non-invasive detection of intracranial pressure
TRANSCRIPT
Non-invasive detection of intracranial pressure
Invitation to ICP workshop in Trondheim in NorwayJune 18-19, 2019
New ICP method§ Developed by ultrasound
specialists at SINTEF (Norway) and neurosurgeons at Universityof Cape Town
§ Uses a novel quantitative surrogate marker for ICP based on the dynamics of the optic nerve sheath, in combination with the optic nerve sheath diameter
The measurement takes a few minutes and doesn't require specialized personnel
Nisonic ICP Measurement
1. Software with proprietary algorithms• Automated
measurements
• User guiding system
2. Optimized probe for imaging the optical nerve sheath
Nisonic P-100 ICP Scanner
CE marked andlaunched at MedicaNovember 2019
Clinical studies
7
1st Clinical Study2015
Animal Study2015
2nd Clinical study2016
Third clinical study2019
Operator Llewellyn Padayachy SINTEF Llewellyn Padayachy Dag Netteland and Eirik Helseth
Site UCT, South Africa SINTEF Trondheim UCT, South Africa Oslo University Hospital
Target group 15 pedriatric patients 4 pigs 28 pedriatric patients Adult TBI patients
Diagnosis hydrocephalus (8), trauma (2), tumor (3) & otherdiagnosis (4)
hydrocephalus (18), trauma (2), tumor (6) & otherdiagnosis (4)
TBI
Equipment and data processing
Philips, post-processingusing Nisonic SW
GE, post-processing usingNisonic SW
Philips, post-processingusing Nisonic SW
SonositeNisonic
Conclusion Conforming deformability(DI) of the ONS as a non-invasive marker of ICP
Good correlation between DI and ICP
DI: specificity of 88.9% and sensitivity of 89.5%DI + ONSD: Sensitivity 94.7, specificity 88.9%
On-going
New sites to be invited to participate in further clinical studies to enhance the concept
KEY PERSONNEL
Jan Biti CEO
Dr. Tormod SelbekkInventor & CTO
Dag BrurokClinical Product Specialist
Cornelia MenderVP Sales & Marketing
Team
Spencer LienUS Advisor
Eirik HelsethProfessor and Neurosurgeon
Oslo University Hospital
Llewellyn PadayachyNeurosurgeon & inventor
University of Cape Town / Oxford
Denise BarbutProfessor in neurology
Weill-Cornell Medical CollegeSerial entrepreneur
Stephan MayerProfessor in neurology
and specialist in neurocritical care
Henry Ford Health System
SCIENTIFIC ADVISORY BOARD