november 6th, 2017 - sbpz...2015/11/03 · 1 meeting program (programa científico) november 6th,...

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Meeting Program (Programa Científico)

NOVEMBER 6th, 2017

NOVEMBER 06th, 2017

14h00 - 20h00 – Registration Gymnasium

16h30 - 17h00 - Meeting Opening Room A Glória

Welcome & Announcements

17h00 - 18h00 - Samuel Pessoa Conference Room A Glória

Chair: Edmundo Grisard Laureado: Alvaro José Romanha (CPqRR–Fiocruz, Belo Horizonte, MG, Brasil) The Personal and Scientific Lifeline of Álvaro José Romanha, a Science Craftsman Mário Steindel (UFSC, Florianópolis, SC, Brasil)

20h00 - 20h30 - Reunião do Conselho/ Board Meeting Room Baependi

20h30 - 22h30 – Poster Session Gymnasium

ODD Numbers/Números ÍMPARES

2


NOVEMBER 7th, 2017

09h00 – 11h00 - OP.01 - Oral Presentations BIOLOGY OF HOST-PARASITE INTERACTION

Room A Glória

Chair: Osvaldo Pompilio De Melo Neto e Marcelo Santos Da Silva HP 001 - Variant antigen profiling in Trypanosoma vivax - a high-throughput approach to antigenic diversity in natural population Sara Silva Silva Pereira (University of Liverpool - UK)

HP 002 - High mobility group b from Trypanosoma cruzi: a putative inflammatory mediator in acute Chagas Pamela Cribb (IBR-CONICET-UNR - ARG)

HP 003 - The TNF receptor 1 in Leishmania amazonensis infection: promotion and regulation of inflammation Leonardo Gomes Vaz (UFMG, MG - BRA)

HP 004 - Trypanosoma cruzi long reads based assembly: revealing the real extent of genome complexity. Luisa Berna Zanotta (Institut Pasteur De Montevideo - URU)

HP 005 - IL-32γ plays a protective role in experimental visceral leishmaniasis Rodrigo Saar Gomes(UFG, GO - BRA)

HP 007 - Trypanosoma rangeli resistance to complement system: Evidences of protein-protein interaction and C3 convertase inhibition Carime Lessa Mansur Pontes (UFSC, SC - BRA)

HP 008 - Towards identification of phospholipid recognized by macrophages RAW in Leishmania (L.) amazonensis . Carolina Lima Jorge (IB-USP, SP - BRA)

09h00 - 11h00 - OP.02 - Oral Presentations

BIOLOGY OF PROTOZOA AND THEIR VECTORS Room B Caxambu

Chair: Fernando Ariel Genta e Claudia Fernanda Dick

PV 001 - Intracellular heme levels modulates thte expression in Trypanosoma cruzi Lucas Pagura (IBR-CONICET, ARG)

PV 002 - Quantifying subcellular structure and organelle dynamics of the Eimeria tenella sporozoite Alana Burrell (Oxford Brookes University, UK)

PV 003 - Protein kinases that regulate Leishmania differentiation Carolina Moura Costa Catta-Preta (University of York, UK)

PV 004 - Trypanosomatids use more origins than the minimum required to complete DNA replication within S-phase period due to replication-transcription conflicts Marcelo Santos Da Silva (Instituto Butantan, SP - BRA)

PV 005 - Lutzomyia longipalpis TGF-β has a role in Leishmania infantum chagasi survival in the vector Tatiana Di-Blasi (IOC-Fiocruz, RJ-BRA)

PV 006 - Arginine methylation as a novel modulator of RNA-binding protein expression and function in Leishmania major Tiago Rodrigues Ferreira (University of York, UK)

PV 007 - Protein kinase C signaling interferes in proliferation, differentiation and metacyclogenesis of Leishmania amazonensis Gabrielle Barcellos Bezerra (IOC-Fiocruz, RJ - BRA)

PV 008 - Comparative transcriptome analysis of procyclic, metacyclic and amastigote stages in Leishmania braziliensis Natália Melquie Monteiro Teles (FMRP- USP, SP-BRA)

