PDI (protein disulfide isomerase)
thioloxidoreductase activity (IC50
= 10 and 85 µM, respectively; 1h preincubation)
by altering PDI secondary conformation via covalent modification of active site
C(397)GHC(400) motif cysteines.
539225-25MG
Rad6 Inhibitor A cell-permeable triazine compound that directly targets human E2 Ubiquitin-
conjugating enzyme Rad6B/HHR6B catalytic site via noncovalent interactions
and effectively inhibits Rad6B-Ub thioester bond formation as well as subsequent
substrate ubiquitination without affecting UbcH5B/UBE2D2-catalyzed BCA2
ubiquitination.
5.00655.0001
RubR1 Activator,
GF-15
A cell-permeable 2'-benzyloxy griseofulvin derivative that displays enhanced
mammalian cancer-selective toxicity (IC50
≤2, ≤4, ≤12, and ≥30 µM against panels
of leukemia, myeloma, solid tumors, and non-malignant cell lines, respectively),
but little antifungal activity, by activating spindle-assembly-checkpoint without
affecting microtubule kinetochore attachment.
5.00495.0001
SKP2 E3 Ligase
Inhibitor I, C1
A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and
p27Kip1 protein levels (10 µM for 16 h in 501 Mel cultures) by preventing Skp2-
Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin
ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) complex.
5.00519.0001
Survivin Inhibitor
III, LLP-3
A cell-permeable, dihydropyridinone compound that selectively disrupts survivin-
Ran interaction in cell-free binding assays (IC50
<0.3 µM) and in U87 glioma cells
(by 55% in 24 h; 20 µM) via direct binding at survivin protein-protein interaction
interface.
5.00614.0001
Temozolomide A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC
[5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA
alkylating activity is employed in anticancer therapy.
5.00609.0001
Cancer (continued)
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine,Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque,Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry,IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation,WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=PeptideInhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,CC=Cell Culture, BM=Bisulfite Modification
VOLUME 4 I 2013
Inflammation & ImmunologyDescription Host Species Reactivity Key Applications Cat. No.
Antibodies
Anti-Bst2 Rabbit Hu WB ABF200
Anti-CD20, clone 2H7 Mouse Hu FC, IP, IHC MABF250
Anti-CD32, clone EP6243 Rabbit Hu WB, IHC MABF193
Anti-CD35, clone EPR6602 Rabbit Hu WB, IHC MABF194
Anti-CD38, clone 2H3-2 Mouse Hu WB, FC MABF238
Anti-CIITA Rabbit Ms, Hu WB, IHC ABF212
Anti-CSF1, clone 2D10 Mouse Hu WB, IHC MABF191
Anti-IL-33, clone 12B3C4 Mouse Hu WB, IHC MABF204
Anti-KARS, clone 8G12C1 Mouse Hu WB, IHC MABF187
Anti-Kininogen-1, clone EPR6097 Rabbit Hu WB, IHC MABF202
Anti-MDA-5, clone EPR6743 Rabbit Hu WB MABF198
Anti-NALP3 Rabbit Hu WB, IF ABF198
Anti-S1P1 Rabbit Ms WB, IHC ABF203
Anti-Tapasin, clone 7F6 Rat Hu, Rt WB, FC MABF249
Anti-TLR4, clone 13E1.1 Mouse Hu FC MABF85
Anti-TRIF Rabbit Hu WB, IHC, IF ABF201
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LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,CC=Cell Culture, BM=Bisulfite Modification
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
Description Details Cat. No.
Small Molecules & Inhibitors
InSolution™ Cytochalasin D,
Zygosporium mansonii
A 10 mM (1 mg/197 µL) sterile-filtered solution of Cytochalasin D,
Zygosporium mansonii (Cat. No. 250255) in DMSO. Cell-permeable fungal
toxin. About 10-fold more potent than cytochalasin B in inhibiting actin
filament function.
5.04776.0001
Rho Inhibitor II, Y16 A cell-permeable pyrazolidinedione compound that is shown to target
RhoGEF DH-PH domain junction with high affinity (Kd = 65 nM) and
effetively prevent RhoGEFs LARG, p115, and PDZ from interacting with
RhoA, while displaying little potency against DBL-RhoA, LBC-RhoA,
intersectin-Cdc42, or TrioN-Cdc42 interaction.
5.04043.0001
VOLUME 4 I 2013 Cell Structure
Metabolism
Description Host Species Reactivity Key Applications Cat. No.
Antibodies
Anti-DSG2 Rabbit Hu WB, IP ABT181
Anti-ALPP, clone 3E5 Mouse Hu IHC, WB MABT457
Anti-CDCP1 Rabbit Hu WB, IHC(P) ABT180
Anti-DYNLT1, clone 7A9F4H10 Mouse Hu WB, IHC MAB1076-I
Anti-EPHB4 Rabbit Hu WB ABC257Anti-IL-1RAcP Rabbit Hu WB, IC ABT333
Anti-IQGAP1 Rabbit Hu WB, IHC(P) ABT186
Anti-L1CAM Rabbit Hu, Rt WB, IHC(P) ABT143
Anti-MSN, clone 2C12 Mouse Hu WB, IHC, FC MABT456
Anti-Oncostatin M, clone EPR7150 Rabbit Hu WB MABT459
Anti-PAK4 Rabbit Hu, Ms, Rt WB, IC ABT144
Anti-Protocadherin-10 Rabbit Hu WB, IHC(P) ABT176
Anti-Tks5, PX domain Rabbit Ms WB, IP ABT102
Anti-TSLP Rabbit Hu, Ms WB, IHC(P), IF ABT330
Anti-Versican, clone 8D8.1 Mouse Hu, Ms IHC, WB MABT161
Anti-ZEB2 Rabbit Hu WB, IC, IF ABT332
Description Host Species Reactivity Key Applications Cat. No.
Antibodies
Anti-Apolipoprotein L1, clone EPR2906 Rabbit Hu WB, IHC MABS387
Anti-LCN13 Rabbit Ms WB ABS311
Anti-TRABID Rabbit Hu WB, IP ABS13
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LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,CC=Cell Culture, BM=Bisulfite Modification
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
VOLUME 4 I 2013Neuroscience
Description Host Species Reactivity Key Applications Cat. No.
