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S.Tekgül.
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Postnatal management of prenatally
diagnosed hydronephrosis
Prof. Dr.Serdar TEKGÜL FEAPU
Division of Pediatric Urology
Department of Urology
Hacettepe University
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EAU/ESPU guidelines, 2014
Hydronephrosis Management evidence based
http://www.uroweb.org/guidelines/online-guidelines/
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Postnatal Management of UPJ
• Definitions
• Modes of presentation
• How to diagnose and follow-up
• When to do surgery !
S.Tekgül.
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General principles !!
• Hydronephrosis = dilatation
– This what we see
– ≠ obstruction
– May be a sign of obstruction ( at UPJ or UVJ)
– May be a sign of reflux
– May be a sign of LUT dysfunction
– Insignificant
S.Tekgül.
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General principles !!
• Obstruction
– Impairment of flow
• Mechanical ( due to extrinsic or intrinsic
pathology narrowing the lumen of the ureter
)
• Functional ( VUR, LUTD)
S.Tekgül.
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Modes of presentation
• Asymptomatic
– Diagnosed in utero ( 60-80%)
– Diagnosed after birth by USG (10%)
• Symptomatic
– Diagnosed early or late after birth with
clinical symptoms
S.Tekgül.
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What is our responsibility?
• Differential diagnosis
– what causes the dilatation?
• Risk analysis
S.Tekgül.
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Asymptomatic baby
Nonsig. PUV Megureter UPJ Reflux
?
Differential diagnosis
Define prognosis
Prenatal USG
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Risk analysis
• Obstruction is the condition that you need to
correct
– if during the follow up there is progression of
dilatation and loss of renal function
• It would be better if you can pick up the
ones which will progress early on before
any imparment in renal function takes place
S.Tekgül.
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S.Tekgül.
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S.Tekgül.
• 28 wk male fetus
• Fetal USG
unilateral hydronephrosis
AP pelvis 10 mm
No additional pathological finding
PARENTS IN PANIC
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S.Tekgül.
Clear Definition (prenatal history)
• Hydronephrosis: AP pelvis > 10 mm
– > 4 mm before 28 wk
– > 7 mm after 28 wk
• Serial USG
• AP pelvis diam / Grade / Paranchyma
• Progression !
• 20 wk > 10 mm, 28 wk >20mm, 36 wk >30 mm IMPORTANT!
• Kidney / ureters / bladder / post.urethra
• Amniotic fluid
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S.Tekgül.
postnatal n AP mm
normal 13 6.3 (5-12)
non-obs 137 11.8 (5-50)
Obstructed 59 22.3 (9-65)
reflux 22 14.4 (5-30)
Amer J Obst Gynec 165:384 1994
24-28 wk of gestation
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S.Tekgül.
Prenatal diagnosis
• Serial investigations
• False positive evaluation % 9-22
• False postivity is higher in low AP diam
• Only 20% of cases are clinically important
• Ratio of undergoing risky group less than
5%
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S.Tekgül.
Which cases are under risk !
• Unilateral cases and all all girls are in the good
group
• All bilateral cases are under risk unless bladder
problem is excluded.
• Boys / bil hydro / thick walled and distanded
bladder / dilated post.urethra / oligohydramniosis
• Good: if there is not oligohydroamniosis at 28th wk
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S.Tekgül.
30 wk male
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S.Tekgül.
Should Intervention Be Done in
the risky Group and Poor Renal
Function?
• Bil hydroureteronephrosis / thick walled
distanded bladder/ hiperecogenous kidney
• Diminished amnionic fluid
• Hypertonic urine in the consecutive samples
? vesicoamniotic shunt
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S.Tekgül.
Succes rate at first time : %10
Cause of 7 death only because of intervention
Crombleholme 1990 Freedman 1996
87 fetus
45 fetus
VA shunt
42 fetus
VA no shunt
16 bad prognosis 29 good prognosis
10 death
6 alive
2 good RF
9 death
20 alive
17 good RF
30 bad prognosis 12 good prognosis
30 death
0 alive
7 death
5 alive
4 good RF
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S.Tekgül.
Prenatal Intervention
• High risk for the mother and baby
• Complication rates up to 45%
• With prenatal intervention does the
– Fetal survival ratio
– Kidney function increase?
• Prenatal intervention is an experimental
procedure
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S.Tekgül.