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NOVEMBER 7th, 2017

09h00 - 11h00 - OP.03 - Oral Presentations TRANSLATIONAL BIOLOGY

Room C Aiuruoca

Chair: Bartira Rossi Bergmann e Carla Cristi Del Campo Avila TB 001 - A model for vaccine testing against Trypanosoma cruzi infection that exploits highly sensitive bioluminescense imaging Gurdip Singh Mann (LSHTM, UK)

TB 002 - Approaching a new therapy for Chagas disease: inhibitors of the Trypanosoma cruzi proline racemase in focus Guilherme Dias De Melo (Institut Pasteur, FRA)

TB 003 - Overexpression of HMGCoA redutase influences the susceptibility to azoles and alters the sterol homeostasis of Leishmania amazonensis Thaís Martins Pereira (IOC-FIOCRUZ, RJ - BRA)

TB 004 - Fluorescent-based click chemistry demonstrates incorporation of thymidine derivatives into intracellular Trypanosoma cruzi DNA Melissa Louise Sykes (Griffith University-AUS)

TB 005 - High content screening of pharmacologically active compounds against Trypanosoma cruzi: impact of different host cell lineages for hit selection Caio H Franco (DMIP/UNIFESP, SP - BRA)

TB 006 - Expression of Trypanosoma antigens in Leishmania tarentolae. Potential for use in rapid serodiagnostic tests (RDTs) Bernadette Concepta Rooney (University of Kent, UK)

TB 007 - Immune-structural association between epitopes and predicted disordered regions Joao Paulo Linhares Velloso (FIOCRUZ, MG-BRA)

TB 008 - Immunoinformatics and data integration: in silico study of features associated to experimentally tested targets for Leishmania vaccine development Daniela De Melo Resende (FIOCRUZ, MG - BRA)

11h00 - 11h30 - COFFEE BREAK Gymnasium

11h30 - 12h00 – Flash Presentantion Room A Glória

HP018 - Immunochemoterapy of Leishmania (Leishmania) amazonensis-infected BALB/c mice with DPPE 1.2 associated to the recombinant cysteine proteinase rLdccys1 plus Propionibacterium acnes.

HP020 - Adenosine A2B receptor blockade controls lesion development in mice infected by Leishmania amazonensis.

HP022 - Mast cells couple intracellular sensing of amastigotes to inflammatory neovascularization in the hamster cheek pouch model of T. cruzi infection.

HP024 - Soluble CD14 and MHCII as biomarkers in canine visceral leishmaniasis.

HP026 - CD11b+ cells and monocytes are important biomarkers in experimental Leishmania major infection under immunosuppression conditions.

HP028 - The ergosome or the sterols pathway? An Omics approach to understand an ancient drug candidate in Leishmania mexicana .

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NOVEMBER 7th, 2017

PV018 - Expression of calpain-like proteins and effects of calpain inhibitor MDL28170 on Strigomonas culicis wild type and aposymbiotic strains.

PV020 - Characterization of Trypanosoma cruzi lipid body fraction reveals the cholesterol pathway after storage in the reservosomes.

PV022 - Assessment of CRISPR-Cas9 genome editing protocols for fast generation of Trypanosoma cruzi knockout parasite cell lines.

PV024 - The dynamic cycle of mRNAs in Trypanosoma cruzi.

PV026 - Fatty acid metabolism in Trypanosoma cruzi: Lipids as an energy source and characterization of an acyl-CoA dehydrogenase.

PV028 - Gene disruption of beta- and delta-amastins from Trypanosoma cruzi by conventional knock out and CRISPR-Cas9 editing.

PV030 - Gene expression remodeling along the Trypanosoma cruzi cell cycle.

TB018 - A modular methodology to integrate gene expression and proteomics data into protein-protein interaction (PPI) networks, using public databases and open source softwares.