Antibodies
Anti-ACBD3, clone EPR8623,
Rabbit Monoclonal
Rabbit Hu WB, FC MABN1045
Anti-α SNAP, clone EPR7372 Rabbit Hu WB, IHC MABN1023
Anti-Aminoacylase-1, clone EPR8444,
Rabbit Monoclonal
Rabbit Hu WB, FC MABN1046
Anti-Annexin A3 Rabbit Hu WB, IHC(P) ABN294
Anti-Annexin A4, clone PA351-29.1.3 Mouse Hu WB, IHC, ELISA MABN480
Anti-APP-C99, clone mC99(1-7) Mouse Hu, Ms WB, IP, IC, IHC MABN381
Anti-APP-C99, clone mC99(70–80) Mouse Hu, Ms WB MABN380
Anti-ARG1, clone EPR6672(B) Rabbit Hu WB, IHC MABN1024
Anti-ARHGDIA, clone 2G3 Mouse Hu, Ms, Mky, Rt WB, IF, FC MABN689
Anti-ARNTL, clone 1C5 Mouse Hu WB, IHC MABN673
Anti-ASS1, clone 2C10 Mouse Hu, Rt, Ms, Mky WB, IHC MABN704
Anti-ATP2A1, clone EPR7321,
Rabbit Monoclonal
Rabbit Hu WB, IHC MABN1025
Anti-BAALC Rabbit Ms, Rt WB ABN254
Anti-CA9, clone 2D3 Mouse Hu WB, IHC, FC MABN713
Anti-CADM4, clone N244/5 Mouse Ms, Rt, Hu WB MABN509Anti-CAM, clone L45/30 Mouse Ms, Hu WB MABN500
Anti-cAMP, clone EP8471 Rabbit All ELISA MABN1026
Anti-Cav3.2 Calcium Channel Subunit,
clone N55/10
Mouse Ms WB MABN487
Anti-CCL2, clone 2D8 Mouse Hu, Ms, Rt, Mky WB, IF, IHC, FC MABN712
Anti-CCT2, clone 5B5C4 Mouse Hu, Ms, Rt, Mky WB, IF, FC MABN686
Anti-CD52, clone EPR3153(2), Rabbit
Monoclonal
Rabbit Hu WB MABN1047
Anti-CD73, clone EPR6115 Rabbit Hu WB, IHC MABN1027
Anti-CHD3, clone 2G4 Mouse Hu, Ms WB, IHC, IF, FC MABN694
Anti-Clcn3, clone N258/5 Mouse Hu, Ms IHC, WB MABN490
Anti-CNGA1/3, clone L36/12 Mouse Rt, Zebrafish, Ms, Fish WB, IHC MABN468
Anti-COASY, clone EPR8246,Rabbit Monoclonal
Rabbit Hu WB, FC MABN1048
Anti-Complex I-75kD Rabbit Hu, Ms, Rt WB, IHC(P) ABN302
Anti-Cullin-5 (CUL5) Rabbit Hu WB, IHC ABN289
Anti-DCX, clone 2G5 Mouse Hu, Ms WB, IHC, IC, FC MABN707
Anti-DISC1 Rabbit Hu WB ABN46
Anti-DLK1, clone 3A10 Mouse Hu, Ms IHC, IF MABN671
Anti-ECH1 Rabbit Hu WB, IHC(P) ABN296
Anti-Ermin, clone 160 Mouse Ms, Rt WB, IC, IHC MABN323
Anti-ETV5, clone 3H3 Mouse Hu WB MABN683
Anti-FABP2, clone 9A9B7B3 Mouse Hu, Ms WB, IF, IHC, FC MABN698
Anti-FGF13A, clone N235/22 Mouse Hu, Ms, Rt WB, IHC MABN539
Anti-Fluorescent Gold Rabbit All IHC(P) AB153-I
Anti-Folate Receptor 1, clone EPR4708(2) Rabbit Hu WB MABN1067
Anti-G6PD, clone 2H7 Mouse Hu WB, IHC, FC MABN696
Anti-GADD45 β, clone EPR1235(2) Rabbit Hu WB MABN1030
Anti-GADD45B Rabbit Hu WB, IHC(P) ABN42
Anti-GIT2 Scaffold Protein, clone N83/48 Mouse Hu WB, IHC MABN469
Anti-GPI, clone 1B7D7 Mouse Hu, Rt WB, IHC, IF MABN691
Anti-GRPR Rabbit Hu WB, IHC(P) ABN295
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0
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,
CC=Cell Culture, BM=Bisulfite Modification
VOLUME 4 I 2013 Neuroscience (continued)
Description Host Species Reactivity Key Applications Cat. No.
Antibodies (continued)
Anti-Hemoglobinδ chain, clone
EPR8322(B), Rabbit Monoclonal
Rabbit Hu WB, IHC MABN1031
Anti-HK2, clone 3D3 Mouse Hu WB, IHC, FC MABN702
Anti-Human IgG1, clone EPR4417 Rabbit Hu WB MABN1055
Anti-Iduna, clone N201/35 Mouse Rt, Hu, Ms WB, IHC MABN647
Anti-IRE1p Rabbit Ms, Hu WB, IC, IHC ABN464
Anti-KDM4A, clone5H1 Mouse Hu WB, IHC, IF MABN685
Anti-Kirrel3, short isoform 3, clone
N320/48
Mouse Hu WB, IHC MABN650
Anti-LCN1, clone 10B10 Mouse Hu WB, IHC, IF MABN670
Anti-LRAT, clone M34-P1F10 Mouse Hu, Ms, Rt WB, IHC, IF MABN644
Anti-LRRK2, clone 8G10 Mouse Hu WB, IHC MABN636
Anti-LRRK2, clone N231B/34 Mouse Rt, Hu WB MABN541
Anti-LysRS, clone EPR7920,
Rabbit Monoclonal
Rabbit Hu WB, IHC, IF MABN1032
Anti-Metadherin, clone 2F11C3 Mouse Hu WB, IHC, FC MABN699
Anti-MGEA5, clone EPR7154(B) Rabbit Hu WB, IHC MABN1033
Anti-MTRR, clone EPR6110 Rabbit Hu WB, IHC MABN1086Anti-Nalcn, clone N185/7 Mouse Hu WB MABN653
Anti-NDUFA1 Rabbit Hu, Ms, Rt WB, IHC(P) ABN360
Anti-NEGR1, clone 5A4.1 Mouse Hu, Ms, Rt WB MABN360
Anti-Neurexin-1-β Mouse Hu, Rt IHC MABN607
Anti-Neuron Specific Enolase Rabbit Hu, Rt, Ms WB, IHC(P) AB951-I
Anti-NGL-1, clone N49A/21 Mouse Rt WB, IHC MABN655
Anti-NGL-2, clone N50/36 Mouse Rt, Ms WB, IHC MABN656
Anti-OCRL/INPP5b, clone N166A/26 Mouse Hu, Rt WB, IHC MABN609
Anti-Pan-GRK, clone N145/20 Mouse Ms WB MABN615
Anti-Paris/ZNF746, clone N196/16 Mouse Hu, Ms, Rt WB MABN476
Anti-PEX7, clone N232/9 Mouse Hu WB, IHC MABN659
Anti-PhyH / PAHX, clone N210/5 Mouse Hu, Ms, Rt WB, IHC MABN660
Anti-PITX3, clone EPR8868 Rabbit Hu WB, FC MABN1052
Anti-Potassium Channel Kv10.1, clone 56 Mouse Hu, Rt IHC, Activity
Assay, IF
MABN378
Anti-PPBP, clone EPR7766,
Rabbit Monoclonal
Rabbit Hu WB MABN1034
Anti-PPP1CA, clone 5E9 Mouse Hu WB MABN690
Anti-Prohibitin Rabbit Hu WB, IHC(P) ABN293
Anti-PSIP1, clone 6E4 Mouse Hu, Mky, Rt WB, IHC, IF MABN674
Anti-PSMA, clone EPR6253,
Rabbit Monoclonal
Rabbit Hu WB, IHC MABN1035
Anti-PTH1R, clone 4D2 Mouse Hu WB, IHC, IF MABN688
Anti-PTK7, clone 4F9 Mouse Hu WB, IHC MABN721
Anti-Rab10, clone 4E2 Mouse Hu, Ms WB, IF MABN730
Anti-Rab7A, clone EPR7588(B),
Rabbit Monoclonal
Rabbit Hu, Rt, Ms WB, IHC MABN1036
Anti-ROCK2, clone EPR7141(B),
Rabbit Monoclonal
Rabbit Hu, Rt WB, IHC MABN1037
Anti-S100a5, clone N176A/3 Mouse Hu WB, IHC MABN662
Anti-S100B Rabbit Hu WB, IHC(P) ABN59
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1
Neuroscience (continued)
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,
CC=Cell Culture, BM=Bisulfite Modification
VOLUME 4 I 2013
Description Host Species Reactivity Key Applications Cat. No.