Asymptomatic patients
Diagnostic tests
Normal UPJ Reflux
?
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S.Tekgül.
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Healthy newborn baby girl
diagnosed with bilateral
hydronephrosis prenatally
during US screening at 28
weeks of gestation.
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S.Tekgül.
Prophylaxy .. Amoxycilin 50 mg / d
Creatinin evaluation .. useless
( if not bilateral)
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S.Tekgül.
What is the first investigation and when?
• USG
• Renal Scan
• VCU
• ASAP
• After 3 days
• End of 1st month
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S.Tekgül.
Baby born with diagnosis of prenatal hydronephrosis
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G 0 G 1 G 2 G 3 G 4
SFU hidronefroz grading
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• Serial studies (periodic follow-up)
– Consistent findings
– In relations to other dynamics
NO SINGLE STUDY WILL GIVE YOU
RELIABLE INFO
S.Tekgül.
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Case: Time course of an intrauterine detected
unilateral hydronephrosis
33 weeks, SFU II hydronephrosis, left kidney
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First day of life, right kidney, SFU 0
Case: Time course of an intrauterine detected
unilateral hydronephrosis
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First day of life, left kidney, SFU 0
Case: Time course of an intrauterine detected
unilateral hydronephrosis
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4th week, left kidney, SFU III
Case: Time course of an intrauterine detected
unilateral hydronephrosis
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4th month, left kidney, SFU I
Case: Time course of an intrauterine detected
unilateral hydronephrosis
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S.Tekgül.
Within first mo VCU- USG
Reflux + PUV
Valve ablation SFU G3-4 / AP renal pelvis diameter
>50 mm 20 -50 mm < 20mm
Reflux-
conservative
•%100 requires surgery
within 6 mo
•% 60 poor DRF
Scintigraphy at the end
of 1st mo
Prenatal diagnosis hydronephrosis
• 20-29mm %30 opx
• 30-39mm %40 opx
• 39-49mm %90 opx
Surgery
DRF < %10 nephrectomy
> %10 pyeloplasty
• < 5 % opx
Surveillance with USG
SFU G 1-2
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S.Tekgül.
Why do we need VCUG ?
• To exclude VUR
• To exclude PUV
• Bladder diverticula
• Other pathologies
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Healthy newborn baby girl
diagnosed with bilateral
hydronephrosis prenatally
during US screening at 28
weeks of gestation.
Incidence of reflux is 18 (10-38) % F>M
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• Incidence of reflux : if postnatal US is normal 16 ( 10 - 24 %)
– Normal postnatal US does not exclude VUR
– Postnatal US is more predictive than prenatal US
• Incidence of reflux in high grade hydronephrosis ( 8 – 28 % )
• Incidence of reflux in low grade hydronephrosis ( 10 – 22 % )
– Variable results ( slightly higher VUR in high grade HN )
• Poor definition of ureteric dilatation and other structural abnormalities.
• The incidence of VUR is similar in uni vs bilateral HN
Walsh G 1999 , Aksu 2005, Liedefelt 2008, Merlini 2007, Ismaili K 2005, Dremsek PA 1997, Mami 2009,
Hothi DK 2009 , Skoog 2010
Predictive value of US findings
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• Postnatal US does not provide definitive
information about presence of reflux.
3 weeks after birth
8 weeks after birth
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S.Tekgül.
Antenatally diagnosed reflux
• Reflux underlies 15-20% of antenatal
dilatations
• Most are low grade and have high
resolution rate
• Scars are generally congenital
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• Absence of hydronephrosis does not rule out the presence of reflux.
• In cases with 2 normal postnatal successive US, VUR is a rare entity and if
present it is low.
• The degree of hydronephrosis is not a good indicator for reflux.
• VCUG is recommended in patients with ultrasound findings of
– bilateral high grade hydronephrosis,
– duplex kidneys,
– ureterocele,
– ureteric dilatation
– abnormal bladders
– presence of cortical abnormalities
• All patients need monitoring for UTI
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S.Tekgül.
J.Urology 162: 1221 1999
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S.Tekgül.
Diuretic renogram
• MAG3
• 2-3 min parenchymal uptake DRF
• 20 min furosemid
• T ½ 10-15min
• Curves
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S.Tekgül.
