novel biomarkers and immunomodulating therapies targeting
TRANSCRIPT
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LUND UNIVERSITY
PO Box 117221 00 Lund+46 46-222 00 00
Novel Biomarkers and Immunomodulating Therapies Targeting CardiovascularDiseases
Yao Mattisson, Ingrid
2019
Document Version:Publisher's PDF, also known as Version of record
Link to publication
Citation for published version (APA):Yao Mattisson, I. (2019). Novel Biomarkers and Immunomodulating Therapies Targeting CardiovascularDiseases. Lund University: Faculty of Medicine.
Total number of authors:1
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Novel Biomarkers and Immunomodulating Therapies Targeting Cardiovascular DiseasesINGRID YAO MATTISSON
EXP. CARDIOVASC. RESEARCH | FACULTY OF MEDICINE | LUND UNIVERSITY
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Department of Clinicla Sciences, MalmöExperimental Cardiovascular Research
Lund University, Faculty of Medicine Doctoral Dissertation Series 2019:39
ISBN 978-91-7619-768-4 ISSN 1652-8220
INGRID YAO MATTISSON was born in Uppsala and moved shortly thereafter to Skåne. She was introduced early into the field of medical research and even before starting her own academic studies she was experienced in taking care of laboratory animals. Ingrid studied molecular biology at Lund University and did several projects after that within the field of Vascular Physiology before she started her PhD studies at the Cardiovascular Research Unit in 2015.
Ingrid successfully continued to work on newly established projects within the field of cardiovascular disease and systemic lupus erythematosus (SLE). It is always with great enthusiasm, ambition and dedication to her work that she undertakes different assignments.
In parallel to research Ingrid has a passion for her Icelandic horses, a valuable contrast to “research life”. In this thesis, Ingrid describes her research findings in a clear and personal way, showing the great amount of knowledge she has gained over the last years.
-Maria Wigren, co-supervisor
9789176
197684
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Faculty opponent
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in vitro
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EbioMedicine
Atherosclerosis
Manuscript
in vitro
Vascular Pharmacology,
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Arteriscler Thromb Vasc Biol,
Stroke
Sci Rep.,
PLoS One.
J Intern Med
Arterioscler Thromb Vasc Biol,
J Am Heart Assoc. 19;8(4):e009874,
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Circulation (ePub ahead of print)
Submitted to ebioMedicine
in vitroSubmitted to Phytoscience
Submitted to Stroke
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γ γ
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in vivo
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αβ
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α
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Costimulation
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γ γ
γ
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β
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γα ε
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Soluble death receptors
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Th1 cells in atherosclerosis
γ
Th2 cells in atherosclerosis
Th17 cells in atherosclerosis
in vivo
Regulatory T cells in atherosclerosis
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B cells in atherosclerosis
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“probably not an autoimmune disease in the classical sense but rather a state of local immune dysfunction resulting in an imbalance between naturally occurring autoimmunity and the regulatory immune cells that should control this autoimmunity”153
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Oral tolerance induction with ApoB100 peptides
ββ
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in vitro
β
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lpr
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gld
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in vitro
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ββ in vitro
.
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Conclusion
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in vitro
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β
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Conclusion
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in vitro
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μ in vitro
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Conclusion
in vitro
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in vitro
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β
lpr
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in vitro
β β
in vitroin vivo
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in vitro β
Conclusion in vitro
in vivo
βin vitro in vivo
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in vivo
in vivo
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Future perspectives
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in vivo
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en face
in vivo
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in vivo
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