Antibodies (continued)
Anti-SBDS, clone EPR7820,
Rabbit Monoclonal
Rabbit Hu WB MABN1038
Anti-SCN4B, clone N168/6 Mouse Hu, Rt WB, IHC MABN654
Anti-SELK Rabbit Ms WB ABN480
Anti-SLC22A3, clone EPR6630 Rabbit Hu WB, IHC MABN1039
Anti-SMAD5, clone 3H9 Mouse Hu, Rt WB, IF, IHC, FC MABN718
Anti-SNAP-23, clone EPR8538,
Rabbit Monoclonal
Rabbit Hu WB, IHC MABN1040
Anti-SNRNP200, clone 3B6.1 Mouse Ms, Rt, Hu WB, IHC MABN297
Anti-Synaptotagmin-12, clone N277/7 Mouse Ms, Rt, Hu WB, IHC MABN519
Anti-Synaptotagmin-7, clone N275/14 Mouse Hu, Ms, Rt WB, IHC MABN665
Anti-SYPL1 Rabbit Hu WB, IHC ABN482
Anti-Tafazzin, clone N173B/13 Mouse Hu WB MABN518
Anti-Thioredoxin 1, clone EPR6110 Rabbit Hu WB, IHC MABN1090
Anti-Thorase/Atad1, clone N125/10 Mouse Ms, Rt, Hu WB, IHC MABN525
Anti-TRIP8b, clone N212A/34 Mouse Hu, Rt, Ms WB MABN666
Anti-TRPML3, clone N268/18 Mouse Hu, Ms, Rt WB MABN667
Anti-Tug, clone EPR8615 Rabbit Hu WB, IHC MABN1091
Anti-TXA2R, clone EPR7336,
Rabbit Monoclonal
Rabbit Hu WB MABN1042
Anti-UCHL3, clone EPR5332,
Rabbit Monoclonal
Rabbit Hu WB, IHC MABN1043
Anti-WIF1, clone 1G5 Mouse Hu, Ms WB, IHC, IF MABN722
Anti-WNK1, clone EPR2726(3),
Rabbit Monoclonal
Rabbit Hu WB, IHC MABN1044
Description Details Cat. No.
Small Molecules & Inhibitors
(+)-WIN 55,212-2 mesylate A potent agonist for cannabinoid receptors with higher affinity to subtype
2 (CB2, Ki = 3.3 nM) than to subtype 1 (CB1, K
i = 62.3 nM).
5.04344.0001
(RS)-PPG A potent and subtype-selective agonist for group III metabotropic
glutamate receptors. 25-fold higher selectivity for mGlu8 (EC50
=0.21 µM
) than for other group III mGlu receptors (EC50
= 5.2, 4.7, and 185 µM for
mGlu4,6,7, respectively). Widely used as anticonvulsant, antidepressant,
anxiolytic, and neuroprotective agent in research.
5.04395.0001
(S)-MCPG A non-selective antagonist for group I/II mGlu receptors (minimal values
of IC50
reported = 40 and 15 µM for mGlu1 and mGlu2, respectively). Often
used as an agent to differentiate excitatory neurotransmissions mediated
by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine,
and GABA in early brain development).
5.04637.0001
Adenosine A2A
Receptor
Antagonist II, SCH-58261
A highly potent and selective antagonist of adenosine A2A receptor
(Ki = 600 pM). Does not affect the activity of other adenosine receptors in
any significant manner (Ki = 287 nM; 5.0 µM, and > 10 µM for A1, A2B,
and A3 receptors, respectively). Displays neuroprotective effects in cerebral
ischaemia in rats, and shown to counteract Parkinsonian-like muscle
rigidity in rats.
119150-10MG
AIDA A relatively potent and selective antagonist for group I mGlu receptor
subtype 1 (pKB = 3.4 for mGlu1a). Complete absence of interacting with
on group II or III mGluRs, or ionotropic glutamate receptors. Widely used
in studying neural plasticity, learning and memory, and fear conditioning.
Centrally active following systemic administration in vivo .
5.04394.0001
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2
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,
CC=Cell Culture, BM=Bisulfite Modification
VOLUME 4 I 2013 Neuroscience (continued)
Description Details Cat. No.
Small Molecules & Inhibitors (continued)
ASIC Channel Modulator
II, GMQ
A positively charged guanidium-containing quinazoline that modulates
ASIC function by blocking acid-induced maximal peak current as well as
by altering ASICs pH dependence for activation and inactivation, enabling
a partial, but sustained ASIC3 activation around neutral pH (4.4% of pH
5-induced peak current with 1 mM GMQ at pH 7.4).
5.00523.0001
BINA A selective positive allosteric modulator for mGlu receptor subtype 2(EC
50 = 33.2 nM in CHO cells expressing human mGlu2). No effect on other
mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties
in mice.
5.04463.0001
BX471 An orally active, selective antagonist for chemokine receptor 1 (CCR-1)
(Ki = 1-5 nM). Has been used in studies related to intracellular calcium
mobilization and migration of leukocytes mediated through CCR-1.
5.04345.0001
CB1 agonist ACEA A potent and highly selective agonist for CB1 receptor. Affinity for CB1
(Ki = 1.4 nM) is more than1400-fold higher than that for CB2 (KMGK =
3100 nM) receptors.
5.04191.0001
CB1 antagonist AM251 A potent and highly selective antagonist for cannabinoid subtype 1 (CB1)
receptor. Affinity for CB1 (IC50
= 8 nM, Ki = 7.49 nM) is more than 306-fold
higher than that for CB2 receptors. Has been used in a study to determine
its interaction with hippocampal neurons to enhance spatial memory in
mice.
5.04275.0001
CB2 agonist, JWH 015 A potent and highly selective agonist for cannabinoid subtye 2 (CB2)receptor. Affinity for CB2 (K
i = 13.8 nM) is more than 28-fold higher than
that for CB1 (Ki = 383 nM) receptors.
5.04274.0001
CB2 Inverse Agonist, SR
144528
A selective inverse agonist for peripheral cannabinoid (CB2) receptors
(Ki = 0.6 nM and 400 nM for CB2 and CB1 receptors, respectively). Has
been used in studies related to control of pain initiation, suppression of
inflammation, and immune activation.
5.04277.0001
CIQ A positive allosteric modulator selective for NR2C/D containing NMDA
receptors (EC50
= 2.7 and 2.8 µM for NR2C and NR2D, respectively).
Increases channel opening frequency of recombinant NR2C/D containing
NMDA receptors by two-fold without altering mean open time or
EC50
values for glutamate or glycine bindings.
5.04519.0001
CL316243 Hydrate A very potent agonist highly se lective for β3 adrenoceptors
(EC50
= 3 nM). Widely used to assess the functional roles of β3
adrenoceptors in glucose homeostasis, thermogenesis, obesity, cardiac
functions, retinal neurotoxicity, and tissue inflammation.
5.04761.0001
CNS-1102 A non-competitive, subunit non-selective, potent antagonist for
NMDA receptors (IC50
= 0.13, 0.068, 0.087, and 0.14 µM for NR2A - D,
respectively). Widely used as neuroprotective agent af ter acute traumatic
brain injury and stroke in animal researches.
5.04522.0001
CP-101,606 A highly select ive antagonist for NR2B subunit containing NMDA receptors
(IC50
= 0.039 µM for NR2B and >100 µM for NR2A, NR2C, and NR2D).
Widely used as neuroprotective, analgesic, antidepressant, and anti-
Parkinsonian agent in research.
5.04523.0001
CP-55940 A potent, non-selective agonist for cannabinoid (CB) receptors
(Ki = 0.6 - 5.0 and 0.7 - 2.6 nM for CB1 and CB2 respectively; EC
50 = 0.2,
0.3 and 5 nM for CB1, CB2 and GRP55 respectively). Often used in
reference or control trials in CB research and the effects are robust in both
behavioral tests and receptor binding assays.
