nuclear imaging in endocrinology: pitfalls and artifacts
TRANSCRIPT
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Nuclear Imaging in Endocrinology: Pitfalls and Artifacts
David Taïeb, Elif Hindié
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FDG-PET in DTC
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Small FDG-avid lung nodules in DTC
3 thyroid cancer patients with apparently solitary FDG-avid lung nodule
A-D: 5mm primary lung adenocarcinoma (TTF1+, anti-Tg-), E-H: Giant cell granulomatous lesions , I-L: Multiple
metastases from a PTC (anti-Tg+) and additional carcinoids (synapto+)
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Retro-thyroid Mass
Goiter developed from the Zuckerkandl’s tubercle
(A) Enhanced CT scan (axial)
(B) Enhanced CT scan (frontal)
(C) Volume rendering image arteria lusoria
(D) 123I scintigraphy: mass of thyroid origin
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P3-derived Adenoma
Subtraction protocol
(A) 99mTc-sestaMIBI
(B) B: 123I
(C) subtraction images
(D) SPECT images of parathyroid adenomas. Typical P3 adenoma which is located at the tip of the left inferior lobe on planar images and remains anterior on SPECT images
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Subtraction protocol
(A) 99mTc-sestamibi pinhole planar image
(B) 123I scan
(C) subtraction image (99mTc-sestamibi-123I) parathyroid lesion in the right lower pole of the thyroid.
(D) The posterior extension of the adenoma on SPECT images is highly suggestive of P4 origin, despite its apparent right inferior origin on planar images
P4-derived Adenoma
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P4-derived Adenoma
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Ectopic Parathyroid Adenoma
99mTc-sestaMIBI scintigraphy. A.
Planar images find a left inferior
parathyroid adenoma. B-D. Fusion
SPECT/CT images (sagittal, axial
and coronal imaging planes) help in
the diagnosis of paraeophageal
ectopic adenoma.
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Echographie + SP
Localisation Pas de localisation
Postérieure Antérieure
Abord latéral vidéo
assisté
Abord central (vidéo)
assisté Cervicotomie
conventionnelle
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(A) 99mTc-sestamibi SPECT images
(B) 99mTc-sestamibi SPECT images:
(C) FDG-PET (CT, PET, fusion)
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M, 74 y
Cal: 2.82 mmol/l
PTH: 12.4 pmol/l (1.6-
6.9)
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FDG PET/CT in Adrenal masses: a non specific tracer
ACC
Metastasis (except renal)
PHEO
Lymphoma
Macronodular Adrenal hyperplasia (Cushing)
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Early post-operative period (March 2006)
ACC
February 2007
August 2007
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False negative 123I-MIBG scintigraphy
A. CT
B. FDG
C. FDOPA
123I-MIBG (post. view)
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123I-MIBG
PHEOs/Abdo PGLs: Se: 83-100% (52-75% in hereditary), Sp>95%
HNPGLs: 18-50%
Ilias I et al, Journal of Nuclear Medicine 2008; Timmers HJ 2009; Timmers HJ et al, Journal of Clinical Endocrinology and Metabolism 2009;
Fiebrich HB et al, J Clin Endocrinol Metab 2009.
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SRS
HNPGLs: Se: 89-100%, Sp: 90%
Muros MA et al, Nucl Med Commun 1998; Telischi FF et al, Otolaryngol Head Neck Surg 2000 ; Schmidt M et al, Eur J Nucl Med Mol Imaging 2002; Bustillo A
et al, Laryngoscope 2004; Duet M et al, J Nucl Med 2003; Koopmans KP et al, Journal of Nuclear Medicine 2008, Gimenez-Roqueplo AP, Journal of Clinical
Endocrinology and Metabolism 2013
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HTA avec lésion
surrénalienne G au
scanner en contexte
de M.de
Recklinghausen
Pas de fixation décelable en région surrénalienne
Fixation ponctuelle en région cervicale
M. Guyot, Bordeaux
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• Pas de fixation du nodule
surrénalienne gauche
• Plage de fixation loge
thyroïdienne gauche
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- Widely distributed: HNPGLs, PHEO and Abdo. PGLs
- 30-35% hereditary (>10 susceptibility genes)
PGLs and PHEOs
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SDHx-related PGLs/PHEOs
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Multiple SDHD-related PGLs
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Genotype/metabolic phenotype (SDHD)
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Genotype/metabolic phenotype (SDHB)
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Timmers HJ et al, Journal of Clinical Oncology 2007; Taieb D et al, Journal of Nuclear Medicine 2009; Timmers HJ et al, Journal of the National
Cancer Institute 2012, Fonte et al, Endocrine-related cancer 2012.
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Early and prolonged pancreatic FDOPA uptake (exo and endocrine): major drawback in adults
Need to revise the protocol
Carbidopa (AADC-I)?: may mask tumor uptake (Kauhanen et
al, JCO 2008)
Timing of acquisition ?
Insulinoma
FDOPA
SRS
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Sporadic
F, 70 y
Hyperinsulinic hypoglycemia
Contrast-enhanced US (1 tumor)>MRI (0)=CT (0)=SRS (0)
Carbidopa premedication, E/D Acq.
Insulinoma: protocol revisited
1 insulinoma pathologically-proven (Ki-67<1%)
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Sporadic
M, 70 y
Hyperinsulinic hypoglycemia
MRI (1 tumors)=CT (1)=SRS (1)
Carbidopa premedication
1 insulinoma pathologically-proven (Ki-67=2-5%)
Insulinoma: protocol revisited
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Non-secreting NET: protocol revisited
FDOPA 5 min
30 min
FDOPA 5 min
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Non-secreting NET: protocol revisited
MEN-1
F, 44 y
Lung carcinoid
pHPT
Current status: non-secreting pancreatic NET and reccurent pHPT
MRI (3 tumors)>CT (2)>SRS (0)
Carbidopa premedication
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Pancreatic NET
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FDG FDOPA
MTC: Persistent/recurrent LN
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Early vs delayed images
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MTC: Intial staging
FDOPA
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Multiple SRS+ lesions
CT MRI
US
SRS FDG FDOPA
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FDOPA thyroid incidentaloma
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Kindly provided by Alessio Imperiale
FDOPA+ pancreatic tumor
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Harlequin syndrome: Excessive paroxysmal sweating and flushing on the left side of her face after physical exercise or emotional stress since 3 years
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PHEOs and BAT activation
MIBG SRS FDOPA
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WT KIT GIST FDG
CT-related GIST
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