nutrition and skin health

Presented by Emily Pearl Seferovich

INCREASED PREVALENCE OF METABOLIC SYNDROME IN PATIENTS WITH ACNE

INVERSA

WHAT IS ACNE INVERSA?

• Common, chronic Inflammatory skin disease

• Major Dermatological Issue in the United States

• Can be painful and leave residual scarring (physical & emotional)

• Is associated with metabolic syndrome, which may result in:

• A) Arteriosclerosis

• B) Coronary Heart Disease

• C) Myocardial Infarction

• D) Stroke

POST ACNE SCARRING

The aim of the study was to investigate the frequency of metabolic disorder criteria in patients suffering from Acne Inversa

to determine the relationship between AI & Metabolic Sydrome

• Criteria for Metabolic Syndrome includes 3 or more of the following:• (1) central obesity: waist circumference 102 cm (male), 88 cm (female),

• (2) hypo-HDL-cholesterolemia: plasma HDL-cholesterol ,40 mg/dl (male), ,50 mg/dl (female),

• (3) hypertriglyceridemia: plasma triglyceride 1.695 mmol/l (150 mg/dl),

• (4) hypertension: blood pressure 130/85 mmHg or use of medication for hypertension,

• (5) hyperglycemia: fasting plasma glucose 6.1 mmol/L (110 mg/dl) or use of medication for hyperglycemia.

STUDY DESIGN

• Case Control Study

• 180 Participants total

• 100 control persons

• 80 cases of Acne Inversa

• Controls matched by age and sex with cases and had never been diagnosed with Acne Inversa

• Participants screened for BMI, Waist Circumference, Blood Pressure, FSTG Blood Lipids, and FSTG Blood sugar, and type/severity of Acne Inversa

STUDY RESULTS• Avg. waist circumference, plasma TG levels, fasting plasma glucose

levels, as well as the blood pressure were significantly higher in AI patients than in control participants

• Avg. plasma HDL levels were lower in AI patients.

• Increased prevalence of the following within Case Cohort:

• Hypertriglyceridemia (odds ratio 2.24)

• Central Obesity (odds ratio 5.88)

• Hypo-HDL-cholesterolemia (odds ratio 4.56)

• Hyperglycemia (odds ratio 4.09)• *odds ratios significantly higher in cases than in controls

Patients without AI Patients with AI0

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Control

1.) Frequency of Hypo-HDL-cholesterolemia 2.) Frequency of Central Obesity


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3.) Frequency of Hypertriglyceridemia


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4.) Frequency of Hypertension

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5.) Frequency of Hyper-Glycaemia


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6.) Frequency of Metabolic Syndrome

Control Control

STUDY CONCLUSIONS• Study findings suggest that chronic inflammation is not the major

driver of the metabolic alterations in AI patients.

• i.e. Chronic Inflammation does not cause metabolic dysfunction

• It is possible that metabolic alterations trigger AI.

• Metabolic Dys. poor blood circulation of respective skin areas.

• Hypoxia inhibits production of IL-22, an important inducer of antibacterial proteins in epithelial tissues

• Poor blood circulation could eventually lead to enhanced cutaneous bacterial persistence and the outbreak of AI

SUMMARY OF STUDY RESULTS• Metabolic syndrome can reduce the body’s ability to fight internal & external

infection

• Acne Inversa exemplifies this phenomenon

• Decreased production of anti-microbial proteins infection

• Proper eating habits and weight maintenance

• Key implications for quality of life – both physical and emotional

• Skin health is important for self confidence

• How do people feel/ react when weight issues are compounded by dermatological ones?

• How do others react to persons with skin conditions that are perceived to represent bodily health?

QUESTIONS?COMMENTS?CONCERNS?

nutrition and skin health

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