Diuretic renogram
•Differential renal function
< %20 %20-40 >%40
•Renogram curve
•T1/2 <10 min 10-20 min >20min
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S.Tekgül.
RU 1/12 M
MAG3 renogram curve is obstructive on the left T1/2 66
min
R %48 L %52
left right
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S.Tekgül.
Factors Effecting Washout
• Renal function
• Hydration
• Bladder status
• Severity of hydronephrosis
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S.Tekgül.
DRF >50 50-40 40-30 20-30
< %20 131 26 12 1
% 20 -40 23 24 32 17
> % 40 3 5 18 23
AP pelvis diam Surgery ratio %
<15 2
15-20 7
20-30 29
30-40 61
40-50 67
>50 100
Dhillon 2000
n:914
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S.Tekgül.
Is IVU required?
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S.Tekgül.
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S.Tekgül.
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S.Tekgül.
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S.Tekgül.
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S.Tekgül.
DRG MR-U
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S.Tekgül.
Within first mo VCU- USG
Reflux + PUV
Valve ablation SFU G3-4 / AP renal pelvis diameter
>50 mm 20 -50 mm < 20mm
Reflux-
conservative
•%100 requires surgery
within 6 mo
•% 60 poor DRF
Scintigraphy at the end
of 1st mo
Prenatal diagnosis hydronephrosis
• 20-29mm %30 opx
• 30-39mm %40 opx
• 39-49mm %90 opx
Surgery
DRF < %10 nephrectomy
> %10 pyeloplasty
• < 5 % opx
Surveillance with USG
SFU G 1-2
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S.Tekgül.
2nd month USG - Renogram
• increase in hydro
• renal func. less than
%40 and/or renogram
obstructive
•No increase in hydro
•renogram non-obstructive
•renal funct. Above 40 % surgery
Control at 3rd. mo
All other situations
bilateral cases
solitary kidneys
!
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Low risk
• AP < 20 mm SFU < G4
– (confirmation in serial USG required)
• Normal function ( equal DRF)
• Follow up by serial USG ( 3 monthly)
• 1 y US ± DTPA/MAG3
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Low risk group
• Impairement in function < 40%
• Symptoms
• Increasing hydro
Will require surgery in 10-15 %
Dhillon et al 2008
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High risk group
• AP > 20
• G4 hydronehrosis
• DRF values vary
• Majority has obstructed curves
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S.Tekgül.
Indication for operation
• High grade hydronephrosis
• Diminished renal function ( <40% )
• Solitary kidney and bilateral pathologies !
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S.Tekgül.
At 4th.month USG - Renogram
•increase in hydro
• more than 10%
decrease in renal
function • no change in hydro
•No sign change in
renal function
-hydro decreased
-improvement in
renal function
control with
USG after 3-6 mo
surgery
control with
renogram and USG after 3-6 mo
symptomatic
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S.Tekgül.
Operation criteria during
surveillance
• Incerase in hydronephrosis
• Worsening in DRF
• Contralateral compensation
• Symptoms
having an obstructed curve is not an
indication itself
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S.Tekgül.
Operation indications
• DRF less than 40%
• Decreasing DRF
• Increasing hydronephrosis
• Symptoms
• Bilateral hydronephosis ( not resolving-
progressive)
• Solitary kidney (not resolving- progressive)
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Pyeloplasty: Anderson Hynes
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2.2 cm
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S.Tekgül.
Not all prenatal hydro’s are obstructive and require surgery
Those which will lead to progressive impairement will require surgery.
The challenge is to pick up the cases who will lead to progressive
loss of function if leaft untreated.
High grade hydronephrosis or pregressive hydronephrosis have
higher risk for loss of renal function.
You may be overtreating the patient if you rush for surgery,
Yet you may also be delayed if you do not operate timely.
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S.Tekgül.
OK 8/12 M no prenatal diagnosis. Left flank mass
USG left G4 hydronephrosis AP pelvis diam 65mm
VCU normal
DTPA right compensated %91 – left non-functional % 9
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S.Tekgül.
What to do?
• Nephrectomy
• Pyeloplasty
• Nephrostomy
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S.Tekgül.
OK 9/12 M daily urine output after percutaneous
nephrostomy ~ 200 ml Cr Cl 25 ml/dk
total Cl 110 ml/dk
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S.Tekgül.
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S.Tekgül.
OK 1y M functioning left kidney after operation