nutritional medicine
DESCRIPTION
Presentation from Woodford 09/10TRANSCRIPT
Nutritional MedicineDr Fatiha Arhbal
The Wellness Oasis
49 Portrush Road
Payneham, Adelaide
MBBS, FRACGP, DCH, DRANZCOG
Board Certified Anti Ageing Physician
Nutritional Medicine
The conventional medical approach
aims for a quick diagnosis and
treatment of acute symptoms.
The Nutritional Medicine approach
aims to get to the source of the
symptoms as well as promoting
health, wellbeing and longevity.
Nutritional Medicine
Over 60% of deaths in Australia result from nutrition related disorders.
Australia has overtaken America as the most obese country.
“Good nutrition leads to health and resistance to disease; poor nutrition leads to ill- health and susceptibility to many diseases.”Nutrition- Chapter 10.3 Oxford Textbook of Medicine, Third Edition
30-40% of all cancers can be prevented by diet.
Donaldson MS.
Nutrition and cancer: a review of the evidence for an anticancer diet.
Nutr J. 2004 Oct 20;3:19.
Nutritional Medicine
“Let food be thy medicine and medicine be thy food” – Hippocrates.
“When the diet is incorrect, medicine does not work, when the diet is correct, medicine is not necessary”- Ayurvedic wisdom.
“No human ever filled a vessel worse than the stomach. Sufficient for any son of Adam are some morsels to keep his back straight. But if it must be, then one third for his food, one third for his drink and one third for his breath”- Prophet Mohammed pbuh.
Nutritional Medicine
Diet
Nutritional Deficiency
Inflammation
Gastrointestinal dysfunction
Detoxification
Oxidative stress
Neurotransmitters
Hormones
Diet
Diet and Wellness
Diet is the major determinant of wellness or illness, cardiovascular, cancer, diabetes are >50% preventable through diet
Food needs to be good tasting and enjoyable
Part of an active lifestyle
Should not be prepared and consumed quickly on the way to more pressing activities
Enjoyment assists in savouring the tastes and textures and may reduce overeating and snacking
Just choosing food to decrease chronic disease makes eating prescriptive and joyless
Diet controls inflammation
Williams MT et al. The role of dietary factors in cancer prevention: beyond fruits and vegetables.
Nutr Clin Pract. 2005 Aug;20(4):451-9.
Calorie Restriction (CR)
Decreases Inflammation CR is the most documented method of
extending lifespan and health span in all species studied
CR decreases inflammatory cytokinesChung, H et al. Molecular InflammationHypothesis of Aging Based on the Anti-
agingmechanism of Calorie Restriction.
Microscopyresearch and techniques 59:264-272
(2002)
Calorie Restriction
10-25% less calories than the Western
Diet
BMI of 19.6
Intermittent fasting may be as effective
Studies in animals, human studies
take a long time
Resveratrol has been shown to mimic
the effects of CR in some animal
species
Diet and Wellness
Macronutrients- Protein, Carbs, Fat
How to combine them?
Zone-type diet 40-30-30 Optimises
Fasting Insulin, Lipids, Inflammation,
Fat storage, Body Composition
Avoid Carbs without phytonutrients
Insulin Studied insulin resistance to predict a variety
of age-related diseases. Baseline measurements of insulin resistance
and related variables were made between 1988-1995 in 208 apparently healthy, non obese
Evaluated 4-11 yr later for the appearance of the following age-related diseases: hypertension, coronary heart disease, stroke, cancer, and type 2 diabetes.
The effect of insulin resistance on the development of clinical events was evaluated by dividing the study group into tertiles of insulin resistance at baseline and comparing the events in these 3 groups.
Clinical endpoints (n = 40) were identified in 37individuals (18%)
of those evaluated, including 12 with hypertension, 3 with
hypertension + type 2 diabetes, 9 with cancer, 7 with coronary
heart disease, 4 with stroke, and 2 with type 2 diabetes.
Twenty-eight out of the total 40 clinical events were seen in 25
individuals (36%) in the most insulin-resistant tertile,
The other 12 occurring in the group with an intermediate degree
of insulin resistance.
Insulin resistance was an independent predictor of all clinical
events,
An age-related clinical event developed in approximately 1 out of
3 healthy individuals in the upper tertile of insulin resistance at
baseline, followed for an average of 6 yr
No clinical events were observed in the most insulin sensitive
tertile
Facchini FS, Hua N, Abbasi F, Reaven GM.
Insulin resistance as a predictor of age-related diseases.