5.04316.0001
Eliprodil A negative allosteric modulator selective for NR2B containing NMDA
receptors (IC50
= 1, >100, and >100 µM for NR2B, NR2A, and NR2C,
respectively). Also a potent ligand for α1 receptor (Ki = 0.013 µM), one ofthe two types of unique non-opioid, non-phencyclidine brain α receptors.
5.04539.0001
Fenobam A potent negative allosteric modulator highly selective for mGluR5
(IC50
= 87 nM; Kd = 54 nM and 31 nM at recombinant mGlu5 receptors
of rat and human, respectively). Biologically active admitted orally or
systematically. A leading therapeutic candidate for treatment of fragile X
syndrome.
5.04684.0001
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1
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,
CC=Cell Culture, BM=Bisulfite Modification
VOLUME 4 I 2013Neuroscience (continued)
Description Details Cat. No.
Small Molecules & Inhibitors (continued)
Ghrelin Receptor Antagonist,
JMV 2959
A 1, 2, 4-triazole derived compound that acts as a potent ghrelin receptor
(GHS-R1a) antagonist (IC50
= 32 nM in a binding assay, dissociation
constant Kb = 19 nM). Shown to reduce hexarelin-induced food intake
[hexarelin (80 µg/kg, cumulative food intake (g of food/100 g of body
weight) at 6 h by acute administration (sc) of JMV 2959 (160 µg/kg)] in rats
without affecting the basal food intake.
345888-10MG
Idazoxan Hydrochloride A non-selective antagonist for α2-adrenoceptors (pKi = 8.01, 7.43, and 7.7
for α2A, α2B, and α2C receptors respectively) and imidazoline receptors.
(pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in
studying functions of the nervous systems, such as learning and memory,
decision making, reward, attention, addiction, depression.
5.04746.0001
LY 367385 Hydrochloride A potent antagonist selective for mGlu1a receptors (IC50
= 8.8 µM and
>100 µM for mGlu1a and mGlu5a, respectively). Negligible effect on
group II and III mGlu receptors. Frequently used in studies assessing the
functional roles of mGlu1a in various brain functions and disorders in
which neural transmissions via mGlu1a receptors are involved.
5.04658.0001
MMPIP A potent negative allosteric modulator highly selective for mGlu7 receptors
(IC50
= 15 nM). No effect on other subtype mGlu receptors. Frequently used
in studies of alcohol and cocaine addition, depression, anxiety and stress
related disorders.
5.04634.0001
MPEP Hydrochloride A non-competitive, highly potent antagonist selective for mGlu5 receptors
(IC50
= 36 nM). Also a positive allosteric modulator of mGlu4and weak
anatagonist of NMDA receptors. Biologically active admitted systematically.
5.04635.0001
Nebivolol Hydrochloride A competitive, highly selective β1-adrenoceptor antagonist (more than
40-fold selective for β1 than β2; Ki1 and β2, respectively). The most
β1-selective chemical of the β-blockers tested so far. Used for treatment of
essential hypertension and highly cardioselective. Induces mild vasodilation
via nitric oxide- and cGMP-depedent pathways. (EC50
= 11.36 µM in renal
arteries).
5.04778.0001
NVP-AAM077 Tetrasodium
Hydrate
A potent antagonist for NMDA receptors. Modestly higher selectivity for
the NR2A than for the NR2B containing NMDA receptors (IC50
= 0.015 and
0.078 µM) but insufficient to discriminate between NR2A and NR2B-
containing NMDA receptors. Widely used for research in synaptic plastic,
learning and memory, and epilepsy.
5.04528.0001
QNZ46 A noncompetitive and voltage-independent antagonist selective for
NR2C/D containing NMDA receptors (IC50
= 6, 3, 229, and >300 µM
for NR2C, NR2D, NR2A, and NR2B, respectively). Inhibition on NR2C/Dcontaining NMDA receptors is glutamate-binding, but not glycine-binding,
dependent.
5.04535.0001
Quisqualic acid A potent agonist highly selective for group I (EC50
≤3 µM) over group II and
III mGlu receptors (EC50
>40 µM) and a potent agonist of AMPA receptors.
Often used for inducing excitotoxic lesions of basal forebrain cholinergic
neurons and spinal neurons.
5.04631.0001
Reboxetine Mesylate A potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1,
129 and >10000 nM for rat NET, SERT and DAT, respectively). Displays
>1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and
muscarinic ACh receptors. Orally active antidepressant.
5.04120.0001
RS 102895 hydrochloride A selective antagonist for CCR2 receptors (IC50
= 0.36 and 17.8
µM for CCR2b and CCR1 receptors, respectively). Blocks monocyte
chemoattractant protein-1 induced calcium influx and chemotaxis
(IC50
= 32 nM and 1.7 µM respectively). A potential anti-inflammatory
therapeutic agent by inhibiting α1A, α1D and 5-HT1A receptors.
5.04376.0001
Salbutamol Hemisulfate A non-selective β2-adrenergic receptor agonist that displays greater
affinity for β2 receptors (EC50
= 600nM) over B1 receptors. Acts as a
bronchiodilating agent. Clinically used for the treatment of asthma and
chronic obstructive pulmonary disease(COPD).
5.04794.0001
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4
VOLUME 4 I 2013 Neuroscience (continued)
Description Details Cat. No.
Small Molecules & Inhibitors (continued)
Salmeterol Xinafoate A potent, selective, and long-lasting β2-adrenoceptor agonist
(EC50
=5.3 nM) that displays bronchodilator actions. Unlike other β2-
adrenoceptor agonists, Salmeterol binds to exo-site domain of β2-AR
receptors, producing a slow onset of action and prolonged activation.
Clinically used for the treatment of asthma and chronic obstructive
pulmonary disease(COPD).
5.04815.0001
Tamsulosin Hydrochloride A selectiveα1A adrenoceptor antagonist that has preferential selectivity
for the α1A adrenoceptor in the prostate versus the α1B adrenoceptor in
the blood vessels (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D
subtypes respectively).
5.04793.0001
TCN-201 A negative allosteric modulator selective for NR2A containing NMDA
receptors (pIC50
= 6.8 and <4.3 µM for NR2A and NR2B, respectively). No
effect on NR2B-containing NMDA receptors with concentrations less than
50 mM.
5.04596.0001
γ-Secretase Inhibitor XXV,
FT-9
FT-9, a cell-permeable NSAID-like compound, is a partially selective
γ-Secretase Inhibitor in both microsomes and whole cells. Displays dose-
dependent inhibition of the γ-secretase cleavage of β-Amyloid Precursor
Protein (APP) and APLP2 with IC50
values against APP ICD (intracellular
domain) and APLP2 ICD of ̃ 260 µM, but there is a less potent effect on
γ-secretase processing of APLP1.
500587-10MG
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,
CC=Cell Culture, BM=Bisulfite Modification
Signaling
Description Host Species Reactivity Key Applications Cat. No.