12h00 - 12h30 - CO.01 – Conference Room A Glória

Chair: Maria Carolina Elias Evolution of the nucleus: Lamina and the nuclear pore complex in trypanosomes Mark Christian Field (University of Dundee, Dundee, UK)

12h30 - 14h00 – LUNCH

14h00 - 16h00 - RT.01 - RoundTable "OMICS" AND METABOLISM TO UNDERSTAND

TRYPANOSOMATIDS BIOLOGY

Room A Glória

Chair: Ariel Mariano Silber RT.01.001 - Metabolic adaptation towards metacyclogenesis in Trypanosoma cruzi: a targeted metabolomics approach María Julia Barisón (Carlos Chagas Institute – Fiocruz Paraná - Curitiba, PR, Brasil)

RT.01.002 - Quantitative proteomics unravels Trypanosoma cruzi chromatin and histone post translational modifications Julia Pinheiro Chagas da Cunha (Butantan, São Paulo, SP, Brasil)

RT.01.003 - Changes in the proteome of Leishmania-infected macrophages Richard Burchmore (University of Glasgow – Glasgow, UK)

RT.01.004 - Purine and pyrimidine transporters of kinetoplastid parasites Harry P. de Koning (University of Glasgow – Glasgow, UK)

14h00 - 16h00 - RT.02 - RoundTable

DISSECTING CELLULAR AND MOLECULAR ASPECTS OF APICOMPLEXAN PARASITES

Room B Caxambu

Chair: Andrea Rodrigues Avila RT.02.001 - Using comparative approaches to understand life cycle evolution in Toxoplasma gondii Jon Patrick Boyle (University of Pittsburgh, Pittsburgh, PA, USA)

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NOVEMBER 7th, 2017

RT.02.002 - Unraveling the composition and function of the Toxoplasma gondii inner membrane complex Peter John Bradley (UCLA, Los Angeles, USA)

RT.02.003 - Histone variants and epigenetic modulation of chromatin in Toxoplasma gondii Sergio Oscar Angel (Univ. Nac. de San Martin, Buenos Aires, Argentina)

RT.02.004 - New molecular tools to study Neospora caninum and other apicomplexan parasites Tiago Wilson Patriarca Mineo (UFU, Uberlândia, MG)


16h30 - 17h00 - MC.01 - Mini Conference Room A Glória

Chair: Narcisa Leal Da Cunha-e-Silva Redox Paradox: The contribution of Reactive Oxygen Species (ROS) in the proliferation and differentiation of Trypanosoma cruzi Marcia Cristina Paes (UERJ, Rio de Janeiro, RJ, Brasil)

16h30 - 17h00 - MC.02 - Mini Conference Room B Caxambu

Chair: Lucile Maria Floeter-Winter Extracellular vesicles in pathogenic protozoans: role during the host-parasite interface Rodrigo Pedro Pinto Soares (FIOCRUZ, Belo Horizonte, MG, Brasil)


Chair: Edmundo Carlos Grisard Blastocrithidia, a trypanosomatid with all three stop codons reassigned Julius Lukes (Czech Academy of Sciences, Prague, Czech Republic)


Chair: Lucile Maria Floeter-Winter Leishmania development in sand flies: insight into specific and non-specific interactions Petr Volf (Charles University, Prague, Czech Republic )

18h30 - 19h30 - Plenary Session of SBPz Room B Caxambu

20h30 - 22h30 - Poster Session Gymnasium

EVEN Numbers/Números PARES

6


NOVEMBER 8th, 2017

09h00 - 11h00 - OP.04 - Oral Presentations BIOLOGY OF HOST-PARASITE INTERACTION

Room A Glória

Chair: Sheila Cristina Nardelli e Grazielle Ribeiro Goes HP 009 - Development of a three-dimensional migration assay for study of Trypanosoma cruzi-mammalian cell interaction Matias Exequiel Rodriguez (Instituto De Investigaciones Biotecnológicas, ARG)

HP 010 - Altering the flagellar pocket shape in Leishmania with Flagellum Attachment Zone mutants causes a loss of development and proliferation in the sand fly vector and pathogenicity in the mammalian host. Jack Daniel Sunter (Oxford Brookes University, UK)

HP 011 - Extracellular vesicles released from B-1 cells infected with Leishmania (Leishmania) amazonensis increased inflammatory response in murine macrophages Maytê Dos Santos Toledo (UNIFESP, SP - BRA)

HP 012 - Antigenicity of the Trypanosoma cruzi MASP multigene family in the vertebrate hosts Laila Viana De Almeida (UFMG, MG - BRA)

