n.o.e. lesson 3 module 2 the nuclear overhauser effect prof. claudio santi prof. claudio santi...
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N.O.E. lesson 3 module 2
The Nuclear Overhauser Effect
Prof. Claudio Santi
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
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N.O.E.
Introduction
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “steady-state”
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “steady-state”
![Page 5: N.O.E. lesson 3 module 2 The Nuclear Overhauser Effect Prof. Claudio Santi Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University](https://reader035.vdocument.in/reader035/viewer/2022070403/56649f295503460f94c41fc7/html5/thumbnails/5.jpg)
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “steady-state”
![Page 6: N.O.E. lesson 3 module 2 The Nuclear Overhauser Effect Prof. Claudio Santi Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University](https://reader035.vdocument.in/reader035/viewer/2022070403/56649f295503460f94c41fc7/html5/thumbnails/6.jpg)
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “stady-state”
![Page 7: N.O.E. lesson 3 module 2 The Nuclear Overhauser Effect Prof. Claudio Santi Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University](https://reader035.vdocument.in/reader035/viewer/2022070403/56649f295503460f94c41fc7/html5/thumbnails/7.jpg)
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “stady-state”
Influence of magnetic field
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “stady-state”
Influence of external relaxation sources
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “stady-state”
![Page 10: N.O.E. lesson 3 module 2 The Nuclear Overhauser Effect Prof. Claudio Santi Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University](https://reader035.vdocument.in/reader035/viewer/2022070403/56649f295503460f94c41fc7/html5/thumbnails/10.jpg)
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “stady-state”
![Page 11: N.O.E. lesson 3 module 2 The Nuclear Overhauser Effect Prof. Claudio Santi Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University](https://reader035.vdocument.in/reader035/viewer/2022070403/56649f295503460f94c41fc7/html5/thumbnails/11.jpg)
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “stady-state”
![Page 12: N.O.E. lesson 3 module 2 The Nuclear Overhauser Effect Prof. Claudio Santi Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University](https://reader035.vdocument.in/reader035/viewer/2022070403/56649f295503460f94c41fc7/html5/thumbnails/12.jpg)
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “stady-state”
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Introduction “NOE-diff”
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “NOE-diff”
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”
![Page 16: N.O.E. lesson 3 module 2 The Nuclear Overhauser Effect Prof. Claudio Santi Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University](https://reader035.vdocument.in/reader035/viewer/2022070403/56649f295503460f94c41fc7/html5/thumbnails/16.jpg)
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”Geometry of trisobstituted olefines
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”Geometry of heterocycles
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”When the coupling costants are not determinant
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”Sometimes it is not usefull
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”Attribution of the faces in cyclic compounds
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”Attribution of the faces in cyclic compounds
![Page 23: N.O.E. lesson 3 module 2 The Nuclear Overhauser Effect Prof. Claudio Santi Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University](https://reader035.vdocument.in/reader035/viewer/2022070403/56649f295503460f94c41fc7/html5/thumbnails/23.jpg)
Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”Assignment of similar groups
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Example “stady-state”Conformational analysis
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Transient NOE
s
I
s
II
II
ss
s
I
NOE
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. Transient NOE and Distances
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. NOESY
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. NOESY
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. ROESY
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. ROESY
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. ROESY
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Additional slidesnot for the presentation
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E.
ADDITIONAL
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E.
ADDITIONAL
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E.
ADDITIONAL
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E.
ADDITIONAL
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E.
ADDITIONAL
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Prof. Claudio Santi Dipartment of Chemistry and Technology of Drugs University of Perugia
N.O.E. ADDITIONAL