Antibodies
Anti-APOL1, clone 1D4 Mouse Hu WB MABS385
Anti-Apolipoprotein L1, clone EPR2906 Rabbit Hu WB, IHC MABS387
Anti-ARG1, clone EPR6671(B) Rabbit Hu, Ms WB MABS388
Anti-Cytochrome P450 17A1,
clone EPR6293
Rabbit Hu WB, IF MABS389
Anti-FABP2, clone EPR7136 Rabbit Hu, Ms, Rt WB MABS390
Anti-FGF23, clone 278-2 Mouse Hu WB MABS460
Anti-G6PD, clone EPR6292 Rabbit Hu WB, IHC MABS391
Anti-GLI1 Rabbit Hu, Rt WB, IHC(P) ABC217
Anti-Gli-1, clone EPR4523 Rabbit Hu WB, IHC MABC678
Anti-LIPE Rabbit Hu WB, IHC, IF ABS432
Anti-Lipin 1 Rabbit Hu WB, IP, IF ABS400
Anti-Monoglyceride Lipase, clone EPR6339 Rabbit Hu WB MABS395
Anti-NFKBIB, clone 7B4 Mouse Hu WB MABS383
Anti-Norrin Rabbit Hu WB, IC ABS440
Anti-Notch 4 Rabbit Hu WB 09-089-I
Anti-phospho LEF (Thr155) Rabbit Hu WB, PIA ABS485
Anti-phospho β Catenin (Ser675) Rabbit Hu WB, PIA ABS481
Anti-phospho-β Catenin (Thr556) Rabbit Hu WB, PIA ABS484
Anti-PIAS2 Rabbit Rt WB, IHC ABS447
Anti-PLAC3 Rabbit Hu WB, IC, IHC ABS444
Anti-PLEKHG7 Rabbit Hu, Ms WB 07-2144
Anti-SHOC2 Rabbit Hu WB, IHC ABS461
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1
Signaling (continued)
Description Details Cat. No.
Small Molecules & Inhibitors
Akt Inhibitor XVI, AT7867 A cell-permeable pyrazolo compound that acts as a potent inhibitor against Akt
(IC50
= 32, 17, and 47 nM against Akt1, Akt2, and Akt3, respectively), PKA (IC50
= 20 nM), and p70S6K (IC50 = 85 nM) in an ATP-competitive manner (K i = 18nM using AKT2), with much reduced potency toward RSK1 (IC
50 >100 nM) and a
panel of 13 other cellular kinases (IC50
>1 µM).
124033-10MG
Bortezomib (MG-341) A cell-permeable dipeptidylboronate compound that selectively inhibits 20S
proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like
activity (kinact/Ki = 38,000, 5,700, and <100 M-1s-1, respectively, in human
20S proteasome assays using 10 µM Suc-LLVY-AMC/Cat. No. 539142, 10 µM
Z-LLE-AMC/Cat. No. 539141, or 50 µM Boc-LRR-AMC as substrate).
5.04314.0001
CaCC Blocker IV,
Benzbromarone
A cell-permeable uricosuric agent that, in addition to its known efficacy in gout
treatment, acts as a reversible CaCC blocker and is reported to be more potent
than NFA (Cat. No. 481987) and NPPB (Cat. No. 484100) in suppressing 500
nM Ionomycin- (Cat. Nos. 407950, 407952, and 407953) induced I- influx in
TMEM16A-expressing HEK293 cells (IC50
= 9.97, 140, and 150 µM, respectively).
5.04041.0001
EphA Antagonist A pyrrolyl benzoic acid that effectively competes against ephrin-B3 for EphA4
binding as well as against ephrin-A1/-A2/-A3/-A5 for EphA2 and EphA4 binding
by targeting EphA2/A4 high affinity ephrin-binding pocket in a reversible
manner, exhibiting much reduced or no potency against ephrin-A4 for EphA2/
EphA4 binding, ephrin-A5 for EphA3/A5/A6/A7 binding, ephrin-B2 for B1/B2/
B3/B4/B6 binding, or ephrin-B2 for EphA4 binding.
5.00713.0001
ERK Inhibitor VIII A cell-permeable pyrimidylpyrrole compound that acts as an active site-
targeting, highly potent and selective ERK1/2 inhibitor (KI <2 nM against Erk2;
[ATP] = 65 µM). Orally available in both mice and rats in vivo .
328011-10MG
FAAH Inhibitor III, URB937 A blood brain barrier-impermeable p-hydroxyphenylcarbamate compound that
acts as a potent and irreversible inhibitor of FAAH activity
(IC50
= 26.8 nM rat brain) with excellent selectivity over monoacylglycerol
lipases (IC50
> 100 µM).
341253-5MG
FATP2 Inhibitor, CB-2 A cell-permeable thioxothiazolindine compound that reversibly inhibits
FATP2-mediated long chain fatty acid uptake in Caco-2 and HepG2, but not
non-FATP2-expressing 3T3-L1 adipocytes, cultures (IC50
= 3.99, 7.55, and 231.1
µM, respectively), while exhibiting much reduced potency toward cellular Acsl
(acyl-CoA synthetase) activity (IC50
= 50 µM).
5.00670.0001
Hsp70 Activator, YM-1 A cell-permeable rhodacyanine derivative that stabilizes heat-shock protein
70 in its ADP-bound, substrate-binding conformation via reversible binding to
Hsp70 nucleotide-binding domain (KD = 4.9 µM) in a manner similar to the
physiological Hsp70 co-chaperone Hip.
5.00615.0001
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,
CC=Cell Culture, BM=Bisulfite Modification
Description Host Species Reactivity Key Applications Cat. No.
Proteins & Enzymes
ATM, active Kinase Assay 14-933
Di-Ubiquitin (Lys48-linked) Recombinant
Protein
Ubiquitin Assay 17-10408
Di-Ubiquitin (Lys63-linked) Recombinant
Protein
Ubiquitin Assay 17-10388
Furin (Human) Recombinant Enzyme Assay 03-237
Furin (Human) Recombinant Protein Enzyme Assay 03-183
MST4, active Kinase Assay 14-928
Smac/DIABLO Enzyme Assay 23-057
STK25, active Kinase Assay 14-929
XIAP, active Enzyme Assay 23-056
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6
Description Details Cat. No.
Small Molecules & Inhibitors (continued)
InhibitorSelect™ mTOR
Signaling Regulators Panel
A panel containing 17 potent and selective small molecule regulators that is
useful for the study of mTOR signaling.
475995-1EA
Licofelone, Potassium Salt,
Monohydrate
A cell-permeable, orally active arylpyrrolizine carboxylate that is structurally and
pharmacologically similar to, but less potent than,
MK-886 (Cat. No. 475889). Effectively suppresses cellular Cox pathway PGE2
production by inhibiting COX-1 and mPGES-1, but not COX-2(IC
50 = 0.8, 6, and >30 µM, respectively).
435801-25MG
L-type Calcium Channel
Blocker VIII
A pyrimidinetrione compound that is reported to selectively block CaV1.3 over
CaV1.2 L-type calcium channel activity (85.4% vs. 8.0% inhibition, respectively,
with 5.5 µM inhibitor; IC50
against CaV1.3 = 1.7 µM) using HEK293 transfectants.
208294-25MG
MALT1 Inhibitor II, Mepazine
Acetate
A cell-permeable phenothiazine that that inhibits MALT1, but not caspase-3 or
-8, proteolytic activity (IC50
= 0.83 and 0.42 µM, respectively, against full-length
or paracaspase domain-catalyzed Ac-LRSR-AMC hydrolysis) in a reversible and
noncompetitive manner.
5.00500.0001
mTOR Activator, MHY1485
(Authophagy Inhibitor III)
A cell-permeable triazine derivative that is shown to increase cellular mTOR
Ser2448 and downstream substrate 4E-BP Thr37/46 phosphorylation level in rat
liver Ac2F cells (1 to 2 µM for 1 h), affecting culture viability only at much higher
concentrations (by 20% after 24 h 20 µM treatment).
5.00554.0001
mTOR Inhibitor XI,
ETP-46464
A cell-permeable quinoline-containing heterotricyclic compound that acts as a
potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50
= 0.6, 14, 36,
170, and 545 nM, respectively) and preferentially suppresses radiation-inducedcellular ATR activity (>90% at 500 nM) over ATM or DNA-PK activity (IC
50 > 5 µM)
in U2OS cells.
5.00508.0001
mTOR Inhibitor XI, Torin1 A cell-permeable pyridinonequinoline derivative that acts as a highly potent,
ATP-competitive inhibibitor against mTOR and DNA-PK (IC50
= 4.32 and 6.34 nM,
respectively), while inhibiting PI 3-K only at much higher concentrations
(IC50
=171 to 533 nM).