HP 013 -Comparison among immunological and molecular tests applying less invasive sampling to detect Leishmania infantum infection in asymptomatic animals from an endemic area in Brazil Erika Moutinho Costa (IOC-FIOCRUZ-RJ-BRA)

HP 014 - Endosomal Toll-like receptors signaling facilitates macrophage resistance to Leishmania major infection through induction of autophagy Natália Carvalho Pellison (USP, BRA)

HP 015 - The use of mesenchymal stromal cells as an alternative treatment for Leishmania amazonensis infection Tadeu Diniz Ramos (UFRJ, RJ - BRA)

HP 016 - BMOOMP-ΑLPHA-I: A potential metaloprotease for treating ileitis induced by Toxoplasma gondii. Tamires Lopes Silva (UFU, MG - BRA)

09h00 - 11h00 - OP.05 - Oral Presentations BIOLOGY OF PROTOZOA AND THEIR VECTORS

Room B Caxambu

Chair: Yara Maria Traub-Cseko e Gabriela De Assis Burle Caldas PV 009 - Heme A synthesis is essential for the survival and infectivity of Trypanosoma cruzi Julia Alejandra Cricco (IBR - CONICET, ARG)

PV 010 - Trypanosoma cruzi high mobility group B protein (TcHMGB) can alter chromatin structure and affects important parasite functions Pamela Cribb (IBR-CONICET-UNR, ARG)

PV 011 - Flagellum length and basal body orientation is affected by the cell cycle dependent protein Cep164C in Trypanosoma brucei Madison Atkins (Oxford Brookes, UK)

PV 012 - A novel ABC thiol transporter in Trypanosoma cruzi involved in the acquired resistance to benznidazole Kelli Monteiro Costa (UFRJ, RJ-BRA)

PV 013 - eIF2α phosphorylation is an important factor for Trypanosoma cruzi homeostasis maintenance and stress response Amaranta Muniz Malvezzi (UNIFESP, SP - BRA)

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NOVEMBER 8th, 2017

PV 014 - SI-2, a quinone derivative sirtuin inhibitor induces programmed cell-death in bloodstream and procyclic forms of T. brucei. Carla Cristi Del Campo Avila (USP, SP - BRA)

PV 015 - Differential analysis of mRNA populations associated to distinct eIF4E translation initiation factors in Trypanosoma brucei Christian Robson De Souza Reis (IAM/FIOCRUZ, PE-BRA)

PV 016 - Functional characterization of AP-1 in Trypanosoma cruzi Cláudia Maria Do Nascimento Moreira (ICC, PR - BRA)

09h00 - 11h00 - OP.06 - Oral Presentations TRANSLATIONAL BIOLOGY

Room C Aiuruoca

Chair: Renato Augusto Damatta e João Luis Reis Cunha TB 09 - Trypanosoma cruzi proline racemase (TcPRAC): A target for development of molecular, serological and imaging tools for chagas disease diagnosis and treatment monitoring Nicolas Coatnoan (Institut Pasteur, FRA)

TB 010 - Identification and evaluation of GTP binding protein of the Leishmania infantum for the serodiagnosis of visceral leishmaniasis of symptomatic and asymptomatic dogs Williane Fernanda Siqueira (UFMG , MG - BRA)

TB 011 - Leishmanicidal activity of withanolides from specie of genus Aureliana Eduardo Raul Pereira Veltri (IOC-FIOCRUZ, RJ - BRA)

TB 012 - The effect of the α-phenyl-tert-butyl-nitrone (PBN) derivative, LQB 303, in the mitochondrial physiology of Trypanosoma cruzi amastigote forms and non-infected mammalian cells Carolina Machado Macedo (UERJ, RJ - BRA)

TB 013 - Comparative transcriptome analysis of antimony resistant and susceptible Leishmania infantum lines Leilane Oliveira Gonçalves (IOC-FIOCRUZ, RJ - BRA)

TB 014 - In silico prediction of drugs and nutraceuticals supplementary to antimonial chemotherapy from Leishmania amazonensis Davi Alvarenga Lima (UFPI, PI - BRA)

TB 015 – N’N-diarylurea I-17 affect trypanosomatids due to activation of eIF2α specific kinase Fabrício Castro Machado (UNIFESP, SP - BRA)

