NIGMS Award: 1U54GM104944-01A1

Mountain West Research ConsortiumClinical Translational Research –

Infrastructure Network

The Mountain West CTR-IN

Robert D. Langer, MD, MPHPrincipal Investigator

Research Professor of Allied Health Sciences, UNLVAssociate Dean for Clinical and Translational Research and Professor

of Family Medicine-Las Vegas, UNSOM

What is it?

$20 million 5 year NIH Grant under the IDeA Program

Involving 13 universities across the 7 IDeA states in the Mountain West Research Consortium

What are the 7 Mountain West states?

Alaska

Hawaii

Idaho

Montana

Nevada

New Mexico

Wyoming

Support: to foster Clinical and Translational Research

(CTR) according to NIH Definitions

for Core Resources to facilitate the development of researchers moving into CTR

BOOTSTRAP CTR ACROSS THE MOUNTAIN WEST

“a rising tide that … … lifts all ships.”

We will sink or swim based on the increase in “R-level” translational

and clinical research that we achieve across the region over

the next 4 years

Who is in it?

What will it do?

Provide Pilot Grants of $40,000-$75,000/yr

Support Mini-Sabbatical and Visiting Scholar awards to build collaborations

Provide Mini-Grants for a variety of activities that can help build independent research

Provide infrastructure and services through Key Component Activities

Funding preference

Promising Early Career or New Investigators developing clinical or translational research programs

Established Investigators moving from bench to translational or clinical

Projects focused on health issues relevant to the region, including those in rural and vulnerable populations

What will it do?

Use an NIH-style approach to applications and funding

Model the processes that clinical and translational investigators need to master to compete successfully for NIH support

Key Component Activities (KCAs)

Education, Mentoring & Career Development KCA

Study Design & Biostatistics KCA

Pilot Grant KCA

Administrative KCA, including editorial support, award management, Annual Meeting

EducationMentoring

Study DesignBiostat

Annual Meeting

ALL AVAILABLE regardless of whether you’ve received a

competitive award from the CTR-IN

What will it do?

Hold an Annual Meeting to share science, motivate, build collaborations, & conduct study business that will: rotate across the 13 partner institutions feature an annual research theme relevant to

health in the regionbring together supported investigators, interested

researchers from the region, key administrators from partners, external scientists, the regional biostat team, and senior project staff

Second Annual Meeting at UNLV June 7 – 11, 2015

free registration, hotel rate ~ $100/night

What’s the current status?

Round 1 Pilot Grants: 24 applications, 6 awarded

Round 1A Pilot Grants: 63 applications, 14 awarded

Round 2 Pilot Grants97 applications, 15 awarded

Year 1 (Rounds 1+1A) Pilot Grants

Round 1 Round 1A Total

Boise State 0 3 3

Idaho State 0 1 1

Montana State 2 1 3

New Mexico State 0 1 1

U Alaska - Anchorage 0 1 1

U Alaska - Fairbanks 0 1 1

U Idaho 0 1 1

U Montana 2 0 2

U Nevada Las Vegas 1 3 4

U Nevada Reno 1 1 2

U Wyoming 0 1 1

6 14 20

What’s the current status?

Round 2 Pilot Grant RFA for 7/1/14 – 6/30/15:Process moved entirely onlineLetters of Intent with Abstacts were due 3/7/14

124 LOIs with Abstracts received

Invitations to submit were provided 3/14/14Applications were due 4/25/14Awards were announced 6/26/14^ via the Pilot Grant

Application Portal

Institution LOIs Apps Awards

U. Alaska Anchorage 8 4 1

U. Alaska Fairbanks 5 5 2

Boise State U. 4 4 1

Idaho State U. 14 14 2

U. Idaho 8 4 1

Montana State U. 8 8 1

U. Montana 5 4 1

New Mexico State U. 9 8 2

UNR 23 17 2

UNLV 30 21 1

U. Wyoming 10 8 1

124 97 15

Year 2 Pilot Grant Summary

Visiting Scholars

Call for 02 Year open through 11/26/14 Early Career or New Investigator status $8,000 to $10,000 including 10% indirect Investigator salary NOT allowed Earliest start date 03/01/15 Funds must be expended by 06/30/15 Applications submitted online Total funds available for all awards in 02 Year: $40,000

Anticipate up to 5 Awards Dependent on quality and budgets of applications received