475991-10MG
mTOR Inhibitor XII, Torin2 A Torin1 (Cat. No. 475991) structural analog that acts as a cell-permeable, potent,
ATP-competitive inhibitor against DNA-PK and mTOR (IC50
= 0.5 and 2.81 nM,
respectively).
475992-10MG
Nef Hck Activation Inhibitor,
B9
A cell-permeable diphenylpyrazolo compound that disrupts HIV accessary protein
Nef dimerization (IC50
= 3 µM in HEK293T cells) and prevents Nef-mediated
Src family kinase Hck activation (IC50
= 2.8 µM) without directly affecting the
catalytic activity of c-Src, Hck, Lck, or Lyn.
5.00653.0001
Nur77 LBD Antagonist, TMPA A cell-permeable phenylacetate compound that blocks Nur77 (TR3) LKB1 nuclear-
sequestering function by antagonizing against Nur77-LKB1 interaction via directbinding at the LKB1 LBD/ligand binding domain
(Kd = 0.14 against 5 µM LKB1 binding to 5 µM full-length Nur77).
492910-10MG
p38 MAP Kinase Inhibitor
XIX, Skepinone-L
A cell-permeable phenylamino-dibenzosuberone-diol with a rigid molecular
structure specifically designed to target hydrophobic region I in p38α & p38β, but
not in other kinases with bulky entrance-blocking gatekeeper residues. Shown to
selectively inhibit p38α (IC50
= 5 nM; [ATP] = 100 µM) and p38β (97% inhibition
at1 µM), while exhibiting little affinity toward 400 other kinase constructs.
506174-5MG
PI 3-K Inhibitor XVIII An N-myristoylated cell-permeable PI 3-K p110β-derived Gβγ-binding peptide
(aa 514-537 in p110β C2-helical linker region) that prevents Gβγ-, but not RTK-,
mediated p100β activation both in cell-free assays (1 µM) and in cultures (30 µM
in p110β/p85/Akt/Gβγ-transfected HEK 293E cells) .
5.00499.0001
PKC Activator VII, CGK062 A cell-permeable coumarin-containing compound that is shown to activate PKC
activity and induce cellular PKCα membrane translocation (Effective conc. 12.5 to
50 µM) as well as PKCα-mediated signaling events.
5.04276.0001
Rho Inhibitor II, Y16 A cell-permeable pyrazolidinedione compound that is shown to target RhoGEFDH-PH domain junction with high affinity (Kd = 65 nM) and effetively prevent
RhoGEFs LARG, p115, and PDZ from interacting with RhoA, while displaying
little potency against DBL-RhoA, LBC-RhoA, intersectin-Cdc42, or TrioN-Cdc42
interaction.
5.04043.0001
RyR-Calstabin Interaction
Stabilizer, S107
A cell-permeable, orally active benzothiazepine that effectively blocks leaky
intracellular calcium release by preventing the dissociation/depletion of calstabin
from the ryanodine receptor (RyR) complex due to receptor modifications, such as
oxidation, S-nitrosylation, hyperphosphorylation, or mutation (complete blockage
of 1 mM tetracaine-induced leakage in murine RyR2 S2808D+/+ myocytes at 1
µM).
5.00469.0001
Sphingosine Kinase Inhibitor
IV, CB5468139
A cell-permeable naphthoquinone derivative that acts as an ATP-competitive
inhibitior against sphingosine kinase 1 (IC50
= 2 µM; [sphingosine] = 10 µM &
[ATP] = 100 µM) and several protein kinases, including, but not limited to, TNK2,
AURKB, Met, Syk, AURKC, Fyn, Flt2, PIM2, MST2, CLK1, Tie1, and Fak (IC50
<2 µM).
5.00489.0001
Stearoyl-CoA Desaturase 1
Inhibitor, MF-438
A cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of
Stearoyl-CoA Desaturase 1 (SCD1) with an IC50 of 2.3 nM.In vivo , it exhibits an ED
50 of 1-3 mg/kg, p.o., in mouse liver PD assays.
569406-10MG
Signaling (continued)
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine,
Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque,Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry,IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation,WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=PeptideInhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,CC=Cell Culture, BM=Bisulfite Modification
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1
Stem Cell Research
Description Host Species Reactivity Key Applications Cat. No.
Antibodies
Anti-ACVR1B Rabbit Hu WB ABD133
Anti-AFP, clone 6E6 Mouse Hu WB MABD170
Anti-BMR2, clone 3F6 Mouse Hu, Ms, Rt, Mky WB, IF, IHC MABD171
Anti-FGFR4, clone 4H2B10B2 Mouse Hu WB, IHC MABD120
Anti-FOXA2, clone 7H4B7 Mouse Hu WB, IHC MABD164
Anti-GATA1, clone 4F5 Mouse Hu WB, IC, IHC MABD167
Anti-Human Nuclei, clone 235-1, Biotin
Conjugate
Mouse Hu IC MAB1281B
Anti-ISL1, clone 1H9 Mouse Hu WB, IF, IHC MABD131
Anti-Lefty, clone EPR5444 Rabbit Hu WB MABD186
Anti-LeX Glycan, clone Forse-1 Mouse Rt WB, IHC, IP MABD125
Anti-LIN28, clone 6D1F9 Mouse Hu WB, IF MABD163
Anti-MATN1 Rabbit Hu, Rt WB, IHC, IF ABD131
Anti-NANOS3 Rabbit Hu WB, IHC(P), IF ABD135
Anti-Nestin, clone 10C2, Biotin Conjugate Mouse Hu IC, IHC MAB5326B
Anti-Nestin, clone rat-401, Biotin
Conjugate
Mouse Ms, Rt IC, IHC MAB353B
Anti-Noggin, clone EPR1561 Rabbit Hu WB MABD184
Anti-Nuclei, clone 3E1.3, Alexa Fluor® 488
conjugate
Mouse Hu IC MAB4383A4
Anti-Nuclei, clone 3E1.3, Biotin Conjugate Mouse Hu IC MAB4383B
Anti-Nuclei, clone 3E1.3, Cy3 Conjugate Mouse Hu IC MAB4383C3
Anti-Osteocalcin, clone EPR3690 Rabbit Hu WB MABD182
Anti-PHOX2B Rabbit Hu WB ABD132
Anti-PRDM1, clone 5E7 Mouse Hu WB MABD129
Anti-PRDM16 Rabbit Hu, Rt WB, IHC, IF ABD130
Anti-RUNX1, clone 5A1 Mouse Hu WB, IF MABD169
Anti-SHH, clone 5H4 Mouse Hu, Ms, Mky WB, FC, IHC MABD175
Anti-THAP11, clone 3F3 Mouse Hu WB, IF, IHC, FC MABD172
Anti-WNT1, clone 10C8 Mouse Hu, Ms WB, IF, IHC, FC MABD168
Anti-Wnt-5a, clone 6F2 Mouse Hu, Rt WB, IF, IHC MABD136
Cell Lines
EmbryoMax® Primary Mouse Embryo
Fibroblasts, Neo Resistant, Irradiated,
passage 3
CC PMEF-NX
EmbryoMax® Primary Mouse Embryo
Fibroblasts, Strain CF1, Irradiated, passage 3
CC PMEF-CFX
Human Adipose Mesenchymal Stem Cells Cell
Differentiation,
CC
SCC038
Human iPSC Derived Neural Progenitors Cell
Differentiation,
CC, Neurotoxicity
SCC035
Culture Media & ReagentsESGRO®-2i Supplement Kit (1000x) Stem CC ESG1120
ESGRO®-2i Supplement Kit (1000x) Stem CC ESG1121
Human STEMCCA™/TAT-Cre Bundle E. coli CC SCR545-CRE
PluriSTEM™ Dispase-II Solution Cell Harvesting,
Stem CC
SCM133
PluriSTEM™ Human ES/iPS Cell Medium Embryo Culture,
Stem CC
SCM130
TAT-Cre Recombinase E. coli CC SCR508
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine,
Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque,Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry,IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation,WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=PeptideInhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,CC=Cell Culture, BM=Bisulfite Modification
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8
Stem Cell Research (continued)
Description Host Species Reactivity Key Applications Cat. No.
