NON ALCOHOLIC STEATOHEPATITIS (NASH)

NON ALCOHOLIC STEATOHEPATITIS(NASH) KESHRI S YADAVJUNIOR RESIDENT SN MEDICAL COLLEGE AGRA

contentsDefinitionIntroductionEpidemiologyCausesPathogenesisClinical features and investigationsPotential therapiesconclusion

Definition

Non alcoholic fatty liver ds(NAFLD) is a clinicopathological syndrome encompasses several clinical entities ranging from simple steatosis to steatohepatits, fibrosis and ESLD in absence of signifcant alcohol intake.

NASH is a part of spectrum of NAFLD and defined as steatosis with hepatocellular ballooning plus lobular inflammation.

Fatty liver disease is defined as more than 5% of the hepatocytes containing fat or more than 5% of the liver weight due to fat.Macrovesicular Fatty Liver ChangesFocal Hepatic Cell Necrosis Acute & Chronic Inflammatry Cell InfiltrationMallory HyalineFibrosis & CirrhosisNo H/O Alcohol Abuse

Non alcoholic fatty liver disease

Although NAFLD was recognized long ago by Zelman, et al. it was blissfully ignored for almost 2.5 decade. Ludwig et al. brought it into the limelight in 1980 and coined the term nonalcoholic steatohepatitis (NASH) for alcohol like liver disease that developed in persons who were not heavy drinkers.

Harrison 19 th ed.

Not heavy drinker who drink