nmr report form 2009 - [the center for cholesterol ... · ldl-p 1350 nmol/l optima l (ldl particle...
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LIPO SCIENCE
LipoScience, Inc. 2500 Sumner Boulevard
Raleigh, NC 27616 www.liposcience.com
The NMR LipoProfile® test may be covered by one or more issued or pending patents, including U.S. Patent Nos. 5,343,389; 6,518,069, 6,576, 471; 6,653,140; and 7,243,030
CLIA:34D0952253
Page 1 of 1 Patient Name Sex Age
Clinician
Patient ID Birth Date Accession Number
Date Collected Date Received Report Date and Time Requisition Number Fasting Status
Client Name Address 1 Address 2 City, State Phone
Client Name and Address Client #/Route #
Zip Fax
LIPOSCIENCE
www.liposcience.com
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1350 LDL-P nmol/L
Optimal
(LDL Particle Number)
Low
Near or above optimal Borderline-High High Very High
Borderline-High High Very High Moderate
mg/dL
<1000
Percentile1
1000-1299 1300-1599 1600-2000 >2000
20th 50th 80th 95th Reference Range 1
LDL-C
HDL-C
(calculated) ***
*** LDL-C cannot be calculated if triglycerides are > 400. LDL-C will be inaccurate if patient is nonfasting
<100 100-129 130-159 160-200 >200
NMR LipoProfile® test
42 mg/dL mg/dL mg/dL
410 185
**** Test not ordered
Desirable ≥ 40 Desirable < 150 Desirable < 150
LDL-P
Lipids
Historical Reporting
Triglycerides Total Cholesterol
07/20/09 1400
LDL-C
1. Reference population compromises 5,362 men and women not on lipid medication enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). More et al. Atherosaclerosis 2007 © 2009 LipoScience, Inc. All rights reserved
400 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1800 1900 2000 4000 6000
20 40 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 400
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1350 LDL-P nmol/L
Optimal
(LDL Particle Number)
Low
Near or above optimal Borderline-High High Very High
Borderline-High High Very High Moderate
mg/dL
<1000
Percentile1
1000-1299 1300-1599 1600-2000 >2000
20th 50th 80th 95th Reference Range 1
LDL-C
HDL-C
(calculated) ***
*** LDL-C cannot be calculated if triglycerides are > 400. LDL-C will be inaccurate if patient is nonfasting
<100 100-129 130-159 160-200 >200
NMR LipoProfile® test
42 mg/dL mg/dL mg/dL
410 185
**** Test not ordered
Desirable ≥ 40 Desirable < 150 Desirable < 150
Lipids
Triglycerides Total Cholesterol
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high 75th 50th 25th low
low 50th 25th 75th high
Large (Pattern A) Small (Pattern B)
HDL-P (total)
LDL SIZE *
SMALL LDL-P
28.1
nmol/L
nm
830
20.4
µmol/L Percentile in Reference Population
Lower CVD Risk Higher CVD Risk LDL and HDL Particles
*Small LDL size and LDL size are associated with CVD risk, but not after LDL-P is taken into account
Particle Concentration and Size
35.1 30.6 26.8
110 506 808
23.0 20.6 19.0 20.5
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www.liposcience.com Genuth & Kahn. Diabetes Care 2008;31:1093-1096
LARGE VLDL-P
SMALL LDL-P
LIPOPROTEIN MARKERS ASSOCIATED WITH INSULIN RESISTANCE1,2
Insulin Sensitive Insulin Resistant
low 25th 50th 75th high
low 25th 50th 75th high
high 75th 50th 25th low
small 25th 50th 75th large
large 75th 50th 25th small
large 75th 50th 25th small
insulin sensitive 25th 50th 75th insulin resistant
8.2 nmol/L
830 nmol/L
µmol/L
2.7
nm
nm
nm
50.4
20.2
8.7
84 0-100
LARGE LDL-P
VLDL SIZE
LDL SIZE
HDL SIZE
LP-IR SCORE**
** The LP-IR SCORE combines the information from the 6 lipoprotein markers to give improved prediction of insulin resistance**
0 100
9.6
INSULIN RESISTANCE SCORE
9.2 8.9
21.1 20.8 20.4
42.1 46.3 51.9
7.5 4.2 3.1
110 506 808
0.8 2.4 6.4
Percentile in Reference Population
These laboratory assays validated by LipoScience have not been cleared by the US Food and Drug Administration. The clinical utility of these laboratory values has not been fully established.
1.Garvey WT et al. Diabetes 2003;532:453-462 2. Goff DC. et al. Metabolism. 2005;54:264-270 © 2009 LipoScience, Inc. All rights reserved
Particle Concentration and Size
LDL and HDL Particles
HDL-P (total)
LARGE VLDL-P
LDL SIZE *
SMALL LDL-P
SMALL LDL-P
Lower CVD Risk Higher CVD Risk
*Small LDL size and LDL size are associated with CVD risk, but not after LDL-P is taken into account
28.1
nmol/L
nm
830
20.4
Percentile in Reference Population µmol/L high 75th 50th 25th low
low 25th 50th 75th high
Large (Pattern A) Small (Pattern B)
LIPOPROTEIN MARKERS ASSOCIATED WITH INSULIN RESISTANCE1,2
Insulin Sensitive Insulin Resistant
low 25th 50th 75th high
low 25th 50th 75th high
high 75th 50th 25th low
small 25th 50th 75th large
large 75th 50th 25th small
large 75th 50th 25th small
insulin sensitive 25th 50th 75th insulin resistant
8.2 nmol/L
830 nmol/L
µmol/L 2.7
nm
nm
nm
50.4
20.2
8.7
84 0-100
LARGE LDL-P
VLDL SIZE
LDL SIZE
HDL SIZE
LP-IR SCORE**
** The LP-IR SCORE combines the information from the 6 lipoprotein markers to give improved prediction of insulin resistance**
0 100
9.6
INSULIN RESISTANCE SCORE
9.2 8.9
21.1 20.8 20.4
42.1 46.3 51.9
7.5 4.2 3.1
110 506 808
0.8 2.4 6.4
Percentile in Reference Population
35.1 30.6 26.8
110 506 808
23.0 20.6 20.5 19.0