nuclear dna v mtdna: principles of inheritancenuclear dna v mtdna: principles of inheritance 11 17...
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![Page 1: Nuclear DNA v mtDNA: principles of inheritanceNuclear DNA v mtDNA: principles of inheritance 11 17 22 13 14 15 20 10 16 12 18 Normal Karyotype MRC Mitochondrial Biology Unit Created](https://reader035.vdocument.in/reader035/viewer/2022071213/602c2564cd8c3004843c938e/html5/thumbnails/1.jpg)
NuclearDNA(nDNA) MitochondrialDNA(mtDNA)
- Foundinthenucleusofthecell- 3,300,000,000bases(A,T,CandG)- Arrangedinlinearchromosomes- Twocopiesofeachchromosome- Maternallyandpaternallyinherited- Containsapproximately20,000genes- 93%ofthegenomeisnon-codingDNA
- Foundinthemitochondrialmatrix- 16,569bases(A,T,CandG)- ArrangedinacircularchainofDNA- Multiplecopiespresent- Maternallyinherited- Contains37genes- 3%ofthegenomeisnon-codingDNA
Mendelianinheritance Non-Mendelianinheritance
Mother:‘healthy’carrier
Father:‘healthy’carrier
‘healthy’child:1in4chance
‘healthy’carrierchild:
2in4chance
‘diseased’child:1in4chance
- Exampleofanautosomalrecessivedisease
- Diseaseseverityiscorrelatedtoratioofhealthytodiseasedmitochondria
Healthymitochondria
Lowlevelofmutation:healthychild
Intermediatelevelofmutation:milddisease
Highlevelofmutation:severedisease
mothercell
oocytes
DiseasedmitochondriawithmutatedmtDNA
Nucleus
NuclearDNAvmtDNA:principlesofinheritance