Kits & Assays
Human Dopaminergic Neurogenesis Kit Cell
Differentiation,
CC, Neurotoxicity
SCR135
Human iPSC Derived Neural Progenitor Kit Cell
Differentiation,
CC, Neurotoxicity
SCR131
Proteins & Enzymes
HumanKine® Cystatin C, Human
Recombinant Xeno-Free
CC GF405
HumanKine® IL-2, Human Recombinant
Xeno-Free
CC GF423
HumanKine® IL-28A, Human Recombinant
Xeno-Free
CC GF425
HumanKine® IL-6, Human Recombinant
Xeno-Free
CC GF430
HumanKine® IL-9, Human Recombinant
Xeno-Free
CC GF431
HumanKine® M-CSF, Human Recombinant
Xeno-Free
CC GF433
HumanKine® PDGFaa, HumanRecombinant Xeno-Free CC GF436
HumanKine® Pro IGF-II, Human
Recombinant Xeno-Free
CC GF437
HumanKine® TGFβ 1, Human Recombinant
Xeno-Free
CC GF439
HumanKine® TGF β 2, Human
Recombinant Xeno-Free
CC GF440
HumanKine® TGFβ 3, Human Recombinant
Xeno-Free
CC GF441
HumanKine® VEGF121, Human
Recombinant Xeno-Free
CC GF444
Description Details Cat. No.Small Molecules & Inhibitors
InSolution™ Wnt Antagonist
I, IWR-1-endo
A 25 mM (5 mg/489 µL) solution of Wnt Antagonist I, IWR-1-endo
(Cat. No. 681669) in DMSO. A cell-permeable p-imidobenzamidoquinoline,
endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a
and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50
= 131 and
56 nM, respectively) and effectively suppress Wnt-stimulated transcription
activity in L-Wnt-STF-based reporter assays (IC50
= 180 nM).
5.04462.0001
iPSC Induction Enhancer II,
OAC1
A cell-permeable pyrrolopyridinyl-benzamide compound that is reported
to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs
cultured in either feeder cell-containing ESC media or in feeder-/serum-
free iSF1 media (1 µM OAC1 treatment starts 48 h after viral transduction).
5.00501.0001
ML243 A cell-permeable, biologically stable, 4-ethyl substituted cinnamide analog
that selectively exerts an inhibitory effect on breast cancer stem-like cells
(EC50
= 2 µM for epithelial-to-mesenchymal transition; HMLE_shEcad).
Exhibits ~32-fold greater selectivity over isogenic control cells(EC50
= 64 µM; HMLE cell line expressing shRNA against eGFPcells;
HMLE_sh_eGFP).
5.04599.0001
Porcn Inhibitor II, C59 A cell-permeable pyridinylphenyl-acetamide that is much more potent than
IWP-2 (Cat. No. 681671) in inhibiting MBOAT family member Porcupine-
mediated Wnt palmitoylation (IC50
= 74 pM in STF reporter assays using
Wnt3a-transfected HEK293).
5.00496.0001
Tankyrase1/2 Inhibitor V,
WIKI4
A cell-permeable triazole derivative that acts as a reversible TNKS inhibitor
(IC50
= 15 nM) and selectively inhibits Wnt/β-catenin, but not NF-κB, TGFβ,
or retinoic acid, signaling pathway-dependent transcription activity.
5.00556.0001
iPSC Induction Enhancer II,OAC1(Cat. No. 5.00501.0001)
EMD Millipore recently introduceda compound, OAC1, that enhances
the reprogramming efficiency of 4F
transcription factors (Oct-4, Sox-2, Klf-4,
and c-Myc) by over 20-fold and accelerates
the appearance of induced pluripotent stem
cell-like colonies.
Recently Li and colleagues from the
Beckman Research Institute of City of Hope
showed that OAC1 activated endogenous
Oct-4, Nanog, Sox-2 and also increased
Tet1 mRNA expression*. The iPSC colonies
derived using this compound exhibited
typical embryonic stem cell morphology,
gene expression pattern, and developmental
potential.
* Li, W. et al. 2012. Identification of Oct4-activating
compounds that enhance reprogramming efficiency. Proc.
Natl. Acad. Sci. USA 109, 20853.
PUBLICATION HIGHLIGHTON SMALL MOLECULES:
For published studies using this new product,
visit: www.emdmillipore.com
For publications on using these small molecules,
visit: www.emd4biosciences.com
LEGEND Species: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=Hamster, Chk=ChickenApplications: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paraffin), IF=Immunofluorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP,
CC=Cell Culture, BM=Bisulfite Modification
8/13/2019 New Products 2013 Version 4
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1
SmartFlare™ Probes - RNA Detection
Description Cat. No.
SmartFlare™ AFP; Human, Cy3 SF-1120
SmartFlare™ Albumin; Human, Cy3 SF-995
SmartFlare™ AMACR; Human, Cy5 SF-985
SmartFlare™ APOE; Human, Cy5 SF-1133
SmartFlare™ APP; Human, Cy5 SF-1139
SmartFlare™ APRIL; Human, Cy3 SF-411
SmartFlare™ AQP5; Human, Cy5 SF-997
SmartFlare™ ATG9B; Human, Cy3 SF-756
SmartFlare™ BACE1; Human, Cy5 SF-1149
SmartFlare™ BCL11B; Human, Cy5 SF-981
SmartFlare™ BCL2; Human, Cy5 SF-1115
SmartFlare™ BDNF; Rat, Cy5 SF-1159
SmartFlare™ BMP4; Human, Cy5 SF-1067
SmartFlare™ BMP4; Mouse, Cy5 SF-1069
SmartFlare™ BMPR1A; Human, Cy3 SF-1108
SmartFlare™ BMPR2; Human, Cy3 SF-1028
SmartFlare™ BMPR2; Mouse, Cy5 SF-1029
SmartFlare™ BRAF; Human, Cy3 SF-1289
SmartFlare™ CD133; Human, Cy3 SF-958
SmartFlare™ CD31; Mouse, Cy3 SF-1284
SmartFlare™ CD73; Mouse, Cy5 SF-955
SmartFlare™ CDKN2A; Human, Cy5 SF-414
SmartFlare™ Collagen I; Human, Cy3 SF-983
SmartFlare™ Collagen I; Human, Cy5 SF-984
SmartFlare™ Cyclophilin A; Rat, Cy5 SF-1094
SmartFlare™ Dot1L; Mouse, Cy5 SF-998
SmartFlare™ E2F1; Human, Cy3 SF-740
SmartFlare™ EZH2; Mouse, Cy5 SF-1123
SmartFlare™ FABP1; Human, Cy5 SF-986
SmartFlare™ FABP3; Human, Cy3 SF-1020
SmartFlare™ FABP3; Human, Cy5 SF-1019
SmartFlare™ FABP4; Human, Cy3 SF-1004
SmartFlare™ FDXR; Human, Cy3 SF-979SmartFlare™ FDXR; Human, Cy5 SF-1119
SmartFlare™ FGFR1; Human, Cy5 SF-1102
SmartFlare™ Frataxin; Human, Cy3 SF-975
SmartFlare™ Frataxin; Human, Cy5 SF-1116
SmartFlare™ GADD45G; Human, Cy3 SF-1114
SmartFlare™ GATA4; Human, Cy5 SF-1097
SmartFlare™ GATA4; Mouse, Cy5 SF-1092
SmartFlare™ GDF3; Human, Cy5 SF-999
SmartFlare™ Glis1; Human, Cy5 SF-1167
SmartFlare™ GNAS; Human, Cy5 SF-1088
SmartFlare™ HBA1/HBA2; Human, Cy5 SF-992
SmartFlare™ HBB; Human, Cy5 SF-993
SmartFlare™ IAPP; Human, Cy5 SF-1177
Description Cat. No.