TB 016 - Evaluation of the leishmanicidal activity of new quinones derivatives and its action on the respiratory chain of Leishmania infantum Viviane Dos Santos Faiões (FIOCRUZ, RJ - BRA)


11h30 - 12h00 - CO.02 - Conference Room A Glória

Chair: Bartira Rossi Bergmann Identifying and Validating New Targets for Neglected Tropical Diseases Patrick Giles Steel (University of Durham, Durham, UK)

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NOVEMBER 8th, 2017

11h30 - 12h00 - CO.03 - Conference Room B Caxambu

Chair: Ariel Mariano Silber Sphingolipid biosynthesis in the apicomplexan protozoa: divergent enzymes in key host:pathogen interactions Paul Denny (Durham University, UK)


Chair: Bruno Dallagiovanna Muniz Unexpected phenotypic variability of Trypanosoma brucei parasites Luísa Miranda Figueiredo (University of Lisboa, Lisboa, Portugal)


Chair: Walderez Ornelas Dutra Molecular pathogenesis of Chagas disease cardiomyopathy Edecio Cunha-Neto (USP, São Paulo, SP, Brasil)

12h30 - 14h00 - LUNCH

14h00 - 16h00 - RT.03 – Round Table

GENOME EDITING AND THE NEW ERA IN THE STUDY OF PROTOZOAN PARASITES

Room A Glória

Chair: Santuza Maria Ribeiro Teixeira RT03.001 - Two essential thioredoxins mediate protein import and gene expression of the Toxoplasma gondii plastid Lilach Sheiner (University of Glaskow, Glaskow, UK) RT03.002 - Development of attenuated vaccine strains of Leishmania using CRISPR-Cas Genome Editing Greg Matlashewski (McGill University, Montreal, Canada) RT3.003 - A CRISPR-Cas9 toolkit for loss-of-function screens in Leishmania Eva Gluenz (University of Oxford, Oxford, UK) RT03.004 - Extending the Trypanosoma cruzi experimental tool box by combining bioluminescence, fluorescence and high-throughput genome editing technology John M. Kelly (London School of Hygiene and Tropical Medicine, London, UK)

14h00 - 16h00 - RT.04 – Round Table IMMUNE RESPONSE TO PROTOZOANS

Room B Caxambu

Chair: Luis Carlos Crocco Afonso

RT04.001 - INTERLEUKIN 32: A New Player In Leishmaniasis

Fátima Ribeiro Dias (UFGO, Goiânia, GO, Brasil)

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NOVEMBER 8th, 2017

RT04.002 - T Follicular helper cells regulate the activation of B lymphocytes and antibody production during Plasmodium vivax infection

Lis Ribeiro do Valle Antonelli (CpRR Fiocruz, Belo Horizonte, MG, Brasil)

RT04.003 - Role of Purinergic Receptors in Controlling of T. gondii Infection

Robson Coutinho Silva (UFRJ, Rio de Janeiro, RJ, Brasil)

RT04.004 - Using Trypanosoma cruzi-derived components as strategies to modulate the host’s immune response: towards the prevention of Chagas disease ardiomyopathy

Walderez Ornelas Dutra (UFMG, Belo Horizonte, MG, Brasil)



Chair: Edmundo Carlos Grisard Density-dependent development and social interaction between African trypanosome species in the mammalian bloodstream Keith Roland Mathews (University Edinburgh, Edinburgh, UK)


Chair: Walter Colli Development of potential diagnostic tests for the control of visceral leishmaniasis Ricardo Toshio Fujiwara (UFMG, Belo Horizonte, MG, Brasil)

17h00 - 18h00 - CC – Closure Conference Room A Glória

Chair: Narcisa Leal Da Cunha-E-Silva RNA-binding proteins and RNA granules: A complex response to a single stress signaling for T. cruzi differentiation Samuel Goldenberg (ICC/Fiocruz, Curitiba, PR, Brasil)

19h00 - 21h00 – Signature of Receipts to SBPz Members

Gymnasium

21h30 - 22h30 CLOSING SESSION

Zigman Brener and Walter Colli Awards and Closing Remarks Room A Glória

november 6th, 2017 - sbpz...2015/11/03 · 1 meeting program (programa científico) november 6th,...

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