Slow Foods vs. Fast Foods
Increased consumption of high density low quality foods
Refined starches, sugars
Unhealthy lipids
Poor in natural antioxidants and fibre
Activates immune system
Produces pro-inflammatory cytokines and decreased production of anti-inflammatory cytokines
Slow Foods vs. Fast Foods
Inflammatory cytokines produce insulin resistance and endothelial dysfunction
Leads to metabolic syndrome and Type 2 diabetes
Fast foods are fast in preparation and are fast in producing health damage
Nutrition vs. drugs to control inflammatory effects
Fast foods speed up inflammation and slow foods slow it down.
How much do you need?
Diet: As best as you can do it
Omega 3: 8 gm per day of EPA + DHA
Phytonutrients: 8 x 100 g servings
vegetables per day
Calories- not too many
Don’t eat more than you need
Don’t drink calories
Pure Water, Green Tea
Polymeal
150 mL of red wine (about half a
glass)
100 g of dark chocolate
400 g of fruits and vegetables
2.7 g of garlic
68 g of almonds
118 g of fish per day four times each
week.
Polymeal Reduce cardiovascular disease events
by 76% Increase life expectancy Men 6.6 years Women 4.8 years The Polymeal promises to be an
effective, non pharmacological, safe, cheap, and tasty alternative to reduce cardiovascular morbidity and increase life expectancy in the general population.
Franco OH et al. The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.BMJ. 2004 Dec 18;329(7480):1447-50.
Nutritional Deficiency
Overfed and undernourished
Surveys show that Australian nutrient intakes fall below the RDI
Average calcium intake less than the RDI in most women
Average folate intake in women aged 19-44 years was only 50% of that required to prevent birth defects
Iron intake below the RDI in 25% of adolescent girls and young women
Zinc well below the RDI in 50% of women and 10% of men more than 19 y
Magnesium intake below the RDI in 25% of women aged over 19
Fruits and vegetables
Fruit and vegetable intake was below
recommended levels in 35% of adults
and 65% of adolescents
65% adults consumed less that the
recommended levels of seafood oils
In adults, beverages accounted for
over 60% of food and beverage
energy intake- ie alcohol and sugar
accounted for over 50% of dietary
energy
RDI
We are taught to believe that the
vitamin and mineral intake at the level
of the Recommended Daily Intake as
set by the NHMRC of Australia is
perfectly adequate for the continued
health of all
We are taught to believe that greater
intakes than this are useless at best
and harmful at worst
RDI
RDIs are the amounts of essential
nutrients that are considered adequate
to meet the nutritional requirements of
healthy people
The RDIs are designed to prevent the
classical nutritional deficiency
diseases
They do not address the extra nutrient
needs of persons with certain chronic
aliments, who smoke, or are on
medications
RDI
New research suggests a role for vitamins and minerals in the prevention or slowing down of many diseases such as heart disease, cancer, cataracts, osteoporosis, and birth defects
The total effects of vitamins on the body are still not fully understood
Further, there is increasing scientific evidence to suggest that higher levels of certain vitamins may be necessary for optimal health and may provide extra protection against disease
RDI
In time, the concept of RDI may well be broadened to include a second set of much higher vitamin levels that optimise their disease preventing properties
It is particularly important to remember that RDI’s are for healthy people
In illness the requirements for nutrients are altered. For example, with stress, trauma or surgery, the requirement for vitamin C may be more than 8 times the RDI for healthy adults and zinc requirements increase for wound healing
Nutrition Unit, Faculty of Medicine, Monash University, 1998
Biochemical Individuality
“Our analysis of metabolic disease that affects cofactor binding, particularly as a result of polymorphic mutations, may present a novel rationale for high-dose vitamin therapy, perhaps hundreds of times the normal dietary reference intake (DRI) in some cases . . . Feeding high doses of the vitamin raises the tissue cofactor concentrations and thereby increases the activity of the defective enzyme.”
Ames, BN et al. Am J Clin Nutr. 2002;75:616-58
Homocysteine
A cardiovascular risk marker Linked with a variety of chronic health
problems- osteoporosis, migraine, obesity, arthritis, depression
Metabolised by B vitamins-B6, B12 and folate
The most common issue is a problem with an enzyme that causes folateactivation within the cell. This is a genetic polymorphism and up to 40% of people have it.