SmartFlare™ IAPP; Rat, Cy5 SF-1181
SmartFlare™ IDH2; Human, Cy3 SF-1124
SmartFlare™ IDH2; Human, Cy5 SF-1084
SmartFlare™ IL8; Human, Cy5 SF-763
SmartFlare™ JAK1; Human, Cy3 SF-1288
SmartFlare™ KDR; Human, Cy3 SF-1282
SmartFlare™ KIF5A; Human, Cy5 SF-1183
SmartFlare™ KLF4; Human, Cy3 SF-918
SmartFlare™ KRAS; Human, Cy3 SF-1117
SmartFlare™ KRAS; Human, Cy5 SF-1089
SmartFlare™ KRT10; Human, Cy5 SF-1055
SmartFlare™ LEPR; Human, Cy3 SF-991
SmartFlare™ LRP1; Human, Cy5 SF-1189
SmartFlare™ LRRK2; Human, Cy5 SF-1191
SmartFlare™ MAP2; Human, Cy3 SF-966
SmartFlare™ MAP2; Mouse, Cy3 SF-968
SmartFlare™ MBP; Human, Cy3 SF-1040
SmartFlare™ MBP; Human, Cy5 SF-1039
SmartFlare™ miR-106b-5p; Human, Cy3 SF-1285
SmartFlare™ miR-124-3p; Mouse, Cy3 SF-1095
SmartFlare™ miR-125b-5p; Human, Cy3 SF-1096
SmartFlare™ miR-134; Human, Cy3 SF-812
SmartFlare™ miR-137; Human, Cy3 SF-814
SmartFlare™ miR-142-3p; Human, Cy5 SF-1128
SmartFlare™ miR-149-5p; Human, Cy5 SF-817
SmartFlare™ miR-153; Human, Cy5 SF-1132
SmartFlare™ miR-182-5p; Human, Cy3 SF-1100
SmartFlare™ miR-186-5p; Human, Cy3 SF-824
SmartFlare™ miR-193a-5p; Human, Cy5 SF-829
SmartFlare™ miR-197-3p; Human, Cy5 SF-1126
SmartFlare™ miR-19b-3p; Human, Cy5 SF-827
SmartFlare™ miR-203a; Human, Cy5 SF-831
SmartFlare™ miR-24-3p; Human, Cy3 SF-1093SmartFlare™ miR-25-3p; Human, Cy5 SF-454
SmartFlare™ miR-290-3p; Mouse, Cy5 SF-1110
SmartFlare™ miR-294-3p; Mouse, Cy5 SF-1197
SmartFlare™ miR-296-3p; Human, Cy5 SF-845
SmartFlare™ miR-301a-5p; Human, Cy5 SF-1113
SmartFlare™ miR-30a-5p; Human, Cy5 SF-1131
SmartFlare™ miR-320-3p; Mouse, Cy5 SF-1101
SmartFlare™ miR-328; Human, Cy3 SF-850
SmartFlare™ miR-339-3p; Human, Cy5 SF-855
SmartFlare™ miR-339-5p; Mouse, Cy5 SF-1111
SmartFlare™ miR-370; Human, Cy3 SF-858
SmartFlare™ miR-370; Human, Cy5 SF-857
SmartFlare™ miR-499a-5p; Human, Cy5 SF-499
Description Cat. No.
SmartFlare™ miR-584-5p; Human, Cy5 SF-1201
SmartFlare™ miR-7-5p; Human, Cy5 SF-869
SmartFlare™ miR-9-5p; Human, Cy3 SF-1091
SmartFlare™ MPL; Human, Cy5 SF-1090
SmartFlare™ MUC2; Human, Cy5 SF-1112
SmartFlare™ NCAM1; Human, Cy5 SF-1087
SmartFlare™ NF1; Human, Cy3 SF-996
SmartFlare™ NGFR; Human, Cy5 SF-1205
SmartFlare™ NPM1; Human, Cy3 SF-1122
SmartFlare™ Nucleostemin; Human, Cy5 SF-1023
SmartFlare™ P2RY2; Human, Cy5 SF-767
SmartFlare™ PARK2; Mouse, Cy5 SF-1213
SmartFlare™ PARK2; Rat, Cy5 SF-1215
SmartFlare™ PAX6; Human, Cy5 SF-1099
SmartFlare™ PDGFRA; Human, Cy5 SF-1121
SmartFlare™ PDPK1; Human, Cy3 SF-802
SmartFlare™ PDX1; Human, Cy5 SF-1059
SmartFlare™ PICALM; Human, Cy5 SF-1129
SmartFlare™ PICALM; Rat, Cy5 SF-1225
SmartFlare™ PINK1; Human, Cy5 SF-1227
SmartFlare™ PINK1; Rat, Cy5 SF-1231
SmartFlare™ PSEN1; Human, Cy5 SF-1233
SmartFlare™ PSEN2; Human, Cy5 SF-1237
SmartFlare™ PTEN; Human, Cy5 SF-1085
SmartFlare™ RET; Human, Cy5 SF-1286
SmartFlare™ S100A9; Mouse, Cy5 SF-1249
SmartFlare™ S100B; Mouse, Cy3 SF-1104
SmartFlare™ S100B; Mouse, Cy5 SF-1086
SmartFlare™ SIX2; Human, Cy3 SF-973
SmartFlare™ SMAD4; Human, Cy3 SF-1127
SmartFlare™ SMARCB1; Human, Cy5 SF-1118
SmartFlare™ SNCA; Human, Cy5 SF-1253
SmartFlare™ SNCA; Mouse, Cy5 SF-1255SmartFlare™ Somatostatin; Human, Cy5 SF-1063
SmartFlare™ SOX9; Human, Cy5 SF-1011
SmartFlare™ SOX9; Mouse, Cy5 SF-1013
SmartFlare™ STK11; Human, Cy3 SF-1105
SmartFlare™ STK11; Human, Cy5 SF-1083
SmartFlare™ Synaptophysin; Human, Cy5 SF-1047
SmartFlare™ Synaptophysin; Mouse, Cy3 SF-1050
SmartFlare™ TAU; Human, Cy5 SF-1051
SmartFlare™ TDGF1; Mouse, Cy5 SF-1098
SmartFlare™ TLE1; Human, Cy3 SF-934
SmartFlare™ TNFRSF21; Human, Cy5 SF-1261
SmartFlare™ UCHL1; Human, Cy5 SF-1273
SmartFlare™ VPS35; Human, Cy5 SF-1277
Introducing SmartFlare™ RNA Detection Probes!Detect miRNA in LIVE Cells!For more information, including application notes and demo videos, please visit: www.emdmillipore.com/smartflare
VOLUME 4 I 2013
8/13/2019 New Products 2013 Version 4
http://slidepdf.com/reader/full/new-products-2013-version-4 20/20
EMD Millipore the M logo STEMCCA PluriSTEM PureProteome PureEpi ChIPAb+ InSolution CpGenome and SmartFlare are trademarks of Merck KGaA Darmstadt GermanyFl C ll t M ChIP Ch i U t t d C lbi h i t d t d k f M k KG A D t dt G
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