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6 Ropinerol7 Epostane8 Nimodipin9 Primidone

10QuetiapineReport Abuse

What is duloxetine?Duloxetine is an antidepressant in a group of drugs called selectiveserotonin and norepinephrine reuptake inhibitors (SSNRIs). Duloxetineaffects chemicals in the brain that may become unbalanced and causedepression.

Duloxetine is used to treat major depressive disorder. It is also used to treat

pain caused by nerve damage in people with diabetes (diabetic neuropathy).Mechanism of Action unknown; however, potentiation of serotonergic andnoradrenergic activity in the CNS is suspected.

What is nesiritide?Nesiritide relaxes and dilates blood vessels, lowering blood pressure.Nesiritide is used to improve breathing in people with congestive heartfailure (CHF).Nesiritide may also be used for purposes other than those listed in thismedication guide

NesiritideClass: Human B-type natriuretic peptideTrade Names:Natrecor

Mechanism of Action:Binds to the particulate guanylate cyclase receptor of vascular smoothmuscle and endothelial cells, leading to dose-dependent reductions inpulmonary capillary wedge pressure and systemic arterial pressure inpatients with heart failure.

What is ziprasidone?

Ziprasidone is an antipsychotic medication. It works by changing the effectsof chemicals in the brain.Ziprasidone is used to manage the symptoms of psychotic disorders such asschizophrenia that may include hearing voices; seeing things or sensingthings that are not there; mistaken beliefs; unusual suspiciousness; orbecoming withdrawn from family and friends. Ziprasidone is also used totreat bipolar mania.

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Mechanism of Action:Antipsychotic activity, apparently because of dopamine and serotoninreceptor antagonism.

Rituximab :

Class: Monoclonal antibodyTrade Names:Rituxan

Mechanism of Action:Rituximab is a monoclonal antibody directed against the CD20 antigen foundon the surface of normal and malignant B lymphocytes. The CD20 antigen isalso expressed on more than 90% of B-cell non-Hodgkin lymphomas (NHL).

Indications and Usage:Relapsed or refractory low-grade or follicular, CD-20 positive, B-cell non-Hodgkin lymphoma.

ContraindicationsIgE-mediated hypersensitivity or anaphylactic reactions to murine proteinsor to any component of this product.

Dipyridamol:

Indications and Usage for DipyridamoleDipyridamole USP tablets are indicated as an adjunct to coumarinanticoagulants in the prevention of postoperative thromboemboliccomplications of cardiac valve replacement.

Mechanism of ActionDipyridamole inhibits the uptake of adenosine into platelets, endothelial cellsand erythrocytes in vitro and in vivo; the inhibition occurs in a dose-dependent manner at therapeutic concentrations (0.5-1.9 g/mL). Thisinhibition results in an increase in local concentrations of adenosine whichacts on the platelet A2-receptor thereby stimulating platelet adenylatecyclase and increasing platelet cyclic-3',5'-adenosine monophosphate(cAMP) levels. Via this mechanism, platelet aggregation is inhibited inresponse to various stimuli such as platelet activating factor (PAF), collagenand adenosine diphosphate (ADP).Dipyridamole inhibits phosphodiesterase (PDE) in various tissues. While the

inhibition of cAMP-PDE is weak, therapeutic levels of dipyridamole inhibitcyclic-3',5'-guanosine monophosphate-PDE (cGMP-PDE), therebyaugmenting the increase in cGMP produced by EDRF (endothelium-derivedrelaxing factor, now identified as nitric oxide).

Precautions with Dipyridamole:GeneralCoronary Artery Disease: Dipyridamole has a vasodilatory effect and should

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be used with caution in patients with severe coronary artery disease (e.g.,unstable angina or recently sustained myocardial infarction). Chest painmay be aggravated in patients with underlying coronary artery disease whoare receiving dipyridamole.Hepatic Insufficiency: Elevations of hepatic enzymes and hepatic failure

have been reported in association with dipyridamole administration.Hypotension: Dipyridamole should be used with caution in patients withhypotension since it can produce peripheral vasodilation

Laboratory TestsDipyridamole has been associated with elevated hepatic enzymes.Drug InteractionsNo pharmacokinetic drug-drug interaction studies were conducted withdipyridamole USP Tablets. The following information was obtained from theliterature.Adenosine: Dipyridamole has been reported to increase the plasma levelsand cardiovascular effects of adenosine. Adjustment of adenosine dosage

may be necessary.Cholinesterase Inhibitors: Dipyridamole may counteract theanticholinesterase effect of cholinesterase inhibitors, thereby potentiallyaggravating myasthenia gravis.