Need high dose B vitamins, large doses of folate or folinic acid
Vitamin and Mineral
Deficiency Vit A- bumpy skin, night blindness, achy,
tired, burning itching eyes, eyeball pain,
inflamed eyelids, frequent colds, sinus
trouble, dull hair, ridged nails that peel
easily, birth defects, fatigue, depression,
insomnia
Vit D- aching bones, joints, exhaustion,
night sweats, aching muscles, rickets,
anxiety, increased cell proliferation
Vit C- fatigue, easy bruising, joint
pains, loss of appetite, depression,
poor wound healing, immune
depression, periodontal disease
Vit E- fatigue, restlessness, insomnia,
increased destruction of red blood
cells, oxidative damage, ageing, calf
tenderness
Vit K- Bleeding disorders, easy
bruising,
Vit B group-
B1- anorexia and weight loss, moody
and irritable, palpitations, memory
loss, impaired co-ordination, CCF,
peripheral neuropathy
B2- angular stomatitis, red tongue,
photophobia, migraine, hair loss
B3- dermatitis, diarrhoea, depression,
low stomach acid, nausea, diarrhoea,
constipation, glossitis, headache,
dementia
B6- low blood sugar, depression,
dandruff, dermatitis, morning nausea,
poor dream recall, PMS, carpal tunnel,
microcytic anaemia
B12- neurologic degeneration, poor
memory, depression, fatigue,
paraesthaesiae, dementia, palpitations
Folate-fatigue, weakness, anorexia,
impaired memory, headaches, large
red cells, vascular disease
EFA- dry flaky skin, dry brittle hair and
nails, acne, alopecia, inflammation,
immune system dysfunction, impaired
wound healing, hormone dysfunction,
vascular disease
Iron- anaemia, learning problems,
poor memory, depression, flat or
spoon shaped nails, hyperactivity,
fatigue, low BP
Calcium- anxiety, irritability,
depression, cramping in calves,
palpitations, HT, period problems
Selenium- cancer, muscle fatigue,
immune depression
Zinc- short stature, tiredness, delayed
would healing, loss of taste and smell,
poor appetite, hyperactivity, stretch
marks, acne, growing pains, white
spots on fingernails, frequent
infections, hair loss, infertility
Manganese- poor bone growth, knee
pain
Magnesium- sensitivity to sounds,
irritability, insomnia, hyperactivity,
cramps, anxiety, HT, palpitations
Chromium and Vanadium- essential
for insulin receptor activity and
deficiency results in insulin resistance,
high cholesterol, fat gain
Vitamin D Pandemic
Balanced diet or living near equator not sufficient
Everyone who does not get lots of sun or ingests at least 2000-10,000 IU per day is at high risk for skeletal and non-skeletal consequences
High rates of Vitamin D Deficiency: USA, Europe, Middle East, India, Asia, Australia and New Zealand
Low Vitamin D Production
Clothing
Sunscreen
Latitude > 37 in winter, Early and late
hours
Skin pigmentation
Body fat
Age: 70 yo produces 4 x less than 20
yo
Drugs-Anticonvulsants, corticosteroids
Vitamin D
Few foods contain vitamin D
Fish liver oils, such as cod liver oil, 1 Tbs. (15 mL) provides 1,360 IU
Fatty fish species, such as:
Herring, 85g (3 oz) provides 1383 IU
Catfish, 85g (3 oz) provides 425 IU
Salmon, cooked, 3.5 oz provides 360 IU
Mackerel, cooked, 3.5 oz, 345 IU
Sardines, canned in oil, drained, 1.75 oz, 250 IU
Tuna, canned in oil, 3 oz, 200 IU
Eel, cooked, 3.5 oz, 200 IU
One whole egg, 20 IU
Fortified Milk 100 IU/cup
For every 100 IU ingested, 25(OH) D3 increases 1 ng/ml
25(OH) D and post-menopausal
Breast Cancer
70% reduction in higher level >75
nmol/L compared to lowest 10
nmol/L
Abbas S et al. Serum 25-
hydroxyvitamin D and risk of post-
menopausal breast cancer--results
of a large case-control study.
Carcinogenesis. 2008 Jan;29(1):93-
9
25(OH) D and pre-menopausal
Breast Cancer
Compared with the lowest category (<30nmol/L), the ORs (95% CI) for the upper categories (30-45, 45-60, >/=60 nmol/L)were 0.68 (0.43-1.07), 0.59 (0.37-0.94) and 0.45 (0.29-0.70), (p = 0.0006)
Abbas S et al. Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case control study. IntJ Cancer. 2008 Oct 6
Vitamin D Deficiency
At least 17 varieties of cancer
Heart disease, stroke, hypertension
Autoimmune diseases, MS
Diabetes, type 1 and 2
Depression
Chronic pain
Osteoarthritis
Vitamin D Deficiency
Osteoporosis
Muscle weakness
Periodontal disease
Childhood bone health
Infectious disease
www.vitamindcouncil.org
Vitamin D physiology
Technically not a "vitamin"
Vitamin D is in a class by itself.
