novel drug delivery in pediatric medulloblastoma
DESCRIPTION
Novel Drug Delivery in Pediatric Medulloblastoma. Group 37 – Arvin Soepriatna (Presenter), Chris Peng , Blessan Sebastian Client: Mr. Mike Sabo, Pulse Therapeutics, Inc. BME 401, Prof. Anastasio 10/28/2013. Need. - PowerPoint PPT PresentationTRANSCRIPT
Novel Drug Delivery in Pediatric Medulloblastoma
Group 37 – Arvin Soepriatna (Presenter), Chris Peng, Blessan Sebastian
Client: Mr. Mike Sabo, Pulse Therapeutics, Inc.BME 401, Prof. Anastasio
10/28/2013
NeedMore efficient treatment process regarding
drug delivery with chemotherapeutic agentsCurrently no method to exclusively target
tumorsChemotherapy side effects are serious
Increased drug dosage without side-effectsShorter and more effective treatment time
Specific Design RequirementsParameters Specifications
Imaging Phantom Size < 3x3 ft
Imaging Phantom Weight ≤ 30 lbs
Magnet Device Controller < 3x3 ft
Magnetic Field Strength < 1 T
Localization Duration < 5 min
Imaging Depth < 10 cm
Standard Operation Time < 4 hrs
System Power Inlet Standard 110V
Phantom Designs• Box Obstacle
Course• 3D Styrofoam
Brain Phantom• Blood Vessel
Phantom
Magnetic Control DeviceCartesia
n
Conical Spherical
Advantages and Disadvantages
Imaging Technology AlternativesPositron Emission Tomography (PET)
Measures γ-rays emission from radioactive tracer[1]
Half-life of tracers[2]
13N ~ 20 min. 18F ~ 110 min.
Recent discoveries 64Cu ~ 12.7 hours [3]
Nanoparticle conjugation[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.[2] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.[3] Anderson, Carolyn J., Farrokh Dehdashti, P. Cutler, Sally Schwarz, Richard Laforest. "64Cu-TETA-Octreotide as a Pet Imaging Agent for Patients with Neuroendocrine Tumors." The Journal of Nuclear Medicine 42.2 (2001): 213-21. Print.
Imaging Technology AlternativesSingle Photon Emission Computed
Tomography (SPECT)Similar to PET
γ-rays emission Radioactive tracer
Average half-lives ~6 hours[1]
Difference from PET[2]
Lower resolution High Noise
[1] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.[2] Rahmim, Arman, and Habib Zaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.
Imaging Technology AlternativesDoppler Ultrasound
Measures the time it takes for pulse signals to be returned to the receiver from its generation.[1]
High resolution imagesProblem:
Distortion through thick bones[2]
High signal to noise ratioTranscranial Ultrasound
Suboccipital Window [3][1] Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.[2] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.[3] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.
Imaging Technology AlternativesSpectral Computed Tomography (CT)
Measures X-ray attenuation coefficient Utilizes photon counting detectors [1]
Broad spectrum info from X-ray Lower dosage of X-ray
High Resolution
[1] Persson, Mats. "Reconstruction of Spectral CT Images." Thesis. Royal Institute of Technology, 2011. Reconstruction of Spectral CT Images. 2011. Web. 26 Oct. 2013.
Advantages and Disadvantages
[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.[2] Rahmim, Arman, and Habib Zaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.
Chosen DesignMagnetic Control Device: Conical Movement
Imaging Technology: Transcranial Doppler Ultrasound
PhantomStyrofoam thickness: 3cm
Model skull + brain IV tubing Diameter: 0.5 cm
CSF = 0.7 – 1.0 mPa*s @37o C[1]
Saline = 0.72 mPa*s[2]
Pathway fixturesPlastic hooksThin plastic cable wires
[1] Roselli, Robert J., and Kenneth R. Diller . Biotransport: Principles and Applications. 1st ed. New York: Springer Science Business Media, 2011. p. 139. eBook. [2] Kestin, Joseph, H. Ezzat Khalifa, et al, et al. "Tables of the Dynamic and Kinematic Viscosity of NaCl Solutions." J. Phys. Chem. Ref. Data. 10.1 (1981): 71-89. Web. 27 Oct. 2013.
Conical Magnetic Control DeviceJoint modification of the machine made by
Pulse TherapeuticsMotor specs for joints
300 WattsMotor specs for rotating magnet
Up to 300 RPM
Peak Voltage Output of MagnetVoltage measured using 3D magnetic
transducer probe
Doppler UltrasoundLocation of transducer
Angle of incidenceProperties of transducer
For adults[1]
3-MHz transducersFor pediatric
5-MHz transducers
[1] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.Image source: Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.
Project Timeline
Team OrganizationTeam Member Responsibilities
Chris Peng Webpage, CAD Specialist, MATLAB specialist
Arvin Soepriatna Progress PresentationImaging Research, Experimental
Analysis
Blessan Sebastian Final PresentationDesign Parameters and Safety,
Phantom Development
Thank you for listening!