nyu medical grand rounds clinical vignette andy levy, md pgy-2 march 26, 2013 u nited s tates d...
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![Page 1: NYU Medical Grand Rounds Clinical Vignette Andy Levy, MD PGY-2 March 26, 2013 U NITED S TATES D EPARTMENT OF V ETERANS A FFAIRS](https://reader036.vdocument.in/reader036/viewer/2022082818/56649efe5503460f94c13435/html5/thumbnails/1.jpg)
NYU Medical Grand Rounds Clinical Vignette
Andy Levy, MD
PGY-2
March 26, 2013
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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Mrs. C is a 39 year old Hispanic female patient who presents with intermittent watery diarrhea for 1 year.
Chief Complaint
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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• The patient originally developed diarrhea and low-grade fever 1 year ago after completing a long course of clindamycin for a dental infection. • She was diagnosed with C. difficile colitis via PCR at an outside hospital and discharged on PO metronidazole • She continued to have watery diarrhea despite multiple courses of PO flagyl and PO vancomycin and was hospitalized at outside hospitals three times over the past year for dehydration.
History of Present Illness
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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• On these admissions she was presumed to have recurrent C. difficile infection as stool PCR was positive. •She was most recently discharged 2 weeks prior to this presentation on PO vancomycin, which she took with no improvement in her diarrhea; she was still having 6-10 watery bowel movements daily w/ some diffuse abdominal pain and postprandial nausea•Pt presented to the emergency department with these symptoms
History of Present Illness
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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Additional History
• Past Medical History: None • Past Surgical History: Dental surgery, appendectomy • Social History: Denies tobacco, alcohol and other illicit drug use. Originally from Mexico, came to the US 13 years ago • Family History: Denies family history of IBD • No Known Drug Allergies• Medications: Vancomycin PO 250mg four times daily
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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Physical Examination
• General: Hispanic female, lying in stretcher, no acute distress
• Vital Signs: T: 98.6 BP:91/61 HR:86 RR:16 and O2 sat:100% on RA
•Patient was orthostatic with dry mucous membranes and diffuse mild abdominal tenderness
• Remainder of the physical exam was normal
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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Laboratory Findings
• CBC: WBC 5.0, Hgb 10.8, Plt 350• Basic Metabolic panel: within normal limits• Hepatic panel: within normal limits• INR, PT, PTT within normal limits • C. diff toxin assay negative x 3, PCR negative x 2• No fecal leukocytes, negative stool culture, stool negative for ova and parasites
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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Other Studies
• Chest X-Ray: no infiltrates, effusions, consolidations
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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• Recurrent C. difficile colitis
Differential Diagnosis
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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• Hospital Day 1:– The patient was started on IV hydration, PO
vancomycin and IV metronidazole
• Hospital Day 2:– Flexible sigmoidoscopy showed normal-appearing
colonic mucosa with no evidence of colitis or pseudomembranes
• Hospital Day 3:– Antibiotics were discontinued after C. diff toxin
assays and PCR were negative
Hospital Course
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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• Hospital Day 4:– Colonoscopy with small area of colitis in ascending
colon and small area of proctitis in rectum, but otherwise colonic mucosa and terminal ileum appeared normal
– Biopsies revealed mucosal lymphoid aggregate throughout most of colon and rectum
• Hospital Day 5-7:– The patient was started on cholestyramine and
probiotics with some improvement in diarrhea– She was discharged on HD 7.
Hospital Course
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS
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• Post-infectious IBS
• Microscopic Colitis
Differential Diagnosis
UNITED STATES
DEPARTMENT OF VETERANS
AFFAIRS