Its metabolic product, 1,25
dihydroxyvitamin D= calcitriol, is a
steroid hormone that targets over
1000 genes
Every cell has a vitamin D receptor
that responds to 1,25 dihydroxyvitamin
D
Cell Junction effects
Apoptosis
Anti-Metastasis
Primary molecular action of Calcitriol is
binding to Vitamin D Receptor (VDR) ,
a member of steroid hormone receptor
superfamily
Initiates gene transcription
VDR needed for growth arrest of cancer
VDR turns on genes for increase in
production of IGFBP-3
Cancer can turn off CYP27b1 inhibiting
D3 production
Vitamin D and CVD
Men with low Vitamin D suffer 2.42 x
more heart attacks
157,000 Americans die every year
If Vit D status was optimised, deaths
prevented 92,500
Statin reduces heart attack 37%, men
with higher Vit D levels reduction is
142%
Cost effective
Life Extension Foundation January
Why Deficient?
The really significant reductions in
sunlight exposure have occurred since
the industrial revolution, just the time
the "diseases of civilization," like
cardiovascular disease, diabetes and
cancer became prominent
Common Causes of
EFA Imbalances
1. Diet high in Ω -6 fats & low in Ω -3
fats
2. Biochemical individuality-altered
delta-6 desaturase activity,
micronutrient deficiencies(B3, B6,
biotin, C, Zn, Mg)
3. Insulin dysregulation
high carbohydrate/ low protein /low
fibre diet
Insufficient dietary chromium,
vanadium, magnesium
Dietary Intake of
Ω-6 and Ω-3 Fats
From 1909 to 1985
Omega-6 fat intake has increased from 1 kg per year to 12 kg per year
The ratio of dietary Ω -6: Ω -3 fats has also increased from ~4:1 to ~25:1
Reasons for increased omega-6 fat intake:
– Vegetable oil (grain-extracted)
– Grain-fed livestock (no longer free-range)
– Decreased wild game consumption
EFA Treatment
All chronic inflammatory conditions,
cardiovascular disease, auto-immune
disease, arthritis, Crohn’s disease,
colitis, allergies
Foetal and neonatal neurological
development
Mother’s health during pregnancy &
lactation
Senile neurological degeneration
Depression and behaviour disorders
(ADHD)
Gastrointestinal dysfunction
Low stomach acid- inability of stomach to digest adequately
Pancreatic dysfunction- low digestive enzymes
Dysbiosis- leading to absorption of toxins Leaky Gut- leading to absorption of large
molecules Activation of GALT leading to immune
system activation Production of neurologically active
chemicals such as amines
Common signs and symptoms of
low gastric acidity Bloating, belching and flatulence immediately after
meals
A sense of “fullness” after eating
Indigestion, diarrhoea, or constipation
Multiple food allergies Nausea after taking supplements
Itching around the anus
Weak, peeling, and cracked fingernails
Dilated blood vessels in the cheeks and nose
Acne
Chronic intestinal parasites or abnormal flora
Undigested food in stool
Chronic candida infections
Upper digestive tract gassiness/bloating
Difficulty digesting protein- especially meat
Diseases associated with low
gastric acidity
Addison’s Disease
Asthma
Coeliac disease
Dermatitis herpetiformis
Diabetes mellitus
Eczema
Gallbladder disease
Hepatitis
Chronic hives
Lupus
Myasthenia gravis
Osteoporosis
Pernicious anaemia
Psoriasis
Rheumatoid arthritis
Rosacea
Sjogren’s syndrome
Thyrotoxicosis
Hypothyroidism
Vitiligo
Protocol for HCL Acid
supplementation Begin by taking one tablet or capsule containing 600 mg of HCL at your next large meal. If this does not aggravate your symptoms (iethere is no burning within half an hour of taking the tablet), at every meal after that of the same size, take one more tablet or capsule. (One at the next meal, two at the meal after that, then three at the next meal.)
If you have no burning within half an hour of taking the tablets, this means you need more acid.