5 Applications and 5 Awards in the 01 Year U Montana – to PG Awardee, U Hawaii, UNLV [3] – one to PG

Awardee

Mini-Sabbaticals

One call for 02 Year -- open through 11/26/14

Mid-Career or Established Investigator status

Up to $20,000 including 10% indirect

Earliest start date 03/01/15

Funds must be expended by 06/30/15

Applications submitted online

Total funds available for all awards in 02 Year: $80,000 Anticipate up to 4 Awards Dependent on quality of applications received

First offered in the 02 Year

Mini-Grants

Two calls for 02 Year – first open through 10/06/14

Preferred uses:

acquisition of pilot data

analysis of existing data with a specific plan to publish

development of an intervention

development of a community-based collaboration

development of a new research collaboration between investigators at two or more institutions within the CTR-IN

Mini-Grants

Up to $10,000 direct costs, plus 10% indirect

Investigator salary NOT allowed

Earliest start date 12/01/14

Second call deadline for 02 Year: 01/14/15

Funds must be expended by 06/30/15

Applications submitted online

Total funds available for all awards in 02 Year: $200,000 Anticipate up to 20 Awards Dependent on quality of applications received

First offered in the 02 Year

Round 3 Pilot Grants

One call for 03 Year – RFA end of January 2015

Earliest start date 07/01/15

Funds must be expended by 06/30/16

Applications submitted online

PEOPLE!

Your First Call …

Your Local Conciergehttp://ctrin.unlv.edu/?page_id=447

Your First Call Once You Decide to Submit a Proposal …

Your Local Biostatisticianhttp://ctrin.unlv.edu/?page_id=186

Senior Leadership

Administrative Core

Bob Langer, UNLV, PI

Jim Kenyon, UNR, Proj Coord

John Foreyt, UNSOM, Eval Dir

Pilot Grants

Curtis Noonan, UMT, Director

Bill Shuttleworth, UNM, Assoc Dir

Education & Mentoring

Jillian Inouye, UNLV, Director

Bruce Shiramizu, UH, Mentoring

Pope Moseley, UNM, Mentoring

Pat Alpert, UNLV, Assoc Dir, Educ

Merle Kataoki-Yahiro, UH, Educ

Craig Molgaard, UMT, Educ

Design, Epidemiology, Biostat

Pope Moseley, UNM, Director

Orrin Myers, UNM, Assoc Dir

UNM CTSA: Richard Larson

website

ctrin.unlv.edu

NIGMS Award: 1U54GM104944-01A1

Admin KCARobert Langer, MD, MPH, KCA DirectorJim Kenyon, PhD, Project Coordinator

CRDEB KCAPope Moseley, MD, KCA Director

CTPG KCACurtis Noonan, PhD, KCA Director

William Shuttleworth, PhD, Associate Director

Internal Advisory Committee Carolyn Yucha, PhD, Co-Chair

Thomas Schwenk, MD, Co-ChairVPRs of all 13 Partner Universities

External Advisory Committee William T. Cefalu, MD, Chair

Jill G. Joseph, MD, PhD, MPH, Co-Chair+6 other members from outside the region

Steering CommitteeRobert Langer, MD, MPH, Principal InvestigatorJim Kenyon, PhD, Project Coordinator, Partners

John Foreyt, PhD, Project Coordinator, T&ERafael Gorospe, MD, PhD, Project Officer

Maria Canto, DDS, MS, MPH, Project Scientist

Executive CommitteePI

2 Project Coordinators3 [4 with PI] KCA Directors

CTSC Coordinator

Principal InvestigatorRobert D. Langer, MD, MPH

CREMCaD KCAJillian Inouye, PhD, KCA Director

Tracking & Evaluation UnitJohn Foreyt, PhD, Project Coordinator

Mentoring UnitBruce Shiramizu, MD,

Associate Director

Education UnitPatricia Alpert, DrPH,

Associate Director

Regional Biostatistician Network

Mountain West CTR-IN Organizational StructureGovernance and Membership

UNM CTSCRichard Larson, MD,

Coordinator

AFFILIATION COLOR CODEUNLV

UNR/UNSOMU. New Mexico

U. MontanaNIH

Other partner InstitutionsOutside the 7 state region

Concierge Network

U. of Nevada, Las Vegas - HostU. Alaska – Anchorage Montana State U. U. Alaska – Fairbanks U. of MontanaU. of Hawaii U. of Nevada, RenoBoise State U. New Mexico State U.Idaho State U. U. of New MexicoU. of Idaho U. of Wyoming