Continue to increase the dose until you reach seven tablets or when you feel a warmth in your stomach, whichever occurs first. A feeling of warmth in the stomach means that you have taken too many tablets for that meal, and you need to take one less tablet for that meal size. It is a good idea to try the larger dose again at another meal to make sure that it was the HCL that caused the warmth and not something else.
After you have found the largest dose that you can take without feeling any warmth, maintain that dose at all meals of similar size. You will need to take less at smaller meals.
When taking a number of tablets or capsules it is best to take them throughout the meal.
As your stomach begins to regain the ability to produce the amount of HCL needed to properly digest your food, you will notice the warm feeling again and will have to cut down the dosage. HCL may be used indefinitely.
Pancreatic insufficiency
Pancreatin
Bromelain
Papain
Dysbiosis
We inherit our intestinal flora from our
mother during birth
Around 2kg of organisms in the gut
Communicate with the immune
system, maintain correct pH, produce
beneficial short chain fatty acids,
vitamins
Poor diet, antibiotics, the OCP,
chemicals can all impact on this
Anti-bacterials :
Standard antibiotics
Garlic
Goldenseal
Artemesia/ChineseWormwood
Anti-fungals :
Standard antifungal agents
Oregano
Thyme
Garlic
Goldenseal
Anti-protozoals:
Standard anti-protozoal agents
Oregano
Thyme
Goldenseal
Artemesia/ChineseWormwood
Endotoxic Binders:
Charcoal
Fibre
Bentonite Clay
Leaky Gut
Leaky gut occurs when the intestinal
lining is damaged and the junctions
between the cells are open
Occurs with food allergy, dysbiosis,
toxins, deficiencies, stress
Large molecules able to cross into
blood stream causing immune
activation and symptoms elsewhere in
the body
Food intolerance
Mediated via IgG not IgE
Intolerance vs Allergy
Causes immune activation, leaky gut,
malabsorption
IBS, fatigue, sinusitis, joint pains,
eczema, learning disorders,
depression
Gluten Allergies: The Tip of The
Iceberg
Up to 30% of all Australians may be
sensitive to gluten not to mention that
1 in 100-200 have the severe form
called Coeliac Disease.
What’s the big deal? The big deal is
that gluten sensitivity appears to be
associated and may be a contributing
factor with a large number of severe
illnesses
Risks and complications of
Coeliac disease
Osteoporosis
Anaemia
Gastrointestinal and liver cancers
Non-Hodgkin’s lymphoma, risk of
lymphoma is reduced on gluten free
diet
All cause mortality is doubled
Risk of adenocarcinoma is high in
patients with a long period of
untreated disease
Who should be tested? If you have a history of any of the following, it would be
advisable to be tested for gluten sensitivity:
Any autoimmune disease
Osteoarthritis
Any abdominal complaints (chronic diarrhea, constipation, IBS, heartburn)
Asthma, psoriasis or eczema, other unexplained rashes
Mouth ulcers
Hair loss
Neurological disease
Autism, ADHD/ADD
Chronic fatigue, fibromyalgia, depression, any psychiatric disorder
Infertility, recurrent miscarriage
Osteoporosis
Liver disease of any type
Type 1 DM
Thyroid disorders
Testing
Blood Coeliac screen
Gene tests DQ2/DQ8
Small Intestinal Biopsy
Other food intolerance can be
detected with IgG testing
Immune System
GI Immune Enhancers:
Whey protein
Saccharomyces boulardii
Glutamine
Arabinogalactans
Probiotics:
Lactobacillus
Saccharomyces boulardii
Bifidobacteria
Prebiotics : usually unnecessary to
supplement if good diet
Inflammation
Inflammation is behind much chronic
illness
Inflammation / Inflam-ageing
Poor diet and insulin resistance
increase inflammation
C-Reactive Protein
CRP Risk factor for illness- Coronary
events, cancer, depression, diabetes
Produced in liver in response to inflammatory cytokines
Can rise 1000 x with acute inflammation
IL-6
TNF alpha
IL- 1 beta
What is your CRP?
Detoxification
Liver detoxification occurs in two
phases
The process changes fat soluble
toxins into water soluble ones so that
they can be excreted into bile or via
the kidneys
Phase 1 creates intermediary
metabolites that are more toxic and
cause more damage, so many anti
oxidants are required in this process
Detoxification
Phase 2 requires amino acids from
proteins so that the metabolites can
be conjugated and excreted
If any of these are missing, the
process will not occur correctly
Phase 1 can be increased with drugs
and toxins
There is great individuality in the
ability of detoxification enzymes
Alternate
Detoxification Programme
Don’t eat the food
Don’t drink the water
Don’t breathe the air
Heavy Metals
Heavy metals occur in the environment, some vaccines, amalgams, fish, old paint, clothing.
Exposure is common, hard to detox, get hidden away
There is individuality in the ability to detox
Children are especially vulnerable as many heavy metals are neurotoxins and can cross the placenta in utero
Heavy metals act as anti nutrients, blocking or using beneficial nutrients
Heavy Metals
Detoxification of heavy metals can be
with the appropriate mineral
supplementation
DMSA- Dimercaptosuccinic acid
DMPS- 2,3-Dimercapto-1-
propanesulfonic acid
EDTA- Ethylenediaminetetraacetic
acid
Heavy Metal Testing
Hair analysis
Urine challenge – collect urine after IV
DMPS
Oxidative stress
Uses of Oxygen in the Body:
1. Energy Production: Oxygen is used to split carbon-carbon bonds, thereby releasing the stored covalent energy to make ATP
2. Detoxification: Oxygen species are added to toxins to make them more polar for elimination
3. Immune Function & Inflammation: Oxidativebursts are the major weapon of the immune system for defense and repair
4. Hormone Production: Oxygen is used for the biotransformation of steroid hormones
Oxygen and Free Radicals
Unfortunately, the body cannot
completely control its use of oxygen
Whenever oxygen is used some of it is
transformed into free radicals
Free Radical Theory of Ageing
Increased oxidant generation
Declining defenses and repair
Accumulation of the end products of oxidative damage
Advanced Glycosylated End Products
Protein Oxidation
Oxidized LDL, Isoprostane F2, Lipid Peroxides
DNA damage
Effective Treatment
Nutritional Anti-Oxidants (Vit A, C, E)
Glutathione, alpha-Lipoic Acid
Plant-based Anti-Oxidants
Resveratrol
EpiGalloCatechinGallate (EGCG)
Many, many, many others
Mineral Co-Factors
Amino Acid Balance and Protein Digestion
Proper Methylation Function (B-Vitamins)
Neurotransmitter Balance
They affect many processes of the
body including mood, pain, hormone
regulation, digestion, and metabolism.
The balance of NTs can facilitate or
hamper well being and impact the
efficacy of treatments.
Common Neurotransmitter-
related
Conditions Depression
Migraine
Anxiety
Obesity/Overweight
Insomnia
PMS
Irritable Bowel Syndrome
ADD/ADHD
Hypertension
Fibromyalgia
Kryptopyrroles An abnormal production of a group of
chemicals called 'pyrroles', this is called
pyroluria, associated with depression and
other mental health disorders.
The pyrroles rob the body of B6 and Zinc
causing them to be excreted in the urine.
Results in a deficiency of B6 and zinc, which
supplementation can correct.
It is most often seen in females.
It is thought that about 10% of a normal
population has pyroluria, which may cause
symptoms when the patient is stressed.
Symptoms
Frequent ear infections, colds, fevers
and chills.
Fatigue
Nervous exhaustion
Insomnia
Poor memory or inability to think
clearly
Hyperactivity
Seizures
Mood swings
Lack of regular periods in girls
Stretch marks in the skin
Impotence in males
Unusual smelling breath and body odour
Inability to tolerate drugs and alcohol
Cold hands and feet
Abdominal pain
Intolerance to some protein foods
Morning nausea and constipation
Difficulty remembering dreams
Frequent head colds and infections
Addictions
Symptoms Pyrolurics can often be identified by their
appearance:
Pale skin. (A dark skinned pyroluric will
have the lightest skin in the family).
A lack of hair on the head, eye brows and
eye lashes.
Teeth in the upper jaw will often be
overcrowded and poor appearance of tooth
enamel.
White marks on fingernails, opaque and
paper thin.
Acne, eczema, and herpes may also be
present.
Pyroluria
Pyroluria can occur at any age but
appears to be brought on by stress.
It is familial and may be a factor in the
development of mental retardation,
epilepsy, hyper activity and
particularly depression.
A family history of mental illness and
all-girl families especially if there is
also a history of miscarried boys.
Hormones
Hormones are anti inflammatory
Enhance quality of life
May not be necessary after other
areas addressed
Nutritional
Medicine
Diet Food
AllergyNutritional
Deficiency
Dysbiosis
Immune
Dysfunction
Hormones
Leaky
Gut
Detoxification
Inflammatio
n
Insulin
Dysregulatio
n
Heavy Metals
Oxidation
Neurotransmitters
